CN106540330A - The preparation method of PLGA magnesium compounds and the method for making orthopedic implant - Google Patents
The preparation method of PLGA magnesium compounds and the method for making orthopedic implant Download PDFInfo
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- CN106540330A CN106540330A CN201611043569.1A CN201611043569A CN106540330A CN 106540330 A CN106540330 A CN 106540330A CN 201611043569 A CN201611043569 A CN 201611043569A CN 106540330 A CN106540330 A CN 106540330A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Abstract
The preparation method of PLGA magnesium compounds and the method for making orthopedic implant with which, belong to orthopaedics degradation material and make and applied technical field.Its technical scheme is：PLGA is added in container, control oil bath temperature melts PLGA for viscous liquid, adds load weighted magnesium powder, stir to being sufficiently mixed, solid-state PLGA magnesium mixing material finished product is prepared after cooling between 190 210 °；Tabular or cylindric is superposed to after the different PLGA magnesium compounds containing magnesium percentage by weight are melted, orthopedic implant is made.The present invention is by the acid-base value of regulation PLGA and the burden control material of magnesium powder, intensity, consistency and elasticity modulus so as to more meet the biomechanics characteristic of bone；Orthopedic implant passes through the cooperation of the different components containing magnesium percentage by weight and skeleton, it is possible to provide preferable support, fixing intensity or filling effect, reaches.
Description
Technical field
The present invention relates to a kind of method for preparing the Biodegradable material that orthopaedics is used, and made using this material
The method of implants, belongs to orthopaedics degradation material and makes and applied technical field.
Background technology
With the development of bioengineering field, Biodegradable material has reached its maturity in the application of medical field,
The application of orthopaedics internal fixation treatment also has been reported that.Compared with traditional orthopaedics internal fixation material, Biodegradable material has more preferably
Histocompatibility, and degradable after being implanted into, it is not necessary to take out, it is to avoid second operation and the bone caused after taking out implants lack
Damage, the patient not enough for osteoporosises or bone storage is highly beneficial.Wherein, polylactic acid-glycollic acid（Hydroxyacetic acid）Copolymer
（PLGA）The important biodegradable macromolecular material of a class, in vivo through hydrolysis be completely decomposed into carbon dioxide and
Water, is excreted by metabolic pathway, and PLGA is formed by lactic acid and glycolic copolymerization, and it has annexed two kinds of polyester materials
Advantage, has not only merged polylactic acid（PLA）Biocompatibility and biological degradation function, it is also controllable etc. excellent with degradation speed
Point, thus bio-medical material is widely used as, such as operation suture thread, controlled drug delivery system, orthopaedics are fixed and tissue repair
Material etc..But sour environment around local organization can be caused after PLGA degradeds, it is different from the pH value of human normal tissue structure,
Affect osteanagenesiss.Magnesium is trace element needed by human, participates in the performance of various enzyme normal functions, its with human body in calcium
There is substantial connection in element, magnesium metal has a facilitation to the deposition of calcium in body, therefore magnesium has certain ossification, and its
Internal degraded can make surrounding tissue slightly alkaline.At present, by polylactic-co-glycolic acid this bioabsorbable polymer material and height
Purity magnesium powder uniformly mixes, and is fabricated to orthopedic implant（Inside-fixture or implant）Also beyond example, if this method can
To realize, the enforcement for orthopaedics internal fixation material and Internal fixation technology is opened up a Tiao Xin roads, and tool is of great significance.
The content of the invention
The technical problem to be solved is to provide a kind of preparation method of PLGA- magnesium compounds and makes bone with which
The method of section's implants, this method are fabricated to orthopedic implant, Ke Yijin by PLGA is uniformly mixed with high-purity magnesium powder
One step improves the physicochemical property and histocompatibility of PLGA so as to which biodegradation rate is more preferably controllable, it is possible to by adjusting
The proportioning of PLGA and high-purity magnesium powder can control the acid-base value of new material, intensity, consistency and elasticity modulus so as to more meet bone
Biomechanics characteristic.
Solve above-mentioned technical problem technical scheme be：
A kind of preparation method of PLGA- magnesium compounds, it is carried out using following steps：
A. determine preparation PLGA- magnesium compounds gross weight be m, wherein content of magnesium for gross weight n%；
B. weigh m × (100-n) % PLGA, while the purity for weighing m × n% be more than 99.9% high-purity magnesium powder it is standby；
C. use silicone oil as oil bath medium, the PLGA after weighing is added in container, container is put in oil bath medium；
D. oil bath medium is heated, control oil bath temperature makes the PLGA in container gradually melt as viscous solution between 190-210 °
State；
E. the magnesium powder after weighing is added in the PLGA of container, stir to being sufficiently mixed；
F. stop heating, the mixture for dissolving in container is poured out in mould and is cooled down, that is, prepared containing percentage by weight
The solid-state PLGA- magnesium compound finished product of n% magnesium.
The preparation method of above-mentioned PLGA- magnesium compounds, it is 1%, 2%, 3%, 4% to be sequentially prepared content of magnesium using said method,
5%......95% PLGA- magnesium compounds.
A kind of method for making orthopedic implant using above-mentioned PLGA- magnesium compounds, it is carried out using following steps：
A. select to make the mould of implants, mould is cuboid or cylinder；
B. select, with the different PLGA- magnesium compounds containing magnesium percentage by weight, to be separately heated in being placed on different containers
190-210 °, the PLGA- magnesium compounds in container are made gradually to melt as viscous liquid；
C. PLGA- magnesium compound of the difference of viscous liquid containing magnesium percentage by weight is slowly added in mould successively, makes phase
PLGA- magnesium compound of the difference of adjacent two-layer containing magnesium percentage by weight has obvious separating surface, forms the structure of multilamellar；
D. mould is uniformly cooled down, is fabricated to the flaggy shape PLGA- magnesium compounds of different content of magnesium gradients.
The method that above-mentioned use PLGA- magnesium compounds make orthopedic implant, adds the PLGA- of mould in step c
The percentage by weight containing magnesium of magnesium compound is that bottom is minimum, is gradually increased upwards, to middle maximum, be then gradually reduced, most go up
The percentage by weight containing magnesium of the PLGA- magnesium compounds of layer is corresponding with the percentage by weight containing magnesium of the PLGA- magnesium compounds of bottom.
A kind of method for making orthopedic implant using above-mentioned PLGA- magnesium compounds, it is carried out using following steps：
A. select to make the mould of implants, mold cylinder body, and prepare the sleeve of different-diameter, the maximum gauge of sleeve is less than
The internal diameter of mould, the sleeve set of different-diameter；
B. select, with the different PLGA- magnesium compounds containing magnesium percentage by weight, to be separately heated in being placed on different containers
190-210 °, the PLGA- magnesium compounds in container are made gradually to melt as viscous liquid；
C. by the difference of viscous liquid containing magnesium percentage by weight PLGA- magnesium compounds be implanted sequentially nesting each sleeve it
Between annular space in, the percentage by weight containing magnesium of the PLGA- magnesium compounds in cylindrical central sleeve is maximum, between each concentric sleeve
Annular space in the percentage by weight containing magnesium of PLGA- magnesium compounds be from inside to outside gradually reduced；
D., after the PLGA- magnesium compounds between each sleeve are cooled into solid-state, middle each sleeve is taken out, retains outmost mould
Then mould is slowly heated, makes each layer PLGA- magnesium compounds in mould gradually melt fusion and be integrally formed by tool.
A kind of method for making orthopedic implant using above-mentioned PLGA- magnesium compounds, it is carried out using following steps：
A. several different PLGA- magnesium compounds containing magnesium percentage by weight, and the molten condition at being kept for 190-210 DEG C are prepared；
B. solid cylindrical columns shape PLGA- magnesium compounds are made in the PLGA- magnesium compounds cooling for selecting percentage by weight containing magnesium maximum；
C. the PLGA- magnesium compounds for making solid cylinder are placed into into percentage by weight containing magnesium positioned at deputy PLGA- magnesium
In mixture liquid, uniform rotation makes the outer layer covers PLGA- magnesium compound liquid of the PLGA- magnesium compounds of solid cylinder,
Cool down after taking out, rotate during above-mentioned PLGA- magnesium compounds liquid is placed again into after cooling, superscribe PLGA- magnesium compound liquid,
Repeat said process, until percentage by weight containing magnesium reaches design requirement positioned at deputy PLGA- magnesium compounds thickness, cool down
To solid states；
D. the solid cylinder comprising two-layer PLGA- magnesium compound is placed into into percentage by weight containing magnesium positioned at the 3rd
In PLGA- magnesium compound liquid, the solid cylinder for including three layers of PLGA- magnesium compounds is made according to above-mentioned steps；
E. the like, the final PLGA- magnesium compound cylinders for making the content of magnesium difference gradient for meeting design requirement.
The invention has the beneficial effects as follows：
The preparation method of the PLGA- magnesium compounds of the present invention adopts oil bath method so that PLGA is uniformly mixed with high-purity magnesium powder,
The percentage by weight containing magnesium of 1%-95% can be realized, it is possible to can control newly with the proportioning of high-purity magnesium powder by adjusting PLGA
The acid-base value of material, intensity, consistency and elasticity modulus so as to more meet the biomechanics characteristic of bone.The present invention further passes through
Different manufacture methods can produce the orthopedic implant of different shape and structure, and these orthopedic implants can be placed on bone
The diverse location of bone, by components of the difference containing magnesium percentage by weight and the cooperation of skeleton, can provide preferably support, fix
Intensity or filling effect, reach.
The present invention is the pioneering of orthopaedics degradation material and orthopedic implant, it is proposed that a kind of to make orthopaedics biodegradation material
The new method of material, while devising the new method that orthopedic implant is made of this new orthopaedics biodegradation material, is orthopaedics
A new way is opened up in the enforcement of internal fixation material and Internal fixation technology, the development of orthopaedics Internal fixation technology is had particularly significant
Meaning.
Description of the drawings
Fig. 1 is a kind of structural representation of tabular orthopedic implant of the present invention；
Fig. 2 is the structural representation of another kind of tabular orthopedic implant of the present invention；
Fig. 3 is a kind of structural representation of cylinder orthopedic implant of the present invention.
In figure, labelling is as follows：1% PLGA- of the PLGA- magnesium compounds 1,2% containing magnesium percentage by weight containing magnesium percentage by weight
PLGA- magnesium compound 4 of the PLGA- magnesium compounds 3,10% containing magnesium percentage by weight containing magnesium percentage by weight of magnesium compound 2,5%,
20% PLGA- magnesium compound 6 of the PLGA- magnesium compounds 5,30% containing magnesium percentage by weight containing magnesium percentage by weight.
Specific embodiment
The preparation method of the PLGA- magnesium compounds of the present invention, it is carried out using following steps：
（1）It is determined that the gross weight of the PLGA- magnesium compounds for preparing is m, wherein n% of the content of magnesium for gross weight；
（2）Weigh m × (100-n) % PLGA, while the purity for weighing m × n% be more than 99.9% magnesium powder it is standby；
（3）Using material of the boiling points such as silicone oil higher than 190-210 ° as oil bath medium, the PLGA after weighing is added to into container
In, container is put in oil bath medium；
（4）Heating oil bath medium, control oil bath temperature make the PLGA in container gradually melt as viscous solution between 190-210 °
State；
（5）The magnesium powder after weighing is added in the PLGA of container, is stirred to being sufficiently mixed；
（6）Stop heating, the mixture for dissolving in container is poured out in mould and is cooled down, that is, prepared containing percentage by weight
The solid-state PLGA- magnesium mixing material finished product of n% magnesium.
The 1% PLGA- magnesium compounds 1 containing magnesium percentage by weight, 2% percentage by weight containing magnesium are sequentially prepared using said method
PLGA- magnesium compounds 2,5% containing magnesium percentage by weight PLGA- magnesium compounds 3,10% containing magnesium percentage by weight PLGA- magnesium
PLGA- magnesium compound 6 of the PLGA- magnesium compounds 5,30% containing magnesium percentage by weight containing magnesium percentage by weight of mixture 4,20%.
The method that the present invention makes the orthopedic implant of tabular using above-mentioned PLGA- magnesium compounds is as follows：
（1）Select to make the mould of implants, mould is cuboid or cylinder；
（2）Select, with the different PLGA- magnesium compounds containing magnesium percentage by weight, to be separately heated in being placed on different containers
190-210 °, the PLGA- magnesium compounds in container are made gradually to melt as viscous liquid；
（3）PLGA- magnesium compound of the difference of viscous liquid containing magnesium percentage by weight is slowly added in mould successively, phase is made
PLGA- magnesium compound of the difference of adjacent two-layer containing magnesium percentage by weight has obvious separating surface, forms the structure of multilamellar；
（4）Mould is uniformly cooled down, the flaggy shape PLGA- magnesium compounds of different content of magnesium gradients are fabricated to.
Fig. 1 shows that one embodiment of the present of invention is as follows：
The bottom of percentage by weight containing magnesium of the tabular PLGA- magnesium compound of making and the superiors are minimum, middle maximum, bottom and most
Upper strata gradually increases to centre.Bottom and the superiors to middle PLGA- magnesium compounds are respectively 1% and contain magnesium percentage by weight
PLGA- magnesium of the PLGA- magnesium compounds 2,5% containing magnesium percentage by weight containing magnesium percentage by weight of PLGA- magnesium compounds 1,2% mixes
PLGA- magnesium compound 4 of the thing 3,10% containing magnesium percentage by weight.
Fig. 2 shows that an alternative embodiment of the invention is as follows：
The bottom of percentage by weight containing magnesium of the tabular PLGA- magnesium compound of making and the superiors are minimum, middle maximum, bottom and most
Upper strata gradually increases to centre.Bottom and the superiors to middle PLGA- magnesium compounds are respectively, 2% contains magnesium percentage by weight
PLGA- magnesium of the PLGA- magnesium compounds 3,10% containing magnesium percentage by weight containing magnesium percentage by weight of PLGA- magnesium compounds 2,5% is mixed
PLGA- magnesium compound 6 of the PLGA- magnesium compounds 5,30% containing magnesium percentage by weight containing magnesium percentage by weight of compound 4,20%.
The present invention makes the method for the orthopedic implant of cylinder using above-mentioned PLGA- magnesium compounds two kinds, respectively such as
Under：
First method is：
（1）Select to make the mould of implants, mold cylinder body, and prepare the thin walled cylinder body of different-diameter, the maximum of sleeve is straight
Internal diameter of the footpath less than mould, the sleeve of different-diameter are set with one heart；
（2）Select, with the different PLGA- magnesium compounds containing magnesium percentage by weight, to be separately heated in being placed on different containers
190-210 °, the PLGA- magnesium compounds in container are made gradually to melt as viscous liquid；
（3）PLGA- magnesium compound of the difference of viscous liquid containing magnesium percentage by weight is implanted sequentially into each sleeve of nesting
Between annular space in, the percentage by weight containing magnesium of the PLGA- magnesium compounds in cylindrical central sleeve is maximum, each concentric sleeve it
Between annular space in the percentage by weight containing magnesium of PLGA- magnesium compounds be from inside to outside gradually reduced；
（4）After the PLGA- magnesium compounds between each sleeve are cooled into solid-state, middle each concentric sleeve are taken out, retains outermost
Then mould is slowly heated by the mould in face, is made each layer PLGA- magnesium compounds in mould gradually melt fusion and is integrally formed.
Second method is：
（1）Prepare several different PLGA- magnesium compounds containing magnesium percentage by weight, and the molten condition at being kept for 190-210 DEG C；
（2）Solid cylindrical columns shape PLGA- magnesium compounds are made in the PLGA- magnesium compounds cooling for selecting percentage by weight containing magnesium maximum；
（3）The PLGA- magnesium compounds for making solid cylinder are placed into into percentage by weight containing magnesium positioned at deputy PLGA- magnesium
In mixture liquid, uniform rotation makes the outer layer covers PLGA- magnesium compound liquid of the PLGA- magnesium compounds of solid cylinder,
Cool down after taking out, rotate during above-mentioned PLGA- magnesium compounds liquid is placed again into after cooling, superscribe PLGA- magnesium compound liquid,
Repeat said process, until percentage by weight containing magnesium reaches design requirement positioned at deputy PLGA- magnesium compounds thickness, cool down
To solid states；
（4）Solid cylinder comprising two-layer PLGA- magnesium compound is placed into into percentage by weight containing magnesium positioned at the 3rd
In PLGA- magnesium compound liquid, the solid cylinder for including three layers of PLGA- magnesium compounds is made according to above-mentioned steps；
（5）The like, the final PLGA- magnesium compound cylinders for making the content of magnesium difference gradient for meeting design requirement.
Fig. 3 shows, in the method for the orthopedic implant of both making cylinders, the center of cylinder contains magnesium for 30%
The PLGA- magnesium compounds 6 of percentage by weight, from inside to outside each layer be respectively 20% containing magnesium percentage by weight PLGA- magnesium compounds
5th, 10% PLGA- magnesium compound 3 of the PLGA- magnesium compounds 4,5% containing magnesium percentage by weight containing magnesium percentage by weight, 2% weight containing magnesium
The PLGA- magnesium compound 1 of the PLGA- magnesium compounds 2,1% containing magnesium percentage by weight of amount percentage ratio.
In actual fabrication, made orthopedic implant can adopt content of magnesium for 1%, and 2%, 3%, 4%, 5%
... 95% PLGA- magnesium compounds, wherein each layer weight percent containing magnesium of several tabulars and cylinder embodiment is such as
Under：
Embodiment A
Ground floor percentage by weight containing magnesium is 1%, and second layer percentage by weight containing magnesium is 5%, and third layer percentage by weight containing magnesium is
10＆, the 4th layer of percentage by weight containing magnesium is 5%, and layer 5 percentage by weight containing magnesium is 1%.
Embodiment B
Ground floor percentage by weight containing magnesium is 2%, and second layer percentage by weight containing magnesium is 7%, and third layer percentage by weight containing magnesium is
15%, the 4th layer of percentage by weight containing magnesium is 30%, and layer 5 percentage by weight containing magnesium is 15%, layer 6 percentage by weight containing magnesium
For 7%, layer 7 percentage by weight containing magnesium is 2%.
Embodiment C
Ground floor percentage by weight containing magnesium is 10%, and second layer percentage by weight containing magnesium is 20%, third layer percentage by weight containing magnesium
For 30%, the 4th layer of percentage by weight containing magnesium is 40%, and layer 5 percentage by weight containing magnesium is 30%, layer 6 weight percent containing magnesium
Than for 20%, layer 7 percentage by weight containing magnesium is 10%.
Embodiment D
Ground floor percentage by weight containing magnesium is 3%, and second layer percentage by weight containing magnesium is 10%, and third layer percentage by weight containing magnesium is
20%, the 4th layer of percentage by weight containing magnesium is 35%, and layer 5 percentage by weight containing magnesium is 95%, layer 6 percentage by weight containing magnesium
For 35%, layer 7 percentage by weight containing magnesium is 20%, and the 8th layer of percentage by weight containing magnesium is 10%, the 9th layer of weight containing magnesium
Percentage ratio is 3%.
In the above-mentioned various orthopedic implants made by PLGA- magnesium compounds material, the content of magnesium of each layer is low, absorbs speed
Degree is slow；Content of magnesium is high, and infiltration rate is fast.Each level content of magnesium can be adjusted, each layer PLGA- is made according to using position and purpose
The thickness and content of magnesium of magnesium compound rationally, can provide preferably support, fixing intensity, or filling effect, reach preferably
Absorb degradation effect.
In Clinical practice, select the principle of different content of magnesium gradient PLGA- magnesium compounds as follows：
It is longer for complicated fracture healing times such as adult's shaft fracture, syntripsises and fractures, need higher-strength
Fixed position, selects outermost layer content of magnesium low（1-2%）, the big implants of thickness；
For adult's long bone setting board of skeleton end fracture and the dry fracture of long bones in children, select outermost layer content of magnesium slightly higher（3-5%）, thickness compared with
Big implants；
For positions such as adult's vertebral fracture, fracture of calcaneus and child's setting board of skeleton end fracture, select outermost layer content of magnesium higher（5-
10%）, the less implants of thickness.
The embodiment treated using the orthopedic implant of the present invention is as follows：
1. intramedullary nail treatment is fractured
During long bone shaft fracture, the intramedullary nail treatment fracture of present invention design is can select.From the present invention design intramedullary pin when,
It is preoperative to shoot strong side x-ray photo, it may be determined that suitable nail diameter, expand marrow amount, and according to needed for serious splintered fracture
Nail length.Nail length proximally should be worn enough to the center of distal end epiphysis.According to the situation in art, select optimal long
The intramedullary pin of degree.The selection of nail diameter size size and the degree crushed mainly according to patient bone.
2. nail-plate treatment is fractured
When long bone fracture involves metaphysis, intra-articular fracture or vertebral fracture, the nail and blade plate of present invention design is can select
Treatment fracture.The preoperative size that should be determined according to imaging data from blade plate and screw.Treatment knee joint peripheral, vertebral body etc.
When main weight bearing area is fractured, the nail-plate made by PLGA materials that magnesium content should be selected higher, to promote these positions to fracture
Quick healing.
3. rivet treatment is fractured or soft tissue injury
When avulsion fracture or tendon stop rupture, rivet is often needed to be fixed.Common rivet fixes nonabsorable, with surrounding
Tissue often reacts.PLGA- magnesium rivet can be absorbed, and for avulsion fracture has promotion bone while fixed little bone piece
The effect of folding healing.
Claims (6)
1. a kind of preparation method of PLGA- magnesium compounds, it is characterised in that：It is carried out using following steps：
A. determine preparation PLGA- magnesium compounds gross weight be m, wherein content of magnesium for gross weight n%；
B. weigh m × (100-n) % PLGA, while the purity for weighing m × n% be more than 99.9% high-purity magnesium powder it is standby；
C. use silicone oil as oil bath medium, the PLGA after weighing is added in container, container is put into into oil bath medium
In；
D. oil bath medium is heated, control oil bath temperature makes the PLGA in container gradually melt as viscous solution between 190-210 °
State；
E. the magnesium powder after weighing is added in the PLGA of container, stir to being sufficiently mixed；
F. stop heating, the mixture for dissolving in container is poured out in mould and is cooled down, that is, prepared containing percentage by weight
The solid-state PLGA- magnesium mixing material finished product of n% magnesium.
2. the preparation method of PLGA- magnesium compounds according to claim 1, it is characterised in that：Using said method successively
It is 1%, 2%, 3% to prepare content of magnesium, the PLGA- magnesium compounds of 4%, 5%......95%.
3. it is a kind of using above-mentioned PLGA- magnesium compounds make orthopedic implant method, it is characterised in that：It adopts following steps
Carry out：
A. select to make the mould of implants, mould is cuboid or cylinder；
B. select, with the different PLGA- magnesium compounds containing magnesium percentage by weight, to be separately heated in being placed on different containers
190-210 °, the PLGA- magnesium compounds in container are made gradually to melt as viscous liquid；
C. PLGA- magnesium compound of the difference of viscous liquid containing magnesium percentage by weight is slowly added in mould successively, makes phase
PLGA- magnesium compound of the difference of adjacent two-layer containing magnesium percentage by weight has obvious separating surface, forms the structure of multilamellar；
D. mould is uniformly cooled down, is fabricated to the flaggy shape PLGA- magnesium compounds of different content of magnesium gradients.
4. it is according to claim 3 make orthopedic implant method, it is characterised in that：Mould is added in step c
The percentage by weight containing magnesium of PLGA- magnesium compounds be that bottom is minimum, gradually increase upwards, to middle maximum, then gradually subtract
It is little, the percentage by weight containing magnesium of the percentage by weight containing magnesium of the PLGA- magnesium compounds of the superiors and the PLGA- magnesium compounds of bottom
It is corresponding.
5. it is a kind of using above-mentioned PLGA- magnesium compounds make orthopedic implant method, it is characterised in that：It adopts following steps
Carry out：
A. select to make the mould of implants, mold cylinder body, and prepare the sleeve of different-diameter, the maximum gauge of sleeve is less than
The internal diameter of mould, the sleeve set of different-diameter；
B. select, with the different PLGA- magnesium compounds containing magnesium percentage by weight, to be separately heated in being placed on different containers
190-210 °, the PLGA- magnesium compounds in container are made gradually to melt as viscous liquid；
C., PLGA- magnesium compounds of the difference of viscous liquid containing magnesium percentage by weight is implanted sequentially each sleeve of nesting
Between annular space in, the percentage by weight containing magnesium of the PLGA- magnesium compounds in cylindrical central sleeve is maximum, each concentric sleeve it
Between annular space in the percentage by weight containing magnesium of PLGA- magnesium compounds be from inside to outside gradually reduced；
D., after the PLGA- magnesium compounds between each sleeve are cooled into solid-state, middle each sleeve is taken out, is retained outmost
Then mould is slowly heated by mould, is made each layer PLGA- magnesium compounds in mould gradually melt fusion and is integrally formed.
6. it is a kind of using above-mentioned PLGA- magnesium compounds make orthopedic implant method, it is characterised in that：It adopts following steps
Carry out：
A. several different PLGA- magnesium compounds containing magnesium percentage by weight, and the molten condition at being kept for 190-210 DEG C are prepared；
B. solid cylindrical columns shape PLGA- magnesium compounds are made in the PLGA- magnesium compounds cooling for selecting percentage by weight containing magnesium maximum；
C. the PLGA- magnesium compounds for making solid cylinder are placed into into percentage by weight containing magnesium positioned at deputy PLGA- magnesium
In mixture liquid, uniform rotation makes the outer layer covers PLGA- magnesium compound liquid of the PLGA- magnesium compounds of solid cylinder,
Cool down after taking out, rotate during above-mentioned PLGA- magnesium compounds liquid is placed again into after cooling, superscribe PLGA- magnesium compound liquid,
Repeat said process, until percentage by weight containing magnesium reaches design requirement positioned at deputy PLGA- magnesium compounds thickness, cool down
To solid states；
D. the solid cylinder comprising two-layer PLGA- magnesium compound is placed into into percentage by weight containing magnesium positioned at the 3rd
In PLGA- magnesium compound liquid, the solid cylinder for including three layers of PLGA- magnesium compounds is made according to above-mentioned steps；
E. the like, the final PLGA- magnesium compound cylinders for making the content of magnesium difference gradient for meeting design requirement.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115591015A (en) * | 2022-10-25 | 2023-01-13 | 季华实验室（Cn） | Degradable metal/polymer composite bone fracture plate and preparation method thereof |
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| CN115591015B (en) * | 2022-10-25 | 2024-01-26 | 季华实验室 | Degradable metal/polymer composite bone fracture plate and preparation method thereof |
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