CN106606425A - Anti-microbial moisturizing composition and preparation method and application thereof - Google Patents
Anti-microbial moisturizing composition and preparation method and application thereof Download PDFInfo
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- CN106606425A CN106606425A CN201611015190.XA CN201611015190A CN106606425A CN 106606425 A CN106606425 A CN 106606425A CN 201611015190 A CN201611015190 A CN 201611015190A CN 106606425 A CN106606425 A CN 106606425A
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- compositionss
- bacteria wet
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention provides an anti-microbial moisturizing composition. The anti-microbial moisturizing composition is prepared from the following components based on weight percentage: 5-20% of hydroxyethyl chitin, 1-10% of radical scavenger and the balance of water, wherein the sum of the weight percentages of the components is equal to 100%. The invention also provides a preparation method of the anti-microbial moisturizing composition, wherein the preparation method comprises the steps of adding the hydroxyethyl chitin and the radical scavenger into water; and stirring until the mixture is fully dissolved to obtain the anti-microbial moisturizing composition. The invention also provides an application of the anti-microbial moisturizing composition, wherein the anti-microbial moisturizing composition, used as an anti-microbial moisturizing additive, is applied to cosmetics or preparations for external application. The moisturizing composition, used as replacement or update products of hyaluronic acid and other moisturizing agents, can be used for the cosmetics or preparations for external application and the like; the anti-microbial moisturizing composition has a better moisturizing effect compared with the prior art; and in addition, the anti-microbial moisturizing composition has the characteristics of low preparation cost, good antimicrobial property and the like.
Description
Technical field
The present invention relates to daily cosmetics field, more particularly to a kind of anti-bacteria wet keeping compositionss, more particularly to a kind of conduct
A kind of anti-bacteria wet keeping compositionss of the adding ingredient in cosmetics and other external preparations, and its preparation method and application.
Background technology
Show according to the study, should be containing 10%～20% moisture in the horny layer of human body skin, water deficient becomes can skin
Coarse and crowfoot cracks are obtained, is tarnished and elasticity, therefore, wetting agent becomes the main function raw material of cosmetics and external preparation.Mesh
Before, the conventional wetting agent of cosmetics and external preparation has glycerol, Propylene Glycol, hyaluronic acid etc., wherein performance most preferably hyalomitome
Acid, it has excellent water suction performance of keeping humidity, is particularly suitable for cosmetics and external preparation.Wherein, CN106063769A is disclosed
A kind of cosmetic composition, it contains the triangle of the induction dedifferented of hyaluronic acid oligomer thing and encapsulating safranine flower extract
Prunus mume (sieb.) sieb.et zucc. plant cell；CN106038338A discloses a kind of aloe moisture-keeping essence, its be by aloe juice, glycerol, Herba Centellae,
Hyaluronic acid, collagen protein, vitamin, Citrus extracting solution, Oleum menthae, Brazil wax, Olive oil quintessence, Mel and go from
The raw materials such as sub- water are made.
Although at present, hyaluronic acid is widely used as additive in the field such as cosmetics and external preparation, due to
, by preparing, extracting and the aspect such as purifying process is limited, this causes it to become the original of most expensive in cosmetics and external preparation for it
One of material.Therefore, seek the replacement or regeneration product of hyaluronic acid, obtained both at home and abroad about scholar and the extensive pass of industry
Note.
The content of the invention
It is an object of the invention to provide a kind of anti-bacteria wet keeping compositionss, its as the wetting agents such as hyaluronic acid replacement or change
For product, for products such as cosmetics and external preparations in, with relative to prior art more preferably moistening effect, in addition,
Also there is the features such as preparation cost is cheap, anti-microbial property is good.Further, the object of the invention also includes providing the anti-bacteria wet keeping
The preparation method and application of compositionss, its preparation method simple possible, preparation cost is low, efficiency high；It is widely used.
To achieve these goals, the technical scheme is that：
A kind of anti-bacteria wet keeping compositionss, its component includes ethoxyl chitin, radical scavenger and water.
Specifically, the ethoxyl chitin provides moisturizing, antibacterial action；The radical scavenger provides antioxygen and is turned into
With.
Further, the percentage by weight of the component is：Ethoxyl chitin 5%～20%, radical scavenger 1%～
10%, remaining is water；Each component percentage by weight sum is 100%.
Further, the degree of etherification falling of the ethoxyl chitin is 1.2～1.7, and weight average molecular weight is 100,000～300,000, is taken off
Acetyl degree is 5%～10%.Preferably, when the anti-bacteria wet keeping compositionss are gel state, the etherificate of the ethoxyl chitin
Spend for 1.4～1.6, weight average molecular weight is 150,000～220,000, and deacetylation is 7%.
Further, described radical scavenger be watermiscible vitamin E or other have similar functions act on from
By base trapping agent, preferably watermiscible vitamin E.
Further, the anti-bacteria wet keeping compositionss are that gel state anti-bacteria wet keeping compositionss or liquid anti-bacteria wet keeping are combined
Thing.Wherein, containing 12%～20% ethoxyl chitin in the gel state anti-bacteria wet keeping compositionss；The liquid anti-bacteria wet keeping
Containing 5%～12% ethoxyl chitin in compositionss.
Technical scheme also includes：
A kind of preparation method of anti-bacteria wet keeping compositionss described above, including：
Step 1：Ethoxyl chitin and radical scavenger are added in water；
Step 2：Stir to being completely dissolved, obtain the anti-bacteria wet keeping compositionss.
Further, in the step 1, the ethoxyl chitin and radical scavenger are using the side being dividedly in some parts
Formula is added in water.
Further, in the step 2, first the system that step 1 is obtained is heated to into 60 DEG C～80 DEG C, then stir to
It is completely dissolved, is finally down to room temperature, obtains the anti-bacteria wet keeping compositionss.
Further, the preparation method includes：The ethoxyl chitin and radical scavenger are added batch-wise
In water, and while addition, stirs on one side.
Specifically, obtained anti-bacteria wet keeping compositionss in aforementioned manners, when the percentage by weight of ethoxyl chitin is 12%
When～20%, anti-bacteria wet keeping compositionss are gel state, and when the percentage by weight of ethoxyl chitin is 5%～12%, antibacterial is protected
Wet compositionss are liquid.
Technical scheme also includes：
A kind of application of anti-bacteria wet keeping compositionss described above, including as a kind of anti-bacteria wet keeping agent cosmetics are added to
Or in external preparation.
Ethoxyl chitin is a kind of important derivatives of chitin, and molecular formula is (C10H17NO6) n, with moisture retention, into
Film and it is soluble in water the features such as, can etherifying reagent be etherified under alkaline environment reacts by chitin and oxirane etc.
Arrive, its performance of keeping humidity is better than glycerol and Propylene Glycol, close hyaluronic acid, and preparation process is simple, low production cost；Additionally,
It is special that ethoxyl chitin also retains biocompatibility, biological degradability and broad spectrum antibacterial, the anti-corrosive properties of chitin etc.
Function, can provide electropositive environment, suppress microorganism and the breeding of mushroom.So, ethoxyl chitin is configured to into wetting agent
It is used in cosmetics and external preparation as the replacement or regeneration product of hyaluronic acid, with suppression mushroom and acarid etc. to skin
Endanger, strengthen epidermis cell metabolic function, prevent lipofuscin deposition, maintenance skin injury, promote dermal blood flow and Hemodynamic environment
Advantage not available for the hyaluronic acids such as rate and other wetting agents.Patent CN1931883A of applicant's previously application discloses one
The preparation method of water soluble ethoxyl chitin is planted, heretofore described ethoxyl chitin can be according to the applicant elder generation
What the preparation method disclosed in front patent was obtained, or other preparation methoies obtain, and this is not limited.
It should be noted that present inventor is by improvement component and proportioning, and further make to improving preparation method
The above-mentioned anti-bacteria wet keeping compositionss for finally giving, in actual application, have compared to the anti-bacteria wet keeping agent of prior art
More remarkable anti-bacteria wet keeping effect.
Ethoxyl chitin, radical scavenger and water are configured to gel state or liquid antibacterial by technical scheme
Moisture-keeping composition, can be directly used for cosmetics and external preparation, or use as aqueous product base, cosmetics base material.It is described anti-
The anti-microbial property of bacterium moisture-keeping composition is good, and performance of keeping humidity is better than glycerol and Propylene Glycol, close hyaluronic acid；More importantly it is made
Standby process is simple, raw material sources are extensive, with low cost.
Specific embodiment
The invention provides a kind of anti-bacteria wet keeping compositionss, its component include ethoxyl chitin, radical scavenger and
Water.
In embodiment, the percentage by weight of the component is：Ethoxyl chitin 5%～20%, radical scavenger 1%
～10%, remaining is water；Each component percentage by weight sum is 100%.
In embodiment, the degree of etherification falling of the ethoxyl chitin is 1.2～1.7, and weight average molecular weight is 100,000～300,000,
Deacetylation is 5%～10%.
In embodiment, described radical scavenger be watermiscible vitamin E or other have what similar functions were acted on
Radical scavenger, preferably watermiscible vitamin E.
In embodiment, the anti-bacteria wet keeping compositionss are gel state anti-bacteria wet keeping compositionss or liquid anti-bacteria wet keeping group
Compound.Wherein, containing 12%～20% ethoxyl chitin in the gel state anti-bacteria wet keeping compositionss；The liquid antibacterial is protected
Containing 5%～12% ethoxyl chitin in wet compositionss.
Present invention also offers a kind of preparation method of anti-bacteria wet keeping compositionss described above, including：
Step 1：Ethoxyl chitin and radical scavenger are added in water；
Step 2：Stir to being completely dissolved, obtain the anti-bacteria wet keeping compositionss.
In embodiment, in the step 1, the ethoxyl chitin and radical scavenger adopt what is be dividedly in some parts
Mode is added in water.
In embodiment, in the step 2, first the system that step 1 is obtained is heated to into 60 DEG C～80 DEG C, is then stirred
To being completely dissolved, room temperature is finally down to, obtains the anti-bacteria wet keeping compositionss.
In embodiment, the preparation method includes：The ethoxyl chitin and radical scavenger are added batch-wise
To in water, and while addition, stirs on one side.
Specifically, obtained anti-bacteria wet keeping compositionss in aforementioned manners, when the percentage by weight of ethoxyl chitin is 12%
When～20%, anti-bacteria wet keeping compositionss are gel state, and when the percentage by weight of ethoxyl chitin is 5%～12%, antibacterial is protected
Wet compositionss are liquid.
Present invention also offers a kind of application of anti-bacteria wet keeping compositionss described above, including as a kind of antibacterial
Wetting agent is added in cosmetics or external preparation.
Embodiment 1
A kind of gel state anti-bacteria wet keeping compositionss, its component and its percentage by weight are：18% ethoxyl chitin, 4% from
By base trapping agent and 78% water；Wherein, the degree of etherification falling of the ethoxyl chitin is 1.5, and weight average molecular weight is 190,000, is taken off
Acetyl degree is 7%；
Its preparation method is：18g ethoxyl chitins and 4g watermiscible vitamin Es are dividedly in some parts in 78g water, are to promote dissolving
Speed, can be heated to 60 DEG C～80 DEG C by system, stir and be down to room temperature to after being completely dissolved, and obtain the gel state anti-bacteria wet keeping
Compositionss；
Its performance test results：Antibiotic rate is 67% within 24 hours, and moisturizing rate is 118%（It it is 30 DEG C in ambient temperature, relative humidity is
(R.H) under conditions of 41%）.
Embodiment 2
A kind of gel state anti-bacteria wet keeping compositionss, its component and its percentage by weight are：12% ethoxyl chitin, 3% from
By base trapping agent and 85% water；
Its preparation method is：12g ethoxyl chitins and 3g watermiscible vitamin Es are dividedly in some parts in 85g water, are stirred to complete
Dissolving, obtains the gel state anti-bacteria wet keeping compositionss；
Its performance test results：Antibiotic rate is 58% within 24 hours, and moisturizing rate is 105%（It it is 30 DEG C in ambient temperature, relative humidity is
(R.H) under conditions of 41%）.
Embodiment 3
A kind of liquid anti-bacteria wet keeping compositionss, its component and its percentage by weight are：8% ethoxyl chitin, 2% free radical
Trapping agent and 90% water；Wherein, the degree of etherification falling of the ethoxyl chitin is 1.2, and weight average molecular weight is 130,000, deacetylated
Spend for 5%；
Its preparation method is：8g ethoxyl chitins and 2g watermiscible vitamin Es are dividedly in some parts in 90g water, and are persistently stirred
To being completely dissolved, the liquid anti-bacteria wet keeping compositionss are obtained；
Its performance test results：Antibiotic rate is 45% within 24 hours, and moisturizing rate is 103%（It it is 30 DEG C in ambient temperature, relative humidity is
(R.H) under conditions of 41%）.
Embodiment 4
A kind of liquid anti-bacteria wet keeping compositionss, its component and its percentage by weight are：5% ethoxyl chitin, 1% free radical
Trapping agent and 94% water；
Its preparation method is：5g ethoxyl chitins and 1g watermiscible vitamin Es are dividedly in some parts in 94g water, and are persistently stirred
To being completely dissolved, the liquid anti-bacteria wet keeping compositionss are obtained；
Its performance test results：Antibiotic rate is 42% within 24 hours, and moisturizing rate is 102%（It it is 30 DEG C in ambient temperature, relative humidity is
(R.H) under conditions of 41%）.
It should be noted that under similarity condition, similar moisturizing or the final testing result of bactericidal composition on the market is low
In or equal to the test result in embodiment 1-4, and from raw material and be prepared into originally, existing moisturizing or antibacterial combination
The overall evaluation level of thing is well below anti-bacteria wet keeping compositionss of the present invention.
The specific embodiment of the present invention has been described in detail above, but it is intended only as example, and the present invention is not limited
It is formed on particular embodiments described above.To those skilled in the art, any equivalent modifications that the present invention is carried out and
Replacement is also all among scope of the invention.Therefore, the impartial conversion made without departing from the spirit and scope of the invention and
Modification, all should cover within the scope of the invention.
Claims (10)
1. a kind of anti-bacteria wet keeping compositionss, it is characterised in that its component includes ethoxyl chitin, radical scavenger and water.
2. anti-bacteria wet keeping compositionss according to claim 1, it is characterised in that the percentage by weight of the component is：Hydroxyl
Ethyl chitin 5%～20%, radical scavenger 1%～10%, remaining is water；Each component percentage by weight sum is 100%.
3. anti-bacteria wet keeping compositionss according to claim 1, it is characterised in that the degree of etherification falling of the ethoxyl chitin is
1.2～1.7, weight average molecular weight is 100,000～300,000, and deacetylation is 5%～10%.
4. anti-bacteria wet keeping compositionss according to claim 1, it is characterised in that described radical scavenger is water solublity
Vitamin E.
5. anti-bacteria wet keeping compositionss according to claim 1, it is characterised in that the anti-bacteria wet keeping compositionss are gel state
Anti-bacteria wet keeping compositionss or liquid anti-bacteria wet keeping compositionss.
6. anti-bacteria wet keeping compositionss according to claim 5, it is characterised in that in the gel state anti-bacteria wet keeping compositionss
Containing 12%～20% ethoxyl chitin.
7. anti-bacteria wet keeping compositionss according to claim 5, it is characterised in that contain in the liquid anti-bacteria wet keeping compositionss
There is 5%～12% ethoxyl chitin.
8. a kind of preparation method of anti-bacteria wet keeping compositionss as claimed in claim 1, it is characterised in that include：
Step 1：Ethoxyl chitin and radical scavenger are added in water；
Step 2：Stir to being completely dissolved, obtain the anti-bacteria wet keeping compositionss.
9. preparation method according to claim 8, it is characterised in that in the step 1, the ethoxyl chitin and from
It is added in water by the way of being dividedly in some parts by base trapping agent；In the step 2, the system that step 1 is obtained is added first
Then heat is stirred to being completely dissolved to 60 DEG C～80 DEG C, is finally down to room temperature, obtains the anti-bacteria wet keeping compositionss.
10. a kind of application of anti-bacteria wet keeping compositionss as claimed in claim 1, it is characterised in that it is protected as a kind of antibacterial
Humectant is added in cosmetics or external preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611015190.XA CN106606425A (en) | 2016-11-18 | 2016-11-18 | Anti-microbial moisturizing composition and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611015190.XA CN106606425A (en) | 2016-11-18 | 2016-11-18 | Anti-microbial moisturizing composition and preparation method and application thereof |
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| CN106606425A true CN106606425A (en) | 2017-05-03 |
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| CN201611015190.XA Pending CN106606425A (en) | 2016-11-18 | 2016-11-18 | Anti-microbial moisturizing composition and preparation method and application thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102100650A (en) * | 2011-01-28 | 2011-06-22 | 武汉耦合医学科技有限责任公司 | Gel medical supply for preventing bedsore and preparation method thereof |
| CN104013639A (en) * | 2014-06-20 | 2014-09-03 | 天津嘉氏堂科技有限公司 | Composition with function of repairing skin and gel agent thereof |
-
2016
- 2016-11-18 CN CN201611015190.XA patent/CN106606425A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102100650A (en) * | 2011-01-28 | 2011-06-22 | 武汉耦合医学科技有限责任公司 | Gel medical supply for preventing bedsore and preparation method thereof |
| CN104013639A (en) * | 2014-06-20 | 2014-09-03 | 天津嘉氏堂科技有限公司 | Composition with function of repairing skin and gel agent thereof |
Non-Patent Citations (3)
| Title |
|---|
| 刘永乐等: "甲壳素、壳聚糖的羟乙基化及应用", 《全国海洋生物技术与海洋药物学术会议论文集》 * |
| 胡祖明等: "《化学纤维成形机理的探索：刘兆峰教授团队论文选集》", 31 August 2011, 东华大学出版社 * |
| 赵长峰等: "《老年健康饮食督导》", 31 January 2003, 山东人民出版社 * |
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