CN106614609A - Medicine for controlling pests - Google Patents
Medicine for controlling pests Download PDFInfo
- Publication number
- CN106614609A CN106614609A CN201611183386.XA CN201611183386A CN106614609A CN 106614609 A CN106614609 A CN 106614609A CN 201611183386 A CN201611183386 A CN 201611183386A CN 106614609 A CN106614609 A CN 106614609A
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- China
- Prior art keywords
- medicine
- pest control
- control according
- person
- halogen
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Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a medicine for controlling pests. The medicine for controlling the pests contains an attracting-killing agent, wherein the containing one or two 5-member or 6-member heteroaromatic rings or 5-member or 6-member non-aromatic heterocyclic rings independently selected from cycle members of C(=O), SO or S(O)2 and is capable of closing octopamine acceptor sites in invertebrate pests, so as to interfere the neurotransmission of the pests. The medicine disclosed by the invention has the inhibitory activity to the octopamine acceptor sites and can be applied to insects, spiders and larvae and habitats of the insects and the spiders. The compound can react with octopamine acceptors in the insects, the spiders and the larvae of the insects and the spiders so as to interfere the neurotransmission in the insects, the spiders and the larvae of the insects and the spiders but not influence mammals, fish and poultries.
Description
Technical field
The present invention relates to the medicine of pest control, more particularly to a kind of agricultural chemicals methods for making and using same, agricultural chemicals impact elder brother
Octopamine receptor position in worm, spider and larva body.
Background technology
Studied for many years with regard to pesticide activity chemical compound lot and mixture, the research is to obtain a kind of product as mesh
Mark, the product to invertebrate such as insect, spider and its larva have selectivity and to vertebrate for example mammal, fish,
Poultry and other species have the toxicity of very little or nontoxic and noresidue and endanger environment in other respects.There are enough agricultural chemicals to live
Property, the most products with commercial significance, it may have toxicity or to be not the mammal of product target, fish, poultry or its
He has injurious effects at species.For example, organic phosphorus compound and carbamates suppress insect and all animal species
Acetylcholinesterase activity.The formamidine of known Spanon and correlation acts on octopamine receptor in insect body, but by
In the carcinogenicity on vertebrate potential cardiac toxic and on animal and the various impact Er Yicong cities on different insects
Exit on.Additionally, these compounds need very high dosage to some castes.
The content of the invention
In order to solve above-mentioned technical problem, the invention provides a kind of medicine for pest control, including：
Attractant, its composition be comprising one or two be independently selected from C (=O), SO or S (O) 2 ring memberses 5- or
6- person's hetero-aromatic ring or 5- or 6- person's non-aromatic heterocyclic；
Wherein, the attractant can close the octopamine receptor position in invertebrate pests body, so as to disturb the evil
The neurotransmission of worm.
Further, the compound of the 5- or 6- person's hetero-aromatic ring is selected from：1- (2- chlorphenyls)-N- [2- (4,5- dihydros-
1- methyl isophthalic acid H- imidazoles -2- bases) -6- aminomethyl phenyls] -3- (trifluoromethyl) -1H- pyrazoles -5- formamides, 1- (3- Chloro-2-Pyridyles
Base)-N- [2- (4,5- dihydro -1- methyl isophthalic acid H- imidazoles -2- bases) -6- aminomethyl phenyls] -3- (trifluoromethyl) -1H- pyrazoles -5- first
Acid amides or N- [the bromo- 2- of 4- (4,5- dihydro -1- methyl isophthalic acid H- imidazoles -2- bases) -6- aminomethyl phenyls] -1- (2- chlorphenyls) -3- (three
Methyl fluoride) -1H- pyrazoles -5- formamides.
Further, the medicine also includes：
Auxiliary compounds, one kind in surfactant, solid diluent and the liquid diluent of its main component or
Several combinations；
Wherein, the auxiliary compounds enable to the invertebrate pests dehydration death.
Further, the 5- or 6- person's hetero-aromatic ring or 5- or 6- person's non-aromatic heterocyclic optionally by 1-3 R1 replace and/
Or 2-4 R2 replaces.
Further, each R1 independently is H, halogen, C1-C6 haloalkyls, C1-C6 halogenated alkoxies or-CN；And it is every
Individual R3 independently is H, halogen, C1-C6 alkyl, C1-C6 haloalkyls, C3-C6 cycloalkyl, C3-C6 halogenated cycloalkyls, C1-C6
Alkoxyl, C1-C6 halogenated alkoxies ,-CN or-NO2.
Further, R1 is C1-C3 alkyl, and it is optionally optionally substituted by halogen；Each R2 independently is H, CF3, OCF3, halogen
Element or-CN.
Further, the medicine also includes：
Activating agent, it can cause attractant to play a role when the invertebrate pests are touched.
Further, the chlorion that the activating agent is adjusted selected from lipid biosynthesis inhibitors, macrolides, GABA
Channel blocker, juvenile hormone mimics, ryanodine receptor ligands, Octopamine receptor ligands, Mitochondrial electron transport inhibitor
The combination of one or more in thing similar with nereistoxin.
The medicine of the present invention has octopamine receptor position inhibitory activity.Can be applied to insect and spider and its larva and
Their habitat.Octopamine receptor in this compound and insect and spider and its larva body reacts, interference insect, spider and
Neurotransmission in its larva body and do not affect mammal, fish and poultry.
Specific embodiment
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described,
Obviously, described embodiment is only a part of embodiment of the invention, rather than the embodiment of whole.Based in the present invention
Embodiment, the every other embodiment that those of ordinary skill in the art are obtained on the premise of creative work is not made,
Belong to the scope of protection of the invention.
The invention provides a kind of medicine for pest control, including：
Attractant, its composition be comprising one or two be independently selected from C (=O), SO or S (O) 2 ring memberses 5- or 6-
Member's hetero-aromatic ring or 5- or 6- person's non-aromatic heterocyclic；
Wherein, the attractant can close the octopamine receptor position in invertebrate pests body, so as to disturb the evil
The neurotransmission of worm.
Further, the compound of the 5- or 6- person's hetero-aromatic ring is selected from：1- (2- chlorphenyls)-N- [2- (4,5- dihydros-
1- methyl isophthalic acid H- imidazoles -2- bases) -6- aminomethyl phenyls] -3- (trifluoromethyl) -1H- pyrazoles -5- formamides, 1- (3- Chloro-2-Pyridyles
Base)-N- [2- (4,5- dihydro -1- methyl isophthalic acid H- imidazoles -2- bases) -6- aminomethyl phenyls] -3- (trifluoromethyl) -1H- pyrazoles -5- first
Acid amides or N- [the bromo- 2- of 4- (4,5- dihydro -1- methyl isophthalic acid H- imidazoles -2- bases) -6- aminomethyl phenyls] -1- (2- chlorphenyls) -3- (three
Methyl fluoride) -1H- pyrazoles -5- formamides.
Further, the medicine also includes：
Auxiliary compounds, one kind in surfactant, solid diluent and the liquid diluent of its main component or
Several combinations；
Wherein, the auxiliary compounds enable to the invertebrate pests dehydration death.
Further, the 5- or 6- person's hetero-aromatic ring or 5- or 6- person's non-aromatic heterocyclic optionally by 1-3 R1 replace and/
Or 2-4 R2 replaces.
Further, each R1 independently is H, halogen, C1-C6 haloalkyls, C1-C6 halogenated alkoxies or-CN；And it is every
Individual R3 independently is H, halogen, C1-C6 alkyl, C1-C6 haloalkyls, C3-C6 cycloalkyl, C3-C6 halogenated cycloalkyls, C1-C6
Alkoxyl, C1-C6 halogenated alkoxies ,-CN or-NO2.
Further, R1 is C1-C3 alkyl, and it is optionally optionally substituted by halogen；Each R2 independently is H, CF3, OCF3, halogen
Element or-CN.
Further, the medicine also includes：
Activating agent, it can cause attractant to play a role when the invertebrate pests are touched.
Further, the chlorion that the activating agent is adjusted selected from lipid biosynthesis inhibitors, macrolides, GABA
Channel blocker, juvenile hormone mimics, ryanodine receptor ligands, Octopamine receptor ligands, Mitochondrial electron transport inhibitor
The combination of one or more in thing similar with nereistoxin.
The medicine of the present invention has octopamine receptor position inhibitory activity.Can be applied to insect and spider and its larva and
Their habitat.Octopamine receptor in this compound and insect and spider and its larva body reacts, interference insect, spider and
Neurotransmission in its larva body and do not affect mammal, fish and poultry.
The above is the preferred embodiment of the present invention, it is noted that for those skilled in the art
For, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications are also considered as
Protection scope of the present invention.
Claims (8)
1. a kind of medicine for pest control, it is characterised in that include：
Attractant, its composition be comprising one or two be independently selected from C (=O), SO or S (O) 2 ring memberses 5- or 6- person it is miscellaneous
Aromatic ring or 5- or 6- person's non-aromatic heterocyclic；
Wherein, the attractant can close the octopamine receptor position in invertebrate pests body, so as to disturb the insect
Neurotransmission.
2. the medicine for pest control according to claim 1, it is characterised in that the change of the 5- or 6- person's hetero-aromatic ring
Compound is selected from：1- (2- chlorphenyls)-N- [2- (4,5- dihydro -1- methyl isophthalic acid H- imidazoles -2- bases) -6- aminomethyl phenyls] -3- (trifluoros
Methyl) -1H- pyrazoles -5- formamides, 1- (3- chloro-2-pyridyls)-N- [2- (4,5- dihydro -1- methyl isophthalic acid H- imidazoles -2- bases) -
6- aminomethyl phenyls] -3- (trifluoromethyl) -1H- pyrazoles -5- formamides or N- [the bromo- 2- of 4- (4,5- dihydro -1- methyl isophthalic acid H- miaows
Azoles -2- bases) -6- aminomethyl phenyls] -1- (2- chlorphenyls) -3- (trifluoromethyl) -1H- pyrazoles -5- formamides.
3. the medicine for pest control according to claim 1 and 2, it is characterised in that the medicine also includes：
Auxiliary compounds, one or more of its main component in surfactant, solid diluent and liquid diluent
Combination；
Wherein, the auxiliary compounds enable to the invertebrate pests dehydration death.
4. the medicine for pest control according to claim 3, it is characterised in that the 5- or 6- person's hetero-aromatic ring or 5-
Or 6- person's non-aromatic heterocyclic is optionally replaced by 1-3 R1 and/or 2-4 R2 replaces.
5. the medicine for pest control according to claim 4, it is characterised in that each R1 independently be H, halogen,
C1-C6 haloalkyls, C1-C6 halogenated alkoxies or-CN；And each R3 independently is H, halogen, C1-C6 alkyl, C1-C6 halos
Alkyl, C3-C6 cycloalkyl, C3-C6 halogenated cycloalkyls, C1-C6 alkoxyls, C1-C6 halogenated alkoxies ,-CN or-NO2.
6. the medicine for pest control according to claim 4 or 5, it is characterised in that R1 is C1-C3 alkyl, its
Selection of land is optionally substituted by halogen；Each R2 independently is H, CF3, OCF3, halogen or-CN.
7. the medicine for pest control according to claim 6, it is characterised in that the medicine also includes：
Activating agent, it can cause attractant to play a role when the invertebrate pests are touched.
8. the medicine for pest control according to claim 7, it is characterised in that the activating agent is selected from lipids, biological
Synthetic inhibitor, macrolides, the Role of chloride channel blockers of GABA regulations, juvenile hormone mimics, ryanodine receptor are matched somebody with somebody
The combination of one or more in body, Octopamine receptor ligands, Mitochondrial electron transport inhibitor thing similar with nereistoxin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611183386.XA CN106614609A (en) | 2016-12-20 | 2016-12-20 | Medicine for controlling pests |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611183386.XA CN106614609A (en) | 2016-12-20 | 2016-12-20 | Medicine for controlling pests |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106614609A true CN106614609A (en) | 2017-05-10 |
Family
ID=58835062
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611183386.XA Pending CN106614609A (en) | 2016-12-20 | 2016-12-20 | Medicine for controlling pests |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106614609A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1259018A (en) * | 1997-06-06 | 2000-07-05 | 艾科斯迈特技术公司 | Non-hazardous pest control |
| CN1543460A (en) * | 2001-08-15 | 2004-11-03 | ��Ļ���Ű˾ | Ortho-heterocyclic substituted aryl amides for controlling invertebrate pests |
-
2016
- 2016-12-20 CN CN201611183386.XA patent/CN106614609A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1259018A (en) * | 1997-06-06 | 2000-07-05 | 艾科斯迈特技术公司 | Non-hazardous pest control |
| CN1543460A (en) * | 2001-08-15 | 2004-11-03 | ��Ļ���Ű˾ | Ortho-heterocyclic substituted aryl amides for controlling invertebrate pests |
Non-Patent Citations (1)
| Title |
|---|
| 杜晓华 等: "以章鱼胺系统为靶标的选择性杀虫杀螨剂", 《农药》 * |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170510 |