CN106422955A - Device and method for rapid, mass and continuous production of nano-grade emulsion or nano-grade suspension liquid - Google Patents
Device and method for rapid, mass and continuous production of nano-grade emulsion or nano-grade suspension liquid Download PDFInfo
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- CN106422955A CN106422955A CN201610763518.XA CN201610763518A CN106422955A CN 106422955 A CN106422955 A CN 106422955A CN 201610763518 A CN201610763518 A CN 201610763518A CN 106422955 A CN106422955 A CN 106422955A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/80—Forming a predetermined ratio of the substances to be mixed
- B01F35/88—Forming a predetermined ratio of the substances to be mixed by feeding the materials batchwise
- B01F35/883—Forming a predetermined ratio of the substances to be mixed by feeding the materials batchwise using flow rate controls for feeding the substances
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/41—Emulsifying
- B01F23/4105—Methods of emulsifying
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/49—Mixing systems, i.e. flow charts or diagrams
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/10—Maintenance of mixers
- B01F35/145—Washing or cleaning mixers not provided for in other groups in this subclass; Inhibiting build-up of material on machine parts using other means
- B01F35/1452—Washing or cleaning mixers not provided for in other groups in this subclass; Inhibiting build-up of material on machine parts using other means using fluids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/60—Safety arrangements
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/80—Forming a predetermined ratio of the substances to be mixed
- B01F35/83—Forming a predetermined ratio of the substances to be mixed by controlling the ratio of two or more flows, e.g. using flow sensing or flow controlling devices
- B01F35/831—Forming a predetermined ratio of the substances to be mixed by controlling the ratio of two or more flows, e.g. using flow sensing or flow controlling devices using one or more pump or other dispensing mechanisms for feeding the flows in predetermined proportion, e.g. one of the pumps being driven by one of the flows
- B01F35/8311—Forming a predetermined ratio of the substances to be mixed by controlling the ratio of two or more flows, e.g. using flow sensing or flow controlling devices using one or more pump or other dispensing mechanisms for feeding the flows in predetermined proportion, e.g. one of the pumps being driven by one of the flows with means for controlling the motor driving the pumps or the other dispensing mechanisms
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- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Fluid Mechanics (AREA)
- Colloid Chemistry (AREA)
Abstract
The invention discloses a device and a method for rapid, mass and continuous production of nano-grade emulsion or nano-grade suspension liquid. As two major types of colloidal materials which are most widely distributed in the nature and most widely applied, emulsion and suspension liquid are massively applied in various industries such as medicine, food, machinery processing, construction, printing and dyeing, petrochemical industry and daily chemical industry. Because of smaller dimensions, nano-grade emulsion and nano-grade suspension liquid have higher specific surface areas, and show a plurality of specific properties such as higher solubility and dissolution rate, lower viscosity, better fluidity, lower light scattering intensity, better light permeability, and the like. According to the invention, a fluid pump is used for continuously transporting fluid; and turbulent blending is carried out in a sealed cavity of a mixer, such that the nano-grade emulsion or nano-grade suspension liquid is prepared. According to the invention, a plurality of systems such as exhausting and mixing, cleaning and liquid emptying, power control, safety protection and the like are integrated, such that rapid, mass, continuous, stable and reliable preparation of the nano-grade emulsion and nano-grade suspension liquid is realized.
Description
Technical field
The present invention relates to a kind of quick, a large amount of, continuous device and method producing nanoemulsions or nano suspending liquid, belong to
Technical field of nanometer material preparation.
Background technology
Emulsion and suspension, as distributed in nature is the widest, most widely used two big class colloidal materials, are widely applied
In the such as every profession and trade such as medicine, food, machining, building, printing and dyeing, petrochemical industry, daily use chemicals, and demand is huge.Emulsion is a kind of liquid
Body is scattered in the multiphase dispersion formed in another kind of immiscible liquid, and suspension is a kind of solid particle dispersions
A kind of multiphase dispersion formed in liquid.Nanoemulsions and nano suspending liquid are because its diameter is than conventional emulsions and suspension
Liquid is less, typically below hundreds of nanometer, therefore has bigger specific surface area, shows as bigger solubility and dissolving speed
Rate, lower viscosity and more preferable mobility, lower light scattering rate and more preferable translucidus and many other specificity
Matter, therefore has great using value.
The methods such as mechanical ball mill, high-pressure homogeneous, dropping stirring are passed through in the preparation of conventional nanoemulsions or nano suspending liquid,
Have the shortcomings that power consumption is high, time-consuming, efficiency is low, product cut size is larger and wider distribution, Given this by Zhu Zhengxi (patent application
Number：CN2015105158105) propose to prepare nanometer by instantaneously nanometer emulsified method (flash nanoemulsification)
Emulsion；Robert Prud ' homme (number of patent application：US20040091546A1；Paper number：Aust.J.Chem.2003,56,
1021.) propose to prepare nano suspending liquid by instantaneous nanometer deposition method (flash nanoprecipitation).But it is above-mentioned
The preparation process of method is all discontinuous, the therefore more difficult mass uniformity controlling between different batches, and preparation amount is less.Device and
Process does not integrate exhaust, cleaning, emptying rate of liquid, security protection etc., makes mixing be subject to pipeline and the interference of internal mixer air more difficult
Ensure preparation reliability and stability, subsequent artefacts' cleaning process loaded down with trivial details it tends to be difficult to meet more production in enormous quantities demand.
Content of the invention
It is an object of the invention to provide a kind of quick, a large amount of, continuous device producing nanoemulsions or nano suspending liquid and
Method.
For reaching above-mentioned purpose, the technical scheme is that：
A kind of quick, a large amount of, continuous device producing nanoemulsions or nano suspending liquid, described device includes pump, organic
Solution reservoir, organic solvent storage tank, water-soluble liquid storage tank, water storage tank, blender, product storage tank and waste tank；
Described organic solution outlet and organic solvent outlet and check-valves CHV1By cross valve FV1And pipeline
It is connected；
Described aqueous solution outlet and water storage tank outlet and check-valves CHV2By cross valve FV2And pipeline is connected；
Described check-valves is connected by pipeline with pump；Described pump is connected by pipeline with flow divider；
Described flow divider DV1One outlet passes through triple valve TV with organic solution reservoir inlet1It is connected；Another outlet
Connection flow gauge FM1；
Described flow divider DV2One outlet passes through triple valve TV with aqueous solution reservoir inlet2It is connected；Another outlet is even
Meet flowmeter FM2；
Described flowmeter is connected by pipeline with blender；Described blender passes through triple valve TV with product storage tank3And
Pipeline is connected；Three triple valves are connected by pipeline with waste tank.
Further, described device includes a) exhaust and mixing system, b) cleaning and emptying rate of liquid system, c) electric power control
System processed, d) security protection system.
A) exhaust and mixing system：
In said apparatus, device pipeline need to be exhausted when preparation starts, be not subject to the effect guaranteeing turbulent closure scheme
The interference of gas.
In said apparatus, raw material liq need to be prepared mixing to be transported to blender higher than certain flow by fluid pump.
Mixing chamber single entry injection speed is more than 0.1m/s, to guarantee to be mixed with high Reynolds number in mixer chamber body.
In said apparatus, system contains flow divider and flowmeter.Flow divider DV1、DV2There iss auxiliary adjustment flow, stream
Gauge FM1、FM2There iss metered flow.
B) cleaning and emptying rate of liquid system：
In said apparatus, have a set of cleaning and emptying rate of liquid system.Production finishes, and pipe-line equipment is carried out and right
Cleaning fluid empties to avoid the corrosion to pipeline and each part for the residue, avoids to the pollution being mixed with next time simultaneously.
C) electric control system：
In said apparatus, there are a set of electric control system, controlling pump P1Or P2Switch and system jerk.Prepared
Run into emergency in journey, open emergency stop switch and can be immediately terminated transporting of all fluids.
D) security protection system：
In said apparatus, it is furnished with emergency stop switch.Run into emergency in preparation process, open emergency stop switch can immediately in
Break the transporting of all fluids.In preparation process, after pressing emergency stop switch, by triple valve TV3Connect waste tank, work as fault
Exclusion, debugging and runtime for a period of time, then by triple valve TV3Recall to product storage tank to continue preparation process.
In said apparatus, described reservoir inlet connects screen pack respectively, and respective liquid flows into storage tank by screen pack.
In said apparatus, described device using can continuous conveying fluid for a long time fluid pump.Described device uses can be empty
Turn fluid pump,
In said apparatus, before and after described pump, respectively there is a circulating reflux pipeline, to prevent after pump pipeline because of liquid during unexpected blocking
Body increased pressure is caused danger.
In said apparatus, increase flow divider DV before blender1、DV2, respectively distribute a branch road and return to feed storage tank, with
Prevent from fluid pressure during blender blocking from increasing severely to cause danger.
In said apparatus, before described pump respectively plus one way stop peturn valve, to prevent pump from surprisingly stopping running or during pipeline blockage,
In pipeline, liquid is due to gravity appearance backflow.
The present invention also provides the method that said apparatus produce nanoemulsions or nano suspending liquid, comprises the following steps：1) arrange
Air：Open pump for a period of time, in organic solution storage tank and water-soluble liquid storage tank, solution priority flows through check-valves, pump, flow divider return
Air in storage tank, in each part of emptying and pipeline；
2) it is mixed with：In organic solution storage tank and water-soluble liquid storage tank, solution priority flows through check-valves, pump, flow divider, and one
Part flows back to storage tank circulation, and another part enters blender mixing through flowmeter, and products obtained therefrom enters product storage tank；
3) clean：Preparation finishes, and pipeline is carried out, the water in organic solvent and water storage tank in organic solvent storage tank
Successively flow through check-valves, pump, flow divider, a part is directly entered waste tank, another part through flowmeter and blender,
After flow to waste tank, all pipelines and part are completed clean；
4) empty cleaning fluid：Disconnect the connection of cross valve and storage tank, allow cross valve connect air, empty each part, pipeline
Interior cleaning fluid, closes pump, completes preparation flow.
In said method, fluid mixing process is blended for high reynolds number turbulent flow, and fluid is injected into blender airtight cavity
Single entry injection speed is more than 0.1m/s.
In said method, described aqueous phase adopts hydrophilic liquid, at least contains one of water or alcohol.Described is hydrophobic
Property compound preparation-obtained product when for liquid be nanoemulsions, compound hydrophobicity ACDLogP represents, its value
More than 0；When for solid-state, preparation-obtained product is nano suspending liquid, and compound hydrophobicity is represented with ACDLogP, its value
More than 2.0.
In said method, the instantaneous turbulent flow blending in a mixer of two-phase liquid, organic solvent diffuses into aqueous phase, hydrophobicity
Compound self aggregation in aqueous phase forms nanoemulsions or nano suspending liquid, and surface reactive material adsorbs in nano-liquid droplet or particle table
Face stops its size further growth it is ensured that the dimensionally stable of nanometer system.The nanoemulsions being formed or nano suspending liquid are from mixed
Clutch flows continually out, and flows into fluid reservoir；Finally continuously transport organic solvent and water pair in preparation facilities pipeline using fluid pump
It is carried out, to terminate whole preparation process..
Compared with prior art, its remarkable advantage is the present invention：
Present invention injecting fluid by way of the continuous conveying fluid of fluid pump to replace by pressing needle cylinder injection enters mixed
Clutch, to realize the continuous preparation of nanoemulsions or nano suspending liquid, and incorporates exhaust, cleaning, emptying rate of liquid, security protection
Etc. system, invented corresponding continuous preparation device, make mixing be not subject to pipeline and internal mixer air interference it is ensured that preparation
Reliability and stability, and be avoided that subsequently loaded down with trivial details manual cleaning, to meet nanoemulsions and nano suspending liquid rapidly, continuously, surely
Fixed reliably production demand.
Brief description
Fig. 1. the present invention prepares the device design drawing of nanoemulsions or nano suspending liquid.
Fig. 2. divided by the particle diameter of the citrus seed oil 175mL nanoemulsions obtained by the method and apparatus of the continuous preparation of the present invention
Butut (average diameter dI=98nm, polydispersity coefficient PDI=0.03).
Fig. 3. the particle diameter distribution of the citrus seed oil 10mL nanoemulsions obtained by the discontinuous preparation method being pressed by syringe
Figure (average diameter dI=138nm, polydispersity coefficient PDI=0.36).
Fig. 4. by the ubiquinone obtained by the method and apparatus of the continuous preparation of the present invention10The particle diameter of 785mL nano suspending liquid
Distribution map (average diameter dI=226nm, polydispersity coefficient PDI=0.20).
Fig. 5. the ubiquinone obtained by discontinuous preparation method being pressed by syringe10The particle diameter of 30mL nano suspending liquid divides
Butut (average diameter dI=232nm, polydispersity coefficient PDI=0.21).
Specific embodiment
Each part and operate with English alphabet code name and represent in Fig. 1 shown device：FO：Organic solution fluid；FW：Water-soluble
Liquor stream body；CO：Organic solvent fluid；CW：Aqueous fluid；VFO：Organic solution storage tank；VFW：Water-soluble liquid storage tank；VCO：Organic solvent stores up
Tank；VCW：Water storage tank；VW：Waste tank；VP：Product storage tank；SR1、SR2、SR3、SR4：Screen pack；TV1、TV2、TV3：Triple valve；
FV1、FV2：Cross valve；CHV1、CHV2：Check-valves；：Flow divider；P1、P2：Pump；M：Blender.Now valve is transferred to left direction
It is denoted as l, right side is denoted as r, is denoted as u above, be denoted as d below.With triple valve, (code name is as TV1) as a example, connect right side organic solution
Storage tank VFo, connect lower section flow divider DV1, it is denoted as TV1(r,d).
A kind of quick, a large amount of, continuous device producing nanoemulsions or nano suspending liquid：Described device includes pump, organic
Solution reservoir, organic solvent storage tank, water-soluble liquid storage tank, water storage tank, blender, product storage tank and waste tank；Described organic molten
Liquid storage tank outlet and organic solvent outlet and check-valves CHV1By cross valve FV1And pipeline is connected；Described aqueous solution storage
Tank outlet and water storage tank outlet and check-valves CHV2By cross valve FV2And pipeline is connected；Described check-valves passes through pipeline with pump
It is connected；Described pump is connected by pipeline with flow divider；Described flow divider DV1One outlet is led to organic solution reservoir inlet
Cross triple valve TV1It is connected；Another exports connection flow gauge FM1；Described flow divider DV2One outlet is entered with water-soluble liquid storage tank
Mouth passes through triple valve TV2It is connected；Another exports connection flow gauge FM2；Described flowmeter is connected by pipeline with blender
Connect；Described blender passes through triple valve TV with product storage tank3It is connected with pipeline；Three triple valves pass through pipeline with waste tank
Connect.
Concrete operation step is as follows：
Part initially sets：TV1(l,d)、TV2(r,d)、TV3(r,u)、FV1(u,d)、FV2(u,d)、DV1(l,r,u)、
DV2(l,r,u).
1. air-discharging：First regulating three-way valve door is to TV1(r,d)、TV2(l,d)、TV3(r, u), regulation flow divider to DV1(l,
u)、DV2(r, u), then adjust cross valve FV respectively1(l,d)、FV2(r, d) connects solution reservoir, opens pump P1And P2For a period of time,
Using storage tank VFoAnd VFwMiddle solution is draining the air in system pipeline.
2. it is mixed with：The synchronous slow flow divider that adjusts is to DV1(l,r,u)、DV2(l, r, u), makes flowmeter FM1And FM2
All reach necessary flow, and when mixing is in stable state, adjust TV3(l, u) connects product storage tank VPContinuously prepared.
3. clean：Preparation finishes, and pipeline is carried out.Scheme one：Regulating three-way valve is to TV1(l,d)、TV2(r, d) and
TV3(r, u) connects waste tank Vw, adjust cross valve respectively to FV1(r, d) and FV2(l, d) connects cleaning solvent storage tank to pipe
Road and blender M synchronize cleaning；Scheme two：Regulating three-way valve is to TV1(l,d)、TV2(r,d)、TV3(r, u) connects waste liquid
Storage tank Vw, regulation flow divider to DV1(l, u) and DV2(r, u), then adjust cross valve immediately to FV1(r, d) and FV2(l, d) connects
Cleaning solvent storage tank, last adjusted in concert flow divider DV1(l, r, u) and DV2(l, r, u) connects blender M and blender is carried out clearly
Wash.
4. empty cleaning fluid：Adjust cross valve to FV simultaneously1(u, d) and FV2(u, d), is passed through air for a period of time, will be residual
Stay the cleaning fluid emptying in system, finally close pump P1And P2.
Embodiment 1：175mL orange oil nano emulsions (citrus seed oil containing 3.0mL and 5.8mL by the continuous preparation of the present invention
Tween 80).
Under normal temperature, take 3.4mL citrus seed oil, 6.6mL Tween 80 to be dissolved in 90mL ethanol respectively and enter organic solution storage through filtering
Tank VFo, take 100mL distilled water to be placed in water-soluble liquid storage tank VFw.Turn on the power operating pump, after air-discharging, adjusted in concert flow divider DV1
And DV2Two-phase is made to be pumped to blender with identical speed.Two-phase liquid abundant turbulent closure scheme, prepared nanometer in blender cavity
Emulsion, uses product storage tank VpCollect emulsion.Last cleaning equipment pipeline.175mL nanoemulsions are finally obtained, remaining 25mL is pipe
Road dead volume and just mixed waste liquid.Using dynamic light scattering, emulsion particle diameter size and distribution are measured, particle diameter distribution such as Fig. 2
Shown, average diameter dI=98nm, polydispersity coefficient PDI=0.03.Particle diameter is less compared with the discontinuous method of example 2, chi
Very little distribution is more homogeneous.
Embodiment 2：By the 10mL orange oil nano emulsions of the discontinuous preparation of syringe pressing (citrus seed oil containing 0.17mL and
0.33mL Tween 80).
At normal temperatures, take 0.17mL citrus seed oil, 0.33mL Tween 80 and 4.5mL ethanol to be sufficiently mixed respectively, suck a pin
Cylinder.5mL distilled water is sucked the syringe of another same size.Connect two syringes and blender two entrance respectively, simultaneously with identical
Speed is quickly by two liquid injecting mixers.Two-phase liquid abundant turbulent closure scheme in blender airtight cavity, gained emulsion from
Mixer outlet flows out.Use container collection emulsion, and with dynamic light scattering, emulsion particle diameter size and distribution are measured, grain
Footpath distribution is as shown in figure 3, average diameter dI=138nm, polydispersity coefficient PDI=0.36.
Embodiment 3：785mL ubiquinone by the continuous preparation of the present invention10Nano suspending liquid (ubiquinone containing 31.2mg10With
38.4mg shitosan).
Take 43.2mg ubiquinone at normal temperatures10It is dissolved in 90mL ethanol and enter organic solution storage tank V through filteringFo, take 43.2mg
Shitosan is dissolved in the 810mL water of pH about 3.0 and is placed in water-soluble liquid storage tank VFw, turn on the power operating pump drain air after, with
Step section flow divider DV1And DV2Make organic phase and aqueous phase with about 1：11 speed ratio is pumped to blender.Two-phase liquid is in mixing
In device cavity, abundant turbulent closure scheme, prepared nano suspending liquid, use product storage tank VpCollect suspension.Last cleaning equipment pipeline.
Pipeline dead volume and just mixed waste liquid are about 115mL, and 785mL nano suspending liquid is finally obtained.Using dynamic light scattering to suspension
Liquid particle size and distribution are measured, and particle diameter distribution is as shown in figure 4, average diameter dI=226nm, polydispersity coefficient PDI=
0.20.Compared with method discontinuous with example 4, prepared nano suspending liquid average grain diameter and monodispersity are all suitable.Embodiment 4：Pass through
The 30mL ubiquinone of the discontinuous preparation of syringe pressing10Nano suspending liquid (ubiquinone containing 1.44mg10With 1.44mg shitosan).
Take 1.44mg ubiquinone at normal temperatures10It is dissolved in 3mL ethanol and sucks a syringe, take 1.44mg shitosan to be dissolved in 27mL's
PH be 4 water in be sufficiently mixed, measure 3mL suck another syringe, in addition 24mL be placed in mixer outlet cut-back product.Connect respectively
Connect two syringes and blender two entrance, simultaneously with identical speed quickly by two-phase injecting mixer.Two-phase liquid is in mixer chamber
Abundant turbulent closure scheme in body, gained suspension flows out from mixer outlet.With dynamic light scattering to suspension particle size and
Distribution is measured, and particle diameter distribution is as shown in figure 5, average diameter dI=232nm, polydispersity coefficient PDI=0.21.
Claims (8)
1. a kind of quick, a large amount of, continuous device producing nanoemulsions or nano suspending liquid it is characterised in that：Described device bag
Include pump, organic solution storage tank, organic solvent storage tank, water-soluble liquid storage tank, water storage tank, blender, product storage tank and waste tank；
Described organic solution outlet and organic solvent outlet and check-valves CHV1By cross valve FV1And pipeline is connected
Connect；
Described aqueous solution outlet and water storage tank outlet and check-valves CHV2By cross valve FV2And pipeline is connected；
Described check-valves is connected by pipeline with pump；Described pump is connected by pipeline with flow divider；
Described flow divider DV1One outlet passes through triple valve TV with organic solution reservoir inlet1It is connected；Another outlet connects
Flowmeter FM1；
Described flow divider DV2One outlet passes through triple valve TV with aqueous solution reservoir inlet2It is connected；Another exports connection flow
Gauge FM2；
Described flowmeter is connected by pipeline with blender；Described blender passes through triple valve TV with product storage tank3And pipeline phase
Connect；Three triple valves are connected by pipeline with waste tank.
2. according to claim 1 device it is characterised in that：Described device include exhaust and mixing system, cleaning and
Emptying rate of liquid system, electric control system, security protection system.
3. according to claim 1 device it is characterised in that：Described reservoir inlet connects screen pack respectively, and respective liquid leads to
Storage tank is flowed into after crossing screen pack.
4. according to claim 1 device it is characterised in that：Described device use idle running, can continuous transport streams for a long time
The fluid pump of body.
5. the method for nanoemulsions or nano suspending liquid is produced it is characterised in that including following based on claim 1 described device
Step：
1) air-discharging：Open pump for a period of time, in organic solution storage tank and water-soluble liquid storage tank solution priority flow through check-valves, pump,
Flow divider returns in storage tank, the air in each part of emptying and pipeline；
2) it is mixed with：In organic solution storage tank and water-soluble liquid storage tank, solution priority flows through check-valves, pump, flow divider, a part
Flow back to storage tank circulation, another part enters blender mixing through flowmeter, products obtained therefrom enters product storage tank；
3) clean：Preparation finishes, and pipeline is carried out, and the water in the organic solvent and water storage tank in organic solvent storage tank is successively
Flow through check-valves, pump, flow divider, a part is directly entered waste tank, another part, through flowmeter and blender, finally flows
Enter waste tank, all pipelines and part are completed clean；
4) empty cleaning fluid：Disconnect the connection of cross valve and storage tank, allow cross valve connect air, in each part of emptying, pipeline
Cleaning fluid, closes pump, completes preparation flow.
6. method according to claim 5 it is characterised in that：Fluid mixing process is blended for high reynolds number turbulent flow, fluid
The single entry injection speed being injected into blender airtight cavity is more than 0.1m/s.
7. method according to claim 5 it is characterised in that：Described aqueous phase adopts hydrophilic liquid, at least contains water
One of or alcohol.Described hydrophobic compound preparation-obtained product when for liquid is nanoemulsions, and compound is dredged
Water degree is represented with ACDLogP, and its value is more than 0；When for solid-state, preparation-obtained product is nano suspending liquid, and compound is dredged
Water degree is represented with ACDLogP, and its value is more than 2.0.
8. method according to claim 5 it is characterised in that：The instantaneous turbulent flow blending in a mixer of two-phase liquid, organic
Sovent diffusion enters aqueous phase, and hydrophobic compound self aggregation in aqueous phase forms nanoemulsions or nano suspending liquid, surface-active substance
Matter absorption stops its size further growth it is ensured that the dimensionally stable of nanometer system in nano-liquid droplet or particle surface.Formed
Nanoemulsions or nano suspending liquid flow continually out from blender, flow into product storage tank；Finally using fluid pump in preparation facilities pipe
Continuously transport organic solvent in road and water is carried out to it, to terminate whole preparation process.
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| CN201610763518.XA CN106422955B (en) | 2016-08-30 | 2016-08-30 | It is a kind of quickly, the device and method of a large amount of, continuous production nanoemulsions or nano suspending liquid |
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| CN108745015A (en) * | 2018-06-29 | 2018-11-06 | 扬州大学 | A kind of preparation method and device of nano-dispersion liquid |
| CN109971003A (en) * | 2017-12-26 | 2019-07-05 | 万华化学集团股份有限公司 | A kind of preparation method and silicone resin nanoparticle dispersion of silicone resin nanoparticle dispersion |
| CN110605036A (en) * | 2019-08-30 | 2019-12-24 | 扬州大学 | Method for impact mixing of non-equal momentum limited jet flow |
| CN112293725A (en) * | 2020-10-21 | 2021-02-02 | 扬州宏远新材料股份有限公司 | Preparation process of food-grade additive polydimethylsiloxane emulsion |
| CN114307708A (en) * | 2022-01-07 | 2022-04-12 | 苏州大学 | Method for continuously preparing drug-loaded nano-emulsion |
| CN115400657A (en) * | 2022-08-29 | 2022-11-29 | 扬州大学 | Portable mobile device for instantly preparing and spraying nano water dispersing agent and using method thereof |
| CN117920015A (en) * | 2024-03-20 | 2024-04-26 | 上海复迪源码生物技术有限公司 | Preparation system and control method for preparing nano preparation |
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| CN114307708A (en) * | 2022-01-07 | 2022-04-12 | 苏州大学 | Method for continuously preparing drug-loaded nano-emulsion |
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