CN106556561A - A kind of fluid particles motion control device - Google Patents
A kind of fluid particles motion control device Download PDFInfo
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- CN106556561A CN106556561A CN201611064257.9A CN201611064257A CN106556561A CN 106556561 A CN106556561 A CN 106556561A CN 201611064257 A CN201611064257 A CN 201611064257A CN 106556561 A CN106556561 A CN 106556561A
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- 239000012530 fluid Substances 0.000 title claims abstract description 110
- 239000002245 particle Substances 0.000 title claims abstract description 86
- 230000033001 locomotion Effects 0.000 title claims abstract description 34
- 238000002604 ultrasonography Methods 0.000 claims abstract description 89
- 230000007246 mechanism Effects 0.000 claims abstract description 41
- 238000001514 detection method Methods 0.000 claims description 7
- 238000012544 monitoring process Methods 0.000 claims description 3
- 230000008054 signal transmission Effects 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 18
- 239000000523 sample Substances 0.000 description 10
- 238000004458 analytical method Methods 0.000 description 7
- 230000008859 change Effects 0.000 description 7
- 238000000034 method Methods 0.000 description 4
- 230000033228 biological regulation Effects 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 230000004913 activation Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 238000000684 flow cytometry Methods 0.000 description 2
- 230000004907 flux Effects 0.000 description 2
- 230000004308 accommodation Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007274 generation of a signal involved in cell-cell signaling Effects 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1404—Handling flow, e.g. hydrodynamic focusing
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
- G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1404—Handling flow, e.g. hydrodynamic focusing
- G01N2015/142—Acoustic or ultrasonic focussing
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Apparatuses For Generation Of Mechanical Vibrations (AREA)
Abstract
A kind of fluid particles motion control device, including：Control main frame, which is at least used for the emission state for controlling ultrasound wave in the fluid particles motion control device；Operating mechanism, with fluid hose and the plural ultrasound emission unit for being distributed in the fluid pipe surface；And connecting line, which connects the ultrasound emission unit and the control main frame；The single or multiple ultrasound emission cell operations positioned at diverse location are controlled by the control main frame and forms the different sound field for acting on fluid particles.The fluid particles motion control device both can be used for the sound field to form different mode, and the sound field can be used for the different focusing effects for realizing fluid particles.
Description
Technical field
The present invention relates to biological analysiss technical field, and in particular to a kind of ultrasonic fluid particle for cell analysis
Motion control device.
Background technology
Flow Cytometry is a kind of utilization flow cytometer to the individual cells being in liquid stream or other biological granule
Etc. the technology for carrying out fast quantitative analysis and sorting.Flow Cytometry can carry out various quantitative analyses to each cell, be
The powerful of rare cell is detected in the tissue such as blood, bone marrow.But rare cell detection generally requires great amount of samples ability
Enough data are collected, this is a challenge for conventional flow cytometer, because large sample means that process time is long, if subtracting
Few time, then need to accelerate sample rate, improve flux, but this can cause the decline of detection sensitivity.
When sample solution enters into flow cytometer, cell random distribution in the three dimensions.Make cell pass through one by one to swash
Light beam, just can guarantee that the accuracy of data acquisition.Overwhelming majority flow cytometer is led to by Hydrodynamic focus realization at present
Cross sheath fluid band kinetocyte and be limited in center, it is established that unicellular stream.Traditional hydrodynamic force focusing technology is received
Many to limit, flow velocity improves the width that can increase sample flow, declines the focusing effect of cell.Cell deviates laser center and gets over
Far, excitating light strength change is bigger, and CV values are also higher.Research worker is frequently necessary to seek to put down between analysis throughput and precision
Weighing apparatus.
At present, the device that particle focusing is carried out using ultrasonic sound field, such as United States Patent (USP) have been occurred in that in prior art
Document US9074977B2, discloses a kind of particle processing meanss for concurrent flow cell analysis, it include one group it is positioned opposite
Realize that cell particle focus on for forming sound field in the acoustic wave emission unit of fluid hose.
However, the device in patent documentation above-mentioned first can only be used to particle focusing, its function and purposes are single；Secondly,
Said apparatus to one group of ultrasound emission unit carry out particle focusing, therefore be only capable of making particle in monoplane or parallel many
Individual plane inner focusing, referring to the accompanying drawing 1 of patent documentation US9074977B2, its fluid particles is focused in single plane, its
Focusing effect is single.Therefore particle focusing arrangement function of the prior art is excessively simple, and focusing effect is single, it is impossible to meet
Different fluid particles difference focusing requirements.
The content of the invention
Therefore, the technical problem to be solved in the present invention is to overcome the function and effect in existing cell analysis focusing arrangement
It is excessively single, it is impossible to meet different focusing and other functions demand, it is a kind of forming different acoustic fields pattern so as to provide, both
The sound field that can be used for simulating different mode can be used for realizing the fluid particles motor control of fluid particles difference focusing effect again
Device.
For this purpose, list whole technical schemes of claims record successively herein：A kind of fluid particles motor control dress
Put, including：Control main frame, which is at least used for the ultrasonic emitting for controlling ultrasound emission unit；Operating mechanism, with fluid hose and
It is distributed in the more than one ultrasound emission unit of the fluid pipe surface；And connecting line, its described ultrasound emission list of connection
First and described control main frame；The single or multiple ultrasound emission cell operations positioned at diverse location are controlled by the control main frame
Formation acts on the different sound field of fluid particles.
Further, the operating mechanism is for realizing fluid particles focusing that fluid particles are focused on, with putting
Focusing tube chamber in the fluid hose, the sound field that the ultrasound emission unit is produced make the grain in the fluid by focusing tube chamber
Son is focused on.
Further, the fluid particles focusing is auxiliary for the assisted focused device enforcement as other focusings
Help focusing.
Further, the control main frame drives the single or multiple ultrasound emission positioned at diverse location on the fluid hose
Cell operation is realizing different Particles Moving results.
Further, the control main frame is operated alone any one the ultrasound emission unit work on the fluid hose
Make；
Or while drive the ultrasound emission cell operation on the fluid hose adjacent surface；
Or while drive the multiple ultrasound emission cell operations on the fluid hose the same face；
Or while drive the ultrasound emission cell operation on the fluid hose opposite face；Or while drive
Ultrasound emission cell operation on four sides of the fluid hose.
Further, the control main frame is by the passage enable of the ultrasonic wave output signal of individually regulation, frequency, width
Value or phase place, to realize different Particles Moving results.
Further, it is additionally provided with for detecting the sensor of the ultrasound emission cell operation state；The sensor
The status signal transmission of detection is to the control main frame monitoring the normal work of ultrasound emission unit.
Further, the sensor is temperature sensor.
Further, the control main frame is at least included for driving the ultrasound-driven mechanism of the ultrasound emission unit.
Further, the ultrasound-driven mechanism can independently drive at least four tunnels including at least the output of four tunnel independences
The ultrasound emission unit.
Further, the ultrasound-driven mechanism includes at least signal generator, power amplifier and output matching circuit.
Further, the control main frame also includes control indication mechanism and power supply signal interface, and the control shows machine
Structure controls the ultrasound emission unit and shows the working condition of the fluid particles motion control device.
Further, the control indication mechanism controls described surpassing by controlling the drive signal of the ultrasound-driven mechanism
The emission state of acoustic emission unit.
Further, the control indication mechanism is to the passage enable of the drive signal, frequency, amplitude and phase place
It is independently controlled.
Technical solution of the present invention, has the advantage that：The ultrasonic fluid particle movement control device of the present invention, mainly
Referring to, a kind of application ultrasound, as the device of fluid particles focus method, is more particularly multiple differences to be controlled by control main frame
The acoustic wave emission unit transmitting sound wave of position forms the focusing system that sound field realizes the various focusing effects of fluid particles.Additionally,
The fluid particles motion control device not only can only be used to realize focusing on, and which can also control multiple diverse locations by control main frame
Acoustic wave emission unit formed different mode sound field.
Description of the drawings
In order to be illustrated more clearly that the specific embodiment of the invention or technical scheme of the prior art, below will be to concrete
Needed for embodiment or description of the prior art, accompanying drawing to be used is briefly described, it should be apparent that, in describing below
Accompanying drawing is some embodiments of the present invention, for those of ordinary skill in the art, before creative work is not paid
Put, can be with according to these other accompanying drawings of accompanying drawings acquisition.
Fig. 1 is the structural representation of the fluid particles motion control device of the present invention；
Sound field emulation when Fig. 2 is the unidirectional ultrasound emission cell operation of fluid particles motion control device of the present invention is illustrated
Figure；
Fig. 3 is the fluid particles motion control device sides adjacent ultrasound emission unit of the present invention while sound field when working is imitated
True schematic diagram；
Fig. 4 is the fluid particles motion control device opposite side ultrasound emission unit of the present invention while sound field when working is imitated
True schematic diagram；
Fig. 5 is the focusing effect four side ultrasound emission unit of fluid particles motion control device of the present invention works simultaneously when
Schematic diagram；
Description of reference numerals：
1- acoustic wave emission units；2- focusings；3- fluid hoses；4- fluid particles focus on tube chamber；5- connecting lines；6- is controlled
Main frame；7- ultrasound-driven mechanism；8- controls indication mechanism；9- power supply signal interfaces；10- external signal interfaces；
Specific embodiment
Technical scheme is clearly and completely described below in conjunction with accompanying drawing, it is clear that described enforcement
Example is a part of embodiment of the invention, rather than the embodiment of whole.Based on the embodiment in the present invention, ordinary skill
The every other embodiment obtained under the premise of creative work is not made by personnel, belongs to the scope of protection of the invention.
Embodiment 1
Fluid particles motion control device as shown in Figure 1, which includes control main frame 6, operating mechanism 2 and attended operation
The connecting line 5 of mechanism 2 and control main frame 6.
Wherein operating mechanism 2 is including at least fluid hose 3, the ultrasound emission unit 1 for launching sound wave, and for detecting
The sensor of 1 working condition of ultrasound emission unit.Fluid hose 3 is tubular structure, and as shown in Figure 1, ultrasound emission unit 1 is arranged
In the surrounded surface of the fluid hose 3 of tubular structure, which is towards the center for being directed at fluid hose 3.When operating mechanism 2 be used for into
When row fluid particles are focused on, which also includes focusing on tube chamber 4 for the fluid particles that particle is focused on, and wherein fluid particles focus on tube chamber
4 shape can be square, circular, polyhedron-shaped or other shapes.
Control main frame 6 at least includes ultrasound-driven mechanism 7, control indication mechanism 8, power supply signal interface 9 and external signal
Interface 10.At least provided with signal generation, power amplification and output matching circuit wherein in ultrasound-driven mechanism 7.Ultrasound-driven
Output of the mechanism 7 including at least four tunnel independences, i.e., can independently drive at least four tunnel ultrasound emission units work separately or together
Make.In the present embodiment, ultrasound-driven mechanism 7 can drive 5 ultrasound emission units on fluid tube wall independently
Work or while work, but is not limited only to above-mentioned form.
Control indication mechanism 8 is used for the work functions and working condition for controlling and showing the device, the control indication mechanism 8
Control or display mode can adopt button, knob, touch screen, display lamp or other modes.Control indication mechanism 8 is by right
The output signal of ultrasound-driven mechanism 7 is adjusted, specifically to its passage enable, the frequency of output signal, amplitude, phase place point
Independent regulation is not carried out, so that the transmitting of ultrasound emission unit 1 forms different sound fields or reaches different focusing effects.
Control main frame 6 is adjusted to the output signal of ultrasound-driven mechanism 7 by controlling indication mechanism 8, is achieved in convection current
The passage of the transmitting acoustic signals of acoustic wave emission unit 1 of 3 surrounding of body pipe, amplitude, frequency, the regulation of phase place.
Control main frame 6 is connected with acoustic emission apparatus by connecting line 5, and specifically, connecting line 5 can connect control main frame 6
Ultrasound-driven mechanism 7 and operating mechanism 2 in acoustic wave emission unit 1, the driving that ultrasound-driven mechanism 7 is sent by connecting line 5
Signal transmission is to ultrasound emission unit 1, while the working condition detection signal of the ultrasound emission unit 1 that sensor is detected is passed
Control main frame 6 is transported to the whether normal work of real-time monitoring ultrasound emission unit 1.Specifically detect that ultrasound emission unit 1 works
The sensor of state can be selected as temperature sensor.
When sound field discharger is used the apparatus as, the sound field which ultimately forms is by controlling ultrasound emission unit 1
Drive number and activation point, or by changing the amplitude of the ultrasound wave drive signal of ultrasound emission unit, phase place, the angle of departure
Spend and change.
When fluid particles focusing arrangement is used the apparatus as, its final actual particle convergence effect equally can be by control
The driving number of ultrasound emission unit 1 and activation point, or the ultrasound wave drive signal by change ultrasound emission unit
Amplitude, phase place, launch angle and change.
Further, the focusing in the acoustic fluid particle focusing arrangement both can be used for individually carrying out fluid particles
Focusing, it is also possible to as auxiliary device fluid particles focusing in aid in other focusing arrangements to strengthen the focusing of fluid particles
Effect.
Secondly, the fluid particles motion control device can be used to carry out fluid particles focusing, but be not limited to as fluid grain
Son is focused on, and it is the one of typical use of the device that fluid particles are focused on.
The operation principle and process of the fluid particles motion control device of the present invention：
(1) when as fluid particles focusing arrangement：
The device launches sound wave by driving acoustic wave emission unit, forms sound field using sound wave acoustic radiation force and produces gesture
Trap, under sound field reflecting, the particle of script random dispersion collects to form focusing effect in potential well region.
During work, the particle fluid being focused is needed to focus on tube chamber 4 by the fluid particles of fluid hose 3.It is wherein ultrasonic
The mode of operation of transmitter unit 1 is controlled by indication mechanism 8 is controlled, and enables different ultrasound-driven mechanisms 7 to drive difference
Ultrasound emission unit 1, realize different fluid particles focusing modes and focusing effect.
And due to driving the position difference of ultrasound emission unit to cause drive pattern difference form different sound fields, and
It is variable by the passage enable of the acoustic drive signals for driving transmitter unit 1 to produce, frequency, amplitude, phase contrast, it is also possible to produce not
Same sound field, when through different sound fields, the particle in fluid can produce difference due to the effect of different acoustic fields to final fluid
Focusing effect.
First, different focusing effects can be realized by adjusting frequency, amplitude and the phase place of acoustic drive signals；Specifically
Ground, in the present embodiment, the frequency-tuning range of drive signal can be set to 200K～10MHz, amplitude range of accommodation can be set to 5V～
100V, phase adjustment range can be set to as 0～360 degree.
Secondly, different focusing effects can be realized by controlling the drive pattern of acoustic wave emission unit；Specifically, ultrasound is sent out
The drive pattern for penetrating unit 1 can be divided into：
1. the ultrasound emission unit being distributed on 3 Arbitrary Relative of fluid hose, two faces is driven simultaneously；Now fluid particles can
In single plane or parallel multiple plane inner focusings, as shown in Figure 4；
2. four ultrasound emission units on 3 four sides of fluid hose around arrangement are driven simultaneously；Now fluid particles can
Realize that single beam or multi beam are focused on, as shown in Figure 5；
(2) when as other motion control devices of fluid particles：
First, different sound fields can be realized by adjusting frequency, amplitude and the phase place of acoustic drive signals；
Secondly, different sound fields can be realized by controlling the drive pattern of acoustic wave emission unit；Specifically, ultrasound emission list
The drive pattern of unit 1 can be divided into：
1. only drive the single ultrasound emission unit on wherein any one face；Now, in the presence of sound field, fluid grain
Son is uniaxially moved to one side, as shown in Figure 2；
2. the several ultrasound emission units along straight line arrangement on any one face are driven；Now, fluid particles are also
Uniaxially move to the same face direction, but as the active length of ultrasound emission unit is elongated, prolong can the action time of sound field
It is long；
3. the ultrasound emission unit being distributed on 3 arbitrary neighborhood of fluid hose, two sides is driven simultaneously；Fluid particles are moved
Space further reduce with respect to the first, uniaxially move to a corner, as shown in Figure 3.
The sound wave of the present invention forms device from unlike conventional fluid dynamic focus, and sound wave focusing technology can be using ultrasound
Ripple is gathered in cell tight in the middle of sample flow, converges in alignment.This technology is not affected by sample rate substantially, energy
Cell strong-focusing is made in laser detection point, it is unrelated with the ratio of sample-sheath fluid, no matter the ratio of sample flow and sheath fluid stream,
Laser detection focus is gathered in cell tight can be made, it is to avoid dispersion.More multi-photon can be so gathered, in high sample
Ensure high accuracy analysis under flux, and sound wave focusing flow cytometer is the step of process whole blood sample and can save sample and prepare, both
Without sample losses, the quality of data is not interfered with yet.Therefore, in the presence of different acoustic fields, the particle of script random dispersion is in gesture
Well area collects to form focusing effect.Including but not limited to particle accumulation is in single plane, in multiple planes, Dan Shu, multi beam
Converged, device can also be adjusted according to the needs of practical application.
Obviously, above-described embodiment is only intended to clearly illustrate example, and the not restriction to embodiment.It is right
For those of ordinary skill in the art, can also make on the basis of the above description other multi-forms change or
Change.There is no need to be exhaustive to all of embodiment.And thus it is extended obvious change or
Among changing still in the protection domain of the invention.
Claims (14)
1. a kind of fluid particles motion control device, including：
Control main frame (6), which is at least used for the ultrasonic emitting for controlling ultrasound emission unit (1)；
Operating mechanism (2), with fluid hose (3) and is distributed in the more than one described ultrasound emission list of the fluid pipe surface
First (1)；
And connecting line (5), which connects the ultrasound emission unit (1) and the control main frame (6)；
It is characterized in that：
Single or multiple ultrasound emission unit (1) work positioned at diverse location are controlled by the control main frame (6) and forms work
For the different sound field of fluid particles.
2. fluid particles motion control device according to claim 1, it is characterised in that：
The operating mechanism (2) is for realizing fluid particles focusing that fluid particles are focused on, with being placed in the fluid
Focusing tube chamber (4) in pipe (3), the sound field that the ultrasound emission unit (1) produces make the grain in the fluid by focusing tube chamber
Son is focused on.
3. fluid particles motion control device according to claim 2, it is characterised in that：The fluid particles focusing
For implementing assisted focused as the assisted focused device of other focusings.
4. the fluid particles motion control device according to any one of claim 1-3, it is characterised in that：The control main frame
(6) drive single or multiple ultrasound emission unit (1) work positioned at diverse location on the fluid hose (3) different to realize
Particles Moving result.
5. fluid particles motion control device according to claim 4, it is characterised in that：The control main frame (6) is individually
Any one the ultrasound emission unit (1) on the fluid hose (3) is driven to work；
Or while drive ultrasound emission unit (1) work on the fluid hose (3) adjacent surface；
Or while drive multiple ultrasound emission unit (1) work on the fluid hose (3) the same face；
Or while drive ultrasound emission unit (1) work on the fluid hose (3) opposite face；
Or while drive ultrasound emission unit (1) work on (3) four sides of the fluid hose.
6. the fluid particles motion control device according to any one of claim 1-5, it is characterised in that：The control main frame
(6) by the passage enable, frequency, amplitude or the phase place that individually adjust ultrasound wave output signal, to realize different particles
Motion result.
7. the fluid particles motion control device according to any one of claim 1-6, it is characterised in that：Be additionally provided with for
Detect the sensor of ultrasound emission unit (1) working condition；The status signal transmission of the sensor detection is to the control
Main frame (6) processed is monitoring the normal work of ultrasound emission unit (1).
8. fluid particles motion control device according to claim 7, it is characterised in that：The sensor is temperature sensing
Device.
9. the fluid particles motion control device according to any one of claim 1-8, it is characterised in that：The control main frame
At least include for driving the ultrasound-driven mechanism (7) of the ultrasound emission unit (1).
10. fluid particles motion control device according to claim 9, it is characterised in that：The ultrasound-driven mechanism (7)
Including at least the output of four tunnel independences, ultrasound emission unit (1) at least described in four tunnels can be independently driven.
The 11. fluid particles motion control devices according to claim 9 or 10, it is characterised in that：The ultrasound-driven machine
Structure (7) is including at least signal generator, power amplifier and output matching circuit.
The 12. fluid particles motion control devices according to any one of claim 9-11, it is characterised in that：The control master
Machine (6) also includes control indication mechanism (8) and power supply signal interface (9), and control indication mechanism (8) controls the ultrasound and send out
Penetrate unit (1) and show the working condition of the fluid particles motion control device.
13. fluid particles motion control devices according to claim 12, it is characterised in that：The control indication mechanism
(8) emission state of the ultrasound emission unit (1) is controlled by controlling the drive signal of the ultrasound-driven mechanism (7).
14. fluid particles motion control devices according to claim 13, it is characterised in that：The control indication mechanism
(8) passage enable to the drive signal, frequency, amplitude and phase place can be independently controlled.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113218822A (en) * | 2021-04-29 | 2021-08-06 | 宋卓 | Focusing structure, particle detection device comprising focusing structure and use method of particle detection device |
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