CN106447262A - Biological sample management method, system and equipment - Google Patents
Biological sample management method, system and equipment Download PDFInfo
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- CN106447262A CN106447262A CN201610848287.2A CN201610848287A CN106447262A CN 106447262 A CN106447262 A CN 106447262A CN 201610848287 A CN201610848287 A CN 201610848287A CN 106447262 A CN106447262 A CN 106447262A
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- G06Q10/087—Inventory or stock management, e.g. order filling, procurement or balancing against orders
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Abstract
The invention discloses a biological sample management method, a biological sample management system and biological sample management equipment. The method comprises the following steps: (1) creating samples, namely, making biological samples which are stored in corresponding positions in one-to-one correspondence with encoding labels, recording initial information of the samples, and performing a warehousing operation; (2) using the samples, namely, generating a sample calling list according to a task and a task authority, performing an ex-warehouse operation and the warehousing operation according to the samples in the list, and ending the task; (3) destroying a sample, namely, acquiring a destroying task with the authority of destroying the sample, performing the ex-warehouse operation on the sample, and generating a new encoding label for the position. The system comprises an experimental management module, a task management module, an ex-warehouse module and a warehousing module. The equipment comprises a label information reading device, a sample memory and an upper computer. According to the biological sample management method, the biological sample management system and the biological sample management equipment, sample management and experiment task management can be realized conveniently; operation arbitrariness is avoided.
Description
Technical field
The invention belongs to biological technical field, more particularly, to a kind of biological specimen management method, system and equipment.
Background technology
Biological specimen because collection capacity is big, experimental implementation is various, experimental period length, preservation condition is the problems such as differ, management
Difficulty is very big.Although at present by the appearance of multiple biological specimen management methods, system, major part is by the management note of biological specimen
Automatization is realized in record, still cannot combine with experimental record, laboratory technician's rights management, causes management cost height, experiment knot
The problems such as fruit cannot be reviewed, operate random.
Content of the invention
Disadvantages described above for prior art or Improvement requirement, the invention provides a kind of biological specimen management method, be
System and equipment, its object is to by carrying out information system management to biological specimen is priority assignation, thus solves biological specimen amount
Greatly, the technical problem that information is numerous and diverse, management cost is high.
For achieving the above object, according to one aspect of the present invention, there is provided a kind of biological specimen management method, including with
Lower step：
(1) newly-built sample, will be stored in the biological specimen of relevant position and code tag corresponds, and records sample
Initialization information, carries out in-stockroom operation；
(2) use sample：Generate according to task and this task right and call sample list, entered according to sample in described list
Row outbound operation and in-stockroom operation, and end task；
(3) destroy sample：Obtain and there is the destruction task destroying this sample authority, outbound operation is carried out to this sample, and
New code tag is generated to this position.
Preferably, described biological specimen management method, will be stored in described in its step (1) biological specimen of relevant position with
Encoding samples label corresponds and is specially：
Encoded according to sample storage location, generate encoding samples label, preferably can adopt bar code or Quick Response Code
Label, is pasted onto outside biological specimen container, as the unique mark of described biological specimen.
Preferably, described biological specimen management method, the initialization information of its step (1) described record sample is specially：
For a certain sample, the initialization information of this sample and sample number are saved in sample data together as record
In storehouse, including positional information, authority information, collection information.
Preferably, described biological specimen management method, the described permission build according to task and this task of its step (2) is adjusted
It is specially with sample list：According to experiment type, generate one or more tasks, and each task is authorized so that being somebody's turn to do
Task has the authority calling sample.
Preferably, described biological specimen management method, its described outbound operation is specially：Coding according to described sample is looked into
Look for the positional information of described sample so that the sample of relevant position is in outbound state, carry out outbound record and take out sample.Institute
The information stating outbound record record is outbound information, preferably includes the information such as outbound time, sample size.
Preferably, described biological specimen management method, its described outbound operation is specially：
According to sample described in the coding lookup of described sample positional information so that relevant position is in binning state, enter
Row warehouse-in records and stores sample.The information of described warehouse-in record record is warehouse-in information, preferably includes entry time, sample size
Etc. information.
According to another aspect of the present invention, there is provided a kind of biological specimen management system, including
Experiment management module, for generating corresponding task according to different experiment types；
Task management module, for being generated according to experiment management module of task, the sample that calls generating described task arranges
Table simultaneously carries out task record；
Go out library module, the sample list of calling for generating according to task management module carries out corresponding outbound to respective sample
Operation；
Enter library module, the sample list of calling for generating according to task management module is accordingly put in storage to respective sample
Operation.
According to another aspect of the present invention, there is provided a kind of biological specimen management equipment is it is characterised in that include label
Information read device, sample storage, and host computer, described label information reading device and described upper mechatronics, institute
State sample storage and described upper mechatronics.
Described sample storage, including multiple and label one-to-one sample storage device, described storage device, is used for
State according to indicated by host computer is turned on and off so that respective sample is in outbound or binning state；
Described label information reading device, is bar code or two-dimensional code scanning device, when sample outbound or warehouse-in, sample is held
The label code on device surface is read out, thus collecting sample outbound information and/or warehouse-in information；
Described host computer, the sample of the collection of label information reading device described in task record for generating according to experiment goes out
Storehouse information and warehouse-in information；And made according to task sample storage relevant position storage device be in outbound or warehouse-in
State.
9th, sample management equipment as claimed in claim 8 is it is characterised in that preserve experimental data in described host computer
Storehouse, assignment database and sample database.
In general, by the contemplated above technical scheme of the present invention compared with prior art, due to for laboratory
Operating process and Permission Design biological specimen management method, system and equipment, following beneficial effect can be obtained：
1st, single, or the sample of a certain feature of bulk lookup can be searched, including original sample, DNA sample or RNA sample
This；
2nd, whether can be completed including task, schedule, if comprise unsuccessfully sample with real-time tracking task status, lose
Lose sample the information such as to reform；
3rd, can follow the tracks of concrete sample state, surpluses, usage amount, pot-life, if carrying out the information of testing etc.；
4th, rights management can be passed through, it is to avoid operation is random, sample use is safer, and experimentation can be reviewed, power
Duty is clearly.
Brief description
Fig. 1 is the biological specimen management method schematic flow sheet that the present invention provides；
Fig. 2 is the biological specimen management system structural representation that the present invention provides；
Fig. 3 is the biological specimen management equipment structural representation that the present invention provides.
Specific embodiment
In order that the objects, technical solutions and advantages of the present invention become more apparent, below in conjunction with drawings and Examples, right
The present invention is further elaborated.It should be appreciated that specific embodiment described herein is only in order to explain the present invention, and
It is not used in the restriction present invention.As long as additionally, involved technical characteristic in each embodiment of invention described below
The conflict of not constituting each other just can be mutually combined.
The biological specimen management method that the present invention provides, as shown in figure 1, comprise the following steps：
(1) newly-built sample, will be stored in the biological specimen of relevant position and code tag corresponds, and records sample
Initialization information, carries out in-stockroom operation；
(1-1) will be stored in the biological specimen of relevant position described in and encoding samples label one-to-one corresponding is specially：
Encoded according to sample storage location, generate encoding samples label, preferably can adopt bar code or Quick Response Code
Label, is pasted onto outside biological specimen container, as the unique mark of described biological specimen.
Described coding rule, for example, number refrigerator, storing basket numbering, sample plane numbering and sample type make numerical digit
Combination forms numbering, described numbering is expressed as coding and forms code tag, described coding is preferably bar code or Quick Response Code.
Described sample type includes：Original sample, DNA sample, RNA sample and other samples.
(1-2) initialization information of described record sample is specially：
For a certain sample, the initialization information of this sample and sample number are saved in sample data together as record
In storehouse, including positional information, authority information, collection information.
Described positional information, for the storage location of this sample, numbers including refrigerator numbering, storing basket numbering, sample plane.
Described authority information includes Permission Levels and/or authorized user.Described Permission Levels can adopt numerical grade, described
Numerical grade, that is, task grade just can call described sample more than or equal to sample grade, otherwise call described sample；Described use
Family private permission, the task that is, user generates is only capable of the sample calling it to be authorized user.In conjunction with both the above authority, for example,
When number grade is equal to sample grade for authorized user, just can call sample；When number grade exceedes sample grade
When can call sample.
Described collection information includes the experiment letter during collecting samples such as samples sources, acquisition mode, collection capacity, effect duration
Breath.
(1-3) carry out in-stockroom operation.
(2) use sample：Generate according to task and this task right and call sample list, entered according to sample in described list
Row outbound operation and in-stockroom operation, and end task.
(2-1) sample list is called to be specially according to the permission build of task and this task described in：According to experiment type, raw
Become one or more tasks, and each task is authorized so that this task has the authority calling sample.
For example extract experiment, generate two tasks, operation task is carried out to original sample, and newly-built sample task.Award
Give the authority of calling to original sample for the task that original sample is operated, the tasks synchronization of newly-built sample is rapid (1).
(2-2) carry out outbound operation, and record experimental result for operation note；
(2-3) carry out in-stockroom operation.
(3) destroy sample：Obtain and there is the destruction task destroying this sample authority, outbound operation is carried out to this sample, and
New code tag is generated to this position.
Described outbound operation, specially：According to sample described in the coding lookup of described sample positional information so that corresponding
The sample of position is in outbound state, carries out outbound record and takes out sample.The information of described outbound record record is believed for outbound
Breath, preferably includes the information such as outbound time, sample size.
Described in-stockroom operation, specially：According to sample described in the coding lookup of described sample positional information so that corresponding
Position is in binning state, carries out warehouse-in and records and store sample.The information of described warehouse-in record record is warehouse-in information, preferably
Including information such as entry time, sample sizes.
The biological specimen management system that the present invention provides, as shown in Fig. 2 include：
Experiment management module, generates corresponding task according to different experiment types.Such as collection experiment, then generate newly-built
Sample task；Extract experiment then to generate using sample and newly-built sample task；Identification experiment then generates and uses sample task；Experiment
Terminate then to generate and destroy sample task.
Task management module, for being generated according to experiment management module of task, the sample that calls generating described task arranges
Table simultaneously carries out task record, the described outbound operation calling sample list to include calling sample and the distribution of this sample and warehouse-in behaviour
Make.
Go out library module, the sample list of calling of the task for generating according to task management module carries out phase to respective sample
Outbound is answered to operate；Described outbound operation, specially：According to sample described in the coding lookup of described sample positional information so that
The sample of relevant position is in outbound state, carries out outbound record and takes out sample.The information of described outbound record record is
Storehouse information, preferably includes the information such as outbound time, sample size.
Enter library module, the sample list of calling of the task for generating according to task management module carries out phase to respective sample
Answer in-stockroom operation；Described in-stockroom operation, specially：According to sample described in the coding lookup of described sample positional information so that
Relevant position is in binning state, carries out warehouse-in and records and store sample.The information of described warehouse-in record record is warehouse-in information,
Preferably include the information such as entry time, sample size.
The biological specimen management equipment that the present invention provides, as shown in figure 3, include：Label information reading device, sample storage
Device, and host computer, described label information reading device and described upper mechatronics, described sample storage is upper with described
Mechatronics.
Described sample storage, including multiple and label one-to-one sample storage device, described storage device, is used for
State according to indicated by host computer is turned on and off so that respective sample is in outbound or binning state；
Described label information reading device, is bar code or two-dimensional code scanning device, when sample outbound or warehouse-in, sample is held
The label code on device surface is read out, thus collecting sample outbound information and/or warehouse-in information；
Described host computer, the sample of the collection of label information reading device described in task record for generating according to experiment goes out
Storehouse information and warehouse-in information；And made according to task sample storage relevant position storage device be in outbound or warehouse-in
State.
It is below embodiment：
Embodiment 1
A kind of biological specimen management system, including：
Experiment management module, generates corresponding task according to different experiment types.Such as collection experiment, then generate newly-built
Sample task；Extract experiment then to generate using sample and newly-built sample task；Identification experiment then generates and uses sample task；Experiment
Terminate then to generate and destroy sample task.
Experiment management module adopts Permission Levels and user authority management experimental duties simultaneously, and described Permission Levels include three
Level：Super keepe is 3 grades, and Project Manager is 2 grades, and laboratory technician is 1 grade, and user right is relative users.Specifically, real
The person of testing can carry out newly-built sample task, and can use task, project management to the Sample Establishing sample oneself with user right
Member can use task to this project all Sample Establishings sample；All samples are carried out by the newly-built sample task of super keepe energy
Sample uses task, and sets up destruction sample task.
Task management module, for being generated according to experiment management module of task, the sample that calls generating described task arranges
Table is simultaneously carried out, to the sample distribution outbound operation in list and in-stockroom operation.
Go out library module, the task for generating according to task management module carries out corresponding outbound operation to respective sample；Institute
State outbound operation, specially：According to sample described in the coding lookup of described sample positional information so that the sample of relevant position
It is in outbound state, carry out outbound record and take out sample.The information of described outbound record record is outbound information, preferably includes
The information such as outbound time, sample size.
Enter library module, the task for generating according to task management module carries out corresponding in-stockroom operation to respective sample；Institute
State in-stockroom operation, specially：According to sample described in the coding lookup of described sample positional information so that relevant position be in into
Storehouse state, carries out warehouse-in and records and store sample.The information of described warehouse-in record record is warehouse-in information, when preferably including warehouse-in
Between, the information such as sample size.
Embodiment 2
A kind of biology sample management method, the specially management method to human mouth saliva sample, comprise the following steps：
(1) newly-built sample, will be stored in the biological specimen of relevant position and code tag corresponds, and records sample
Initialization information；This process automatically generates sample plane, and corresponding with actual sample plate, generate simultaneously also to include sample plane concrete
Save location.
(1-1) 2000 parts of disposable collection are corresponded with 2000 parts of code tags, concrete operations are as follows：By 2000
Part bar-code label, is pasted onto outside the probe tube of saliva sample；
Described label is according to following rule encoding：First, described label is category label, and second to the 4th is sample
Plate is numbered, and the 5th is storing basket numbering, and the 6th is refrigerator numbering.Category label includes original sample and is denoted as A, DNA sample
It is denoted as that B, RNA sample is denoted as C and other samples are denoted as D.
Because 2000 parts of samples are all original sample, under two refrigerators could store, therefore numbering is A000？1 to
A999？, 1 to A000？2 to A999？2；Wherein "？" represent corresponding storing basket numbering.
(1-2) initialization information of described record sample is specially：
For every portion sample, the initialization information of this sample and sample number are saved in sample number together as record
According in storehouse, including positional information, authority information, collection information.
Described positional information is that the refrigerator numbering of this sample, plant basket numbering, sample plane are numbered.Described authority information, power
Limit rank is 1, and user right is the corresponding laboratory technician of experiment supervisor's distribution.The Permission Levels of experiment supervisor are 2, the power of laboratory technician
Limit rank is 1, when Permission Levels are identical, that is, during laboratory technician's operation, only have the laboratory technician of this sample of users authority, can grasp
Make sample；When authority is superior to the Permission Levels of sample, this sample can be used.
The user authority setting of the sample selected is corresponding laboratory technician by the present embodiment experiment supervisor, thus realize sample dividing
Join.
After laboratory technician's acquisition task, it is acquired according to sample inventory, and record collection information.Described collection information includes
The experiment information during collecting samples such as samples sources, acquisition mode, collection capacity, effect duration.
(1-3) carry out in-stockroom operation：Sample is carried out barcode scanning by laboratory technician, and the positional information being obtained according to barcode scanning, by sample
It is stored in the sample plane of corresponding numbering.
(2) use sample：Generate according to task and this task right and call sample list, entered according to sample in described list
Row outbound operation and in-stockroom operation, and end task.
(2-1) sample list is called to be specially according to the permission build of task and this task described in：According to experiment type, raw
Become one or more tasks, and each task is authorized so that this task has the authority calling sample.
Taking the experiment of saliva sample DNA extraction as a example, extraction experiments experiment person receives after extracting experimental duties the present embodiment, phase
Sample is answered to be endowed the user right of laboratory technician.Experiment supervisor generates 5 tasks, assigns them to five laboratory technicians, everyone holds
Experimental result is uploaded after the completion of extraction by the DNA extraction of 96 samples of row, and experiment supervisor can follow the tracks of whole development of projects, with
And sample extraction success rate, and experiment of reforming is decided whether according to sample success or not.
Laboratory technician generates two tasks, and DNA sample extracts the newly-built sample task of sample after task and extraction.
Extraction task is specially：
(2-2) carry out outbound operation, and record experimental result for operation note；
Laboratory technician, according to the task of oneself, obtains the sample inventory calling, and the locking on respective sample plate is opened, and takes out sample
This simultaneously carries out barcode scanning record, record outbound time, sample size.
Carry out DNA extraction experiment, and experimental result is uploaded.
(2-3) carry out in-stockroom operation.
Laboratory technician carries out barcode scanning to sample, and respective sample plate is in sample state of can depositing, and places sample, and records warehouse-in
Information, including entry time and sample size.
Newly-built sample task such as step (1), only in sample number, sample class is labeled as B.
Experimental result is sent to experiment supervisor.After experiment supervisor confirms that experiment finishes, super supervisor is asked to carry out sample
Destroy.
(3) destroy sample：Obtain and there is the destruction task destroying this sample authority, outbound operation is carried out to this sample, and
New code tag is generated to this position.
The present embodiment, sample is expired, sample exception or sample using after finishing, super keepe can carry out sample pin
Ruin process, outbound operation is carried out to sample, sample is taken out, record is destroyed reason, after the destruction time, this position generated new
Code tag.
Embodiment 3
A kind of biological specimen management equipment, i.e. Oryza sativa L. sample management management equipment, including
Label information reading device, sample storage, and host computer, described label information reading device is upper with described
Mechatronics, described sample storage and described upper mechatronics.
Described sample storage, including multiple and label one-to-one sample storage device, described storage device, is used for
State according to indicated by host computer is turned on and off so that respective sample is in outbound or binning state；
Described label information reading device, is bar code or two-dimensional code scanning device, when sample outbound or warehouse-in, sample is held
The label code on device surface is read out, thus collecting sample outbound information and/or warehouse-in information；
Described host computer, for recording sample outbound information and the warehouse-in letter of described label information reading device collection
Breath；And made according to task sample storage relevant position storage device be in outbound or binning state.
Experimental data base, assignment database and sample database is preserved in described host computer；
The implementing result of the task that described experimental data base is generated according to experiment by Project Manager, typing experimental data
Storehouse, for its time of every test data sheet, Project Manager, the inter-related task generating, test result information；
Described assignment database, for record the corresponding experiment of each task, tasks carrying people, task use sample,
Implementing result；
Described sample database, for recording initial information, outbound information, warehouse-in information and the destruction letter of each sample
Breath.
Described experimental data base, assignment database and sample database can be used for inquiring about, and such as laboratory supervisor thinks
The solution Oryza sativa L. sample that in May last year part gathers, the surpluses of original sample, deposit position, and if appropriate for continuation test.Root
According to laboratory sample management system, find the Oryza sativa L. sample of May typing by temporal information, according to type classification, screen
Go out original sample, and concrete test sample is selected according to the remaining situation of original sample, and tested.
As it will be easily appreciated by one skilled in the art that the foregoing is only presently preferred embodiments of the present invention, not in order to
Limit the present invention, all any modification, equivalent and improvement made within the spirit and principles in the present invention etc., all should comprise
Within protection scope of the present invention.
Claims (9)
1. a kind of biological specimen management method is it is characterised in that comprise the following steps：
(1) newly-built sample：Will be stored in the biological specimen of relevant position and code tag corresponds, and record the initial of sample
Change information, carries out in-stockroom operation；
(2) use sample：Generate according to task and this task right and call sample list, gone out according to sample in described list
Storehouse operation and in-stockroom operation, and end task；
(3) destroy sample：Obtain and there is the destruction task destroying this sample authority, outbound operation is carried out to this sample, and to this
Position generates new code tag.
2. biological specimen management method as claimed in claim 1 is it is characterised in that will be stored in corresponding positions described in step (1)
The biological specimen put is corresponded with encoding samples label and is specially：
Encoded according to sample storage location, generate encoding samples label, preferably can adopt bar code or two-dimension code label,
It is pasted onto outside biological specimen container, as the unique mark of described biological specimen.
3. biological specimen management method as claimed in claim 1 records the initial of sample it is characterised in that step (1) is described
Change information is specially：
For a certain sample, the initialization information of this sample and sample number are saved in sample database together as record
In, including positional information, authority information, collection information.
4. biological specimen management method as claimed in claim 1 it is characterised in that step (2) described according to task and this
The permission build of business calls sample list to be specially：According to experiment type, generate one or more tasks, and each task is entered
Row authorizes so that this task has the authority calling sample.
5. the biological specimen management method as described in Claims 1-4 any one is it is characterised in that described outbound operation has
Body is：According to sample described in the coding lookup of described sample positional information so that the sample of relevant position is in outbound state,
Carry out outbound record and take out sample.The information of described outbound record record is outbound information, preferably includes outbound time, sample
The information such as amount.
6. the biological specimen management method as described in Claims 1-4 any one is it is characterised in that described outbound operation has
Body is：
According to sample described in the coding lookup of described sample positional information so that relevant position is in binning state, entered
Storehouse records and stores sample.The information of described warehouse-in record record is warehouse-in information, preferably includes the letter such as entry time, sample size
Breath.
7. a kind of biological specimen management system is it is characterised in that include
Experiment management module, for generating corresponding task according to different experiment types；
Task management module, for being generated according to experiment management module of task, generate described task calls sample list simultaneously
Carry out task record；
Go out library module, the sample list of calling for generating according to task management module carries out corresponding outbound behaviour to respective sample
Make；
Enter library module, the sample list of calling for generating according to task management module is accordingly put in storage behaviour to respective sample
Make.
8. a kind of biological specimen management equipment is it is characterised in that include label information reading device, sample storage, Yi Jishang
Position machine, described label information reading device and described upper mechatronics, described sample storage and described upper mechatronics.
Described sample storage, including multiple and label one-to-one sample storage device, described storage device, for basis
State indicated by host computer is turned on and off so that respective sample is in outbound or binning state；
Described label information reading device, is bar code or two-dimensional code scanning device, to sample container table when sample outbound or warehouse-in
The label code in face is read out, thus collecting sample outbound information and/or warehouse-in information；
Described host computer, the sample outbound letter of the collection of label information reading device described in task record for generating according to experiment
Breath and warehouse-in information；And made according to task sample storage relevant position storage device be in outbound or warehouse-in shape
State.
9. sample management equipment as claimed in claim 8 it is characterised in that preserve in described host computer experimental data base,
Assignment database and sample database.
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| CN201610848287.2A CN106447262A (en) | 2016-09-23 | 2016-09-23 | Biological sample management method, system and equipment |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610848287.2A CN106447262A (en) | 2016-09-23 | 2016-09-23 | Biological sample management method, system and equipment |
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| CN201610848287.2A Pending CN106447262A (en) | 2016-09-23 | 2016-09-23 | Biological sample management method, system and equipment |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107451777A (en) * | 2017-07-27 | 2017-12-08 | 广州赛莱拉干细胞科技股份有限公司 | The approaches to IM and platform that biological sample bank sample preserves temporarily |
| CN109146014A (en) * | 2017-06-26 | 2019-01-04 | 全国畜牧总站 | Germ plasm resource identifies management equipment and its operating method |
| CN113393189A (en) * | 2021-06-08 | 2021-09-14 | 中国科学院水生生物研究所 | Experimental animals sperm cryopreservation storehouse management system |
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| CN109146014A (en) * | 2017-06-26 | 2019-01-04 | 全国畜牧总站 | Germ plasm resource identifies management equipment and its operating method |
| CN107451777A (en) * | 2017-07-27 | 2017-12-08 | 广州赛莱拉干细胞科技股份有限公司 | The approaches to IM and platform that biological sample bank sample preserves temporarily |
| CN113393189A (en) * | 2021-06-08 | 2021-09-14 | 中国科学院水生生物研究所 | Experimental animals sperm cryopreservation storehouse management system |
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Application publication date: 20170222 |