CN106478434A - A kind of method of production 2 methylamino, 5 chlorobenzophenone - Google Patents
A kind of method of production 2 methylamino, 5 chlorobenzophenone Download PDFInfo
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- CN106478434A CN106478434A CN201610762499.9A CN201610762499A CN106478434A CN 106478434 A CN106478434 A CN 106478434A CN 201610762499 A CN201610762499 A CN 201610762499A CN 106478434 A CN106478434 A CN 106478434A
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- production
- methylamino
- chlorobenzophenone
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The embodiment of the invention discloses a kind of method of production 2 methylamino, 5 chlorobenzophenone, the production method includes：Ethanol solution first being put in autoclave, then putting into 35 chlorphenyl isoxazoles, toluene, Raney's nickel catalyst, after 110 DEG C of intensification, 90 DEG C of two formicesters of dropping of cooling, are filled with hydrogen after completion of dropping, react 5 hours under 100 DEG C, not higher than 0.5 MPa of pressure；To crystallization kettle, 15 DEG C of crystallization below rejection filters of cooling obtain product for keeping temperature press filtration；Product is dried.Implement the embodiment of the present invention, have the advantages that：The production of the present invention adds catalyst, and uses hydrogen reducing, and the finished product purity for therefore finally drawing is higher, and yield is also higher.
Description
Technical field
The present invention relates to the production method of chemical substance, more particularly to a kind of 2- methylamino -5- chlorobenzophenone that produces
Method.
Background technology
In the prior art, because the application surface of 2- methylamino -5- chlorobenzophenone is more narrow, therefore this change of development ＆ production
Enterprise or the research institute for learning thing is less.Therefore, the finished product purity of existing 2- methylamino -5- chlorobenzophenone is relatively low, and produces
Rate is not high.
Content of the invention
Embodiment of the present invention technical problem to be solved is, produces for existing 2- methylamino -5- chlorobenzophenone
A kind of problem that product purity is relatively low, yield is not high, it is proposed that method for producing 2- methylamino -5- chlorobenzophenone.
In order to above-mentioned technical problem is solved, a kind of production 2- methylamino -5- chlorobenzophenone is embodiments provided
Method, the method for production 2- methylamino -5- chlorobenzophenone includes：Ethanol solution is first put in autoclave, then
3-5- chlorphenyl isoxazole, toluene, Raney's nickel catalyst is put into, 90 DEG C of two formicesters of dropping of cooling, completion of dropping after 110 DEG C of intensification
After be filled with hydrogen, react 5 hours under 100 DEG C, not higher than 0.5 MPa of pressure；Keeping temperature press filtration is lowered the temperature to crystallization kettle
15 DEG C of crystallization below rejection filters obtain product；Product is dried.
Wherein, the ethanol solution is industrial alcohol solution that concentration is 85%.
Implement the embodiment of the present invention, have the advantages that：The production of the present invention adds catalyst, and uses hydrogen
Gas is reduced, and the finished product purity for therefore finally drawing is higher, and yield is also higher.
Description of the drawings
In order to be illustrated more clearly that the embodiment of the present invention or technical scheme of the prior art, below will be to embodiment or existing
Accompanying drawing to be used needed for technology description is had to be briefly described, it should be apparent that, drawings in the following description are only this
Some embodiments of invention, for those of ordinary skill in the art, on the premise of not paying creative work, acceptable
Other accompanying drawings are obtained according to these accompanying drawings.
Fig. 1 is the flow chart of the method for the production 2- methylamino -5- chlorobenzophenone of first embodiment of the invention.
Specific embodiment
Below in conjunction with the accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is carried out clear, complete
Site preparation is described, it is clear that described embodiment is only a part of embodiment of the present invention, rather than whole embodiments.It is based on
Embodiment in the present invention, it is every other that those of ordinary skill in the art are obtained under the premise of creative work is not made
Embodiment, belongs to the scope of protection of the invention.
Refer to the stream of the method for the production 2- methylamino -5- chlorobenzophenone that Fig. 1, Fig. 1 are first embodiment of the invention
Cheng Tu.In the present embodiment, the method for production 2- methylamino -5- chlorobenzophenone includes：
In step s 11, first put into ethanol solution in autoclave, then put into 3-5- chlorphenyl isoxazole, toluene,
Raney's nickel catalyst, heat up 90 DEG C of two formicesters of dropping of cooling after 110 DEG C, is filled with hydrogen after completion of dropping, 100 DEG C, not higher than
React 5 hours under 0.5 MPa of pressure.Ethanol solution is industrial alcohol solution that concentration is 85%.
In step s 12, to crystallization kettle, 15 DEG C of crystallization below rejection filters of cooling obtain product for keeping temperature press filtration；
In step s 13, product is dried.
Implement the embodiment of the present invention, have the advantages that：The production of the present invention adds catalyst, and uses hydrogen
Gas is reduced, and the finished product purity for therefore finally drawing is higher, and yield is also higher.
Presently preferred embodiments of the present invention is the foregoing is only, not in order to limit the present invention, all essences in the present invention
Within god and principle, any modification, equivalent substitution and improvement that is made etc., should be included within the scope of the present invention.
Claims (2)
1. a kind of method for producing 2- methylamino -5- chlorobenzophenone, it is characterised in that the production 2- methylamino -5- chlorine two
The method of Benzophenone includes：
Ethanol solution is first put in autoclave, then puts into 3-5- chlorphenyl isoxazole, toluene, Raney's nickel catalyst, rise
After 110 DEG C of temperature, 90 DEG C of two formicesters of dropping of cooling, are filled with hydrogen after completion of dropping, under 100 DEG C, not higher than 0.5 MPa of pressure
Reaction 5 hours；
To crystallization kettle, 15 DEG C of crystallization below rejection filters of cooling obtain product for keeping temperature press filtration；
Product is dried.
2. the method for production 2- methylamino -5- chlorobenzophenone according to claim 1, it is characterised in that the ethanol
Solution is industrial alcohol solution that concentration is 85%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610762499.9A CN106478434A (en) | 2016-08-30 | 2016-08-30 | A kind of method of production 2 methylamino, 5 chlorobenzophenone |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610762499.9A CN106478434A (en) | 2016-08-30 | 2016-08-30 | A kind of method of production 2 methylamino, 5 chlorobenzophenone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106478434A true CN106478434A (en) | 2017-03-08 |
Family
ID=58273909
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610762499.9A Pending CN106478434A (en) | 2016-08-30 | 2016-08-30 | A kind of method of production 2 methylamino, 5 chlorobenzophenone |
Country Status (1)
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| CN (1) | CN106478434A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107892653A (en) * | 2017-11-09 | 2018-04-10 | 华中药业股份有限公司 | A kind of processing method of diazepam first mother liquor |
| CN113956167A (en) * | 2021-10-19 | 2022-01-21 | 枣阳市福星化工有限公司 | Preparation process of 2-methylamino-5-chlorobenzophenone |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1460141A (en) * | 1975-10-02 | 1976-12-31 | Ranbaxy Lab Ltd | Preparation of substituted aminobenzophenones |
| CN1086207A (en) * | 1992-10-20 | 1994-05-04 | 胡钊侠 | The preparation method of keto-amine and derivative thereof |
| WO2009056556A1 (en) * | 2007-10-31 | 2009-05-07 | Smithkline Beecham Corporation | Substitute 1, 6-naphthyridines for use as scd inhibitors |
-
2016
- 2016-08-30 CN CN201610762499.9A patent/CN106478434A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1460141A (en) * | 1975-10-02 | 1976-12-31 | Ranbaxy Lab Ltd | Preparation of substituted aminobenzophenones |
| CN1086207A (en) * | 1992-10-20 | 1994-05-04 | 胡钊侠 | The preparation method of keto-amine and derivative thereof |
| WO2009056556A1 (en) * | 2007-10-31 | 2009-05-07 | Smithkline Beecham Corporation | Substitute 1, 6-naphthyridines for use as scd inhibitors |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107892653A (en) * | 2017-11-09 | 2018-04-10 | 华中药业股份有限公司 | A kind of processing method of diazepam first mother liquor |
| CN113956167A (en) * | 2021-10-19 | 2022-01-21 | 枣阳市福星化工有限公司 | Preparation process of 2-methylamino-5-chlorobenzophenone |
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Application publication date: 20170308 |
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| RJ01 | Rejection of invention patent application after publication |