CN1066181A - Distillate for skin care - Google Patents

Abstract

This invention distillate for skin care belongs to chemical field.Phytic acid is used for medical raw material, and prevent biting, body infectious agent etc. has report.The present invention relates to phytic acid is primary raw material, adds small amount of N aCl, Na ₂CO ₃It is simple to make the distillate for skin care method, and skin is not had spot, but and skin moistening.

Description

Distillate for skin care

The invention belongs to chemical field.

Phytic acid is used for medical material at present, anti-phage-infect agent etc. has report, with phytic acid is that primary raw material creation skin medicinal liquid Ceng Wei has report, treatments such as the clinical common various skins that cause because of antibacterial, virus, fungus, sarcoptic mite sodium thiosulfate commonly used, glacial acetic acid, Cray azoles frost, sulfur, weak effect is easy to generate drug resistance.The present invention seeks to have stronger inhibitory action to skin superficial part, deep fungal and antibacterial.

Implementation method of the present invention is:

1. in thin planting acid, add NaCl aqueous solution and micro-Na ₂CO ₃Aqueous solution.

Content is about more than 2.6% of medicinal liquid, and the molecular formula of mixed liquor is:

C ₆H ₁₈O ₂₄P ₆+NaCl+Na ₂CO ₃

2. rare mixed liquor adds 7.5% active carbon, after the stirring, in the suction jacket steam pot, heats to 78 ℃, is pressed into then in the filtrate machine and filters.

3. the mixed liquor after filtering is pressed in the vacuum concentration pan, evaporates a large amount of moisture content with 65 ℃ temperature, keeps being dissolved in 45 ℃ of concentrating under reduced pressure again, ends to measuring density 1.35.

4. mixed liquor is pressed in the cooling pan and cools off, and filters with qualitative filter paper then.

5. the mixed liquor after filtering splashes into 0.05 natural fragrant liquid and gets product.

Distillate for skin care quality standard and detection method

Index

The project indicator

The green and brown sugar colour paste liquid of outward appearance

C ₆H ₁₈O ₂₄P ₆≥35%

Phos≤0.02%

Cl ^-Sodium chloride 〉=2.6%

50 ₄-2 sulfate≤0.02%

As arsenic≤0.005%

Pb ^{+ 2}+ X heavy metal≤0.005%

Detection method

1. taking by weighing phytic acid medicinal liquid sample 0.5(± 0.0002g) put into conical flask, add water 100ml, is indicator with phenolphthalein.To pink, be terminal point with 0.1 equivalent NaOH titer titration.

C ₆H ₁₈O ₂₄P ₆Degree (x) is calculated as follows:

x＝ (0.11×V×C)/(G) ×100

In the formula

V-NaOH titer consumption ml

The C-NaOH equivalent is dense to cross (N)

G-example weight gram (g)

0.11-the gram number of every milliequivalent (N) phytic acid medicinal liquid

2. accurately take by weighing sample 0.1g(± 0.0002g) and add the 50ml distilled water, add 0.2N hydrochloric acid again and transfer PH=1.9～2.2, be heated to 60 ℃, add the 1m xylenol orange, use the titration of standard thorium nitrate fast, becoming pink by yellow is terminal point.

x＝ (N·V·0.3300)/(W) ×100

In the formula:

N=Th(No ₃) ₄Standardization equivalent (N)

V=Th(No ₃) ₄The volume that consumes is counted ml

W=example weight (g)

0.3300=work as Th(No for every milligram ₃) ₄The gram number that is equivalent to the phytic acid medicinal liquid.

Determination of inorganic phosphorus

Reagent and solution: 10% ammonia, analytical pure 2.5% ammonium molybdate is got the 12.5g ammonium molybdate and is dissolved in the 100ml hot water, puts in the cold 500ml of pouring into the volumetric flask, is diluted to scale.

10% anti-bad west acid (interim adapted) is dissolved in the 9ml water with the anti-bad western acid of 1g.

5NH ₂SO ₄Solution is got 6.7g gram diluting concentrated sulfuric acid to 50ml.

Assay method: take by weighing 0.1 the gram sample (± 0.0002g) add the 7ml distilled water, be neutralized to PH=7 with 10% ammonia, add 1ml, 5N equivalent H ₂SO ₄, with 0-5 ℃ of this solution cooling, adding the anti-bad west acid of 1ml12.5% molybdenum acid ammonia solution and 1ml10% again after molten 0-5 ℃ in ice is placed 30 minutes, institute is blue color, must not be deeper than standard.

Standard is to get same simultaneously processing of 0.02mg phosphorus (ρ) impurity mark liquid sample.Acetic acid 1ml adds 4% ammonium oxalate solution 5ml and shakes up, and places 10 minutes, and institute is concentration and must not be deeper than reference colour.

Standard is to get impurity titer and the same simultaneously processing of sample.

Sodium chloride is measured: accurately claim the about 0.25(of sample ± 0.0002g) in 250 milliliters of conical flasks, add 50 milliliters in water, add 50 milliliters of 0.1N silver nitrate solutions, 3 milliliters of 3 milliliters in nitric acid and pin base benzene, add after the jolting and mill 2 milliliters of ammonium alum indicators, extremely red with the titration of 0.1N ammonium thiocyanate solution.

Nacl = (V ₁·N ₁- V ₂·N ₂)·0.0 5 8 4.)/(G) ×100

In the formula:

V ₁=institute adds the milliliter number of silver nitrate solution.

V ₂=titration spends the milliliter number of ammonium thiocyanate solution.

N ₁The equivalent concentration of=used silver nitrate solution.

N ₂The equivalent concentration of the used ammonium thiocyanate solution of=titration.

G=takes by weighing the gram number of sample.

Determining sulphate:

Reagent and solution

3NHCl solution, 20%B ₂Cl ₂Solution, 10% ammonia.

Assay method: take by weighing sample 0.5g(± 0.0002g) be dissolved in the 25ml distilled water,, add 1ml with 10% ammonia regulator solution PH=7,3N hydrochloric acid in 30-35 ℃ water-soluble in insulation 10 minutes, add 3ml20%BaCl again ₂Solution shakes up and places the concentration be in 30 minutes and must not go deep into standard.

Standard is to get every milliliter of silver sulfate standard solution and same simultaneously processing of sample that contains 0.1mg.

Determination of Heavy Metal:

Reagent or solution

2: 3 solution of ammonia, the 3N hydrochloric acid solution.

30% glacial acetic acid, saturated hydrogen sulfide water (interim adapted).

Plumbous standard solution: every ml is equivalent to 0.01mg

Assay method: sample thief 2g adds water 10ml and a phenolphthalein indication in the 50ml nessler colorimetric tube, drip an amount of 2: 3 ammonia spirit to solution and show pink.Add 3N hydrochloric acid 4.5ml and make into 25ml with an amount of distilled water, in another 50ml nessler colorimetric tube behind leading standard solution 5ml and the 30% glacial acetic acid 2ml, adding distil water is diluted to 25ml, coupon and standard pipe is added saturated each 10ml of hydrogen sulfide water respectively shake up, and in the dark places 10 minutes.With putting on paper, in top perspective sample color comparison tube, show color and must not go deep into standard pipe.

The mensuration of arsenic:

Reagent and solution

15% potassium iodide, 40% stannous chloride solution, hydrochloric acid, sulphuric acid, arsenic-less metal zinc.

Lead acetate cotton with 5% lead acetate solution impregnation absorbent cotton, is extracted, and is stored in the air-tight bottle.

The every ml of arsenic standard solution is equivalent to the AS of 0.005m.

Assay method: the 1g(that materialses ± 0.1) put into conical flask, add water 23ml15% liquor kalii iodide 5ml, 5 of 40% tin chloride solutions.Shake up, placed 10 minutes, add the 2g arsenic-less metal zinc, on the glass device (Arsenic analyzer) of the lead acetate cotton that installed of packing into immediately and mercuric bromide reagent paper, be positioned over 25-30 ℃ dark place 60 minutes, the pale brown color that the mercuric bromide reagent paper manifests must not be deeper than standard.

Standard is to draw the same simultaneously processing of 1ml titer.

Manufacture method operation of the present invention is few, technology is simple, quality good, non-environmental-pollution, nothing are paid property such as effect, and skin is not had spot, do not recur, but and skin moistening.

Claims (4)

1, the present invention relates to phytic acid is that main material is made skin dew method, it is characterized in that adding in the thin planting acid NaCl aqueous solution and micro-Na ₂CO ₃The molecular formula of aqueous solution is:

C ₆H ₁₈O ₂₄P ₆+NaCl+Na ₂CO ₃。

2, add 7.5% active carbon according to the described rare mixed liquor of claim 1, after the stirring, in the suction jacket steam pot, heat, be pressed into then in the filtrate machine and filter to 78 ℃.

3, be pressed in the vacuum concentration pan according to the mixed liquor after claim 1, the 2 described filtrations, evaporate a large amount of moisture content, keep being dissolved in 45 ℃ of concentrating under reduced pressure again with 65 ℃ temperature.End to measuring density 1.35.

4, be pressed in the cooling pan and cool off according to claim 1,2,3 described mixed liquors, after filtering with qualitative filter paper then, splash into 0.05% natural fragrant liquid and get product.

Matching method:

Phytic acid 35%

Sodium bicarbonate 0.05%

Sodium chloride 2.6-4.8%

Moisture content 62.3%