CN106604723A8 - It is easier to the improvement of the pharmaceutical preparation of ultrasonic transdermal transfer - Google Patents

It is easier to the improvement of the pharmaceutical preparation of ultrasonic transdermal transfer Download PDF

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Publication number
CN106604723A8
CN106604723A8 CN201580036489.0A CN201580036489A CN106604723A8 CN 106604723 A8 CN106604723 A8 CN 106604723A8 CN 201580036489 A CN201580036489 A CN 201580036489A CN 106604723 A8 CN106604723 A8 CN 106604723A8
Authority
CN
China
Prior art keywords
sodium dihydrogen
formula
dihydrogen phosphate
reduced
easier
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201580036489.0A
Other languages
Chinese (zh)
Other versions
CN106604723A (en
Inventor
小B·K·雷丁
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bkr Ip Holdco LLC
Original Assignee
Bkr Ip Holdco LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bkr Ip Holdco LLC filed Critical Bkr Ip Holdco LLC
Publication of CN106604723A publication Critical patent/CN106604723A/en
Publication of CN106604723A8 publication Critical patent/CN106604723A8/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0047—Sonopheresis, i.e. ultrasonically-enhanced transdermal delivery, electroporation of a pharmacologically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/08—Limbs
    • A61M2210/083—Arms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/10—Trunk

Abstract

A kind of method for changing medicine ultrasound transdermal transfer, methods described is by the excipient solution in improved formulations, wherein described excipient solution mixes with active component, so that excipient solution is modified to be easier to response ultrasound and penetrates skin with faster speed transmission medicine under ultrasonic excitation.A kind of example of excipient change includes：It is changed into the formula that sodium greatly reduces or preservative ingredient is less from the formula of the phosphoric acid sodium dihydrogen of standard, the preparation that sodium dihydrogen phosphate is reduced, thus thoroughly, it includes response sound：Amount of the sodium dihydrogen phosphate in formula is reduced to provide the preparation that a sodium dihydrogen phosphate is reduced；The material is prepared with the formula reduced according to sodium dihydrogen phosphate.
CN201580036489.0A 2014-07-09 2015-07-09 Modification of pharmaceutical preparations to make them more conducive to ultrasonic transdermal delivery Pending CN106604723A (en)

Applications Claiming Priority (17)

Application Number Priority Date Filing Date Title
US201461998788P 2014-07-09 2014-07-09
US201461998790P 2014-07-09 2014-07-09
US61/998,790 2014-07-09
US61/998,788 2014-07-09
US201461999589P 2014-08-01 2014-08-01
US61/999,589 2014-08-01
US201562125837P 2015-02-02 2015-02-02
US62/125,837 2015-02-02
USPCT/US2015/039268 2015-07-06
US2015039272 2015-07-06
USPCT/US2015/039236 2015-07-06
USPCT/US2015/039264 2015-07-06
US2015039236 2015-07-06
US2015039264 2015-07-06
USPCT/US2015/039272 2015-07-06
US2015039268 2015-07-06
PCT/US2015/039831 WO2016004443A2 (en) 2014-07-03 2015-07-09 Modification of pharmaceutical preparations to make them more conducive to ultrasonic transdermal delivery

Publications (2)

Publication Number Publication Date
CN106604723A CN106604723A (en) 2017-04-26
CN106604723A8 true CN106604723A8 (en) 2017-07-07

Family

ID=58994796

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580036489.0A Pending CN106604723A (en) 2014-07-09 2015-07-09 Modification of pharmaceutical preparations to make them more conducive to ultrasonic transdermal delivery

Country Status (4)

Country Link
EP (1) EP3164120A2 (en)
JP (1) JP2017523237A (en)
CN (1) CN106604723A (en)
WO (1) WO2016004443A2 (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050075599A1 (en) * 2001-08-24 2005-04-07 Redding Bruce K. Ultrasonically enhanced saline treatment for burn damaged skin
WO2004060447A2 (en) * 2002-12-31 2004-07-22 Ultra-Sonic Technologies, L.L.C. Transdermal delivery using encapsulated agent activated by ultrasound and/or heat
WO2006091763A2 (en) * 2005-02-24 2006-08-31 Dermisonics, Inc. Ultrasonically assisted dermal or transdermal delivery substance preparation
US20140114234A1 (en) * 2011-03-23 2014-04-24 Bruce K Redding, JR. Systems and Methods for Enhancing the Delivery of Compounds to Skin Pores using Ultrasonic Waveforms

Also Published As

Publication number Publication date
WO2016004443A3 (en) 2016-03-24
EP3164120A2 (en) 2017-05-10
CN106604723A (en) 2017-04-26
JP2017523237A (en) 2017-08-17
WO2016004443A2 (en) 2016-01-07

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Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
CI01 Correction of invention patent gazette

Correction item: Priority

Correct: 61/998,788 2014.07.09 US|61/998,790 2014.07.09 US|61/999,589 2014.08.01 US|62/125,837 2015.02.02 US|PCT/US2015/039236 2015.07.06 US|PCT/US2015/039268 2015.07.06 US|PCT/US2015/039264 2015.07.06 US|PCT/US2015/039272 2015.07.06 US

False: 61/998,788 2014.07.09 US|61/998,790 2014.07.09 US|61/999,589 2014.08.01 US|62/125,837 2015.02.02 US|PCT/US2015/039236 2015.07.06 US|PCT/US2015/039268 2015.07.06 US

Number: 17

Volume: 33

CI01 Correction of invention patent gazette
CI02 Correction of invention patent application

Correction item: Priority

Correct: 61/998,788 2014.07.09 US|61/998,790 2014.07.09 US|61/999,589 2014.08.01 US|62/125,837 2015.02.02 US|PCT/US2015/039236 2015.07.06 US|PCT/US2015/039268 2015.07.06 US|PCT/US2015/039264 2015.07.06 US|PCT/US2015/039272 2015.07.06 US

False: 61/998,788 2014.07.09 US|61/998,790 2014.07.09 US|61/999,589 2014.08.01 US|62/125,837 2015.02.02 US|PCT/US2015/039236 2015.07.06 US|PCT/US2015/039268 2015.07.06 US

Number: 17

Page: The title page

Volume: 33

CI02 Correction of invention patent application
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20170426

WD01 Invention patent application deemed withdrawn after publication