CN106435778A - Use method for compound core-spun electrostatic spinning sprayer - Google Patents
Use method for compound core-spun electrostatic spinning sprayer Download PDFInfo
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- CN106435778A CN106435778A CN201611066610.7A CN201611066610A CN106435778A CN 106435778 A CN106435778 A CN 106435778A CN 201611066610 A CN201611066610 A CN 201611066610A CN 106435778 A CN106435778 A CN 106435778A
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- inner tube
- pendular ring
- tube
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- 238000000034 method Methods 0.000 title claims abstract description 50
- 238000010041 electrostatic spinning Methods 0.000 title claims abstract description 23
- 150000001875 compounds Chemical group 0.000 title claims abstract description 15
- 238000009987 spinning Methods 0.000 claims abstract description 11
- 239000007788 liquid Substances 0.000 claims abstract description 10
- 238000002474 experimental method Methods 0.000 claims abstract description 5
- 230000008569 process Effects 0.000 claims description 26
- 230000008595 infiltration Effects 0.000 claims description 9
- 238000001764 infiltration Methods 0.000 claims description 9
- 239000008367 deionised water Substances 0.000 claims description 8
- 229910021641 deionized water Inorganic materials 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 239000002086 nanomaterial Substances 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 5
- 230000000149 penetrating effect Effects 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 4
- 238000005253 cladding Methods 0.000 claims description 2
- 238000004140 cleaning Methods 0.000 abstract description 4
- 239000002657 fibrous material Substances 0.000 abstract description 4
- 238000012545 processing Methods 0.000 abstract description 3
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 239000003814 drug Substances 0.000 abstract description 2
- 239000003937 drug carrier Substances 0.000 abstract description 2
- 229940079593 drug Drugs 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 69
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 12
- 238000013461 design Methods 0.000 description 10
- 239000000835 fiber Substances 0.000 description 10
- 208000012886 Vertigo Diseases 0.000 description 6
- 230000002209 hydrophobic effect Effects 0.000 description 6
- 239000002131 composite material Substances 0.000 description 5
- 229920002873 Polyethylenimine Polymers 0.000 description 4
- 238000011017 operating method Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 239000011258 core-shell material Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
Classifications
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0061—Electro-spinning characterised by the electro-spinning apparatus
- D01D5/0069—Electro-spinning characterised by the electro-spinning apparatus characterised by the spinning section, e.g. capillary tube, protrusion or pin
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/24—Formation of filaments, threads, or the like with a hollow structure; Spinnerette packs therefor
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/24—Formation of filaments, threads, or the like with a hollow structure; Spinnerette packs therefor
- D01D5/247—Discontinuous hollow structure or microporous structure
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/28—Formation of filaments, threads, or the like while mixing different spinning solutions or melts during the spinning operation; Spinnerette packs therefor
- D01D5/30—Conjugate filaments; Spinnerette packs therefor
- D01D5/34—Core-skin structure; Spinnerette packs therefor
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Textile Engineering (AREA)
- Nozzles (AREA)
Abstract
The invention provides a use method for a compound core-spun electrostatic spinning sprayer. The used sprayer is composed of an inner pipe and an outer pipe. The operation steps include: 1) cleaning inner and outer surfaces of the inner pipe and the outer pipe according to the property of the solution applied to experiment; 2) filling the feed liquid in the inner pipe and the outer pipe, starting a liquid supply system for the inner pipe and starting the liquid supply system for the outer pipe, and vice versa; 3) setting parameters of electrifying spinning; 4) after the spinning ending, cleaning the inner pipe and the outer pipe, drying and standing by. The use method has the beneficial effects that the mixing electrostatic spinning for the solutions containing two or more than two different components can be realized; a great convenience is supplied for processing the multifunctional chemical fiber materials with a nuclear shell structure and a porous structure; the use method can be widely applied to the fields of drug slow release, tissue engineering, drug carrier, and the like; the user can operate according to a single-needle sprayer; the operation technique is simple.
Description
Technical field
The present invention relates to a kind of using method of electrostatic spinning nozzle, from using, it is a kind of based on method of electrostatic spinning
Obtain the using method of the electrostatic spinning nozzle of compound core-spun fiber.
Background technology
Coaxial electrostatic spinning method is to improve, on the basis of electrostatic spinning, a kind of technique that device develops, and can be used to make
The fibrous material of standby specific function structure, its appearance compensate for common electrostatic spin processes and preparing offbeat form fiber when institute
The defect existing.But, due to the shower nozzle of coaxial electrostatic spinning, and operating procedure and its strict it is not easy to control generate double
Layer or compound fiber, the distance that particularly interior syringe needle pipeline stretches out outer syringe needle pipeline is the key that the coaxial injection stream of impact is formed
Sexual factor：When distance is too little, interior conduit solution is easily blocked by the solution of outer layer pipe, and interior syringe needle solution can not smoothly flow
Go out, now under electric field force effect, internal layer solution cannot stretch, and only outer layer solution forms jet.When distance is too big, solution
Outer surface along inner tubal wall flows out it is impossible to coat interior syringe needle extension completely, and then leads to many solution from syringe needle surrounding
Project it is impossible to obtain stable coaxial injection stream.
Therefore, solve the above problems, need a kind of accurate, easy-operating coaxial electrostatic spinning shower nozzle of design and its user
Method, can prepare the support of the fibrous material offer technology of core-cored structure, hollow structure and multilevel hierarchy, and then widen nanometer
The application of fiber.
Content of the invention
The technical scheme is that：A kind of using method of compound core-spun electrostatic spinning nozzle, the shower nozzle of use is by interior
Pipe and outer tube composition.The termination closing of inner tube, tube head is in H4High sharp cone distal, in the tube head base H of distance closing3The ground of size
Side, is machined with an anti-phase equal pendular ring, apart from anti-phase equal pendular ring H2The place of size, is machined with a little equal pendular ring, away from
From little equal pendular ring H1The place of size, is machined with an equal greatly pendular ring.The design of all pendular rings is by the solution of above-mentioned outlet very
It is coated uniformly on well in inner tube circumferential wall, it is to avoid line stream occurs and leads to various solution mixing uneven.In the equal greatly liquid of distance
The place of h size above ring, is machined with vertical inner tube axially, and 2 of lateral direction penetrating inner tube diameter to being much of openings；Away from
From the place of h size greatly all below pendular ring, it is machined with vertical inner tube axially, lateral direction penetrating inner tube diameter, direction and upper insertion
2 symmetrical lower openings of mouth cruciform symmetry arrangement.The openings of mutually cruciform symmetry arrangement design, it is to avoid solution is at one
Pile up it is easy to solution is sprawled on direction.The design of the lateral direction penetrating mouth of inner tube, changes tube opening all one inside and outside former Coaxial nozzle
Cause, be easily caused the problem that each component has little time mutually to mix or interior outer cladding is bad.Design in avoiding former coaxially quiet
The inside and outside shower nozzle needle tubing of Electrospun shower nozzle, in spinning process, because the parameter settings such as inside and outside syringe needle tube spacing, length are bad,
And its inner tube causing difficult problem uneven with the mixing of outer tube different component solution.In the concordant line in upper openings top starts
Pipe surface, until the surface of tube head, is all machined with the body process surface with the infiltration of inner tube solution；Equal pendular ring and little all greatly
The surface of pendular ring, be all machined with inner tube in all pendular rings greatly of solution infiltration of flowing process surface and little equal pendular ring process table
Face, and there is downward drainage micro nano structure；The surface of anti-phase equal pendular ring, be machined with outer tube in flowing solution leaching
Profit with inner tube in the anti-phase equal pendular ring that mutually do not infiltrate of solution of flowing process surface, and only there is the micro-nano of solution coating
Surface texture, does not have the structure of downward drain.This is the one of innovative point of the present invention it is therefore intended that the solution that flows out inner tube
Rapidly it is paved with interior pipe surface, be that another solution next step of outer tube uniformly coats the solution that inner tube flows out, or uniformly mix
The solution closing inner tube outlet outflow is prepared.Meanwhile, at anti-phase equal pendular ring, because outer tube solution easily coats, it is possible to more
Coated by the solution of outer tube well or mix.
It is characterized in that, using method is as follows.
The first step, according to used by experiment, the property of solution, cleans inner and outer tubes outer surface with solvent or deionized water；Again
Open the liquid-supplying system of each pipeline, clean the internal channel 0.5h of inner tube outer tube with solvent or deionized water, dry inner and outer tubes
Stand-by.
Second step, installs the feed flow of inner and outer tubes, first opens the liquid-supplying system of inner tube, treats that the tube head of inner tube has solution
Drippage, and remain a constant speed drippage 5min-8min, then over pipe liquid-supplying system, treat outer tube solution coat inner tube solution, and
There are solution drips in tube head, remain a constant speed drippage 5min-8min；Or, first open the liquid-supplying system of outer tube, treat the solution of outer tube
There are solution drips in tube head, and the drippage 5min-8min that remains a constant speed, then open the liquid-supplying system of inner tube, treat that the solution of inner tube is wrapped
Overlay in the solution of outer tube, and have solution drips in tube head, remain a constant speed drippage 5min-8min.
3rd step, sets receiving range as 20cm ~ 30cm, with voltage 12kv ~ 20kv, outer tube flow velocity 5 mL/h ~ 15mL/
H, inner tube flow velocity 0.5mL/h ~ 2 mL/h, are initially powered up spinning.
4th step, after spinning terminates, repeat step one, clean inner and outer tubes, dry stand-by.
In technique scheme, the opening diameter of the upper openings of the shower nozzle being usedOnStraight with the opening of lower openings
FootpathUnder, between size relationship beOn= 1.5ϕUnder.Purpose of design is to ensure that the upper openings of inner tube and lower openings
Solution, under the reasonable caliber and flow velocity calculating, the solution of upper and lower two-layer outlet, can converge rapidly, uniformly spread over inner tube
Surface.Described upper openings following arrive greatly all pendular ring apart from h=3On, the upper following of lower openings arrive equal pendular ring and little greatly
All pendular ring apart from h=3On.The thickness h of described anti-phase equal pendular ring, little equal pendular ring and equal greatly pendular ring1Unanimously, h1= ϕOn.Design
Purpose, also for ensureing the upper openings of inner tube and the solution of lower openings, can uniformly spread over interior pipe surface, simultaneously
Uniformly coat with the solution being flowed out by auxiliary tube；Or, the solution being flowed out with auxiliary tube is uniformly mixed prepares.
In technique scheme, all the distance between pendular ring and little equal pendular ring H greatly of the shower nozzle being used1≥5 ϕOn,
Little equal pendular ring and the distance between anti-phase equal pendular ring H2≥5（ϕOn+ ϕUnder）, anti-phase equal pendular ring is to tube head base apart from H3=2
（H1+ H2）, wedge angle angle [alpha]=60 ° ~ 90 ° of tube head.The selection defining experiment optimized parameter of distance and angle it is therefore an objective to
Ensure another solution that the solution of outer tube outflow and inner tube flow out, have enough flow processs to mix or coat.In high-pressure electrostatic
It is ensured that being one during stretching.
In technique scheme, the outer tube of the shower nozzle being used（12）Internal diameter radius and inner tube（1）Exterior radius only
Difference L0≥5ϕOn；Anti-phase equal pendular ring（2）Radius and inner tube（1）Exterior radius difference L3=0.5 ϕOn~ 4ϕOn；Little equal pendular ring
（3）Outer radius and inner tube（1）Exterior radius difference L2= 0.5 ϕUnder~ 2ϕUnder；Equal greatly pendular ring（2）Outer radius and inner tube
（1）Exterior radius difference L1=0.5 ϕOn~ 2ϕOn；Said inner tube（1）Stretch out outer tube（12）Flat mouth end apart from h0=
2L0.So that the solution of outer tube and inner tube can uniformly mix, under identical parameters setting, its flow velocity and inner tube is molten for this design
The flow velocity of liquid is essentially identical, simplifies the parameter setting of operation, unified arrange parameter.
Above-mentioned technical conditions design, is that the present invention can prepare different composite electrostatic spinnings fine according to different experiments
Dimension.If the solution of outer tube and the solution of inner tube are all the same hydrophilic or hydrophobic, can use the present invention.Both wave solution
Send out speed similar, can easily form mixing composite fibre, such as both solution evaporation speed have difference, can easily be formed core-
The composite fibre of shell shape structure.If the solution of outer tube is hydrophilic, the solution of another inner tube is hydrophobic, and the present invention also can
With.Or, the solution of inner tube is hydrophilic, and the solution of outer tube is hydrophobic, and the present invention also can use.Also core-shell structure copolymer can easily be formed
The composite fibre of layer structure.
Compared with existing conventional coaxial electrostatic spinning, the present invention has following the coaxial electrostatic spinning shower nozzle of present invention design
Beneficial effect.
（1）Because several material solutions have mixed and have been integrated before high-voltage electrostatic spinning, in the setting of operating parameter
Cheng Zhong, can be operated according to single needle pipe shower nozzle, only need to form compound taylor cone at the closing tip of shower nozzle of the present invention, continue
And the fiber from the stretched same axle housing-core composite construction being coated stratum nucleare by shell of Taylor cone.Operating procedure is simple.
（2）Meanwhile, it is capable to realize the mixing electrostatic spinning of the solution of two or more different components, for processing nucleocapsid structure,
Hollow structure, the functional fiber material of loose structure provide very big facility.
（3）The present invention can be widely applied for the fields such as medicament slow release, organizational project and pharmaceutical carrier.
Brief description
Fig. 1 is the inner tube structure schematic front view of the present invention.
Fig. 2 is the inner tube structure size marking schematic diagram of the present invention.
Fig. 3 is the assembling structure schematic front view of the present invention.
Fig. 4 is the assembling structure elevational schematic view of the present invention.
Wherein：1. inner tube；2. anti-phase equal pendular ring；3. little equal pendular ring；4. equal greatly pendular ring；5. go up openings；6. body is processed
Surface；7. all pendular ring processes surface greatly；8. descend openings；9. little equal pendular ring processes surface；10. anti-phase equal pendular ring processes surface；
11. tube heads；12. outer tubes.
Specific embodiment
Further the present invention is illustrated with reference to the accompanying drawings and examples.
Specific embodiment one
The present invention's. a kind of using method of compound core-spun electrostatic spinning nozzle, the shower nozzle of use is by inner tube 1 and 12 groups of outer tube
Become.All pendular rings greatly on all surfaces of pendular ring 4 and little equal pendular ring 3 greatly process surface 7 and little equal pendular ring process surface 9, have downwards
The solution infiltration of flowing in the micro nano structure of drainage, with inner tube.At the anti-phase equal pendular ring on the surface of anti-phase equal pendular ring 2
The solution infiltration of reason surface 10 and the inner flowing of outer tube 12 with inner tube in the solution that flows mutually do not infiltrate, there is no downward drain
Structure.Inner tube 1 internal diameter 2mm, the opening diameter of upper openings 5On=0.75mm, the opening diameter of lower openings 8Under=
0.5mm.Upper openings 5 following arrive greatly all pendular ring 4 apart from h=2.25mm, the upper following of lower openings 8 arrives equal pendular ring 4 He greatly
Little equal pendular ring 3 apart from h=2.25mm.The thickness h of anti-phase equal pendular ring 2, little equal pendular ring 3 and equal greatly pendular ring 41Unanimously, h1=
0.75mm.
All the distance between pendular ring 4 and little equal pendular ring 3 H greatly1=8mm, the distance between little equal pendular ring 3 and anti-phase equal pendular ring 2
H2=7.5mm, anti-phase equal pendular ring 2 arrive tube head 11 base apart from H3=15.5mm, the high H of tube head 114≥H1, the wedge angle angle of tube head
Degree α=90 °.
The internal diameter radius of outer tube 12 and the exterior radius of inner tube 1 only poor L0=3.75mm；Anti-phase equal pendular ring 2 radius and inner tube 1
Exterior radius difference L3=1.5mm；Difference L of the exterior radius of little equal pendular ring 3 outer radius and inner tube 12= 1mm；Equal greatly liquid
Difference L of the exterior radius of ring 2 outer radius and inner tube 11=1.5mm；Inner tube 1 stretch out the flat mouth end of outer tube 12 apart from h0=
7.5mm.
Inner tube 1 surface starting from the concordant line in upper openings 5 top, until the surface of tube head 11, is machined with hydrophilic, thin
The body of oil processes surface 6.Equal greatly pendular ring 4 and the surface of little equal pendular ring 3, are all machined with hydrophilic, oleophobic all pendular rings greatly and process
Surface 7 and little equal pendular ring process surface 9, and have the micro nano structure of downward drainage.The surface of anti-phase equal pendular ring 2, plus
Work has hydrophobic, oleophylic anti-phase equal pendular ring to process surface 10, and only has the micro-nano surface structure that solution coats, not downwards
The structure of drain.Operating procedure is as follows.
The first step, deionized water cleans inner tube 1 surface, cleans outer tube 12 outer surface 6 times with chloroform.Open each again
The liquid-supplying system of pipeline, deionized water cleans the internal channel 0.5h of inner tube 1, cleans the internal channel of outer tube 12 with chloroform
0.5h, dries inner tube 1 and outer tube 12 is stand-by.
Second step, the Poly(D,L-lactide-co-glycolide PLGA of molecular weight 100,000 is dissolved in chloroform, is configured to 15%
（w/v）Solution, loads in the liquid-supplying system of outer tube 12.Molecular weight 60,000 polyethyleneimine PEI is configured to 30%（w/v）Water-soluble
Liquid, loads in the liquid-supplying system of inner tube 1.First open the liquid-supplying system of inner tube 1, treat that the tube head 11 of inner tube 1 has solution drips, and protect
Hold and at the uniform velocity drip 5min, then open the liquid-supplying system of outer tube 12, treat that the solution of outer tube 12 coats the solution of inner tube 1, and in tube head
11 have solution drips, and remain a constant speed drippage 8min.
3rd step, sets receiving range as 20cm, with voltage 12kv, outer tube 12 flow velocity 10mL/h, inner tube 1 flow velocity 0.6mL/
H, is initially powered up spinning.Obtain the compound core-spun electrospun fibers of nucleocapsid structure.
4th step, after spinning terminates, repeat step one, cleaning inner tube 1 and outer tube 12, dry stand-by.
Specific embodiment two
A kind of using method of compound core-spun electrostatic spinning nozzle of the present invention, the shower nozzle of use is made up of inner tube 1 and outer tube 12.
All pendular rings greatly on all surfaces of pendular ring 4 and little equal pendular ring 3 greatly process surface 7 and little equal pendular ring process surface 9, have downward drain
The solution infiltration of flowing in the micro nano structure of effect, with inner tube.The anti-phase equal pendular ring on the surface of anti-phase equal pendular ring 2 processes table
The solution infiltration of face 10 and the inner flowing of outer tube 12 with inner tube in the solution of flowing mutually do not infiltrate, there is no the knot of downward drain
Structure.Inner tube 1 internal diameter 1.25mm, the opening diameter of upper openings 5On=0.6mm, the opening diameter of lower openings 8Under=
0.4mm.Upper openings 5 following arrive greatly all pendular ring 4 apart from h=1.8mm, the upper following of lower openings 8 arrives equal pendular ring 4 He greatly
Little equal pendular ring 3 apart from h=1.8mm.The thickness h of anti-phase equal pendular ring 2, little equal pendular ring 3 and equal greatly pendular ring 41Unanimously, h1= 0.6mm.
All the distance between pendular ring 4 and little equal pendular ring 3 H greatly1=4.2mm, between little equal pendular ring 3 and anti-phase equal pendular ring 2 away from
From H2=5mm, anti-phase equal pendular ring 2 arrive tube head 11 base apart from H3=18.4mm, the high H of tube head 114≥H1, the point of tube head 11
Angle angle [alpha]=60 °.
The internal diameter radius of outer tube 12 and difference L of the exterior radius of inner tube 10=3mm；Anti-phase equal pendular ring 2 radius and inner tube 1
Difference L of exterior radius3=1.2mm；Difference L of the exterior radius of little equal pendular ring 3 outer radius and inner tube 12= 0.6mm；Equal greatly liquid
Difference L of the exterior radius of ring 2 outer radius and inner tube 11=1.2mm；Inner tube 1 stretch out the flat mouth end of outer tube 12 apart from h0=
6mm.
Inner tube 1 surface starting from the concordant line in upper openings 5 top, until the surface of tube head 11, is machined with hydrophobic parent
The body of oil processes surface 6.Equal greatly pendular ring 4 and the surface of little equal pendular ring 3, are all machined with the equal greatly pendular ring process table of hydrophobic oleophilic oil
Face 7 and little equal pendular ring process surface 9, and have the micro nano structure of downward drainage.The surface of anti-phase equal pendular ring 2, processing
The anti-phase equal pendular ring having hydrophilic oleophobic processes surface 10, and only has the micro-nano surface structure that solution coats, and does not draw downwards
The structure of stream.Operating procedure is as follows.
The first step, deionized water cleans outer tube 12 surface, cleans inner tube 1 outer surface with chloroform；Open each pipe again
The liquid-supplying system on road, deionized water cleans the internal channel 0.5h of outer tube 12, cleans the internal channel of inner tube 1 with chloroform
0.5h, dries inner tube 1 and auxiliary tube 5 is stand-by.
Second step, the Poly(D,L-lactide-co-glycolide PLGA of molecular weight 100,000 is dissolved in chloroform, is configured to 15%
（w/v）Solution, loads in the liquid-supplying system of inner tube 1.Molecular weight 60,000 polyethyleneimine PEI is configured to 30%（w/v）Aqueous solution,
Load in the liquid-supplying system of outer tube 12.First open the liquid-supplying system of outer tube 12, treat that the solution of outer tube 12 has solution to drip in tube head 11
Fall, remain a constant speed drippage 5min.Open the liquid-supplying system of inner tube 1 again, treat that the solution of inner tube 1 is wrapped by, and tube head 11 has solution
Drippage, and the drippage 8min that remains a constant speed.
3rd step, sets receiving range as 30cm, with voltage 20kv, outer tube 12 flow velocity 12mL/h, inner tube 2 flow velocity 1mL/h,
It is initially powered up spinning.Obtain the compound core-spun electrospun fibers of intermediate porous.
4th step, after spinning terminates, repeat step one, cleaning inner tube 1 and outer tube 12, dry stand-by.
Claims (4)
1. a kind of using method of compound core-spun electrostatic spinning nozzle, the shower nozzle of use is by inner tube（1）And outer tube（12）Composition, interior
Pipe（1）Termination closing, tube head（11）In H4High sharp cone distal, in the tube head of distance closing（11）Base H3The place of size, plus
Work has an anti-phase equal pendular ring（2）, apart from anti-phase equal pendular ring（2）H2The place of size, is machined with a little equal pendular ring（3）,
Apart from little equal pendular ring（3）H1The place of size, is machined with an equal greatly pendular ring（4）；In the equal greatly pendular ring of distance（4）Top h chi
Very little place, is machined with vertical inner tube（1）Axially, lateral direction penetrating inner tube（1）2 of internal diameter are to being much of openings（5）；Away from
From equal greatly pendular ring（4）The place of lower section h size, is machined with vertical inner tube（1）Axially, lateral direction penetrating inner tube（1）Internal diameter, direction
With upper openings（5）2 symmetrical lower openings of cruciform symmetry arrangement（8）；From upper openings（5）The concordant line in top starts
Inner tube（1）Surface, until tube head（11）Surface, be all machined with and inner tube（1）The body of solution infiltration processes surface
（6）；Equal greatly pendular ring（4）With little equal pendular ring（3）Surface, be all machined with and inner tube（1）In flowing solution infiltration equal greatly
Pendular ring processes surface（7）Process surface with little equal pendular ring（9）, and there is the micro nano structure of downward drainage；Anti-phase equal liquid
Ring（2）Surface, be machined with and outer tube（12）In flowing solution infiltration and inner tube（1）In flowing solution mutually do not soak
The anti-phase equal pendular ring of profit processes surface（10）, and only there is the micro-nano surface structure that solution coats, there is no the knot of downward drain
Structure；It is characterized in that, using method is as follows：
The first step, according to used by experiment, the property of solution, cleans inner tube with solvent or deionized water（1）And outer tube（12）Appearance
Face；Open the liquid-supplying system of each pipeline again, clean inner tube with solvent or deionized water（1）Outer tube（12）Internal channel 0.5h, dry
Dry inner tube（1）And outer tube（12）Stand-by；
Second step, installs inner tube（1）And outer tube（12）Feed flow, first open inner tube（1）Liquid-supplying system, treat inner tube（1）'s
Tube head（11）Have solution drips, and remain a constant speed drippage 5min-8min, then over manage（12）Liquid-supplying system, treat outer tube（12）
Solution cladding inner tube（1）Solution, and in tube head（11）There are solution drips, remain a constant speed drippage 5min-8min；Or, first
Open outer tube（12）Liquid-supplying system, treat outer tube（12）Solution in tube head（11）There are solution drips, and the drippage that remains a constant speed
5min-8min, then open inner tube（1）Liquid-supplying system, treat inner tube（1）Solution be covered by outer tube（12）Solution in, and
Tube head（11）There are solution drips, remain a constant speed drippage 5min-8min；
3rd step, sets receiving range as 20cm ~ 30cm, with voltage 12kv ~ 20kv, outer tube（12）Flow velocity 5 mL/h ~ 15mL/
H, inner tube（1）Flow velocity 0.5mL/h ~ 2 mL/h, is initially powered up spinning；
4th step, after spinning terminates, repeat step one, clean inner tube（1）And outer tube（12）, dry stand-by.
2. according to claim 1. a kind of using method of compound core-spun electrostatic spinning nozzle it is characterised in that：Made
The upper openings of shower nozzle（5）Opening diameterOnWith lower openings（8）Opening diameterUnder, between size relationship be
ϕOn= 1.5ϕUnder；Described upper openings（5）Following arrive equal pendular ring greatly（4）Apart from h=3On, lower openings（8）Upper
Arrive equal greatly pendular ring below（4）With little equal pendular ring（3）Apart from h=3On；Described anti-phase equal pendular ring（2）, little equal pendular ring（3）With big
All pendular rings（4）Thickness h1Unanimously, h1= ϕOn.
3. according to claim 1. a kind of using method of compound core-spun electrostatic spinning nozzle it is characterised in that：Made
The equal greatly pendular ring of shower nozzle（4）With little equal pendular ring（3）The distance between H1≥5 ϕOn, little equal pendular ring（3）With anti-phase equal liquid
Ring（2）The distance between H2≥5（ϕOn+ ϕUnder）, anti-phase equal pendular ring（2）To tube head（11）Base apart from H3=2（H1+
H2）, tube head（11）Wedge angle angle [alpha]=60 ° ~ 90 °.
4. according to claim 1. a kind of using method of compound core-spun electrostatic spinning nozzle it is characterised in that：Made
The outer tube of shower nozzle（12）Internal diameter radius and inner tube（1）Exterior radius difference L0≥5ϕOn；Anti-phase equal pendular ring（2）Half
Footpath and inner tube（1）Exterior radius difference L3=0.5 ϕOn~ 4ϕOn；Little equal pendular ring（3）Outer radius and inner tube（1）Outer
Difference L of wall radius2= 0.5 ϕUnder~ 2ϕUnder；Equal greatly pendular ring（2）Outer radius and inner tube（1）Exterior radius difference L1=
0.5 ϕOn~ 2ϕOn；Said inner tube（1）Stretch out outer tube（12）Flat mouth end apart from h0= 2L0.
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| WO2010090868A2 (en) * | 2009-01-21 | 2010-08-12 | The Florida International University Board Of Trustees | Needle-in-needle electrospinning spinneret |
| US20110076250A1 (en) * | 2001-10-10 | 2011-03-31 | Belenkaya Bronislava G | Biodegradable Absorbents and Methods of Preparation |
| CN202809021U (en) * | 2012-05-30 | 2013-03-20 | 湖南博弈飞装备新材料研究所 | Electrostatic spinning device |
| CN204491055U (en) * | 2015-03-06 | 2015-07-22 | 北京化工大学 | A kind of spout cyclone type is prepared nanometer and to be twisted thread electrostatic spinning nozzle device |
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2016
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110076250A1 (en) * | 2001-10-10 | 2011-03-31 | Belenkaya Bronislava G | Biodegradable Absorbents and Methods of Preparation |
| WO2010090868A2 (en) * | 2009-01-21 | 2010-08-12 | The Florida International University Board Of Trustees | Needle-in-needle electrospinning spinneret |
| CN202809021U (en) * | 2012-05-30 | 2013-03-20 | 湖南博弈飞装备新材料研究所 | Electrostatic spinning device |
| CN204491055U (en) * | 2015-03-06 | 2015-07-22 | 北京化工大学 | A kind of spout cyclone type is prepared nanometer and to be twisted thread electrostatic spinning nozzle device |
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