CN106483127A - A kind of DNA self-assembly magnetic bead photodetector system based on DNA computer - Google Patents
A kind of DNA self-assembly magnetic bead photodetector system based on DNA computer Download PDFInfo
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- CN106483127A CN106483127A CN201510539508.3A CN201510539508A CN106483127A CN 106483127 A CN106483127 A CN 106483127A CN 201510539508 A CN201510539508 A CN 201510539508A CN 106483127 A CN106483127 A CN 106483127A
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Abstract
The invention discloses a kind of DNA self-assembly magnetic bead photodetector system based on DNA computer, including control system, and electrically connect with control system magnetic bead photodetector system, display；The magnetic bead photodetector system includes microscope, photodiode silicon chip, control panel and source of parallel light device；The source of parallel light device is arranged above microscope；The photodiode silicon chip is fixed on below microscope；The source of parallel light device is made up of bulb, focused lamp cover and convex lens；The focused lamp cover is arranged on the outside of bulb；The bulb is arranged on above convex lens；The photodiode silicon chip is electrically connected with control panel with source of parallel light device.The DNA self-assembly magnetic bead photodetector system based on DNA computer of the present invention, is a kind of quick, effective, low cost and the detecting system calculated suitable for DNA.
Description
Technical field
The present invention relates to a kind of DNA computer detecting system, and in particular to a kind of DNA self-assembly magnetic bead photodetector system based on DNA computer, belong to field of computer technology.
Background technology
Due to the extensive gene information demand that human genome project area produces, DNA detection technique becomes the focus of scientists in recent years；Detection instrument and the method for quicker, easy and inexpensive DNA sequence dna and DAN molecular specificity hybridization etc. are needed at present, the DNA hybridization detection technique of most of early stages is mainly using experimental instrument and equipments such as light microscopes, for example, fluorescent marker is recognized by laser confocal microscope detecting system to detect DNA hybridization signal, but the development of this technology is bulky due to detecting instrument, cost intensive receives serious restriction, is therefore gradually substituted by more and more easy, inexpensive detection techniques.Development with microelectric technique, DNA electric transducer and high-density DNA array have been used widely, especially play an important role in DNA detection, the essence of DNA electric transducer technology is that the hybridization information for matching DNA base is converted into discernible electric signal, it provides the interface of the DNA detection in molecule rank and signal conversion, preferably can combine with computer technology, read the hybridization signal of DNA, testing result required for obtaining, wherein have and DNA probe molecule is affixed directly to electrode surface for the detection of DNA electrochemical hybridization, the electro-detection of DNA hybridization signal is also realized using microfluidic system；However; these methods are also difficult to fully achieve the detection of DNA single base mismatch; and the electric signal for detecting is very faint, it usually needs increase the step of nano particle or enzyme marker realize signal enhancing to complete detection process, expend substantial amounts of detection time.Therefore, in order to solve problem above, a kind of new DNA Photoelectric Detection platform is urgently designed, DNA hybridization signal is detected using the strong and weak change of visible light signal, detection platform in system is made up of the silicon integrated circuit of compatible DNA probe self assembly, and target dna sequence is connected with magnetic bead within the system, after target dna sequence is hybridized with DNA probe molecule, magnetic bead will be covered and form dark space in carrier surface, and the photodiode array below carrier now just can detect the change in optical signal before and after DNA hybridization reaction, export dna hybridization signal.
Content of the invention
（One）Technical problem to be solved
For solving the above problems, the present invention proposes a kind of DNA self-assembly magnetic bead photodetector system based on DNA computer, detecting system that is quick, effective, inexpensive and calculating suitable for DNA.
（Two）Technical scheme
The DNA self-assembly magnetic bead photodetector system based on DNA computer of the present invention, including control system, and electrically connect with control system magnetic bead photodetector system, display；The magnetic bead photodetector system includes microscope, photodiode silicon chip, control panel and source of parallel light device；The source of parallel light device is arranged above microscope；The photodiode silicon chip is fixed on below microscope；The source of parallel light device is made up of bulb, focused lamp cover and convex lens；The focused lamp cover is arranged on the outside of bulb；The bulb is arranged on above convex lens；The photodiode silicon chip is electrically connected with control panel with source of parallel light device.
Further, the control system is DNA computer.
Preferably, the bulb is osram lamp.
（Three）Beneficial effect
Compared with prior art, the DNA self-assembly magnetic bead photodetector system based on DNA computer of the present invention, the shade area of coverage that target dna sequence coupled bead is formed is quickly formed after DNA hybridization reaction, the step of completely avoid deposition of silver, save the time for strengthening DNA photosignal, simply, fast, and judge that the degree of accuracy of DNA hybridization signal is high；Magnetic bead particles have magnetic adsorption capacity, are separated DNA is carried out, and can preferably play a part of to delete non-solution, and not destroy sample, can carry out operation is repeated several times in DNA calculating process.
Description of the drawings
Fig. 1 is the overall structure diagram of the present invention；
Fig. 2 is the structural representation of the source of parallel light device of the present invention.
Specific embodiment
A kind of DNA self-assembly magnetic bead photodetector system based on DNA computer as depicted in figs. 1 and 2, including control system 1, and electrically connect with control system 1 magnetic bead photodetector system 2, display 3；2 system of magnetic bead Photoelectric Detection includes microscope 5, photodiode silicon chip（Not shown）, control panel 4 and source of parallel light device 6；The source of parallel light device 6 is arranged at 5 top of microscope；The photodiode silicon chip（Not shown）It is fixed on 5 lower section of microscope；The source of parallel light device 6 is made up of bulb 22, focused lamp cover 21 and convex lens 23；The focused lamp cover 21 is arranged on 22 outside of bulb；The bulb 22 is arranged on 23 top of convex lens；The photodiode silicon chip（Not shown）Electrically connect with control panel 4 with source of parallel light device 6.
The control system 1 is DNA computer.
The bulb 22 is osram lamp.
Embodiment described above is only that the preferred embodiment of the present invention is described, and not the spirit and scope of the present invention is defined.On the premise of without departing from design concept of the present invention; various modifications and improvement that this area ordinary person is made to technical scheme; protection scope of the present invention all should be dropped into, the technology contents that the present invention is claimed, all record in detail in the claims.
Claims (3)
1. a kind of DNA self-assembly magnetic bead photodetector system based on DNA computer, it is characterised in that：Including control system, and electrically connect with control system magnetic bead photodetector system, display；The magnetic bead photodetector system includes microscope, photodiode silicon chip, control panel and source of parallel light device；The source of parallel light device is arranged above microscope；The photodiode silicon chip is fixed on below microscope；The source of parallel light device is made up of bulb, focused lamp cover and convex lens；The focused lamp cover is arranged on the outside of bulb；The bulb is arranged on above convex lens；The photodiode silicon chip is electrically connected with control panel with source of parallel light device.
2. the DNA self-assembly magnetic bead photodetector system based on DNA computer according to claim 1, it is characterised in that：The control system is DNA computer.
3. the DNA self-assembly magnetic bead photodetector system based on DNA computer according to claim 1, it is characterised in that：The bulb is osram lamp.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510539508.3A CN106483127A (en) | 2015-08-30 | 2015-08-30 | A kind of DNA self-assembly magnetic bead photodetector system based on DNA computer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510539508.3A CN106483127A (en) | 2015-08-30 | 2015-08-30 | A kind of DNA self-assembly magnetic bead photodetector system based on DNA computer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106483127A true CN106483127A (en) | 2017-03-08 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510539508.3A Pending CN106483127A (en) | 2015-08-30 | 2015-08-30 | A kind of DNA self-assembly magnetic bead photodetector system based on DNA computer |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106483127A (en) |
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2015
- 2015-08-30 CN CN201510539508.3A patent/CN106483127A/en active Pending
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| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170308 |
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| WD01 | Invention patent application deemed withdrawn after publication |