CN106539696B - The application of 5-ALA - Google Patents

The application of 5-ALA Download PDF

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Publication number
CN106539696B
CN106539696B CN201611114188.8A CN201611114188A CN106539696B CN 106539696 B CN106539696 B CN 106539696B CN 201611114188 A CN201611114188 A CN 201611114188A CN 106539696 B CN106539696 B CN 106539696B
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ala
polyvinyl alcohol
facial mask
composite material
prepared
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CN106539696A (en
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张艺萌
王清清
魏取福
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Jiangnan University
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Jiangnan University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0212—Face masks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8129—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical; Compositions of hydrolysed polymers or esters of unsaturated alcohols with saturated carboxylic acids; Compositions of derivatives of such polymers, e.g. polyvinylmethylether
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/004—Aftersun preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • D—TEXTILES; PAPER
    • D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
    • D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
    • D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
    • D04H1/40—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties
    • D04H1/42—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties characterised by the use of certain kinds of fibres insofar as this use has no preponderant influence on the consolidation of the fleece
    • D04H1/4382—Stretched reticular film fibres; Composite fibres; Mixed fibres; Ultrafine fibres; Fibres for artificial leather
    • D—TEXTILES; PAPER
    • D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
    • D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
    • D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
    • D04H1/70—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres
    • D04H1/72—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged
    • D04H1/732—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged by fluid current, e.g. air-lay

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Engineering & Computer Science (AREA)
  • Textile Engineering (AREA)
  • Chemical & Material Sciences (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Radiation-Therapy Devices (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention discloses the application of 5-ALA, specially application of the 5-ALA in light skin rejuvenating facial mask.The smooth skin rejuvenating facial mask is using non-woven fabrics as substrate, and composite material of the surface deposition load containing photosensitizer, wherein composite material is polyvinyl alcohol/styryl pyridinium condensation product of 5-ALA.5-ALA and the compound back loading of polyvinyl alcohol/styryl pyridinium are prepared light skin rejuvenating facial mask by the present invention, break the scope of conventional 5-ALA photon hydrogel local use, as daily skin repair, the product for the treatment of.In addition, polyvinyl alcohol/styryl pyridinium the condensation product and face mask substrate material of present invention combination electrostatic spinning and the functional electrospinning 5-ALA of generating positive and negative voltage craft of orientated deposition techniques realization is online compound.

Description

The application of 5-ALA
Technical field
The invention belongs to medical and beauty treatment fields, the new opplication more particularly to 5-ALA for being related to a kind of photosensitizer exist The preparation method of application and the facial mask in facial mask.
Background technique
With economic rapid development, people increasingly focus on the maintenance of personal skin quality, and wherein facial mask is particularly subject to favor. Skin problem is all often as caused by some cumulative bad light injuries, specifically includes light aging, wrinkle, epidermis irregularly become Thin, mottled pigmentation etc..The skin care products of traditional facial mask as just cleaning, nursing and nutrition skin of face come using, Skin problem can not be solved from root problem.
Photodynamic therapy (Photodynamic Therapy, PDT) is developed in recent years a kind of new physico Treatment technology is learned, the basic principle is that photosensitizer carries out energy jump under the excitation of specific wavelength light source, is then turned energy It moves and gives biology intracorporal oxygen, the latter forms singlet oxygen, free radical or radical ion etc., they act on target cell, cause Cell death or apoptosis.PDT with effectively, can concertedness, repeatability and the advantages such as relative cost is low attract extensive attention.
5-ALA (5-ALA) is used as a kind of endogenic biochemical substances, be it is a kind of can local use photosensitive agent Matter.1999, U.S. FDA had approved sharp Forlan aminoguanidine hydrochloride ketone valeric acid liniment (Levulan Kerastick, hydrochloric acid 5- amino Ketone valeric acid, Dusa drugmaker, the U.S.) it is used for the treatment of actinic keratosis.Light power is most active in dermal application Field first is that local use 5-ALA smear, it is right to be converted into protoporphyrin IX (PPIX) in vivo under the action of special wavelength light Target tissue plays lethal effect, is based on the mechanism, and 5-ALA is widely used in the treatment of skin disease and the improvement of skin quality.Report Road confirms that it has improvement skin texture, fine wrinkles and facial sallow, facial spot, wrinkle, facial sun damage, actinicity Keratosis and other effects is widely popularized in beauty hospital.
Polyvinyl alcohol-styryl pyridinium condensation product (PVA-SbQ) is a kind of novel light-sensitive material, is had good Biocompatibility and hydrophily, photonasty is high, and dimerization reaction can occur under ultraviolet light, and being formed has reticular structure Polymer.
Solution electrostatic spinning technique is to overcome polymer solution surface tension by applying high-pressure electrostatic to polymer solution And it is made to be drafted into the micron order even polymer fiber of Nano grade in electrostatic field.
Summary of the invention
The technical issues of solution: the new application in order to develop 5-ALA is applied in daily skin nursing, The preparation method of the application and the facial mask that the present invention provides a kind of 5-ALAs in facial mask.
Technical solution: application of the 5-ALA in light skin rejuvenating facial mask.
Preferably, the smooth skin rejuvenating facial mask is using non-woven fabrics as substrate, composite material of the surface deposition load containing photosensitizer.
Further, the composite material is polyvinyl alcohol/styryl pyridinium condensation product of 5-ALA.
Further, the substrate is spunlace non-woven cloth, wet nonwoven fabrics, needle punched non-woven fabrics, appointing in hydrophilic nonwoven fabrics It anticipates one kind.
Preferably, the content of the 5-ALA in the composite is 0.5~2%.
The light skin rejuvenating facial mask, wherein containing 5-ALA.
The preparation method of the light skin rejuvenating facial mask comprising the steps of:
(1) photosensitizing agent solution is prepared: under the conditions of 20~30 DEG C, 5-ALA being dissolved in deionized water, 500rpm Stirring 5~15 minutes；
(2) prepared by composite material: polyvinyl alcohol/styryl pyridinium, 500rpm stirring 8 being added into photosensitizing agent solution ~12 hours, polyvinyl alcohol/styryl pyridinium accounted for the 40~60% of composite material total amount；
(3) prepared by composite nano-fiber membrane: composite material prepared by step (2) being placed in syringe, syringe needle Add zero potential, the plate of face mask substrate material covering adds positive potential, and high-pressure electrostatic spins composite nano-fiber membrane, wherein voltage be -18~- 20kV, syringe needle jet velocity are 0.1~0.4mL/h, and spinning distance is 12~18cm；
(4) finished product: using composite nano-fiber membrane made from UV irradiation step (3), wherein ultraviolet wavelength λ= 365nm, exposure intensity are 50~200mW/cm2, irradiation time is 0.5~5 hour.
The utility model has the advantages that (1) is of the invention by 5-ALA and the compound back loading system of polyvinyl alcohol/styryl pyridinium Standby light skin rejuvenating facial mask, breaks the scope of conventional 5-ALA photon hydrogel local use, repairs as daily skin Multiple, treatment product；(2) present invention combines electrostatic spinning and generating positive and negative voltage craft of orientated deposition techniques to realize functional electrospinning 5- amino The polyvinyl alcohol of ketone valeric acid/styryl pyridinium condensation product and face mask substrate material it is online compound；(3) facial mask of the present invention For improving skin texture, fine wrinkles, facial sallow, spot, facial sun damage and actinic keratoma etc. with good Effect.
Detailed description of the invention
Fig. 1 is polyvinyl alcohol/styryl pyridinium nano fibrous membrane scanning electron of unsupported 5-ALA Microscope figure；
Fig. 2 is the scanning electron microscope diagram of smooth skin rejuvenating facial mask of the present invention.
Specific embodiment
Following embodiment further illustrates the contents of the present invention, but should not be construed as limiting the invention.Without departing substantially from In the case where spirit of that invention and essence, to modification made by the method for the present invention, step or condition and replaces, belong to the present invention Range.Unless otherwise specified, the conventional means that technological means used in embodiment is well known to those skilled in the art.
Embodiment 1
Application of the 5-ALA in light skin rejuvenating facial mask.
The smooth skin rejuvenating facial mask is using non-woven fabrics as substrate, composite material of the surface deposition load containing photosensitizer.
The composite material is polyvinyl alcohol/styryl pyridinium condensation product of 5-ALA.
The content of the 5-ALA in the composite is 0.5%.
The light skin rejuvenating facial mask, wherein containing 5-ALA.
The preparation method of the light skin rejuvenating facial mask comprising the steps of:
(1) photosensitizing agent solution is prepared: under the conditions of 25 DEG C, 5-ALA being dissolved in deionized water, 500rpm stirring 5 Minute；
(2) prepared by composite material: polyvinyl alcohol/styryl pyridinium, 500rpm stirring being added into photosensitizing agent solution 10 hours, polyvinyl alcohol/styryl pyridinium accounted for the 60% of composite material total amount；
(3) prepared by composite nano-fiber membrane: composite material prepared by step (2) being placed in syringe, syringe needle Adding zero potential, the plate of face mask substrate material covering adds positive potential, and high-pressure electrostatic spins composite nano-fiber membrane, and wherein voltage is -18kV, Syringe needle jet velocity is 0.3mL/h, and spinning distance is 15cm；
(4) finished product: using composite nano-fiber membrane made from UV irradiation step (3), wherein ultraviolet wavelength λ= 365nm, exposure intensity 150mW/cm2, irradiation time is 3 hours.
Embodiment 2
Application of the 5-ALA in light skin rejuvenating facial mask.
The smooth skin rejuvenating facial mask is using non-woven fabrics as substrate, composite material of the surface deposition load containing photosensitizer.
The composite material is polyvinyl alcohol/styryl pyridinium condensation product of 5-ALA.
The content of the 5-ALA in the composite is 1%.
The light skin rejuvenating facial mask, wherein containing 5-ALA.
The preparation method of the light skin rejuvenating facial mask comprising the steps of:
(1) photosensitizing agent solution is prepared: under the conditions of 20 DEG C, 5-ALA being dissolved in deionized water, 500rpm stirring 10 minutes；
(2) prepared by composite material: polyvinyl alcohol/styryl pyridinium, 500rpm stirring 8 being added into photosensitizing agent solution Hour, polyvinyl alcohol/styryl pyridinium accounts for the 50% of composite material total amount；
(3) prepared by composite nano-fiber membrane: composite material prepared by step (2) being placed in syringe, syringe needle Adding zero potential, the plate of face mask substrate material covering adds positive potential, and high-pressure electrostatic spins composite nano-fiber membrane, and wherein voltage is -19kV, Syringe needle jet velocity is 0.1mL/h, and spinning distance is 12cm；
(4) finished product: using composite nano-fiber membrane made from UV irradiation step (3), wherein ultraviolet wavelength λ= 365nm, exposure intensity 150mW/cm2, irradiation time is 5 hours.
Embodiment 3
Application of the 5-ALA in light skin rejuvenating facial mask.
The smooth skin rejuvenating facial mask is using non-woven fabrics as substrate, composite material of the surface deposition load containing photosensitizer.
The composite material is polyvinyl alcohol/styryl pyridinium condensation product of 5-ALA.
The content of the 5-ALA in the composite is 2%.
The light skin rejuvenating facial mask, wherein containing 5-ALA.
The preparation method of the light skin rejuvenating facial mask comprising the steps of:
(1) photosensitizing agent solution is prepared: under the conditions of 30 DEG C, 5-ALA being dissolved in deionized water, 500rpm stirring 15 minutes；
(2) prepared by composite material: polyvinyl alcohol/styryl pyridinium, 500rpm stirring being added into photosensitizing agent solution 12 hours, polyvinyl alcohol/styryl pyridinium accounted for the 40% of composite material total amount；
(3) prepared by composite nano-fiber membrane: composite material prepared by step (2) being placed in syringe, syringe needle Adding zero potential, the plate of face mask substrate material covering adds positive potential, and high-pressure electrostatic spins composite nano-fiber membrane, and wherein voltage is -20kV, Syringe needle jet velocity is 0.4mL/h, and spinning distance is 18cm；
(4) finished product: using composite nano-fiber membrane made from UV irradiation step (3), wherein ultraviolet wavelength λ= 365nm, exposure intensity 120mW/cm2, irradiation time is 4 hours.
Examples 1 to 3 combination electrostatic spinning and generating positive and negative voltage craft of orientated deposition techniques realize functional electrospinning 5-ALA/ PVA-SbQ composite nano fiber and basis material it is online compound.It will spin standby PVA-SbQ by electrostatic spinning technique is counter and receive Rice tunica fibrosa is scanned the observation of electron microscope, as shown in Figure 1, it can be seen that prepared PVA-SbQ nanofiber The fiber surface of film is smooth, and its diameter is evenly distributed, without apparent adhesion or thickness section.When passing through electrostatic spinning technique 5-ALA/PVA-SbQ composite nano fiber is prepared, electron microscope observation is scanned to obtained composite nano-fiber membrane, As shown in Fig. 2, it can be seen that the fiber surface of composite nano-fiber membrane is still smooth, but the diameter of fiber is unevenly distributed It is even, Adhesion formation fenestral fabric is generated between fiber.The above results show that 5-ALA generates PVA-SbQ composite nano fiber It influences, obtains the membrane material of novel load photosensitizer.
Photodynamic therapy (photodynamic therapy, PDT) is a kind of novel therapeutic skin developed in recent years The method of skin disease.Using additional photosensitizer or photosensitizer precursor, the excitation photoactivation photosensitizer of specific wavelength is given, to cause Cellular oxidation stress reaction leads to the death of specific target cell.Compared with the treatments such as traditional operation, injection, there is opposite choosing Select specificity, toxic side effect is small, Noninvasive, without add up toxicity the features such as.
Present invention firstly provides functional form photosensitizer 5-ALA is loaded in electro spinning nano fiber, preparation has light The facial mask of the tender skin effect of power is substituted routine 5-ALA photon hydrogel in the form of facial mask, breaches current 5-ALA light power The use theory for treating conventional method.
Photosensitizer 5-ALA is for improving skin texture, fine wrinkles and facial sallow, facial spot, wrinkle, facial daylight Damage, actinic keratoma etc. all have good function and effect, thus the function and effect of the material are different from common facial mask tool There is diversity.

Claims (1)

1. the preparation method of smooth skin rejuvenating facial mask, which is characterized in that comprise the steps of:
(1) photosensitizing agent solution is prepared: under the conditions of 20~30 DEG C, 5-ALA being dissolved in deionized water, 500rpm stirring 5 ~15 minutes；
(2) prepared by composite material: polyvinyl alcohol/styryl pyridinium, 500rpm stirring 8~12 being added into photosensitizing agent solution Hour, polyvinyl alcohol/styryl pyridinium accounts for the 40~60% of composite material total amount；
(3) prepared by composite nano-fiber membrane: composite material prepared by step (2) being placed in syringe, syringe needle adds zero The plate of potential, face mask substrate material covering adds positive potential, and high-pressure electrostatic spins composite nano-fiber membrane, wherein voltage be -18~- 20kV, syringe needle jet velocity are 0.1~0.4mL/h, and spinning distance is 12~18cm；
(4) finished product: using composite nano-fiber membrane made from UV irradiation step (3), wherein ultraviolet wavelength λ=365nm, Exposure intensity is 50~200mW/cm2, irradiation time is 0.5~5 hour.
CN201611114188.8A 2016-12-07 2016-12-07 The application of 5-ALA Active CN106539696B (en)

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Publication number Priority date Publication date Assignee Title
CN109091412B (en) * 2018-09-20 2021-08-10 江南大学 ALA-PDT light skin-tendering mask and preparation method thereof
CN110559204B (en) * 2019-10-11 2021-09-21 中国科学院过程工程研究所 5-aminolevulinic acid hydrogel composition and preparation method and application thereof
CN111437209A (en) * 2020-04-26 2020-07-24 华熙生物科技股份有限公司 Self-luminous photon skin-tendering hyaluronic acid moisturizing mask
CN111388349A (en) * 2020-04-26 2020-07-10 华熙生物科技股份有限公司 Facial mask containing moisturizing and whitening essence and preparation method thereof

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CN101829025A (en) * 2010-04-27 2010-09-15 马兆成 Bioactive facial mask and preparation method therefore
CN101843578A (en) * 2010-05-14 2010-09-29 东华大学 Nanofiber membrane carrying anti-tumor photosensitizer and preparation method thereof
CN102670415A (en) * 2012-04-20 2012-09-19 费兰克·K·高 Nano fiber paper mask
CN103183833A (en) * 2012-12-14 2013-07-03 江南大学 Method for preparing photo-crosslinked sodium alginate/polyvinyl alcohol-styryl pyridinium condensate composite film
CN104877667A (en) * 2015-04-01 2015-09-02 北京师范大学 Fluorescent response thin-film material having humidity sensitive characteristics and preparation method thereof
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