CN106562974A - BiscarpamontamineA-containing medicine for inhibiting acute inflammation - Google Patents
BiscarpamontamineA-containing medicine for inhibiting acute inflammation Download PDFInfo
- Publication number
- CN106562974A CN106562974A CN201610925053.3A CN201610925053A CN106562974A CN 106562974 A CN106562974 A CN 106562974A CN 201610925053 A CN201610925053 A CN 201610925053A CN 106562974 A CN106562974 A CN 106562974A
- Authority
- CN
- China
- Prior art keywords
- biscarpamontaminea
- medicine
- scutellarein
- acute inflammation
- containing medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses BiscarpamontamineA-containing medicine for inhibiting acute inflammation. Active ingredients of the medicine comprise BiscarpamontamineA, and also comprise scutellarein. Through the combined application of the BiscarpamontamineA and the scutellarein, experiment results prove that the BiscarpamontamineA and the scutellarein have good effects on inhibiting the acute inflammation at the ratio of (5:1) to (8:1).
Description
Technical field
The present invention relates to a kind of be used to suppress acutely inflamed medicine comprising BiscarpamontamineA, belong to medical skill
Art field.
Background technology
BiscarpamontamineA is published in Biscarpamontamines A and B, an Aspidosperma
Iboga Bisindole Alkaloid and an Aspidosperma−Aspidosperma Bisindole Alkaloid,
from Tabernaemontana sphaerocarpa J. Nat. Prod., 2009, 72 (9), 1686–1690。
Publication Date (Web): August 27, 2009.BiscarpamontamineA be it is a kind of have two it is new
Bisindole alkaloid, with brand-new skeleton.It is found by the applicant that BiscarpamontamineA and scutellarein synergy pair
There is good effect in acute inflammation is suppressed.
The content of the invention
For the problem that above-mentioned prior art is present, the present invention provides a kind of BiscarpamontamineA that includes to be used to press down
Make acutely inflamed medicine.
To achieve these goals, the technical solution used in the present invention is：It is a kind of to use comprising BiscarpamontamineA
In suppressing acutely inflamed medicine, effective ingredient to include BiscarpamontamineA, structural formula is as follows：
Effective ingredient includes also including scutellarein.
Calculate according to weight, BiscarpamontamineA and scutellarein ratio are 1:1-20:1.
One kind that the present invention is provided is used to suppress the acutely inflamed medicine of red swollen feet comprising BiscarpamontamineA,
By BiscarpamontamineA and scutellarein use in conjunction, test result indicate that, BiscarpamontamineA and open country
Baicalin is 5:1-8:1 has good cooperative effect for suppression acute inflammation.
Specific embodiment
Described above is only the general introduction of technical solution of the present invention, in order to better understand the technological means of the present invention,
And can be practiced according to the content of description and ordinary skill in the art means, the animal experiment example of the present invention is done below
It is described in further detail.
Chinese:Scutellarein, No. CAS:529-53-3, the companies such as one hundred extraction bio tech ltd are planted in Nanjing to be had
Sell.
The preparation method of compound BiscarpamontamineA involved in the present invention is referring to document：
（Biscarpamontamines A and B, an Aspidosperma−Iboga Bisindole Alkaloid and an
Aspidosperma−Aspidosperma Bisindole Alkaloid, from Tabernaemontana
sphaerocarpa J. Nat. Prod., 2009, 72 (9), 1686–1690。Publication Date (Web):
August 27, 2009）.
Pharmacodynamics test is studied
Modeling：The male white mouse that 210 body weight are 28～30g is taken, 21 groups, 10 per group are randomly divided into.Use 1% agar
Liquid medicine is subcutaneously injected in the left back sufficient plantar middle part of every white mice, is caused scorching.30min after inflammation is caused to carry out muscle respectively to white mice
Inject corresponding medicine.Blank group is to saline.
Experimental technique：1h, 4h, 8h before and after inflammation is caused to survey left and right metapedes volume with volumetric method.Ask swollen with the sufficient difference in volume in left and right
Swollen rate, and matched group and each medicine group are compared, curative effect (p of each medicine group of table 1 to white mice foot swelling caused by agar<
0.05)。
A is BiscarpamontamineA, and B is scutellarein.
Test result indicate that：BiscarpamontamineA and scutellarein are 5:1-8:The foot swelling rate of 1 group of rat is equal
Substantially less than blank group and its other groups.It can be seen that BiscarpamontamineA and scutellarein are 5:1-8:1 is swollen for suppression
Swollen acute inflammation has good cooperative effect.
Claims (3)
1. it is a kind of to be used to suppress acutely inflamed medicine comprising BiscarpamontamineA, it is characterised in that effective ingredient bag
BiscarpamontamineA is included, structural formula is as follows：
2. a kind of BiscarpamontamineA that includes according to claim 1 is used to suppress acutely inflamed medicine, its
It is characterised by, effective ingredient also includes scutellarein.
3. a kind of BiscarpamontamineA that includes according to claim 2 is used to suppress acutely inflamed medicine, its
It is characterised by, calculates according to weight, BiscarpamontamineA and scutellarein ratio is 1:1-20:1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610925053.3A CN106562974A (en) | 2016-10-30 | 2016-10-30 | BiscarpamontamineA-containing medicine for inhibiting acute inflammation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610925053.3A CN106562974A (en) | 2016-10-30 | 2016-10-30 | BiscarpamontamineA-containing medicine for inhibiting acute inflammation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106562974A true CN106562974A (en) | 2017-04-19 |
Family
ID=58534315
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610925053.3A Withdrawn CN106562974A (en) | 2016-10-30 | 2016-10-30 | BiscarpamontamineA-containing medicine for inhibiting acute inflammation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106562974A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1260189A (en) * | 1998-12-31 | 2000-07-19 | 承德医学院中药研究所 | Application of radix scutellariae stem and leaf to pharmaceutical industry |
| CN105362274A (en) * | 2015-12-08 | 2016-03-02 | 淄博齐鼎立专利信息咨询有限公司 | Application of biscarpamontamine A in preparation of rhinitis pharmaceuticals |
| CN105456272A (en) * | 2015-12-16 | 2016-04-06 | 淄博齐鼎立专利信息咨询有限公司 | Application of Biscarpamontamine A in preparing medicine for increasing red blood cells |
-
2016
- 2016-10-30 CN CN201610925053.3A patent/CN106562974A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1260189A (en) * | 1998-12-31 | 2000-07-19 | 承德医学院中药研究所 | Application of radix scutellariae stem and leaf to pharmaceutical industry |
| CN105362274A (en) * | 2015-12-08 | 2016-03-02 | 淄博齐鼎立专利信息咨询有限公司 | Application of biscarpamontamine A in preparation of rhinitis pharmaceuticals |
| CN105456272A (en) * | 2015-12-16 | 2016-04-06 | 淄博齐鼎立专利信息咨询有限公司 | Application of Biscarpamontamine A in preparing medicine for increasing red blood cells |
Non-Patent Citations (1)
| Title |
|---|
| KAZUMASA ZAIMA等: "Biscarpamontamines A and B, an Aspidosperma-Iboga Bisindole Alkaloid and an Aspidosperma-Aspidosperma Bisindole Alkaloid, from Tabernaemontana sphaerocarpa", 《J. NAT. PROD.》 * |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20170419 |
|
| WW01 | Invention patent application withdrawn after publication |