CN106511977A - Collagen dressing - Google Patents
Collagen dressing Download PDFInfo
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- CN106511977A CN106511977A CN201610963851.5A CN201610963851A CN106511977A CN 106511977 A CN106511977 A CN 106511977A CN 201610963851 A CN201610963851 A CN 201610963851A CN 106511977 A CN106511977 A CN 106511977A
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- Prior art keywords
- collagen
- shitosan
- woven fabrics
- wound
- dressing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
- A61L15/325—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention relates to the field of medicines and particularly relates to collagen dressing. A composition provided by the invention comprises chitosan or a derivative and a collagen. The invention further provides collagen dressing comprising a chitosan non-woven fabric. By virtue of good biocompatibility, antibacterial activity and heal-promoting action of chitosan and combining the action of promoting wound repair of the collagen, the wound is more effectively promoted to be healed and wound disinfection treatment measures are reduced.
Description
Technical field
The present invention relates to drug world, more particularly to a kind of collagen plaster dressing.
Background technology
The surface of a wound is normal skin (tissue) causes injury the factor such as surgical operation, external force, heat, electric current, chemical substance, low in the external world
Damage caused by lower of the effect such as temperature and body internal factor such as local blood supply obstacle.It is often accompanied by the broken of skin integrity
The loss of evil idea and a certain amount of normal structure, meanwhile, the normal function of skin is damaged, also referred to as wound or wound.The surface of a wound is repaiied
Multiple both wound reparations.
Wound healing (Wound healing) refer to due to the effect of the factor of causing injury cause tissue disappearance after, local organization
By regenerating (Regeneration), repairing (Repair), rebuild (Reconstruction), a series of pathology repaired
Physiology course.Substantially it is that body is fitted to a kind of intrinsic defense of the tissue cell insult caused by the effect of various adverse factors
Answering property is reacted.This Regeneration and Repair show lose institutional framework recovery on, also can recover its function to some extent.So
And, the histiocytic reparation of loss can be original histiocytic " restoring completely " --- ----referred to as " regenerate "
(Regeneration)；Can also be substituting original histocyte, to be formed " not complete by nonspecific connective tissue proliferation
It is complete to restore " ----(Repair), but referred to as " repair ", both different results, its process are but identicals.The surface of a wound is healed
ABC regeneration (Regeneration) regeneration of conjunction is the compensation for forfeiture tissue and cell, therefore is wound healing
Initiating and basis.Under normal circumstances, some tissues and cell constantly can consume, it is aging and dead, and constantly by of the same race thin
Born of the same parents' division and proliferation is supplemented, referred to as physiological regeneration (Physiological regeneration), such as coming off for epidermis
With renewal, the and for example periodic apoptosis of haemocyte and supplement.Cell after it is characterized in that regenerating maintains original structure completely
With function, therefore referred to as completeness regeneration (Complete regeneration).And after the histocyte caused by damaging is lost
Regeneration, referred to as pathological regeneration (Pathological regeneration) or prosthetic regeneration.
Collagen plaster dressing is used for the rear surface of a wound of the Minimally Invasive Surgeries such as laser therapy, promotes the surface of a wound, suppresses cicatrization.At present
The collagen plaster dressing of most of patent notes, is adsorbed in conventional non-woven fabrics material, merely with collagen using collagen liquid
Promote the effect of wound repair.
Conventional material non-woven fabrics only plays flap coverage and acts on, and the functional components without wound healing, and
There is no the effect of prevention trauma surface infestation, need to take the extra surface of a wound to disinfect measure, increase surface of a wound nursing difficulty.
The content of the invention
In view of this, the present invention provides a kind of collagen plaster dressing.Present invention utilizes the biocidal property of shitosan and promotion wound
Face healing properties, flap coverage play wound healing and pre- aseptic effect, the medical adhesive containing shitosan non-woven fabrics
Former sticking dressing collagen solution not only played collagen promote wound repair effect, also using shitosan it is antibacterial and promote the surface of a wound
The effect of healing, more effectively wound healing.
In order to realize foregoing invention purpose, the present invention provides technical scheme below：
The invention provides a kind of composition, including shitosan or derivatives thereof and collagen.
In some specific embodiments of the present invention, shitosan or derivatives thereof and collagen in the composition
Mass ratio is (1～50):(0.01～10).
In some specific embodiments of the present invention, chitosan derivatives described in the composition are selected from shitosan season
Ammonium salt, shitosan carboxylate, chitosan acetate or chitosan hydrochloride.
The present invention some specific embodiments in, the deacetylation of shitosan described in the composition be 30%～
100%.
Present invention also offers application of the composition in the medicine for preparing antibacterial and/or wound repair.
Present invention also offers a kind of sticking dressing, including the composition that the present invention is provided.
In some specific embodiments of the present invention, the sticking dressing includes collagen solution and shitosan non-woven fabrics；It is described
Collagen solution is made up of collagen and conventional medical accessory, and wherein collagen content is 0.01～0.5%.
In some specific embodiments of the present invention, described in the sticking dressing, the thickness of shitosan non-woven fabrics is
0.01mm～0.5cm.
Present invention also offers the preparation method of the sticking dressing, comprises the steps：
Step 1：Collagen dissolving is taken, collagen solution is obtained；
Step 2：Take shitosan non-woven fabrics of the shitosan or derivatives thereof using wet spinning or electrostatic spinning process；
Step 3：Take shitosan non-woven fabrics obtained in step 2 to mix with collagen solution obtained in step 1, encapsulate.
Present invention also offers described sticking dressing or sticking dressing obtained in described preparation method prepare it is antibacterial and/or
Application in the medicine of wound repair.
The invention provides a kind of composition, including shitosan or derivatives thereof and collagen.Additionally provide containing shell
The collagen plaster dressing of glycan non-woven fabrics, is acted on using the good biocompatibility of shitosan, biocidal property and promoting healing, incorporating collagen
Albumen itself promotes the effect of wound repair, more effectively wound healing, reduces the surface of a wound and disinfects measure.
Specific embodiment
The invention discloses a kind of collagen plaster dressing, those skilled in the art can use for reference present disclosure, be suitably modified work
Skill parameter is realized.Specifically, all similar replacements and change are aobvious and easy for a person skilled in the art
See, they are considered as being included in the present invention.The method of the present invention and application are described by preferred embodiment,
Related personnel substantially can in without departing from present invention, spirit and scope to method described herein and application be modified or
It is appropriate to change and combine, realize and apply the technology of the present invention.
A kind of medical collagen sticking dressing containing shitosan non-woven fabrics, which is made up of collagen solution and shitosan non-woven fabrics.
Collagen solution is made up of collagen and conventional medical accessory, and wherein collagen content is 0.01-0.5%.Shitosan non-woven fabrics
Middle deacetylating degree of chitosan is between 30%-100%；Shitosan can be shitosan, and chitosan derivatives are (such as chitosan quaternary ammonium
Salt, shitosan carboxylate, chitosan acetate etc.), can be one of which material or mixture；Shitosan nonwoven thickness exists
Between 0.01mm-0.5cm.
Present invention also offers a kind of preparation method of the medical collagen sticking dressing containing shitosan non-woven fabrics, including it is following
Step：
Collagen is dissolved by step 1, prepares collagen solution；
Step 2 shitosan raw material is prepared into shitosan non-woven fabrics using wet spinning or electrostatic spinning process；
Step 3 loads the shitosan non-woven fabrics for preparing in aluminium foil bag, adds collagen solution, aluminium foil bag sealing；
Aluminium foil bag is proceeded to outsourcing operation by step 4, completes outsourcing.
Note：Can be with using process is aseptic or the mode such as irradiation sterilization makes final products aseptic.If irradiation sterilization, in aluminium foil bag
Sealing is carried out after terminating, and irradiation sterilization irradiation dose is between 5kGy-25kGy.
The invention provides a kind of composition, including shitosan or derivatives thereof and collagen.Additionally provide containing shell
The collagen plaster dressing of glycan non-woven fabrics, is acted on using the good biocompatibility of shitosan, biocidal property and promoting healing, incorporating collagen
Albumen itself promotes the effect of wound repair, more effectively wound healing, reduces the surface of a wound and disinfects measure.
In a kind of collagen plaster dressing that the present invention is provided, raw materials used and reagent can be buied by market.
With reference to embodiment, the present invention is expanded on further：
Embodiment 1
A kind of to contain shitosan non-woven fabrics medical collagen sticking dressing, which constitutes (glue by collagen solution and shitosan non-woven fabrics
The mass ratio of former albumen and shitosan is 0.01g:1g.Wherein shitosan non-woven fabrics raw material is shitosan.
Embodiment 2
It is a kind of to contain shitosan non-woven fabrics medical collagen sticking dressing, its be made up of collagen solution and shitosan non-woven fabrics (with
The mass ratio of shitosan meter, collagen and shitosan is 1g：10g.Wherein shitosan non-woven fabrics raw material is chitosan quaternary ammonium salt.
Embodiment 3
It is a kind of to contain shitosan non-woven fabrics medical collagen sticking dressing, its be made up of collagen solution and shitosan non-woven fabrics (with
The mass ratio of shitosan meter, collagen and shitosan is 10g:50g.Wherein shitosan non-woven fabrics raw material is carboxymethyl chitosan
Sugar.
Embodiment 4
It is a kind of to contain shitosan non-woven fabrics medical collagen sticking dressing, its be made up of collagen solution and shitosan non-woven fabrics (with
The mass ratio of shitosan meter, collagen and shitosan is 1g:8g.Wherein shitosan non-woven fabrics raw material is chitosan acetate.
Embodiment 5
It is a kind of to contain shitosan non-woven fabrics medical collagen sticking dressing, its be made up of collagen solution and shitosan non-woven fabrics (with
The mass ratio of shitosan meter, collagen and shitosan is 2g:10g.Wherein shitosan non-woven fabrics raw material is chitosan hydrochloride.
Embodiment 6
It is a kind of to contain shitosan non-woven fabrics medical collagen sticking dressing, its be made up of collagen solution and shitosan non-woven fabrics (with
The mass ratio of shitosan meter, collagen and shitosan is 1g:12g.Wherein shitosan non-woven fabrics raw material is chitosan hydrochloride.
Embodiment 7
A kind of to contain shitosan non-woven fabrics medical collagen sticking dressing, which is (poly- with shell by collagen solution and shitosan non-woven fabrics
The mass ratio of sugar meter, collagen and shitosan is 1.2g:9g is constituted.Wherein shitosan non-woven fabrics raw material is that shitosan and shell are poly-
Sugar derivatives mixture, wherein mass ratio are as follows：
Comparative example
Existing components and content are：Polyethylene：Collagen=15：0.1, polyethylene nonwoven is 15g, collagen solution
20ml, collagen total amount are 0.1g, are divided into water 19.9g more than collagen solution.
9 bacteriostatic test of embodiment
Bacteriostatic test is tested according to FZ/T 52012-2011 regulation bacteriostatic test methods, and result of the test is shown in Table 1.With
Bacteriostasis rate ＞ 50% is that standard is judged with bacteriostasis, judges with bactericidal action by standard of bacteriostasis rate ＞ 90%, and presses down
Bacterium rate ＜ 50% can consider for standard and do not have bacteriostasis.
Bacteriostatic test result difference is it will be evident that 6 bacteriostasis rate of embodiment 1- embodiment and the presence of comparative example bacteriostasis rate extremely show
Write difference (p ＜ 0.01).
1 bacteriostatic test result of table
10 wound repair animal experiment of embodiment
Using 3 healthy adult rabbits, 8 positions are chosen along back backbone both sides, size about 1cm × 1cm, back cropping,
Alcohol disinfecting process, simulates the superficial second degree burn surface of a wound, carries out surface of a wound covering using embodiment 1-7 and comparative example, wherein every rabbit
The each surface of a wound in backbone both sides carries out surface of a wound covering using comparative example, and the remaining surface of a wound is carried out using embodiment 1-7 and comparative example
The surface of a wound is covered, and observes wound healing situation.
7 days and 14 days wound healing situations after starting to animal dressing, viewing test according to normal dressing change method.Test knot
Fruit is it is found that the more conventional non-woven fabrics medical collagen sticking dressing product of chitosan-containing non-woven fabrics medical collagen sticking dressing can be effectively pre-
Anti- infection, reduces surface of a wound disinfection nursing, effectively facilitates the surface of a wound.
Table 2
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (10)
1. a kind of composition, it is characterised in that including shitosan or derivatives thereof and collagen.
2. composition according to claim 1, it is characterised in that the mass ratio of shitosan or derivatives thereof and collagen
For (1～50):(0.01～10).
3. composition according to claim 1 and 2, it is characterised in that the chitosan derivatives are selected from chitosan quaternary ammonium
Salt, shitosan carboxylate, chitosan acetate or chitosan hydrochloride.
4. the composition according to any one of claims 1 to 3, it is characterised in that the deacetylation of the shitosan is
30%～100%.
5. the composition according to any one of Claims 1-4 in the medicine for preparing antibacterial and/or wound repair should
With.
6. a kind of sticking dressing, it is characterised in that include the composition as described in any one of Claims 1-4.
7. sticking dressing according to claim 6, it is characterised in that including collagen solution and shitosan non-woven fabrics；
The collagen solution is made up of collagen and conventional medical accessory, and wherein collagen content is 0.01～0.5%.
8. sticking dressing according to claim 6, it is characterised in that the thickness of the shitosan non-woven fabrics be 0.01mm～
0.5cm。
9. the preparation method of the sticking dressing according to any one of claim 6 to 8, it is characterised in that comprise the steps：
Step 1：Collagen dissolving is taken, collagen solution is obtained；
Step 2：Take shitosan non-woven fabrics of the shitosan or derivatives thereof using wet spinning or electrostatic spinning process；
Step 3：Take shitosan non-woven fabrics obtained in step 2 to mix with collagen solution obtained in step 1, encapsulate.
10. sticking dressing according to any one of claim 6 to 8 or patch obtained in preparation method as claimed in claim 9
Application of the dressing in the medicine for preparing antibacterial and/or wound repair.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610963851.5A CN106511977A (en) | 2016-11-04 | 2016-11-04 | Collagen dressing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610963851.5A CN106511977A (en) | 2016-11-04 | 2016-11-04 | Collagen dressing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106511977A true CN106511977A (en) | 2017-03-22 |
Family
ID=58327037
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610963851.5A Pending CN106511977A (en) | 2016-11-04 | 2016-11-04 | Collagen dressing |
Country Status (1)
| Country | Link |
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| CN (1) | CN106511977A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107441479A (en) * | 2017-08-08 | 2017-12-08 | 广东海洋大学 | Marine active peptide/chitin burn ointment for treating scald and preparation method thereof |
| CN113975448A (en) * | 2021-11-26 | 2022-01-28 | 李毅 | Collagen composite dressing and preparation method thereof |
| CN115948913A (en) * | 2022-12-16 | 2023-04-11 | 浙江剑利美针织服饰有限公司 | Antibacterial underwear knitted fabric and preparation method thereof |
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| CN101721691A (en) * | 2008-11-04 | 2010-06-09 | 上海高科联合生物技术研发有限公司 | Preparation for treating and restoring infective wound surface and preparation method thereof |
| CN104189945A (en) * | 2014-09-29 | 2014-12-10 | 福州大学 | Double-layered composite biological dressing and adhesive-free compound technology thereof |
| CN104474573A (en) * | 2014-11-27 | 2015-04-01 | 绍兴金石生物工程有限公司 | Biological mask and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101721691A (en) * | 2008-11-04 | 2010-06-09 | 上海高科联合生物技术研发有限公司 | Preparation for treating and restoring infective wound surface and preparation method thereof |
| CN104189945A (en) * | 2014-09-29 | 2014-12-10 | 福州大学 | Double-layered composite biological dressing and adhesive-free compound technology thereof |
| CN104474573A (en) * | 2014-11-27 | 2015-04-01 | 绍兴金石生物工程有限公司 | Biological mask and preparation method thereof |
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| 余丕军等: "胶原蛋白-壳聚糖复合纳米纤维膜用于皮肤缺损的修复", 《中国组织工程研究与临床康复》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107441479A (en) * | 2017-08-08 | 2017-12-08 | 广东海洋大学 | Marine active peptide/chitin burn ointment for treating scald and preparation method thereof |
| CN107441479B (en) * | 2017-08-08 | 2018-12-21 | 广东海洋大学 | Marine active peptide/chitin burn ointment for treating scald and preparation method thereof |
| CN113975448A (en) * | 2021-11-26 | 2022-01-28 | 李毅 | Collagen composite dressing and preparation method thereof |
| CN115948913A (en) * | 2022-12-16 | 2023-04-11 | 浙江剑利美针织服饰有限公司 | Antibacterial underwear knitted fabric and preparation method thereof |
| CN115948913B (en) * | 2022-12-16 | 2024-06-14 | 浙江剑利美针织服饰有限公司 | Antibacterial underwear knitted fabric and preparation method thereof |
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Inventor after: Chen Haijia Inventor after: Ge Xiaohu Inventor after: Wang Yifei Inventor after: Hou Changbin Inventor after: Wang Xiaoyan Inventor after: Wang Dianliang Inventor after: He Yong Inventor before: Chen Haijia Inventor before: Ge Xiaohu Inventor before: Wang Yifei Inventor before: Hou Changbin Inventor before: Wang Xiaoyan |
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Application publication date: 20170322 |