CN106501204A - A kind of novel nucleic acids Protein Detection instrument - Google Patents
A kind of novel nucleic acids Protein Detection instrument Download PDFInfo
- Publication number
- CN106501204A CN106501204A CN201710032090.6A CN201710032090A CN106501204A CN 106501204 A CN106501204 A CN 106501204A CN 201710032090 A CN201710032090 A CN 201710032090A CN 106501204 A CN106501204 A CN 106501204A
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- China
- Prior art keywords
- detector
- panel
- nucleic acids
- detection instrument
- novel nucleic
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 102000039446 nucleic acids Human genes 0.000 title claims abstract description 17
- 108020004707 nucleic acids Proteins 0.000 title claims abstract description 17
- 150000007523 nucleic acids Chemical class 0.000 title claims abstract description 17
- 238000002331 protein detection Methods 0.000 title claims abstract description 16
- 230000035945 sensitivity Effects 0.000 claims abstract description 22
- 230000003287 optical effect Effects 0.000 claims abstract description 14
- 239000012530 fluid Substances 0.000 claims abstract description 13
- 238000001514 detection method Methods 0.000 claims abstract description 7
- 230000005540 biological transmission Effects 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 3
- 238000005265 energy consumption Methods 0.000 abstract description 2
- 238000010438 heat treatment Methods 0.000 abstract description 2
- 238000005516 engineering process Methods 0.000 description 8
- 238000003199 nucleic acid amplification method Methods 0.000 description 7
- 230000003321 amplification Effects 0.000 description 6
- 239000007788 liquid Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000011901 isothermal amplification Methods 0.000 description 2
- 238000003752 polymerase chain reaction Methods 0.000 description 2
- 238000007397 LAMP assay Methods 0.000 description 1
- 102000018120 Recombinases Human genes 0.000 description 1
- 108010091086 Recombinases Proteins 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/33—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using ultraviolet light
Abstract
The invention discloses a kind of novel nucleic acids Protein Detection instrument, there is housing, the side of housing is provided with panel, panel is provided with display screen, it is characterized in that, ultraviolet source is sequentially provided with housing, detector mounting groove, detector, ultraviolet optical pickup apparatus and circuit logarithm plate, panel is provided with into fluid controller, feed liquor control handle and sensitivity adjusting knob, described ultraviolet source can send wavelength for 180 400nm ultraviolet lights, detector has the sample cell passed through for detection sample, the two ends of the sample cell connect feed tube and drain pipe respectively, sample cell is in the detector mounting groove.The device have the advantages that：Reliable in quality, stable performance, sensitive, easy to use.The well-designed processing of wavelength selection mechanism, accurate positioning, operation are soft, and LED numerical monitors, instrument exquisiteness are attractive in appearance.Ultraviolet source is low in energy consumption, and heating is less and stable.
Description
Technical field
The present invention relates to nucleic acid-protein detection correlative technology field, and in particular to a kind of novel nucleic acids Protein Detection instrument.
Background technology
With the development of science and technology, detection of nucleic acids has been increasingly being applied to medical diagnosiss, food safety detection
In field.At present conventional nucleic acid amplification method has amplification technique based on classical Common Polymerase Chain Reaction (PCR) and new
Emerging isothermal amplification technology, such as cross primer isothermal amplification technology (CPA), loop-mediated isothermal amplification technology (LAMP), strand displacement
Amplification (SDA), the amplification (HDA) for relying on unwindase, restructuring polymeric enzymatic amplification (RPA), amplification (RAA) of recombinase-mediated etc..
As the high sensitivity of nucleic acid amplification technologies, the yield of amplified production are very high, Aerosol is therefore faced.
Nucleic acid-protein detection method needs the operation of professional at present, is unfavorable for promoting, and easily causes intersection without dye.
Content of the invention
The invention aims to making up the deficiencies in the prior art, there is provided a kind of stable new of reliable in quality performance
Nucleic acid-protein detector.
In order to reach the purpose of the present invention, technical scheme is as follows：
A kind of novel nucleic acids Protein Detection instrument, with housing, the side of housing is provided with panel, and panel is provided with display
Screen, it is characterised in that be sequentially provided with ultraviolet source, detector mounting groove, detector, ultraviolet optical pickup apparatus and circuit in housing
Logarithm plate, panel are provided with into fluid controller, feed liquor control handle and sensitivity adjusting knob, and described ultraviolet source can be sent out
Go out wavelength for 180-400nm ultraviolet lights,
The two ends that detector has the sample cell passed through for detection sample, the sample cell connect feed tube respectively and go out liquid
Pipe, sample cell are arranged in the detector mounting groove,
Filter runner is installed near the side of ultraviolet source on detector mounting groove, filter runner can turn around its center of circle
Move and be provided with four filter holes, filter piece is respectively arranged with each filter hole, on the ultraviolet light optical filter that ultraviolet source sends
Convergent hole, optically focused detects the concentration of material on sample cell, and again on ultraviolet optical pickup apparatus, circuit logarithm plate goes out data to light
Optical signal is changed into current signal afterwards to be shown on display screen.
Preferably, in the upper left side of panel, detector is fixed on housing display location.
Preferably, control handle and sensitivity adjusting knob are additionally provided with the panel, and control handle is used for fluid flow
Control is adjusted, sensitivity adjusting knob is used for adjusting detector sensitivity.
Preferably, the control handle and sensitivity adjusting knob on described panel is to carry out function choosing when detector works
Select and sensitivity adjusting, display screen shows testing result.
Preferably, A zero-setting buttons are also equipped with the panel and adjust T buttons.
Preferably, the described fluid controller that enters includes that movable part, fixed component and roller group, roller group are located at movable part
The downside of part, the pipe of feed liquor is through movable part and roller group and being wound on the upside of roller group, the center of roller group
There is the power transmission shaft for driving which to rotate.
Preferably, a wheel is provided with fixed component, and movable part is provided with depression bar, the lower end of depression bar and wheel
Connection, wheel are placed in a fixed space and can only rotate in the space of the fixation, the connection of depression bar and wheel
Marginal position of the place near wheel.
Preferably, the roller group has two parallel arrangement of rotating disks, be provided between rotating disk and rotating disk 3 cylindrical
Roller, power transmission shaft are connected with the rotating disk.
The device have the advantages that：
Reliable in quality, stable performance, sensitive, easy to use.The well-designed processing of wavelength selection mechanism, accurate positioning, behaviour
Make soft, LED numerical monitors, instrument exquisiteness are attractive in appearance.Ultraviolet source is low in energy consumption, and heating is less and stable.
Description of the drawings
Fig. 1 is the structural representation of nucleic acid-protein detector of the present invention.
Fig. 2 is the structural representation inside nucleic acid-protein detector of the present invention.
Fig. 3 is the structural representation of nucleic acid-protein detector detector of the present invention.
Fig. 4 is the structural representation that nucleic acid-protein detector of the present invention enters fluid controller.
Fig. 5 is the dorsal view that nucleic acid-protein detector of the present invention enters fluid controller.
Side structure schematic views of the Fig. 6 for roller group.
Specific embodiment
With reference to embodiment, the invention will be further described, but protection scope of the present invention is not limited solely to implement
Example.
In conjunction with shown in Fig. 1-Fig. 5, a kind of novel nucleic acids Protein Detection instrument, with housing 1, the side of housing 1 is provided with face
Plate 2, panel 2 are provided with display screen 14.Ultraviolet source 7, detector mounting groove 4, detector 5, ultraviolet light are sequentially provided with housing 1
Reception device 6 and circuit logarithm plate 15, panel 2 are provided with into fluid controller 3, feed liquor control handle 12 and sensitivity adjusting knob
13, described ultraviolet source 7 can send wavelength for 180-400nm ultraviolet lights.
There is on detector 5 sample cell 16 passed through for detection liquid sample, the two ends of the sample cell 16 connect respectively
Feed tube 8 and drain pipe 9, sample cell 16 is in the detector mounting groove 4.
Side on detector mounting groove 4 near ultraviolet source 7 is provided with filter runner 10, and filter runner 10 can surround which
The center of circle rotates and is provided with four filter holes 11, is respectively arranged with filter piece, the ultraviolet lighting that ultraviolet source 7 sends in each filter hole 11
The convergent hole that penetrates on optical filter, optically focused detect the concentration of material on sample cell 16, light again on ultraviolet optical pickup apparatus 6, electricity
Optical signal is changed into current signal after going out data and is shown on display screen 14 by road logarithm plate 15.Ultraviolet optical pickup apparatus 6 can be with
Optical signal is changed into current signal, ultraviolet optical pickup apparatus side is circuit logarithm plate 15, the input of current signal amplified device
Logarithmic converter is arrived, finally by circuit logarithm plate 15, the signals such as the concentration of protein, nucleic acid is changed into, and by display screen display
Illustrate and.
Display screen 14 is located at the upper left side of panel 2, and detector 5 is fixed on housing 1.Control handle is additionally provided with panel 2
12 and sensitivity adjusting knob 13, control handle 12 is used for fluid flow and adjusts control, and sensitivity adjusting knob 13 is used for adjusting
Detector sensitivity.Control handle 12 and sensitivity adjusting knob 13 on panel 2 is to carry out function selecting when detector works
And sensitivity adjusting, display screen 14 shows testing result.A zero-setting buttons 18 are also equipped with panel 2 and adjust T buttons 17.
Include that movable part 18, fixed component 19 and roller group 22, roller group 22 set in conjunction with fluid controller 3 shown in Fig. 6, is entered
In the downside of movable part, the pipe of feed liquor is through movable part 18 and roller group 22 and being wound on the upper of roller group 22
Side, the center of roller group 22 have the power transmission shaft 23 for driving which to rotate.Roller group 22 has two parallel arrangement of rotating disks 222,
3 cylindrical rollers 221 are provided between rotating disk and rotating disk, the two ends of roller 221 are connected on two rotating disks 222, pass
Moving axis 23 is connected with the rotating disk.
A wheel 21 is provided with fixed component, and movable part 18 is provided with depression bar 17, the lower end of depression bar 17 and wheel
Son 21 connects, and wheel 21 is placed in a fixed space and can only be in rotation in the space of the fixation, depression bar 17 and wheel
Marginal position of the junction of son 21 near wheel (i.e. depression bar is not connected with the center of wheel).
During work, first open A zero-setting buttons 18 and adjust T buttons 17, sensitivity adjusting knob 13 is rotated to 100%T, makes sample
Product pond printing opacity, now detects the data for obtaining as blank radix.Sensitivity adjusting knob 13 is rotated to 1A or 2A, open into
3 feed liquor of fluid controller, starts to detect.Ultraviolet source 7 sends ultraviolet, through the regulation to filter runner 10, difference may be selected
The light of wavelength is entered inside detector mounting groove 4 and is impinged upon on sample cell 16, and nucleic acid-protein is detected.
During feed liquor, by down-pressed pole 17, push movable part 18 and abut with fixed component 19, movable part 18 and fixed part
Space between part 19 diminishes, also, at the roller 221 of the top A1, the 18 tight patch of movable part of roller 221 and upside
Close, feed tube is blocked at the roller of the top, liquid sample cannot flow.In the case where power transmission shaft drives, roller group is sent out
Raw rotation, the roller of the top A1 are departed from feed tube and movable part, and the roller at A2 presses feed tube and constantly rotates,
Now can smooth feed liquor, when the roller being rotated further to A2 reaches the top, feed tube is closed.It is rotated further, A3
Roller presses feed tube and constantly rotates, and makes liquor sample enter sample cell, until A3 rollers reach the top position.It is further continued for
Rotate, repeat said process, when roller 221 presses feed tube and rotates, reached the effect of feed liquor.
Finally it should be noted that：Above example only not limits technology described in the invention in order to the present invention to be described
Scheme, therefore, although this specification with reference to each above-mentioned embodiment to present invention has been detailed description, this
Field it is to be appreciated by one skilled in the art that still can modify to the present invention or equivalent, and all are without departing from this
The technical scheme of the spirit and scope of invention and its improvement, its all should be covered in scope of the presently claimed invention.
Claims (8)
1. a kind of novel nucleic acids Protein Detection instrument, with housing (1), the side of housing is provided with panel (2), and panel is provided with aobvious
Display screen (14), it is characterised in that be sequentially provided with ultraviolet source (7), detector mounting groove (4), detector (5), ultraviolet in housing
Optical pickup apparatus (6) and circuit logarithm plate (15), panel (2) are provided with into fluid controller (3), feed liquor control handle (12) and spirit
Sensitivity adjusting knob (13), described ultraviolet source (7) can send wavelength for 180-400nm ultraviolet lights,
Detector (5) has the sample cell (16) passed through for detection sample, and the two ends of the sample cell connect feed tube (8) respectively
With drain pipe (9), sample cell (16) in the detector mounting groove,
The upper side near ultraviolet source of detector mounting groove (4) is provided with filter runner (10), and filter runner (10) can be surrounded
Its center of circle rotates and is provided with four filter holes (11), is respectively arranged with filter piece in each filter hole (11), and ultraviolet source (7) sends
Convergent hole on ultraviolet light optical filter, concentration of the optically focused in the upper detection material of sample cell (16), light arrive ultraviolet light-receiving again
On device (6), optical signal is changed into current signal after going out data and is shown on display screen (14) by circuit logarithm plate (15).
2. novel nucleic acids Protein Detection instrument according to claim 1, it is characterised in that display screen (14) is located at panel (2)
Upper left side, detector (5) is fixed on housing (1).
3. novel nucleic acids Protein Detection instrument according to claim 1, it is characterised in that be additionally provided with control rotation on the panel
Button (12) and sensitivity adjusting knob (13), control handle are used for fluid flow and adjust control, and sensitivity adjusting knob is used for adjusting
Section detector sensitivity.
4. novel nucleic acids Protein Detection instrument according to claim 1, it is characterised in that the control on described panel (2)
Knob (12) and sensitivity adjusting knob (13) are to carry out function selecting and sensitivity adjusting, display screen (14) when detector works
Show testing result.
5. novel nucleic acids Protein Detection instrument according to claim 1, it is characterised in that be also equipped with A tune on the panel
Zero button (18) and tune T buttons (17).
6. novel nucleic acids Protein Detection instrument according to claim 1, it is characterised in that described enters fluid controller (3) bag
Movable part (18), fixed component (19) and roller group (22) is included, roller group is worn located at the downside of movable part, the pipe of feed liquor
The upside of roller group is crossed between movable part and roller group and is wound on, the center of roller group has the power transmission shaft for driving which to rotate
(23).
7. novel nucleic acids Protein Detection instrument according to claim 6, it is characterised in that be provided with fixed component
Wheel (21), movable part are provided with depression bar (17), and the lower end of depression bar is connected with wheel, and wheel is placed in a fixed space
And can only rotate in the space of the fixation, the marginal position of the junction of depression bar and wheel near wheel.
8. novel nucleic acids Protein Detection instrument according to claim 7, it is characterised in that the roller group have two parallel
The rotating disk (222) of setting, is provided with 3 cylindrical rollers (221) between rotating disk and rotating disk, power transmission shaft is connected with the rotating disk.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710032090.6A CN106501204A (en) | 2017-01-17 | 2017-01-17 | A kind of novel nucleic acids Protein Detection instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710032090.6A CN106501204A (en) | 2017-01-17 | 2017-01-17 | A kind of novel nucleic acids Protein Detection instrument |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106501204A true CN106501204A (en) | 2017-03-15 |
Family
ID=58345302
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710032090.6A Pending CN106501204A (en) | 2017-01-17 | 2017-01-17 | A kind of novel nucleic acids Protein Detection instrument |
Country Status (1)
| Country | Link |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101021477A (en) * | 2007-03-07 | 2007-08-22 | 博奥生物有限公司 | Hot air circulating temperature controlling real-time fluorescent quantitative PCR detector |
| CN101389956A (en) * | 2005-12-21 | 2009-03-18 | 柳在泉 | Bio memory disc and bio memory disc drive apparatus, and assay method using the same |
| CN201449370U (en) * | 2009-06-04 | 2010-05-05 | 南京大学 | Multi-wavelength nucleic acid protein chromatographic separation detection device |
| CN201681011U (en) * | 2010-03-03 | 2010-12-22 | 青岛康原药业有限公司 | Nucleic acid protein purification detecting instrument |
| CN203275309U (en) * | 2013-05-29 | 2013-11-06 | 杭州索莱尔博奥生物技术有限公司 | Nucleic acid and protein detection imager |
| CN106018309A (en) * | 2016-05-05 | 2016-10-12 | 武汉光昱科技有限公司 | Multifunctional nucleic acid protein detection system |
-
2017
- 2017-01-17 CN CN201710032090.6A patent/CN106501204A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101389956A (en) * | 2005-12-21 | 2009-03-18 | 柳在泉 | Bio memory disc and bio memory disc drive apparatus, and assay method using the same |
| CN101021477A (en) * | 2007-03-07 | 2007-08-22 | 博奥生物有限公司 | Hot air circulating temperature controlling real-time fluorescent quantitative PCR detector |
| CN201449370U (en) * | 2009-06-04 | 2010-05-05 | 南京大学 | Multi-wavelength nucleic acid protein chromatographic separation detection device |
| CN201681011U (en) * | 2010-03-03 | 2010-12-22 | 青岛康原药业有限公司 | Nucleic acid protein purification detecting instrument |
| CN203275309U (en) * | 2013-05-29 | 2013-11-06 | 杭州索莱尔博奥生物技术有限公司 | Nucleic acid and protein detection imager |
| CN106018309A (en) * | 2016-05-05 | 2016-10-12 | 武汉光昱科技有限公司 | Multifunctional nucleic acid protein detection system |
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| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170315 |
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| RJ01 | Rejection of invention patent application after publication |