CN106551700A - A kind of survey blood glucose method for measuring in several ways and demarcating elimination systematic error - Google Patents
A kind of survey blood glucose method for measuring in several ways and demarcating elimination systematic error Download PDFInfo
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- CN106551700A CN106551700A CN201510626639.5A CN201510626639A CN106551700A CN 106551700 A CN106551700 A CN 106551700A CN 201510626639 A CN201510626639 A CN 201510626639A CN 106551700 A CN106551700 A CN 106551700A
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Abstract
The present invention provides a kind of survey blood glucose method for measuring in several ways and demarcating elimination systematic error.Its technical field belongs to the accurate measurement method of the portable glucose meter of medical measurement device.User is repeatedly measured and is contrasted by different time using the measured value for having invasive blood sugar instrument and non-invasive blood sugar instrument, the user is obtained using non-invasive blood sugar instrument blood glucose value and the corresponding relation for taking blood blood glucose meter blood glucose value, so as to correct the different system error that non-invasive blood sugar instrument is produced in Different Individual measurement.
Description
Technical field patent of the present invention is related to a kind of measuring method, especially the accurate measurement method of portable glucose meter.
The portable blood sugar measuring instrument that technical background is circulated in the market mostly is invasive blood sugar instrument.User need to be applied to blood on special test paper, will
Reagent paper is measured in being put into measuring instrument.This mode can not only make patient feel pain, and increase makes the difficulty that patient compliance treats, and can increase
The possibility that patient catches, is also easy to cause because reagent paper is contaminated or caused measurement result has a very big error more than useful life, and because
Use for blood taking needle and reagent paper increased the measurement cost of user.
Non-invasive blood sugar instrument is still at the initial stage at home, and external non-invasive blood sugar instrument is divided into measurement interstitial fluid, measurement INFRARED ABSORPTION light, integrates ultrasonic biography
The blood glucose meter of technology is held in heat conduction.Although these blood glucose meter effectively can be avoided invasive blood sugar instrument adverse effect, because the change of tissue temperature, metabolism
The impact of the individual variations such as the concentration of product, the interference of other materials, the measurement result of non-invasive blood sugar instrument have larger system to miss with real blood sugar concentration
Differ from and have obvious individual variation.Along with existing technology is all that single physiological data is measured, and the physiological situation of human body is complicated, profit
There is very big incidental error by way of the blood glucose value that algorithm is calculated with single physiological data.These factors cause the measurement result of non-invasive blood sugar instrument
With less clinical meaning.
The content of the invention
It is an object of the invention to overcome the weak point of prior art, and propose that a kind of noinvasive that can overcome interindividual variation surveys blood glucose method.Make
Blood glucose method is surveyed with two kinds and above noinvasive to obtain the physiological data of measured organization and calculate blood glucose value using special algorithm, blood is surveyed to reduce noinvasive
The incidental error of sugared concentration.Measurement result is demarcated using the blood glucose value for having invasive blood sugar instrument measurement, algorithm is improved according to calibration result makes
The result that algorithm is calculated in follow-up measurement closer to real blood glucose value, so as to correct the systematic error of non-invasive blood sugar instrument.Using this measuring method
Blood glucose meter, compared with original technology, incidental error and systematic error all can be less for its measurement result.
According to prior art, the blood glucose value in human body can be calculated with special algorithm using the physiological values that non-invasive blood sugar instrument is measured.But because
Body difference, can produce different deviations when calculating the blood glucose value of different users with same algorithm, need to calculate for each gauger for this
Different algorithms is reducing error.Difference between the blood glucose value drawn by algorithm and true blood glucose value is varied with each individual, but each individual deviation
Always it is intended to a particular value, therefore numerical value that the numeric ratio prior art of the non-invasive measurement Jing after algorithm process obtains can be made more by correction algorithm
It is close to true blood glucose value.Blood glucose value by repeatedly measuring and comparing the numerical value and invasive measurement Jing after original algorithm process, can calculate original calculation
The error amount that method is produced in the measured.By the error amount for calculating and then innovatory algorithm being corrected in follow-up measurement, make the measured using improvement
The numerical value and real blood glucose value that algorithm draws afterwards is consistent.After non-invasive blood sugar instrument is with there is invasive blood sugar instrument measured value to be consistent, user can
Replace having invasive blood sugar instrument with non-invasive blood sugar instrument, so as to the cost for avoiding the pain for taking blood and reduce follow-up measurement.
At least include four parts, invasive measurement end, non-invasive measurement with the non-invasive blood sugar instrument (hereinafter referred to as " product ") of the technology in this patent that is related to
End, calculating end and display end.Invasive measurement end surveys blood glucose technology using the existing blood that takes, and effect is measurement blood glucose value by measurement result incoming calculating
End.Non-invasive measurement end has two kinds and above by ultrasound, conducts, thermal capacitance, current measurement, and optical meanss etc. measure the sender unit of blood glucose method and sense
Receiver, can obtain the physiological values of the measured organization of two kinds and the above and measurement result input is calculated end.Calculate end and receive two groups and the above
The physiological data and blood glucose value of measured organization or the only physiological data of reception measured organization.When measured group that the data for receiving are two groups and the above
When the physiological data knitted and blood glucose value：End is calculated by the blood glucose value for receiving incoming display end, and the two groups of data for receiving are utilized by the algorithm for storing
Blood glucose value is calculated, the blood glucose value of calculating is compared with true blood glucose value and the error that the algorithm of original storage is produced is calculated, is corrected in the algorithm
This error is simultaneously stored in the algorithm after correction in calculating end.When physiological data of the data for receiving for measured organization：End is calculated using storage
Algorithm and receive data calculate blood glucose value and by the blood glucose value for calculating be input into display end.Display end effect is to show the numerical value for calculating end input
Show and feed back to user.
Using the product initial stage, due to the individual variation that the factors such as the change of tissue temperature, the concentration of metabolite, the interference of other materials are caused,
Product registration can have larger difference with real blood glucose value.In order to accurately calculate the mode that this species diversity is produced, product surveys blood using various noinvasive
Sugared technology obtains more rich physiological data, and needs a period of time as the demarcation phase.Invasive measurement end and noinvasive are used simultaneously repeatedly within the demarcation phase
Measurement end, further to expand calculating sample.After repeatedly invasive measurement end and non-invasive measurement end is used simultaneously, calculating end can be with reference to measurement in the recent period
As a result the algorithm to storing is improved, and makes product registration convergent with true blood glucose value.When product registration and true blood glucose value in repeatedly measuring error
Very little, you can be considered as product demarcate the phase terminate.After the demarcation phase terminates, you can not used invasive blood sugar instrument within a period of time, only drawn by product
Blood glucose value.
Specific embodiment
1., using the product initial stage, the demarcation phase through certain hour is needed.Within the demarcation phase, user repeatedly used noinvasive in one day simultaneously
Measurement end and invasive measurement end simultaneously learn blood glucose value from display end, calculate end using the built-in algorithm of the value revision obtained in this period.
2., after the completion of algorithm modification, the system prompt user demarcation phase terminates.After the demarcation phase terminates, user can be in follow-up survey blood glucose process
In only using non-invasive measurement end measure blood glucose value.
3., after a period of time, with the change of body physiological state, user is again introduced into the demarcation phase, and circulates 1,2 steps.
Claims (5)
1. a kind of measuring method, it is characterised in that：Physiological values are obtained using two kinds and above non-invasive manner and blood glucose is calculated by general-purpose algorithm
Value.By going out the error that general-purpose algorithm is produced at the measured with the blood glucose value comparing calculation for having invasive blood sugar instrument measurement, amendment general-purpose algorithm is obtained more
Meet the correction algorithm of the physiological situation of the measured, so that noinvasive surveys the blood glucose value that blood glucose method more accurately reflects out the measured.
2. according to the measuring method described in claim 1, it is characterised in that：During blood glucose is surveyed using this kind of method, once or multiple mark
Periodically.Regularly purpose is to collect enough sample datas accurately to calculate the error produced at the measured with algorithm to mark.
3. measuring method according to claim 2, it is characterised in that：After collecting enough data and calculating correction algorithm, phase knot is demarcated
Beam.The measured only can calculate blood glucose value using correction algorithm.
4. measuring method according to claim 2, it is characterised in that：After the demarcation phase terminates, the measured can periodically use invasive blood
Sugared instrument measures blood glucose value, and the blood glucose value calculated by the blood glucose value for having invasive blood sugar instrument measurement and using innovatory algorithm is compared.Purpose is to calculate to improve
Method further provides for sample data and monitors whether innovatory algorithm can accurately calculate blood glucose value.
5. measuring method according to claim 4, it is characterised in that：The blood glucose value that calculates when innovatory algorithm and have what invasive blood sugar instrument was measured
When blood glucose value continuous several times have relatively large deviation or the measured physiological situation that great change occurs, the measured can be again introduced into the demarcation phase and be changed with correcting
Enter algorithm.
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| CN201510626639.5A CN106551700A (en) | 2015-09-28 | 2015-09-28 | A kind of survey blood glucose method for measuring in several ways and demarcating elimination systematic error |
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| CN201510626639.5A CN106551700A (en) | 2015-09-28 | 2015-09-28 | A kind of survey blood glucose method for measuring in several ways and demarcating elimination systematic error |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108042106A (en) * | 2017-11-14 | 2018-05-18 | 李明 | Artificial intelligence deviation rectifying method for improving detection precision of human body sign non-invasive detection equipment |
| CN108261286A (en) * | 2017-11-29 | 2018-07-10 | 北京华夏光谷光电科技有限公司 | A kind of lossless blood sugar test and the multiplexing earmuff of the laser acupuncture ear acupuncture point |
| CN108937955A (en) * | 2017-05-23 | 2018-12-07 | 广州贝塔铁克医疗生物科技有限公司 | The adaptive wearable blood glucose bearing calibration of personalization and its means for correcting based on artificial intelligence |
| CN116602668A (en) * | 2023-07-06 | 2023-08-18 | 深圳大学 | Full-automatic intelligent blood sugar detection system |
-
2015
- 2015-09-28 CN CN201510626639.5A patent/CN106551700A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108937955A (en) * | 2017-05-23 | 2018-12-07 | 广州贝塔铁克医疗生物科技有限公司 | The adaptive wearable blood glucose bearing calibration of personalization and its means for correcting based on artificial intelligence |
| CN108042106A (en) * | 2017-11-14 | 2018-05-18 | 李明 | Artificial intelligence deviation rectifying method for improving detection precision of human body sign non-invasive detection equipment |
| CN108261286A (en) * | 2017-11-29 | 2018-07-10 | 北京华夏光谷光电科技有限公司 | A kind of lossless blood sugar test and the multiplexing earmuff of the laser acupuncture ear acupuncture point |
| CN116602668A (en) * | 2023-07-06 | 2023-08-18 | 深圳大学 | Full-automatic intelligent blood sugar detection system |
| CN116602668B (en) * | 2023-07-06 | 2023-10-31 | 深圳大学 | Full-automatic intelligent blood sugar detection system |
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Application publication date: 20170405 |
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