CN106618517A - Method for evaluating arterial elastic function through pulse waves on basis of arm position variation - Google Patents
Method for evaluating arterial elastic function through pulse waves on basis of arm position variation Download PDFInfo
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- CN106618517A CN106618517A CN201611110808.0A CN201611110808A CN106618517A CN 106618517 A CN106618517 A CN 106618517A CN 201611110808 A CN201611110808 A CN 201611110808A CN 106618517 A CN106618517 A CN 106618517A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/02007—Evaluating blood vessel condition, e.g. elasticity, compliance
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7235—Details of waveform analysis
Abstract
The invention discloses a method for evaluating an arterial elastic function through pulse waves on basis of arm position variation. The method comprises the following steps: taking an arm of a subject as a reference arm; taking the other arm as a moving arm; synchronously measuring pulse signals of radial arteries of the two arms; recognizing collected signals by using signal analysis software; for the pulse signal at each testing position of each subject, intercepting pulse signals in set periods according to the starting point, and respectively performing normalization processing on the signals in the set periods; calculating the width of a waveform at the peak of a set percentage of the normalized pulse signals; taking the other arm of the subject as a reference arm for performing the same operation; calculating and analyzing the mean and variance of the peak width of the set percentage in two rounds of repeated experiments of each subject, and quantizing the waveform change conditions of the pulse signals in different positions of the arm, so that the arterial elastic function can be accurately evaluated according to the waveform variation.
Description
Technical field
The present invention relates to signal analysis field, and in particular to a kind of pulse wave assessment artery bullet changed based on arm position
The method of sexual function.
Background technology
Artery is played an important role in cardiovascular physiology and Pathological Physiology.There is artery natural elastic can reflect
Artery performance change under different pressures.The elastic performance of artery is relevant with many clinics and physiologic factor, and wherein artery holds
Product compliance is the parameter of a typical quantitative measurment arterial elasticity.At present the method for assessment arterial elasticity is mainly adopted
Non-invasive mode is used, is corresponding blood vessel Volume Changes to be obtained by the pressure of change blood vessel and is obtained.But due to measurement
The continuous change of diameter, therefore measurement more accurately direct measurement mode cannot be used.
Because pulse wave is affected larger by measurement system noise, and pulse wave signal itself is very faint, therefore existing
Measurement appraisal procedure can make pulse signal that there is poor measurement accuracy, have impact on assessment artery results of property reliability
Property, and do not further investigate pulse signal waveform difference in varied situations.
The problems referred to above are the problems that should be paid attention to and solve during research pulse signal.
The content of the invention
To solve the deficiency that prior art is present, the invention discloses a kind of pulse wave assessment changed based on arm position
The method of arterial elasticity, this method is simple, convenient, it is easy to clinical practice, improves existing method and is difficult to measure, grasps
Situations such as making complicated.
For achieving the above object, concrete scheme of the invention is as follows：
A kind of method that pulse wave changed based on arm position assesses arterial elasticity, comprises the following steps：
Step S1：Using one of arm of measured as arm is referred to, the horizontal level of body side is positioned over；Separately
One arm is motion arm, is in turn fixed in different test angles；
Step S2：The pulse signal of two arm radial arterys of synchro measure；
Step S3：The signal for collecting is identified using signal analysis software；
Step S4：To the pulse signal on each test position of each measured, the pulse letter in setting cycle is intercepted
Number, and respectively this setting periodic signal is normalized to form normalization pulse signal；
Step S5：The width of waveform at the peak value of the setting percentage for calculating normalization pulse signal；
Step S6：Change another arm of measured carries out identical operation, repeat the above steps S1- step as with reference to arm
Rapid S5, is tested again, and the first round experiment of measured terminates；
Step S7：Repeat step S1- step S6, the second wheel experiment of measured terminates；
Step S8：The measurement of above-mentioned steps S1- step S7 is carried out to other multidigit the measured and is processed, calculate each
Measured's two-wheeled repeats the mean value and variance of the spike width of the setting percentage of experiment；
Step S9：Using signal analysis software to motion hand under Difference angles and the peak for setting percentage with reference to hand
Value width value carries out pairing contrast, and to paired comparisons are carried out in diverse location with reference to hand and motion hand parameter P value is obtained, according to
Judge the correlation of the position of arm and the width of pulse signal with reference to P values, assessment then judges position and the artery bullet of arm
The correlation of sexual function.
Further, in step sl, during the pulse signal of two arm radial arterys of measurement, one of hand of measured
Arm is positioned over the horizontal level of body side as arm is referred to；Another arm be motion arm, be in turn fixed to
The horizontal level of body side is relatively in 90 °, 45 °, 0 °, -45 °, in -90 ° of angles, correspondence when measuring Difference angles respectively
Arm radial artery pulse signal.
Further, in step s 2, each angular surveying time phase during the pulse signal of two arm radial arterys of measurement
Together.
Further, in step s 2, in the pulse signal of measurement arm radial artery, each angle needs to meet at this
The pulse signal in setting cycle can be obtained under time of measuring.
Further, in step s3, the signal for collecting is identified using signal analysis software, finds out and mark
The starting point of each pulse cycle.
Further, in step s 4, the pulse signal in setting cycle is intercepted according to starting point.
Further, in step s 4, make after normalized this setting cycle signal have the identical time and
Amplitude, then makes even and is respectively formed normalization pulse signal.
Further, in step s 5, the width of waveform at the peak value of the setting percentage for calculating normalization pulse signal
When, this sets percentage as 60%.
Beneficial effects of the present invention：
The present invention can produce change using the waveform of arm pulse signal in diverse location, by the pulse of motion arm
Signal waveform is contrasted with the pulse signal waveform with reference to arm, the change to arm waveform of pulse signal in diverse location
Change situation is quantified, and arterial elasticity is accurately assessed so as to the variable quantity according to waveform.
The present invention is measured in diverse location to both hands arm to radial artery, the difference between individuality can be eliminated, with operation
The advantages such as simple, high accuracy, it is easy to clinical application, be the later stage arterial elasticity performance researched and proposed it is a kind of new
Method, and provide direction to study vascular diseases from now on.
Description of the drawings
Fig. 1 is instrumentation plan of the arm in diverse location in the present invention；
Fig. 2 (a)-Fig. 2 (e) be the right arm of a certain tested person in the present invention as motion hand, left arm as referring to hand,
In the oscillogram of diverse location；
Fig. 3 (a)-Fig. 3 (b) is the grand mean and variogram that 60% spike width in experiment is repeated twice in the present invention.
Specific embodiment：
Below in conjunction with the accompanying drawings the present invention is described in detail：
Artery sclerosis can make vascular wall be hardened, reduce, follow the string, and thrombus be formed then, due to human pulse signal
Width and arteriosclerosis degree be in negative correlation, i.e., when Degree of arteriosclerosis is high, the speed of pulse raising and lowering is than hard
The blood vessel for changing low degree is fast, the narrowed width of pulse signal is shown as, along with its measuring method is simple and easy to do and does not have
Wound, width value of the pulse signal at 60% is most obvious to the difference of change in location, therefore the application is used at 60% peak value
The width value of waveform is used as one of index for judging ductus arteriosus wall performance.
The elasticity of artery is depended on along the artery wave velocity that arteriogram is propagated, if ignoring the impact of viscosity, arteriogram
Spread speed can be approximately by Bramwell and Hill's equation (Bramwell and Hill equation)：
V is the blood volume of unit length artery, and ρ is density of blood 1050kg/m3, C is arterial volumes compliance.
Can obtain from equation (1), if unknown blood volume or artery radius, absolute arterial volumes cannot get by PWV
Compliance.
But, according to the definition of arterial volumes compliance, Bramwell and Hill's equation can be write：
According to equation (2) and arterial volume dilatancy (Dv), equation below can be obtained：
If the elasticity of peripheral arterial system is big, the blood of greater proportion will be ejected into Peripheral arteries.Therefore arm is elevated
When, blood pressure is reduced, and arterial elasticity becomes big, and radial pulse will have broader impulse waveform.In our study, it was observed that arteries and veins
The width of punching is consistent with above-mentioned theory, and the width value at 60% is most obvious to the difference of change in location, therefore is sentenced by conduct
One of index of disconnected ductus arteriosus wall performance.
The model for describing artery performance change under stress conventional at present is the propositions such as Hardy and Forster
Physiology elasticity indexes model and Langewouters arc tangent models.Used as the function of arterial pressure P, arterial volume dilatancy can
To be expressed as：
Elasticity indexes model：
Langewouters arc tangent models：
a1, a2, a3, b1, b2It is parameter unknown in model, model parameter can adopt the curve in Matlab tool boxes to intend
Conjunction is calculated.Our data are assessed with least square method, our experimental data is very high with the fitting degree of model.
The method of the pulse wave analysis arterial elasticity based on arm in diverse location, for measuring measured or so
Arterial pulse signal at the radial artery of both hands, and then pulse signal is normalized draws normalization waveform, it is described
Method is mainly included the following steps that：
Step one：The tested personnel that 24 men and women's quantity are not waited is chosen, experiment is ready for.
Step 2：Measured is allowed after the quiet 5min that lies in the quiet, environment of constant temperature, first round experiment is proceeded by.
Step 3：It is another using the arm of measured as the 0 ° of position of level being placed in reference to arm with body parallel
Arm has five test positions as motion arm：90°、45°、0°、-45°、-90°.Using equipment by the motion of the measured
Arm is fixed to certain test position, as shown in figure 1, be placed on the 0 ° of position of level with body parallel with reference to arm (left hand),
Motion arm (right hand) is firstly placed on -90 ° of positions, and using piezoelectric transducer the arteries and veins on the two arm radial arterys in left and right is measured simultaneously
Fight signal, time of measuring is 40s.Then motion arm is put on other test positions and is tested, time of measuring is still
40s, repeats the step, and until motion arm completes test on 5 test positions, this measurement terminates.Then referring to hand
Arm is exchanged with action arm, and the test of above-mentioned 5 positions of repetition, first round test terminates.Second wheel test is first round test
Repetition.
Step 4：Pulse starting point mark is carried out to the 20 road signals for collecting using MATLAB softwares, is found out and is often believed all the way
Number pulse starting point.
Step 5：11 continuous cycles are intercepted according to starting point, each cycle is normalized：Amplitude is 1, weight
Sample frequency is 1000.
Step 6：11 normalized signal periodic signals of five positions of each tested person are averaged respectively, are drawn
Go out left and right motion hand and refer to normalization pulse signal of the hand 5 positions, shown in such as Fig. 2 (a)-Fig. 2 (e).
Step 7：The width value of waveform at 60% peak value of the normalization pulse signal obtained in calculation procedure six, and it is right
It is averaging.
Step 8：24 the measured are carried out with the measurement of above-mentioned steps and is processed, drawn out two-wheeled and repeat experiment
The average of waveform widths and standard variance figure (as shown in Fig. 3 (a)-Fig. 3 (b)), average, standard variance and pairing at 60% peak value
Analysis result is as shown in table 1.
Table 1
Step 9：Action hand under diverse location is matched with the 60% peak width angle value with reference to hand using SPSS softwares
Comparative analysis, judges that arm position changes the impact situation changed to pulse wave.
, with reference to comparison of wave shape of the arm on diverse location, wherein Fig. 2 (a) -2 (e) is respectively to joining for motion arm
Hand is examined in 0 ° of position, waveform of the motion arm in 90 °, 45 °, 0 °, -45 °, -90 ° of five various locations, dotted line is reference
Hand waveform, solid line is motion hand waveform.From Fig. 2 (a) -2 (e) as can be seen that motion arm is at 90 °, 45 °, 0 °, -45 °, -90 °
In the time period of five diverse locations, it is basically unchanged with reference to the waveform of arm, and the waveform of motion arm changes very greatly.At 0 °
When, motion arm coincide substantially with the waveform with reference to arm；In 90 °, 45 °, 50% peak value and above position, motion arm
Waveform is significantly wider than the waveform with reference to hand, in -45 °, -90 °, 50% peak value and above position, and the waveform widths of motion arm
Less than the width with reference to hand.In 90 °, 45 °, 0 °, -45 °, -90 ° of five various locations, the waveform of motion arm is in peak value
60% or so width totally progressively reduces, and so as to illustrate, arm position has significantly impact on radial artery waveform.
Calculate 24 measured left and right arm respectively 5 position waveforms 60% spike width grand mean and side
Difference, obtains Fig. 3 (a)-Fig. 3 (b).It with the right hand is to refer to arm that Fig. 3 (a) is, left hand is motion hand, respectively 90 °, 45 °, 0 ° ,-
45 °, the grand mean on -90 ° of five positions and variogram；Accordingly, it with left hand is to refer to arm that Fig. 3 (b) is, the right hand is motion
Grand mean and variogram of the hand on 90 °, 45 °, 0 °, -45 °, -90 ° of five positions.It can be seen that motion arm
60% peak value waveform width progressively reduces on 90 °, 45 °, 0 °, -45 °, -90 ° of five positions, is regular.
Using SPSS softwares, to paired comparisons are carried out in diverse location with reference to hand and motion hand parameter P value, P values are obtained
It is a declining indicator for credible result degree, P values are bigger, and the association that more must not believe that variable in sample is respectively become in totality
The reliability index of amount association.Work as P>When 0.05, both degrees of correlation are represented less, conversely, working as P<When 0.05, represent that both are notable
Related.When left hand in -45 ° and the right hand in 0 °, -45 ° when, P>0.05, both are incoherent, in other positions, P<
0.05, show as significantly correlated.Therefore deduce that, in most cases, the position of arm is with the width of pulse signal
Related, and then say that the position of arm connects each other with the degree of artery sclerosis.
It should be noted that the application is using the most obvious index (at peak value 60%) of difference in numerous indexs, and
The most obvious index of this difference is not the difference of the people with vascular diseases and healthy person, even if being all between healthy person, should
The change of index is also obvious, therefore selects the point to obtain high efficiency in blood vessel assessment.
The present invention is analyzed by the data to collecting, and explores the influence factor of arm pulse signal.Measurement has
The advantages such as operation is simple, high accuracy, are that reliable basis has been established in the research of the pulse signal in later stage.
Although the above-mentioned accompanying drawing that combines is described to the specific embodiment of the present invention, not to present invention protection model
The restriction enclosed, one of ordinary skill in the art should be understood that on the basis of technical scheme those skilled in the art are not
Need the various modifications made by paying creative work or deformation still within protection scope of the present invention.
Claims (8)
1. a kind of method that pulse wave changed based on arm position assesses arterial elasticity, comprises the following steps：
Step S1：Using one of arm of measured as arm is referred to, the horizontal level of body side is positioned over；Another
Arm is motion arm, is in turn fixed in different test angles；
Step S2：The pulse signal of two arm radial arterys of synchro measure；
Step S3：The signal for collecting is identified using signal analysis software；
Step S4：To the pulse signal on each test position of each measured, the pulse signal in setting cycle is intercepted, and
Respectively this setting periodic signal is normalized to form normalization pulse signal；
Step S5：The width of waveform at the peak value of the setting percentage for calculating normalization pulse signal；
Step S6：Change another arm of measured carries out identical operation, repeat the above steps S1- step as with reference to arm
S5, is tested again, and the first round experiment of measured terminates；
Step S7：Repeat step S1- step S6, the second wheel experiment of measured terminates；
Step S8：The measurement of above-mentioned steps S1- step S7 is carried out to other multidigit the measured and is processed, calculate each tested
Person's two-wheeled repeats the mean value and variance of the spike width of the setting percentage of experiment；
Step S9：Using signal analysis software to motion hand under Difference angles and the peak width for setting percentage with reference to hand
Angle value carries out pairing contrast, parameter P value is obtained to paired comparisons are carried out in diverse location with reference to hand and motion hand, according to reference
P values judge the correlation of the position of arm and the width of pulse signal, and assessment then judges position and the arterial elasticity work(of arm
The correlation of energy.
2. the method that a kind of pulse wave changed based on arm position as claimed in claim 1 assesses arterial elasticity, its
It is characterized in that, in step sl, during the pulse signal of two arm radial arterys of measurement, one of arm of measured is used as reference
Arm, is positioned over the horizontal level of body side；Another arm is motion arm, is in turn fixed to and body side
Horizontal level is relatively in 90 °, 45 °, 0 °, -45 °, in -90 ° of angles, corresponding arm oar is moved when measuring Difference angles respectively
The pulse signal of arteries and veins.
3. the method that a kind of pulse wave changed based on arm position as claimed in claim 1 assesses arterial elasticity, its
It is characterized in that, in step s 2, each angular surveying time is identical during the pulse signal of two arm radial arterys of measurement.
4. the method that a kind of pulse wave changed based on arm position as described in claim 1 or 3 assesses arterial elasticity,
It is characterized in that, in step s 2, in the pulse signal of measurement arm radial artery, each angle needs to meet in the time of measuring
The pulse signal in setting cycle can be obtained down.
5. the method that a kind of pulse wave changed based on arm position as claimed in claim 1 assesses arterial elasticity, its
It is characterized in that, in step s3, the signal for collecting is identified using signal analysis software, finds out and mark each pulse week
The starting point of phase.
6. the method that a kind of pulse wave changed based on arm position as described in claim 1 or 5 assesses arterial elasticity,
It is characterized in that, in step s 4, the pulse signal in setting cycle is intercepted according to starting point.
7. the method that a kind of pulse wave changed based on arm position as claimed in claim 1 assesses arterial elasticity, its
It is characterized in that, in step s 4, the signal that this setting cycle is made after normalized has identical time and amplitude, Ran Houqu
It is average to form normalization pulse signal.
8. the method that a kind of pulse wave changed based on arm position as claimed in claim 1 assesses arterial elasticity, its
It is characterized in that, in step s 5, at the peak value of the setting percentage for calculating normalization pulse signal during the width of waveform, the setting hundred
Divide than being 60%.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107622259A (en) * | 2017-10-20 | 2018-01-23 | 山东大学 | A kind of T wave detecting methods, electrocardiogram (ECG) data analysis method and device |
| CN111000537A (en) * | 2019-12-24 | 2020-04-14 | 中国人民解放军陆军军医大学第一附属医院 | Method for correcting influence of age, sex and blood pressure on pulse wave propagation speed |
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Cited By (3)
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| CN107622259A (en) * | 2017-10-20 | 2018-01-23 | 山东大学 | A kind of T wave detecting methods, electrocardiogram (ECG) data analysis method and device |
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| CN111000537A (en) * | 2019-12-24 | 2020-04-14 | 中国人民解放军陆军军医大学第一附属医院 | Method for correcting influence of age, sex and blood pressure on pulse wave propagation speed |
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