CN106422016A - Mouse non-invasive trachea intubation instrument - Google Patents
Mouse non-invasive trachea intubation instrument Download PDFInfo
- Publication number
- CN106422016A CN106422016A CN201611080975.5A CN201611080975A CN106422016A CN 106422016 A CN106422016 A CN 106422016A CN 201611080975 A CN201611080975 A CN 201611080975A CN 106422016 A CN106422016 A CN 106422016A
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- feet
- resistance
- mice
- noinvasive
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/04—Tracheal tubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D3/00—Appliances for supporting or fettering animals for operative purposes
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Emergency Medicine (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Animal Husbandry (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Measuring Fluid Pressure (AREA)
Abstract
The invention discloses a mouse non-invasive trachea intubation instrument. The instrument comprises a pressure probe communicated with a pressure amplification device, the pressure amplification device is connected with a pressure sensor, the output end of the pressure sensor is connected with an input end of an amplification circuit, and the output end of the amplification circuit is connected with an indication device. The trachea intubation instrument can distinguish the airway from the esophagus of a mouse, and accordingly airway intubation operation is indicated.
Description
Technical field
The present invention relates to biomedical sector, more particularly, to a kind of mice noinvasive tracheal intubation instrument.
Background technology
Because the air flue of mice is very narrow, the tracheal intubation operation that rear end has esophagus therefore currently a popular again is all by fiber crops
Liquor-saturated lower tracheostomy tube operation, such operation wound and bleeding directly affect the success of experiment and result to the strike of mice
Stability.
If through row noinvasive direct cannulation, operation under the non-narcotism of animal is difficult to carry out.Even if carrying out anesthesia procedure,
Intubation is also easily strayed into esophagus, causes to be administered unsuccessfully, has a strong impact on experimental result.
Content of the invention
The present invention is intended to provide mice noinvasive tracheal intubation instrument, air flue and the esophagus of mice can be distinguished, and then indicate fast
Fast airway intubation operation.
For reaching above-mentioned purpose, the present invention employs the following technical solutions realization：
Mice noinvasive tracheal intubation instrument disclosed by the invention, including pressure detection pin, described pressure detection pin hollow, pressure
Detect pin connection pressure amplifying device, described pressure amplifying device connects pressure transducer, and the output of described pressure transducer is even
Connect the input of amplifying circuit, the output connection indication device of described amplifying circuit.
Preferably, described amplifying circuit includes instrumentation amplifier and operational amplifier, and described pressure transducer is
Mpx2010dp, described instrumentation amplifier is ad620an, and described operational amplifier is ua741cp, and described instruction device is electric current
Table, 4 feet of pressure transducer connect 3 feet of instrumentation amplifier, and 2 feet of pressure transducer connect 2 feet of instrumentation amplifier, instrument
Resistance R6 is connected, 6 feet of instrumentation amplifier connect one end of resistance R7, the other end of resistance R7 between 1 foot of amplifier, 8 feet
Connect one end, 2 feet of operational amplifier of resistance R3, the other end of resistance R3 connects the centre tap of potentiometer RV1, potentiometer
The two ends of RV1 connect one end of resistance R1, one end of resistance R2 respectively, and the other end of resistance R1 connects DC source anode, electricity
The other end of resistance R2 connects DC source negative terminal, is connected feedback branch, operational amplifier between 2 feet of operational amplifier and 6 feet
6 feet connect one end of resistance R8, the other end of resistance R8 connects one end of ammeter, the other end ground connection of ammeter, pressure
1 foot ground connection of sensor, 5 feet of instrumentation amplifier, 3 feet of operational amplifier are all grounded, and 3 feet of pressure transducer, instrument are put
Big 7 feet of device, 7 feet of operational amplifier are all connected with DC source anode, and 4 feet of instrumentation amplifier, 4 feet of operational amplifier are equal
Connect DC source negative terminal.
Preferably, the voltage between described DC source anode and ground is 12V, between described DC source negative terminal and ground
Voltage is -12V.
Preferably, described feedback branch is one of following two ways：
Mode 1：One end of 2 feet connection resistance R4 of operational amplifier, the 6 of the other end concatenation operation amplifier of resistance R4
Foot；
Mode 2：One end of 2 feet connection resistance R4 of operational amplifier, one end of other end connection resistance R5 of resistance R4,
One moving contact of single-pole double-throw switch (SPDT) SW1, the other end of resistance R5 connects another moving contact of single-pole double-throw switch (SPDT) SW1,
6 feet of the static contact concatenation operation amplifier of single-pole double-throw switch (SPDT) SW1.
Further, it is connected filter capacitor C1, described DC source negative terminal and ground between described DC source anode and ground
Between connect filter capacitor C2.
Preferably, described potentiometer RV1 is JML3590S.
Preferably, described ammeter is indicator type current meter.
Further, present invention additionally comprises electrical box, described single-pole double-throw switch (SPDT) SW1, potentiometer RV1 or ammeter are installed
Front in electrical box.
Preferably, described pressure amplifying device includes the cylindrical cavity closed, and an end face setting of described cylindrical cavity is axially
Passage, the side wall of cylindrical cavity arranges two radial passages, and the internal diameter of described axial passage is more than the internal diameter of radial passage, described pressure
Power detects pin and passes through soft pipe connection radial passage, and described pressure transducer passes through soft pipe connection radial passage.
Further, present invention additionally comprises mouse fixing, described mouse fixing includes swash plate, horizontal plate and draws
Line, the base of described swash plate is connected with horizontal plate, and swash plate forms angle with horizontal plate, and described bracing wire is located at the upper of swash plate upper surface
Side, bracing wire horizontally set, the two ends of bracing wire are fixed on swash plate by support column；The upper surface attachment cushion of described horizontal plate；
Present invention additionally comprises for the optical fiber lamp irradiating mice cervical region.
The using method of the present invention is as follows：Mice is lain and is placed on swash plate, the mouth of mice is opened, the tooth of mice hangs over
In bracing wire, using optical fiber light irradiation mouse carotid portion, pressure detection pin is directed at gas port or the esophageal orifice of mice, due to gas port
There is air pressure change, esophageal orifice no air pressure change, so that it is determined that the position of gas port, it is channeled into the trachea noinvasive intubation behaviour that passes through
Make.
Beneficial effects of the present invention are as follows：
1st, the present invention is channeled into trachea noinvasive intubation of passing through, it is to avoid misplug, simple to operate, reliable；
2nd, amplifying circuit adopts instrumentation amplifier and precision operational-amplifier to constitute two-stage and amplify, simple and reasonable, smart
Degree is high, strong antijamming capability.
3rd, during feedback branch employing mode 2, the amplification of convertible amplifying circuit, realize bigness scale and the thin gearshift surveyed.
4th, single-pole double-throw switch (SPDT) SW1, potentiometer RV1 and ammeter are arranged on the front of electrical box, convenient operation.
Brief description
Fig. 1 is the theory diagram of the present invention；
Fig. 2 is the schematic diagram of amplifying circuit；
Fig. 3 is the structural representation of mice fixed plate and optical fiber lamp；
In figure：1- pressure detection pin, 2- cylindrical cavity, 3- first flexible pipe, 4- pressure transducer, 5- amplifying circuit, 6- instruction
Device, 7- second flexible pipe, 8- swash plate, 9- horizontal plate, 10- bracing wire, 11- cushion, 12- support column, 13- optical fiber lamp.
Specific embodiment
In order that the objects, technical solutions and advantages of the present invention become more apparent, below in conjunction with accompanying drawing, the present invention is entered
Row further describes.
As shown in figure 1, mice noinvasive tracheal intubation instrument, including pressure detection pin 1, pressure detection pin 1 hollow, pressure amplifies
Device includes the cylindrical cavity 2 closed, an end face setting axial passage of cylindrical cavity 2, and the side wall of cylindrical cavity 2 arranges two radial directions
Passage, the internal diameter of axial passage is more than the internal diameter of radial passage, and pressure detection pin 1 connects radial passage, pressure by the first flexible pipe 3
Force transducer 4 connects radial passage by the second flexible pipe 7, and the output of pressure transducer 4 connects the input of amplifying circuit 5, amplifies
The output connection indication device 6 of circuit 5.
As shown in Fig. 2 amplifying circuit 5 includes instrumentation amplifier and operational amplifier, described pressure transducer is
Mpx2010dp, described instrumentation amplifier is ad620an, and described operational amplifier is ua741cp, and described instruction device is electric current
Table, 4 feet of pressure transducer connect 3 feet of instrumentation amplifier, and 2 feet of pressure transducer connect 2 feet of instrumentation amplifier, instrument
Resistance R6 is connected, 6 feet of instrumentation amplifier connect one end of resistance R7, the other end of resistance R7 between 1 foot of amplifier, 8 feet
Connect one end, 2 feet of operational amplifier of resistance R3, the other end of resistance R3 connects the centre tap of potentiometer RV1, potentiometer
The two ends of RV1 connect one end of resistance R1, one end of resistance R2 respectively, and the other end of resistance R1 connects DC source anode, electricity
The other end of resistance R2 connects DC source negative terminal, is connected feedback branch, operational amplifier between 2 feet of operational amplifier and 6 feet
6 feet connect one end of resistance R8, the other end of resistance R8 connects one end of ammeter, the other end ground connection of ammeter, pressure
1 foot ground connection of sensor, 5 feet of instrumentation amplifier, 3 feet of operational amplifier are all grounded, and 3 feet of pressure transducer, instrument are put
Big 7 feet of device, 7 feet of operational amplifier are all connected with DC source anode, and 4 feet of instrumentation amplifier, 4 feet of operational amplifier are equal
Connect DC source negative terminal.
Voltage between DC source anode and ground is 12V, and the voltage between described DC source negative terminal and ground is -12V,
It is connected filter capacitor C1 between DC source anode and ground, between described DC source negative terminal and ground, be connected filter capacitor C2.
Feedback branch is one of following two ways：
Mode 1：One end of 2 feet connection resistance R4 of operational amplifier, the 6 of the other end concatenation operation amplifier of resistance R4
Foot；
Mode 2：One end of 2 feet connection resistance R4 of operational amplifier, one end of other end connection resistance R5 of resistance R4,
One moving contact of single-pole double-throw switch (SPDT) SW1, the other end of resistance R5 connects another moving contact of single-pole double-throw switch (SPDT) SW1,
6 feet of the static contact concatenation operation amplifier of single-pole double-throw switch (SPDT) SW1.
Present invention additionally comprises electrical box, single-pole double-throw switch (SPDT) SW1, potentiometer RV1 and ammeter are just being arranged on electrical box
Face, potentiometer RV1 adopts JML3590S, and ammeter adopts indicator type current meter.
As shown in figure 3, present invention additionally comprises mouse fixing, mouse fixing includes swash plate 8, horizontal plate 9 and draws
Line 10, the base of swash plate 8 is connected with horizontal plate 9, and swash plate 8 forms angle with horizontal plate 9, and bracing wire 10 is located at swash plate 8 upper surface
Top, bracing wire 10 horizontally set, the two ends of bracing wire 10 are fixed on swash plate 8 by support column 12；The upper surface attachment of horizontal plate 9
Cushion 11, present invention additionally comprises for the optical fiber lamp 13 irradiating mice cervical region.
Certainly, the present invention also can have other various embodiments, in the case of without departing substantially from present invention spirit and its essence, ripe
Know those skilled in the art to make various corresponding changes according to the present invention and deform, but these corresponding changes and deformation
The protection domain of appended claims of the invention all should be belonged to.
Claims (10)
1. mice noinvasive tracheal intubation instrument it is characterised in that：Including pressure detection pin, pressure detection pin connection pressure amplifies dress
Put, described pressure amplifying device connects pressure transducer, the output of described pressure transducer connects the input of amplifying circuit, described
The output connection indication device of amplifying circuit.
2. mice noinvasive tracheal intubation instrument according to claim 1 it is characterised in that：Described amplifying circuit includes instrument and puts
Big device and operational amplifier, described pressure transducer is mpx2010dp, and described instrumentation amplifier is ad620an, and described computing is put
Big device is ua741cp, and described instruction device is ammeter, and 4 feet of pressure transducer connect 3 feet of instrumentation amplifier, and pressure passes
2 feet of sensor connect 2 feet of instrumentation amplifier, connection resistance R6 between 1 foot of instrumentation amplifier, 8 feet, and the 6 of instrumentation amplifier
Foot connects one end of resistance R7, and the other end of resistance R7 connects one end of resistance R3,2 feet of operational amplifier, and resistance R3's is another
One end connects the centre tap of potentiometer RV1, and the two ends of potentiometer RV1 connect one end of resistance R1, one end of resistance R2 respectively,
The other end of resistance R1 connects DC source anode, and the other end of resistance R2 connects DC source negative terminal, 2 feet of operational amplifier
It is connected feedback branch between 6 feet, 6 feet of operational amplifier connect one end of resistance R8, the other end of resistance R8 connects electric current
One end of table, ammeter the other end ground connection, 1 foot ground connection of pressure transducer, 5 feet of instrumentation amplifier, the 3 of operational amplifier
Foot is all grounded, and 3 feet of pressure transducer, 7 feet of instrumentation amplifier, 7 feet of operational amplifier are all connected with DC source anode, instrument
4 feet of device amplifier, 4 feet of operational amplifier are all connected with DC source negative terminal.
3. mice noinvasive tracheal intubation instrument according to claim 2 it is characterised in that：Described DC source anode and ground
Between voltage be 12V, the voltage between described DC source negative terminal and ground be -12V.
4. mice noinvasive tracheal intubation instrument according to claim 2 it is characterised in that：Described feedback branch is following two kinds
One of mode：
Mode 1：2 feet of operational amplifier connect one end of resistance R4,6 feet of the other end concatenation operation amplifier of resistance R4；
Mode 2：2 feet of operational amplifier connect one end of resistance R4, and the other end of resistance R4 connects one end of resistance R5, hilted broadsword
One moving contact of commutator SW1, the other end of resistance R5 connects another moving contact of single-pole double-throw switch (SPDT) SW1, hilted broadsword
6 feet of the static contact concatenation operation amplifier of commutator SW1.
5. mice noinvasive tracheal intubation instrument according to claim 2 it is characterised in that：Described DC source anode and ground
Between connect filter capacitor C1, be connected filter capacitor C2 between described DC source negative terminal and ground.
6. mice noinvasive tracheal intubation instrument according to claim 2 it is characterised in that：Described potentiometer RV1 is
JML3590S.
7. mice noinvasive tracheal intubation instrument according to claim 2 it is characterised in that：Described ammeter is pointer electric current
Table.
8. the mice noinvasive tracheal intubation instrument according to claim 4,6 or 7 it is characterised in that：Also include electrical box, described
Single-pole double-throw switch (SPDT) SW1, potentiometer RV1 or ammeter are arranged on the front of electrical box.
9. mice noinvasive tracheal intubation instrument according to claim 1 it is characterised in that：Described pressure amplifying device includes sealing
The cylindrical cavity closing, an end face setting axial passage of described cylindrical cavity, the side wall of cylindrical cavity arranges two radial passages, described
The internal diameter of axial passage is more than the internal diameter of radial passage, and described pressure detection pin passes through soft pipe connection radial passage, described pressure
Sensor passes through soft pipe connection radial passage.
10. mice noinvasive tracheal intubation instrument according to claim 1 it is characterised in that：Also include mouse fixing, institute
State mouse fixing and include swash plate, horizontal plate and bracing wire, the base of described swash plate is connected with horizontal plate, swash plate and horizontal plate shape
Become angle, described bracing wire is located at the top of swash plate upper surface, bracing wire horizontally set, and the two ends of bracing wire are fixed on tiltedly by support column
On plate；The upper surface attachment cushion of described horizontal plate；
Also include the optical fiber lamp for irradiating mice cervical region.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611080975.5A CN106422016A (en) | 2016-11-30 | 2016-11-30 | Mouse non-invasive trachea intubation instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611080975.5A CN106422016A (en) | 2016-11-30 | 2016-11-30 | Mouse non-invasive trachea intubation instrument |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106422016A true CN106422016A (en) | 2017-02-22 |
Family
ID=58223683
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611080975.5A Pending CN106422016A (en) | 2016-11-30 | 2016-11-30 | Mouse non-invasive trachea intubation instrument |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106422016A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20190097967A (en) * | 2018-02-13 | 2019-08-21 | 김권태 | Pressure Instillator |
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|---|---|---|---|---|
| CN1513417A (en) * | 2003-07-07 | 2004-07-21 | 深圳迈瑞生物医疗电子股份有限公司 | Electronic device for measuring blood-pressure |
| CN1731105A (en) * | 2005-08-10 | 2006-02-08 | 陈宇 | Fluid flow rate detector |
| US20090143996A1 (en) * | 2007-11-26 | 2009-06-04 | Kai Karlsson | Airway sensor |
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| CN202182740U (en) * | 2011-08-02 | 2012-04-04 | 威海文润测控设备有限公司 | Porous steady-flow differential pressure type flow meter |
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| CN202666147U (en) * | 2012-07-25 | 2013-01-16 | 西安交通大学医学院第一附属医院 | Pressure-monitored trachea cannula |
| CN203341849U (en) * | 2013-06-14 | 2013-12-18 | 中国人民解放军第四军医大学 | Mouse oral trachea cannula |
| CN205280157U (en) * | 2015-12-28 | 2016-06-01 | 广州七喜医疗设备有限公司 | Differential pressure formula flow measurement mechanism |
| CN205460312U (en) * | 2016-03-14 | 2016-08-17 | 马慧 | Judge in trachea whether successful device of intubate rapidly |
| CN205649562U (en) * | 2016-04-15 | 2016-10-19 | 河南医学高等专科学校 | A fixed station for experimental animals trachea cannula |
-
2016
- 2016-11-30 CN CN201611080975.5A patent/CN106422016A/en active Pending
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1513417A (en) * | 2003-07-07 | 2004-07-21 | 深圳迈瑞生物医疗电子股份有限公司 | Electronic device for measuring blood-pressure |
| CN1731105A (en) * | 2005-08-10 | 2006-02-08 | 陈宇 | Fluid flow rate detector |
| US20090143996A1 (en) * | 2007-11-26 | 2009-06-04 | Kai Karlsson | Airway sensor |
| CN201361336Y (en) * | 2009-02-24 | 2009-12-16 | 广州医学院第二附属医院 | Rat tracheal intubation device guided by internally-arranged optical fiber |
| CN202182740U (en) * | 2011-08-02 | 2012-04-04 | 威海文润测控设备有限公司 | Porous steady-flow differential pressure type flow meter |
| CN202182741U (en) * | 2011-08-02 | 2012-04-04 | 威海文润测控设备有限公司 | Differential pressure type flow meter |
| CN202666147U (en) * | 2012-07-25 | 2013-01-16 | 西安交通大学医学院第一附属医院 | Pressure-monitored trachea cannula |
| CN203341849U (en) * | 2013-06-14 | 2013-12-18 | 中国人民解放军第四军医大学 | Mouse oral trachea cannula |
| CN205280157U (en) * | 2015-12-28 | 2016-06-01 | 广州七喜医疗设备有限公司 | Differential pressure formula flow measurement mechanism |
| CN205460312U (en) * | 2016-03-14 | 2016-08-17 | 马慧 | Judge in trachea whether successful device of intubate rapidly |
| CN205649562U (en) * | 2016-04-15 | 2016-10-19 | 河南医学高等专科学校 | A fixed station for experimental animals trachea cannula |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20190097967A (en) * | 2018-02-13 | 2019-08-21 | 김권태 | Pressure Instillator |
| KR102037858B1 (en) | 2018-02-13 | 2019-10-29 | 김권태 | Pressure Instillator |
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| PB01 | Publication | ||
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Application publication date: 20170222 |