CN106590392A - Water-based OP protecting agent for pharmaceutical packaging and preparation method thereof - Google Patents
Water-based OP protecting agent for pharmaceutical packaging and preparation method thereof Download PDFInfo
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- CN106590392A CN106590392A CN201611049542.3A CN201611049542A CN106590392A CN 106590392 A CN106590392 A CN 106590392A CN 201611049542 A CN201611049542 A CN 201611049542A CN 106590392 A CN106590392 A CN 106590392A
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- aqueouss
- protective agent
- medical packaging
- water
- diisocyanate
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D175/00—Coating compositions based on polyureas or polyurethanes; Coating compositions based on derivatives of such polymers
- C09D175/04—Polyurethanes
- C09D175/06—Polyurethanes from polyesters
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
- C08G18/40—High-molecular-weight compounds
- C08G18/58—Epoxy resins
- C08G18/585—Epoxy resins having sulfur
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D175/00—Coating compositions based on polyureas or polyurethanes; Coating compositions based on derivatives of such polymers
- C09D175/04—Polyurethanes
- C09D175/08—Polyurethanes from polyethers
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D7/00—Features of coating compositions, not provided for in group C09D5/00; Processes for incorporating ingredients in coating compositions
- C09D7/20—Diluents or solvents
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2201/00—Properties
- C08L2201/08—Stabilised against heat, light or radiation or oxydation
Abstract
The invention belongs to the chemical field and relates to a water-based OP protecting agent for pharmaceutical packaging. The water-based OP protecting agent comprises, by mass, 40% to 49.5% of an anionic polyurethane emulsion, 25% to 30% of an ethanol solution having a volume fraction of 95%, 25% to 30% of deionized water and 0.2% to 2% of an antisticking agent. The water-based OP protecting agent is prepared from environmentally friendly raw materials, does not cause the damage to the personnel and pollution on the environment, can meet the requirements of wetting spreading on the aluminum foil without use of a leveling wetting assistant, has low readily oxidizable substance content amd good normal temperature stability, can be operated simply and can form a film having good adhesive force, smoothness and transparency. The OP protecting agent has good temperature resistance.
Description
Technical field
The invention belongs to chemical field, and in particular to for the aqueouss OP protective agent and preparation method thereof of medical packaging.
Background technology
PTP aluminium foils are the important component parts of blister package, and OP protective layers are the important component parts of PTP aluminium foils, its master
It is to make PTP aluminium foil surface lights smooth to act on, and improves the antiacid alkali erosiveness of PTP aluminium foils, extends the shelf-life of medicine, with
And protection printing layer, ink is effectively bonded with Al foil substrate, prevent ink from coming off.
Protective agent used by coating PTP protection foil layers is referred to as OP protective agents.OP protective agents currently used in the market are more
All it is solvent based product, is coated with after the organic solvent dilutings such as front ethyl acetate and uses.Suffer from the drawback that：Ethyl acetate solvent
Highly volatile, is easy to burning and causes production accident in high temperature drying tunnel；Cleaning equipment needs to use organic solvent, organic in recent years
Solvent substantial appreciation of prices, increased production cost；A large amount of solvents are volatized into surrounding enviroment in coating process, strong to environment and human body
Health forms harm, and especially plant operations workman, can cause damage to the liver of human body and nervous system；It is organic used in production
Solvent can not possibly be escaped all from coating in a short time, and with drug packaging, and the organic solvent remained in coating will be by
Gradually volatilize, spread, accumulating in bubble-cap, being adsorbed by medicine, so will then cause the potential safety hazard of drug packaging；Temperature tolerance compared with
Difference, the heat-sealing in high speed blister package medicine produces high temperature, and OP protective agents are easily carbonized and produce pungent taste and color change, this
" greenization " package development trend will not all be met a bit.Also minority aqueous aluminum foil protecting agent uses in test, but generally
Have the following disadvantages：Need during coating with the dilution of the hydrophilic organic solvents such as part ethanol, isopropanol；Due to the surface tension of water
Greatly, shrinkage cavity phenomenon is usually occurred on base material aluminium foil；Aqueous aluminum foil protecting agent drying temperature is higher than solvent-borne type；Thermostability and
Adhesive force is not as good as traditional solvent-borne protective agent etc..
The content of the invention
In view of this, it is an object of the invention to provide a kind of aqueouss OP protective agent for medical packaging.
To realize object above, the technical scheme is that：
For the aqueouss OP protective agent of medical packaging, it is made up of following mass percent component：Anionic polyurethane breast
Liquid 40%～49.5%, volume fraction is 95% ethanol solution 25%～30%, deionized water 25%～30% and antiplastering aid
0.2%～2%；
The Polyurethane Emulsion of Negative-ion Type is prepared from by following mass percent component：Polyhydric alcohol 9.6%～14%,
Bisphenol-s epoxy resin 1.2%～1.75%, diisocyanate 5%～7.5%, polyalcohols chain extender 0.8%～
2.25%th, hydrophilic chain extender 0.8%～1.5%, fatty amines chain extender 0.02%～0.125%, catalyst 0.01%～
0.025% and deionized water 75%～80%.
The bisphenol-s epoxy resin is 185S or 300SS.
Further, the antiplastering aid is wax emulsion.
Further, the polyhydric alcohol is PEPA, polyether polyol, benzoic anhydride polyester polyol, polycaprolactone polyol
One or more in alcohol, polycarbonate polyol.
Further, the diisocyanate is toluene di-isocyanate(TDI), 1,6- hexamethylene diisocyanates, isophorone
Diisocyanate, methyl diphenylene diisocyanate, XDI, naphthalene -1,5- diisocyanate, tetramethyl
One or more in XDI.
Further, the polyalcohols chain extender is ethylene glycol, Propylene Glycol, neopentyl glycol, 1,6- hexanediol, diethyl two
Alcohol, dipropylene glycol, 3- methyl isophthalic acids, 5- pentanediols, 1,3 butylene glycol, BDO, diglycol, trihydroxy methyl third
One or more in alkane, dihydromethyl propionic acid, dimethylolpropionic acid；
Further, the hydrophilic chain extender is ethylenediamine base ethylsulfonic acid sodium.
Further, the fatty amines chain extender be ethylenediamine, isophorone diamine and 4,4 '-diaminourea -3,3 '-dichloro
One or more in diphenyl-methane.
Further, the fatty amines chain extender is by ethylenediamine, isophorone diamine and 4,4 '-diaminourea -3,3 '-dichloro
Diphenyl-methane is according to 3:1:1 quality is formed than proportioning.
Further, the catalyst is one or more in dibutyl tin laurate, stannous octoate, isooctyl acid bismuth.
The present invention also aims to the protectant preparation method of aqueouss OP for medical packaging is protected, including such as
Lower step：
A. the preparation of Polyurethane Emulsion of Negative-ion Type：By polyhydric alcohol and bisphenol-s epoxy resin in 100 DEG C～120 DEG C temperature
The lower vacuum dehydration 2h of degree, is cooled to 70 DEG C～80 DEG C, adds 0.5～1h of di-isocyanate reaction, adds polyalcohols chain extension
Agent and catalyst, react 3～5h at a temperature of 70 DEG C～80 DEG C, and period adds the acetone equivalent to 1～2.5 times of reactant liquor quality
The viscosity of performed polymer is adjusted, then is cooled to 40 DEG C～45 DEG C, add hydrophilic chain extender 10～25min of insulation reaction, add reaction
The water emulsification that 3～5 times of liquid quality, adding fatty amines chain extender carries out rear 30～60min of chain extension, and vacuum distillation goes out acetone and obtains
Polyurethane Emulsion of Negative-ion Type；
B. the protectant preparation of aqueouss OP：By aqueous polyurethane emulsion obtained in step A and ethanol solution, deionized water and
Antiplastering aid is mixed and stirred for uniformly, obtains final product the aqueouss OP protective agent for medical packaging.
The beneficial effects of the present invention is：
(1) the formula material environmental protection of the application, due to as diluent, do not result in only with ethanol personnel injury and
The pollution of environment, while the wetting and spreading on aluminium foil also can be met in the case of without levelling wetting aid.(2) formula
In be not added with the conventional amino resins of traditional OP protective coatings, readily oxidizable substance content is low.(3) formula does not require the use of firming agent,
For one-component coating, ordinary temperature stability is good, simple to operate.(4) film forming postadhesion power, smooth degree and the transparency are good.(5) in formula
Special source materials bisphenol-s epoxy resins used in the aqueous polyurethane emulsion synthesis for using, due to introducing-SO2- pole
Property group, have more preferable adhesive property, heat stability, toughness, dimensional stability and preferable chemistry than bisphenol A type epoxy resin
Stability, its heat distortion temperature improves 60～70 DEG C than bisphenol A type epoxy resin, makes OP protective agents have preferable temperature tolerance.
Specific embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and should not be taken as limiting the scope of the invention.It is unreceipted in preferred embodiment
The experimental technique of actual conditions, generally according to normal condition.Wax emulsion in following examples is purchased from Germany KEIM-ADDITEC
Company, model E-389.
Embodiment 1
For the aqueouss OP protective agent of medical packaging, it is made up of following mass percent component：Anionic polyurethane breast
Liquid 49.5%, volume fraction is 95% ethanol solution 25%, deionized water 25% and wax emulsion 0.5%；
The Polyurethane Emulsion of Negative-ion Type is prepared from by following mass percent component：PEPA (molecular weight
2000) 14%, bisphenol-s epoxy resin 185S 1.75%, toluene di-isocyanate(TDI) 5%, ethylene glycol 2.25%, ethylenediamine base
Ethylsulfonic acid sodium 1.5%, ethylenediamine 0.125%, dibutyl tin laurate 0.025% and deionized water 75.35%.
The protectant preparation method of aqueouss OP for medical packaging, comprises the steps：
A. the preparation of Polyurethane Emulsion of Negative-ion Type：By PEPA and bisphenol-s epoxy resin 185S at 100 DEG C DEG C
At a temperature of vacuum dehydration 2h, be cooled to 70 DEG C, add toluene di-isocyanate(TDI) reaction 0.5h, add ethylene glycol and tin dilaurate
Dibutyl tin, reacts 5h at a temperature of 70 DEG C, and period adds and adjusts the viscous of performed polymer equivalent to the acetone of 2.5 times of reactant liquor quality
Degree, then it is cooled to 45 DEG C, ethylenediamine base ethylsulfonic acid sodium insulation reaction 25min is added, add the water and milk of 5 times of reactant liquor quality
Change, adding ethylenediamine carries out rear chain extension 30min, and vacuum distillation goes out acetone and obtains Polyurethane Emulsion of Negative-ion Type；
B. the protectant preparation of aqueouss OP：By aqueous polyurethane emulsion obtained in step A and ethanol solution, deionized water and
Wax emulsion is mixed and stirred for uniformly, obtains final product the aqueouss OP protective agent for medical packaging.
The aqueouss OP protective agent that the present embodiment is obtained is coated on medical aluminium foil, is dried at 160 DEG C, then takes polyester adhesive
Adhesive tape laterally homogeneously pressing specimen surface, is peeled off rapidly with 160 °～180 ° directions, and protective agent surface is without substantially coming off；Will examination
The protective agent of sample is overlapped with aluminium foil former material, in being placed in heat-sealing instrument, is sealed (heat seal condition：200 DEG C of temperature, pressure 0.2Mpa,
Time 1s), taking-up lets cool, and sample is separated with aluminium foil former material, and observation protective agent surface is without obvious stick-down.
Embodiment 2
For the aqueouss OP protective agent of medical packaging, it is made up of following mass percent component：Anionic polyurethane breast
Liquid 40%, volume fraction is 95% ethanol solution 28%, deionized water 30% and wax emulsion 2%；
The Polyurethane Emulsion of Negative-ion Type is prepared from by following mass percent component：Polyether polyol (molecular weight
2000) 9.67%, bisphenol-s epoxy resin 300SS 1.2%, 1,6- hexamethylene diisocyanates 7.5%, Propylene Glycol
0.8%th, ethylenediamine base ethylsulfonic acid sodium 0.8%, isophorone diamine 0.02%, stannous octoate 0.01% and deionized water
80%.
The protectant preparation method of aqueouss OP for medical packaging, comprises the steps：
A. the preparation of Polyurethane Emulsion of Negative-ion Type：By polyether polyol and bisphenol-s epoxy resin 300SS at 120 DEG C
At a temperature of vacuum dehydration 2h, be cooled to 80 DEG C, add 1,6- hexamethylene diisocyanates reaction 1h, add Propylene Glycol and pungent
Sour stannous, react 3h at a temperature of 80 DEG C, and period adds the viscosity that performed polymer is adjusted equivalent to the acetone of 1 times of reactant liquor quality,
40 DEG C are cooled to again, ethylenediamine base ethylsulfonic acid sodium insulation reaction 10min is added, and add the water emulsification of 3 times of reactant liquor quality, then
Isophorone diamine is added to carry out rear chain extension 60min, vacuum distillation goes out acetone and obtains Polyurethane Emulsion of Negative-ion Type；
B. the protectant preparation of aqueouss OP：By aqueous polyurethane emulsion obtained in step A and ethanol solution, deionized water and
Wax emulsion is mixed and stirred for uniformly, obtains final product the aqueouss OP protective agent for medical packaging.
The aqueouss OP protective agent that the present embodiment is obtained is coated on medical aluminium foil, is dried at 160 DEG C, then takes polyester adhesive
Adhesive tape laterally homogeneously pressing specimen surface, is peeled off rapidly with 160 °～180 ° directions, and protective agent surface is without substantially coming off；Will examination
The protective agent of sample is overlapped with aluminium foil former material, in being placed in heat-sealing instrument, is sealed (heat seal condition：200 DEG C of temperature, pressure 0.2Mpa,
Time 1s), taking-up lets cool, and sample is separated with aluminium foil former material, and observation protective agent surface is without obvious stick-down.
Embodiment 3
For the aqueouss OP protective agent of medical packaging, it is made up of following mass percent component：Anionic polyurethane breast
Liquid 42.7%, volume fraction is 95% ethanol solution 28.5%, deionized water 28.5% and wax emulsion 0.3%；
The Polyurethane Emulsion of Negative-ion Type is prepared from by following mass percent component：PEPA (molecular weight
2000) 10%, benzoic anhydride polyester polyol (molecular weight 1000) 2.5%, bisphenol-s epoxy resin 185S 1.6%, isophorone
Diisocyanate 7.5%, trimethylolpropane 0.4%, dihydromethyl propionic acid 1.6%, ethylenediamine base ethylsulfonic acid sodium 1.35%,
Isophorone diamine 0.04%, dibutyl tin laurate 0.01% and deionized water 75%.
The protectant preparation method of aqueouss OP for medical packaging, comprises the steps：
A. the preparation of Polyurethane Emulsion of Negative-ion Type：By PEPA, benzoic anhydride polyester polyol and bisphenol S type epoxy
Resin 185S vacuum dehydration 2h at a temperature of 120 DEG C, are cooled to 80 DEG C, add isoflurane chalcone diisocyanate reaction 0.5h, then
Trimethylolpropane, dihydromethyl propionic acid and dibutyl tin laurate are added, 3.5h is reacted at a temperature of 80 DEG C, period adds
The viscosity of performed polymer is adjusted equivalent to 2 times of acetone of reactant liquor quality, then is cooled to 45 DEG C, addition ethylenediamine base ethylsulfonic acid sodium
Insulation reaction 10min, adds the water emulsification of 3 times of reactant liquor quality, and adding isophorone diamine carries out rear chain extension 30min, subtracts
Pressure distills out acetone and obtains Polyurethane Emulsion of Negative-ion Type；
B. the protectant preparation of aqueouss OP：By aqueous polyurethane emulsion obtained in step A and ethanol solution, deionized water and
Wax emulsion is mixed and stirred for uniformly, obtains final product the aqueouss OP protective agent for medical packaging.
The aqueouss OP protective agent that the present embodiment is obtained is coated on medical aluminium foil, is dried at 160 DEG C, then takes polyester adhesive
Adhesive tape laterally homogeneously pressing specimen surface, is peeled off rapidly with 160 °～180 ° directions, and protective agent surface is without substantially coming off；Will examination
The protective agent of sample is overlapped with aluminium foil former material, in being placed in heat-sealing instrument, is sealed (heat seal condition：200 DEG C of temperature, pressure 0.2Mpa,
Time 1s), taking-up lets cool, and sample is separated with aluminium foil former material, and observation protective agent surface is without obvious stick-down.
Embodiment 4
For the aqueouss OP protective agent of medical packaging, it is made up of following mass percent component：Anionic polyurethane breast
Liquid 43.3%, volume fraction is 95% ethanol solution 28.25%, deionized water 28.25% and wax emulsion 0.2%；
The Polyurethane Emulsion of Negative-ion Type is prepared from by following mass percent component：PEPA (molecular weight
2000) 9.3%, polycaprolactone polyol (molecular weight 2000) 2%, bisphenol-s epoxy resin 300SS 1.5%, isophorone
Diisocyanate 7.3%, trimethylolpropane 0.3%, 1,4- butanediols 0.9%, dihydromethyl propionic acid 0.5%, tin dilaurate
Dibutyl tin 0.01%, ethylenediamine base ethylsulfonic acid sodium 1.17%, isophorone diamine 0.02% and deionized water 77%.
The protectant preparation method of aqueouss OP for medical packaging, comprises the steps：
A. the preparation of Polyurethane Emulsion of Negative-ion Type：By PEPA, polycaprolactone polyol and bisphenol S type epoxy tree
Fat 300SS vacuum dehydration 2h at a temperature of 110 DEG C, are cooled to 75 DEG C, add isoflurane chalcone diisocyanate reaction 1h, add
Trimethylolpropane, dihydromethyl propionic acid, dimethylolpropionic acid and dibutyl tin laurate, at a temperature of 75 DEG C 4h is reacted,
Period adds and adjusts the viscosity of performed polymer equivalent to the acetone of 1.8 times of reactant liquor quality, then is cooled to 40 DEG C, adds ethylenediamine base
Ethylsulfonic acid sodium insulation reaction 15min, adds the water emulsification of 3.5 times of reactant liquor quality, adds after isophorone diamine carries out
Chain extension 30min, vacuum distillation goes out acetone and obtains Polyurethane Emulsion of Negative-ion Type；
B. the protectant preparation of aqueouss OP：By aqueous polyurethane emulsion obtained in step A and ethanol solution, deionized water and
Wax emulsion is mixed and stirred for uniformly, obtains final product the aqueouss OP protective agent for medical packaging.
The aqueouss OP protective agent that the present embodiment is obtained is coated on medical aluminium foil, is dried at 160 DEG C, then takes polyester adhesive
Adhesive tape laterally homogeneously pressing specimen surface, is peeled off rapidly with 160 °～180 ° directions, and protective agent surface is without substantially coming off；Will examination
The protective agent of sample is overlapped with aluminium foil former material, in being placed in heat-sealing instrument, is sealed (heat seal condition：200 DEG C of temperature, pressure 0.2Mpa,
Time 1s), taking-up lets cool, and sample is separated with aluminium foil former material, and observation protective agent surface is without obvious stick-down.
Embodiment 5
For the aqueouss OP protective agent of medical packaging, it is made up of following mass percent component：Anionic polyurethane breast
Liquid 45%, volume fraction is 95% ethanol solution 27%, deionized water 27% and wax emulsion 1%；
The Polyurethane Emulsion of Negative-ion Type is prepared from by following mass percent component：Benzoic anhydride polyester polyol (point
Son amount 2000) 5.2%, benzoic anhydride polyester polyol (molecular weight 1000) 5.2%, bisphenol-s epoxy resin 300SS 1.6%, 1,
6- hexamethylene diisocyanates 3.2%, isophorone diisocyanate 3.2%, trimethylolpropane 0.4%, 1,4- fourths two
Alcohol 0.8%, neopentyl glycol 0.4%, dihydromethyl propionic acid 0.6%, stannous octoate 0.015%, ethylenediamine base ethylsulfonic acid sodium
1.35%th, isophorone diamine 0.035% and water 78%.
The protectant preparation method of aqueouss OP for medical packaging, comprises the steps：
A. the preparation of Polyurethane Emulsion of Negative-ion Type：Benzoic anhydride polyester polyol and bisphenol-s epoxy resin 300SS are existed
Vacuum dehydration 2h at a temperature of 115 DEG C, is cooled to 80 DEG C, adds 1,6- hexamethylene diisocyanates, the Carbimide. of isophorone two
Ester reacts 1h, neopentyl glycol, BDO, trimethylolpropane, dihydromethyl propionic acid and stannous octoate is added, at 75 DEG C
At a temperature of react 4h, period adds and adjusts the viscosity of performed polymer equivalent to the acetone of 2.2 times of reactant liquor quality, then is cooled to 42
DEG C, ethylenediamine base ethylsulfonic acid sodium insulation reaction 15min is added, the water emulsification of 4 times of reactant liquor quality is added, add different Fo Er
Ketone diamidogen carries out rear chain extension 45min, and vacuum distillation goes out acetone and obtains Polyurethane Emulsion of Negative-ion Type；
B. the protectant preparation of aqueouss OP：By aqueous polyurethane emulsion obtained in step A and ethanol solution, deionized water and
Wax emulsion is mixed and stirred for uniformly, obtains final product the aqueouss OP protective agent for medical packaging.
The aqueouss OP protective agent that the present embodiment is obtained is coated on medical aluminium foil, is dried at 160 DEG C, then takes polyester adhesive
Adhesive tape laterally homogeneously pressing specimen surface, is peeled off rapidly with 160 °～180 ° directions, and protective agent surface is without substantially coming off；Will examination
The protective agent of sample is overlapped with aluminium foil former material, in being placed in heat-sealing instrument, is sealed (heat seal condition：200 DEG C of temperature, pressure 0.2Mpa,
Time 1s), taking-up lets cool, and sample is separated with aluminium foil former material, and observation protective agent surface is without obvious stick-down.
Embodiment 6
For the aqueouss OP protective agent of medical packaging, it is made up of following mass percent component：Anionic polyurethane breast
Liquid 49.5%, volume fraction is 95% ethanol solution 25%, deionized water 25% and wax emulsion 0.5%；
The Polyurethane Emulsion of Negative-ion Type is prepared from by following mass percent component：Polycarbonate polyol (point
Son amount 2000) 2.4%, benzoic anhydride polyester polyol (molecular weight 1000) 7.2%, bisphenol-s epoxy resin 185S 1.75%, two
Methylenebis phenyl isocyanate 5%, isophorone diisocyanate 2.5%, trimethylolpropane 1.25%, neopentyl glycol 1%,
Isooctyl acid bismuth 0.025%, ethylenediamine base ethylsulfonic acid sodium 1.5%, isophorone diamine 0.125% and deionized water
78.875%.
The protectant preparation method of aqueouss OP for medical packaging, comprises the steps：
A. the preparation of Polyurethane Emulsion of Negative-ion Type：By polycarbonate polyol 2.5%, benzoic anhydride polyester polyol and bis-phenol
S type epoxy resin 185S vacuum dehydration 2h at a temperature of 120 DEG C, are cooled to 80 DEG C, add methyl diphenylene diisocyanate, different
Isophorone diisocyanate reacts 1h, adds trimethylolpropane, neopentyl glycol and isooctyl acid bismuth, reacts at a temperature of 75 DEG C
5h, period adds and adjusts the viscosity of performed polymer equivalent to the acetone of 1.9 times of reactant liquor quality, then is cooled to 42 DEG C, adds second two
Amido ethylsulfonic acid sodium insulation reaction 15min, adds the water emulsification of 4 times of reactant liquor quality, and adding isophorone diamine is carried out
Chain extension 45min afterwards, vacuum distillation goes out acetone and obtains Polyurethane Emulsion of Negative-ion Type；
B. the protectant preparation of aqueouss OP：By aqueous polyurethane emulsion obtained in step A and ethanol solution, deionized water and
Wax emulsion is mixed and stirred for uniformly, obtains final product the aqueouss OP protective agent for medical packaging.
The aqueouss OP protective agent that the present embodiment is obtained is coated on medical aluminium foil, is dried at 160 DEG C, then takes polyester adhesive
Adhesive tape laterally homogeneously pressing specimen surface, is peeled off rapidly with 160 °～180 ° directions, and protective agent surface is without substantially coming off；Will examination
The protective agent of sample is overlapped with aluminium foil former material, in being placed in heat-sealing instrument, is sealed (heat seal condition：200 DEG C of temperature, pressure 0.2Mpa,
Time 1s), taking-up lets cool, and sample is separated with aluminium foil former material, and observation protective agent surface is without obvious stick-down.
Embodiment 7
For the aqueouss OP protective agent of medical packaging, it is made up of following mass percent component：Anionic polyurethane breast
Liquid 43%, volume fraction is 95% ethanol solution 30%, deionized water 26% and wax emulsion 1%；
The Polyurethane Emulsion of Negative-ion Type is prepared from by following mass percent component：Benzoic anhydride polyester polyol (point
Son amount 1000) 4.8%, polycaprolactone polyol (molecular weight 2000) 3.6%, polycarbonate polyol (molecular weight 2000)
3.2%th, bisphenol-s epoxy resin 300SS 1.2%, XDI 2%, naphthalene -1,5- diisocyanate
2%th, tetramethylxylylene diisocyanate 1%, 1,6-HD 0.15%, diethylene glycol 0.15%, dipropylene glycol
0.1%th, 3- methyl isophthalic acids, 5- pentanediols 0.3%, 1,3 butylene glycol 0.1%, ethylenediamine base ethylsulfonic acid sodium 1.345%, ethylenediamine
0.03%th, isophorone diamine 0.01%, 4,4 '-diaminourea -3,3 '-dichloro diphenyl methane 0.01%, di lauric dibutyl
Stannum 0.01%, stannous octoate 0.005%, isooctyl acid bismuth 0.01% and deionized water 79.98%.
The protectant preparation method of aqueouss OP for medical packaging, comprises the steps：
A. the preparation of Polyurethane Emulsion of Negative-ion Type：Benzoic anhydride polyester polyol, polycaprolactone polyol, Merlon is more
The first alcohol and bisphenol-s epoxy resin 300SS vacuum dehydration 2h at a temperature of 105 DEG C, is cooled to 72 DEG C, adds phenylenedimethylidyne two
Isocyanates, naphthalene -1,5- diisocyanate, tetramethylxylylene diisocyanate reaction 1h, add 1,6 hexanediol,
Diethylene glycol, dipropylene glycol, 3- methyl isophthalic acids, it is 5- pentanediols, 1,3 butylene glycol, dibutyl tin laurate, stannous octoate, different pungent
Sour bismuth, reacts 4h at a temperature of 75 DEG C, and period adds the viscosity that performed polymer is adjusted equivalent to the acetone of 1.6 times of reactant liquor quality,
42 DEG C are cooled to again, ethylenediamine base ethylsulfonic acid sodium insulation reaction 10min is added, and add the water emulsification of 5 times of reactant liquor quality, then
Add ethylenediamine, isophorone diamine and 4,4 '-diaminourea -3 that rear chain extension 30min is carried out in 3 '-dichloro diphenyl methane, reduce pressure
Distill out acetone and obtain Polyurethane Emulsion of Negative-ion Type；
B. the protectant preparation of aqueouss OP：By aqueous polyurethane emulsion obtained in step A and ethanol solution, deionized water and
Wax emulsion is mixed and stirred for uniformly, obtains final product the aqueouss OP protective agent for medical packaging.
The aqueouss OP protective agent that the present embodiment is obtained is coated on medical aluminium foil, is dried at 160 DEG C, then takes polyester adhesive
Adhesive tape laterally homogeneously pressing specimen surface, is peeled off rapidly with 160 °～180 ° directions, and protective agent surface is without substantially coming off；Will examination
The protective agent of sample is overlapped with aluminium foil former material, in being placed in heat-sealing instrument, is sealed (heat seal condition：200 DEG C of temperature, pressure 0.2Mpa,
Time 1s), taking-up lets cool, and sample is separated with aluminium foil former material, and observation protective agent surface is without obvious stick-down.
Embodiment 8
For the aqueouss OP protective agent of medical packaging, it is made up of following mass percent component：Anionic polyurethane breast
Liquid 46%, volume fraction is 95% ethanol solution 28.3%, deionized water 25.5% and wax emulsion 0.2%；
The Polyurethane Emulsion of Negative-ion Type is prepared from by following mass percent component：Polycarbonate polyol (point
Son amount 2000) 14%, bisphenol-s epoxy resin 185S 1.75%, naphthalene -1,5- diisocyanate 7.475%, a contracting diethyl two
Alcohol 0.3%, dihydromethyl propionic acid 0.2%, dimethylolpropionic acid 0.2%, ethylenediamine base ethylsulfonic acid sodium 1%, 4,4 '-diamino
Base -3,3 '-dichloro diphenyl methane 0.05%, stannous octoate 0.025% and deionized water 75%.
The protectant preparation method of aqueouss OP for medical packaging, comprises the steps：
A. the preparation of Polyurethane Emulsion of Negative-ion Type：By polycarbonate polyol and bisphenol-s epoxy resin 185S 110
Vacuum dehydration 2h at a temperature of DEG C, is cooled to 75 DEG C, adds naphthalene -1,5- di-isocyanate reaction 0.5h to add a contracting diethyl two
Alcohol, dihydromethyl propionic acid, dimethylolpropionic acid and stannous octoate, react 4h at a temperature of 70 DEG C, and period is added equivalent to reaction
The acetone that 1 times of liquid quality adjusts the viscosity of performed polymer, then is cooled to 40 DEG C, addition ethylenediamine base ethylsulfonic acid sodium insulation reaction
18min, adds the water emulsification of 3 times of reactant liquor quality, adds 4, and 4 '-diaminourea -3,3 '-dichloro diphenyl methane carries out rear chain extension
30min, vacuum distillation goes out acetone and obtains Polyurethane Emulsion of Negative-ion Type；
B. the protectant preparation of aqueouss OP：By aqueous polyurethane emulsion obtained in step A and ethanol solution, deionized water and
Wax emulsion is mixed and stirred for uniformly, obtains final product the aqueouss OP protective agent for medical packaging.
The aqueouss OP protective agent that the present embodiment is obtained is coated on medical aluminium foil, is dried at 160 DEG C, then takes polyester adhesive
Adhesive tape laterally homogeneously pressing specimen surface, is peeled off rapidly with 160 °～180 ° directions, and protective agent surface is without substantially coming off；Will examination
The protective agent of sample is overlapped with aluminium foil former material, in being placed in heat-sealing instrument, is sealed (heat seal condition：200 DEG C of temperature, pressure 0.2Mpa,
Time 1s), taking-up lets cool, and sample is separated with aluminium foil former material, and observation protective agent surface is without obvious stick-down.
Finally illustrate, above example is only unrestricted to illustrate technical scheme, although with reference to compared with
Good embodiment has been described in detail to the present invention, it will be understood by those within the art that, can be to the skill of the present invention
Art scheme is modified or equivalent, and without deviating from the objective and scope of technical solution of the present invention, it all should cover at this
In the middle of the right of invention.
Claims (10)
1. the aqueouss OP protective agent of medical packaging is used for, it is characterised in that be made up of following mass percent component：Anionic
Polyaminoester emulsion 40%～49.5%, volume fraction is 95% ethanol solution 25%～30%, deionized water 25%～30%
With antiplastering aid 0.2%～2%；
The Polyurethane Emulsion of Negative-ion Type is prepared from by following mass percent component：Polyhydric alcohol 9.6%～14%, bis-phenol
S types epoxy resin 1.2%～1.75%, diisocyanate 5%～7.5%, polyalcohols chain extender 0.8%～2.25%, parent
Water chain extender 0.8%～1.5%, fatty amines chain extender 0.02%～0.125%, catalyst 0.01%～0.025% and go
Ionized water 75%～80%.
2. the aqueouss OP protective agent of medical packaging is used for according to claim 1, it is characterised in that the antiplastering aid is wax breast
Liquid.
3. the aqueouss OP protective agent of medical packaging is used for according to claim 1, it is characterised in that the polyhydric alcohol is polyester
One or more in polyhydric alcohol, polyether polyol, benzoic anhydride polyester polyol, polycaprolactone polyol, polycarbonate polyol.
4. the aqueouss OP protective agent of medical packaging is used for according to claim 1, it is characterised in that the diisocyanate is
Toluene di-isocyanate(TDI), 1,6- hexamethylene diisocyanates, isoflurane chalcone diisocyanate, diphenylmethane diisocyanate
One kind in ester, XDI, naphthalene -1,5- diisocyanate, tetramethylxylylene diisocyanate
Or it is various.
5. the aqueouss OP protective agent of medical packaging is used for according to claim 1, it is characterised in that the polyalcohols chain extension
Agent be ethylene glycol, Propylene Glycol, neopentyl glycol, 1,6- hexanediol, diethylene glycol, dipropylene glycol, 3- methyl isophthalic acids, 5- pentanediols, 1,
3- butanediols, BDO, diglycol, in trimethylolpropane, dihydromethyl propionic acid, dimethylolpropionic acid
Plant or various.
6. the aqueouss OP protective agent of medical packaging is used for according to claim 1, it is characterised in that the hydrophilic chain extender is
Ethylenediamine base ethylsulfonic acid sodium.
7. the aqueouss OP protective agent of medical packaging is used for according to claim 1, it is characterised in that the fatty amines chain extension
Agent is ethylenediamine, isophorone diamine and 4,4 '-diaminourea -3,3 ' one or more in-dichloro diphenyl methane.
8. the aqueouss OP protective agent of medical packaging is used for according to claim 7, it is characterised in that the fatty amines chain extension
Agent is by ethylenediamine, isophorone diamine and 4,4 '-diaminourea -3,3 '-dichloro diphenyl methane is according to 3:1:1 quality is than proportioning
Into.
9. the aqueouss OP protective agent of medical packaging is used for according to claim 1, it is characterised in that the catalyst is February
One or more in dilaurylate, stannous octoate, isooctyl acid bismuth.
10. the protectant preparation method of aqueouss OP for medical packaging described in claim 1, it is characterised in that include as
Lower step：
A. the preparation of Polyurethane Emulsion of Negative-ion Type：By polyhydric alcohol and bisphenol-s epoxy resin at a temperature of 100 DEG C～120 DEG C
Vacuum dehydration 2h, is cooled to 70 DEG C～80 DEG C, adds 0.5～1h of di-isocyanate reaction, add polyalcohols chain extender and
Catalyst, reacts 3～5h at a temperature of 70 DEG C～80 DEG C, and period adds and adjusted equivalent to the acetone of 1～2.5 times of reactant liquor quality
The viscosity of performed polymer, then it is cooled to 40 DEG C～45 DEG C, hydrophilic chain extender 10～25min of insulation reaction is added, add reactant liquor matter
3～5 times of water emulsification of amount, adding fatty amines chain extender carries out rear 30～60min of chain extension, vacuum distillation go out acetone obtain it is cloudy from
Subtype polyaminoester emulsion；
B. the protectant preparation of aqueouss OP：By aqueous polyurethane emulsion obtained in step A and ethanol solution, deionized water and anti-stick
Agent is mixed and stirred for uniformly, obtains final product the aqueouss OP protective agent for medical packaging.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611049542.3A CN106590392A (en) | 2016-11-25 | 2016-11-25 | Water-based OP protecting agent for pharmaceutical packaging and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611049542.3A CN106590392A (en) | 2016-11-25 | 2016-11-25 | Water-based OP protecting agent for pharmaceutical packaging and preparation method thereof |
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| Publication Number | Publication Date |
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| CN106590392A true CN106590392A (en) | 2017-04-26 |
Family
ID=58593091
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611049542.3A Pending CN106590392A (en) | 2016-11-25 | 2016-11-25 | Water-based OP protecting agent for pharmaceutical packaging and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110832000A (en) * | 2018-03-22 | 2020-02-21 | 南京邦鼎生物科技有限公司 | Composition and method for preparing film and application thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103450778A (en) * | 2013-08-20 | 2013-12-18 | 广东新供销天保再生资源发展有限公司 | Waterborne OP protective agent for PTP aluminum foils for foods and drugs and preparation method thereof |
| CN104017532A (en) * | 2014-06-27 | 2014-09-03 | 重庆中科力泰高分子材料股份有限公司 | High-strength solvent-free polyurethane adhesive and preparation method thereof |
| CN105086915A (en) * | 2015-08-31 | 2015-11-25 | 重庆中科力泰高分子材料股份有限公司 | Aqueous VC binder used for pharmaceutical packaging and preparation method thereof |
| CN105131243A (en) * | 2015-08-31 | 2015-12-09 | 重庆中科力泰高分子材料股份有限公司 | Epoxy-modified sulfonic waterborne polyurethane emulsion and preparing method and application thereof |
-
2016
- 2016-11-25 CN CN201611049542.3A patent/CN106590392A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103450778A (en) * | 2013-08-20 | 2013-12-18 | 广东新供销天保再生资源发展有限公司 | Waterborne OP protective agent for PTP aluminum foils for foods and drugs and preparation method thereof |
| CN104017532A (en) * | 2014-06-27 | 2014-09-03 | 重庆中科力泰高分子材料股份有限公司 | High-strength solvent-free polyurethane adhesive and preparation method thereof |
| CN105086915A (en) * | 2015-08-31 | 2015-11-25 | 重庆中科力泰高分子材料股份有限公司 | Aqueous VC binder used for pharmaceutical packaging and preparation method thereof |
| CN105131243A (en) * | 2015-08-31 | 2015-12-09 | 重庆中科力泰高分子材料股份有限公司 | Epoxy-modified sulfonic waterborne polyurethane emulsion and preparing method and application thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110832000A (en) * | 2018-03-22 | 2020-02-21 | 南京邦鼎生物科技有限公司 | Composition and method for preparing film and application thereof |
| CN110832000B (en) * | 2018-03-22 | 2020-06-19 | 南京邦鼎生物科技有限公司 | Composition and method for preparing film and application thereof |
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