CN106421934B - A kind of preparation method of the hydrophilic superslide coating for medical apparatus surface - Google Patents
A kind of preparation method of the hydrophilic superslide coating for medical apparatus surface Download PDFInfo
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/04—Macromolecular materials
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- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/04—Macromolecular materials
- A61L29/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/048—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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Abstract
The invention discloses a kind of preparation methods of hydrophilic superslide coating for medical apparatus surface, it is characterised in that the raw material comprising following parts by weight: the hydroxyvinyl pyrrolidone polymer of 5~15 mass parts, the isocyanates of 0.5~8 mass parts, the isocyanate crosslinking of 0.2~8 mass parts, the levelling agent of 0.05~0.5 mass parts, 73.5~94.25 mass parts solvent A；First raw material is uniformly mixed in proportion under room temperature when preparing hydrophilic superslide coating and coating composition is made after stirring 3~6h, then coating composition is coated on medical apparatus surface using dip-coating or spraying method, 20~40min is dried at 50~60 DEG C, hydrophilic superslide coating is made, possess the excellent effect for persistently playing hydrophilic superslide.The medical instrument that hydrophilic superslide coating prepared by the present invention makes especially suitable for polyvinyl chloride, polyurethane, nylon, acrylate, polyether-ether-ketone polar materials, such as catheter, ureter bracket, seal wire, angiography catheter, endoscopy sheath, foley's tube, drainage tube, central venous catheter.
Description
Technical field
The invention belongs to medical field of new materials, are related to one kind and are used for polyvinyl chloride, polyurethane, nylon, acrylate, gather
The materials such as ether ether ketone production medical instrument, as catheter, ureter bracket, seal wire, angiography catheter, endoscopy sheath,
The preparation method of the hydrophilic superslide coating on the surfaces such as foley's tube, drainage tube, central venous catheter
Background technique
Medical apparatus surface coating functions coating makes medical instrument obtain hydrophilic, lubrication, antibacterial, anticoagulation, anti-tissue
The performances such as hyperplasia have been to improve medical instrument effect, mitigate uncomfortable patient, enhancing therapeutic effect, the important technology for reducing infection rate
Scheme.And with the progress of medical technology, it is a large amount of to possess superslide, antibacterial, anticoagulation, drug control by medical coating surface modifying
Puncture needle, seal wire, conduit, catheter sheath, bracket, the sacculus for the functions such as releasing are widely applied in clinic, are brought to patient
Happiness.
In the medical instrument of coating surface modifying, coating hydrophilic superslide coating is most basic clinical application.Such as urethral catheterization
The insertion and replacement of pipe, vessel catheter, guide wire support, because of the presence of surface hydrophilic lubricating coating, thus reduce surface and
Friction between vascular wall improves biocompatibility, is easier to operate to medical treatment.In clinical application, patient's pain
It drastically reduces, and greatly reduces the risk of vascular wall breakage.In addition, hydrophilic superslide coating has been demonstrated splendid life
Object compatibility and anticalcium fouling performance.Therefore, coating hydrophilic superslide coating in medical apparatus surface has widest clinic
Using.
The hydrophilic superslide coating for being able to satisfy clinical application must be good with medical apparatus surface adhesiveness, not easily to fall off, biology
Compatibility is good；Wet friction coefficient is low simultaneously, and repeatedly resistance to wiping can be recycled.
Currently, the hydrophilic superslide coating for medical instrument of mainstream passes through heat cure and the cured method system of UV mostly
It is standby.
Using the coating of thermal curing methods, usually by matter acid, polyacrylamide, polyvinylpyrrolidone, chitosan, poly-
The Hydrophilic lubrications such as ethylene oxide ether polymer, aromatic isocyanate and isocyanate crosslinking, function additive, in a solvent instead
It answers, generates the urethanes with cross-linked structure, Hydrophilic lubrication polymer is limited in cross-linked network, is then coated with
To medical apparatus surface, solvent is dried, obtaining surface has persistent hydrophilic superslide effect.Also the technical solution having is adopted
With acrylic compounds and related cross-links agent, Hydrophilic lubrication polymer reaction prepares coating.This method is advantageous in that
Use and prepare simple, matched coating equipment is simple, dried after dip-coating or spraying, can coating medical instrument simultaneously it is interior
Outer surface.But defect is in Hydrophilic lubrication polymer and cross-linked network that there is no strong adsorption capacity or chemical bonded refractories
It closes, persistence is relatively poor, and many medical device products is caused only to be used only once coating shedding twice, causes serious secondary anti-
It answers.Such as United States Patent (USP) US4875287 and US20090048537, use Kollidon 90 as hydrophilic lubrication group
Point, it is mixed after then being dissolved with polyurethane adhesive with solvent and obtains coating, but this can not be such that resistance to wiping properties improve.
Using the coating of UV curing method, usually by photoinitiator, n-vinyl pyrrolidone monomer, vinyl pyrrole
Polyurethane-modified polyacrylate class compound, the function additive of alkanone polymer, UV curable, are uniformly mixed, so in a solvent
After be coated to medical apparatus surface, after dry out solvent, obtaining surface cure with ultraviolet light irradiation certain time has persistence
Hydrophilic superslide effect.This method is advantageous in that vinylpyrrolidone monomer, vinyl pyrrolidone polymer, poly- ammonia
Ester modified acrylate compounds can under the photoinitiator effect initiated polymerization, it is strong to ultimately generate Chemical bonding
Cross-linked network keeps the hydrophilic superslide of Bulk coat and durability all more excellent without free water-soluble substances.This method
Defect is: initiator residue problem；Medical instrument and opaque instrument interior surface for wall thickness, ultraviolet rays without
Method, which penetrates, can not also solidify, thus inner surface can not applying coating, influence anticalcium fouling performance of instrument etc., and can only make
With the lower spraying process of efficiency；Meanwhile in order to control dry coating thickness after coating, it will usually solvent regulation be added, so that applying
It just can be carried out ultraviolet irradiation after drying and volatilizing solvent when covering, keep production process and relevant device more cumbersome.Such as
US8163327 is exactly the viscosity for regulating and controlling UV coating composition with solvent, and experienced " dry-UV coating process " can just make medical treatment
Instrument obtains hydrophilic superslide effect.
So optimizing to existing coating technology, the persistence and lubrication of heat-curable coating are especially improved
Property, have great importance to improving the therapeutic effect of instrument, improving production efficiency.
Summary of the invention
The purpose of the present invention is to provide a kind of preparation method of hydrophilic superslide coating for medical apparatus surface, inventions
Method based on heat cure has synthesized a kind of second that whole cross-linked structure can be formed with isocyanates, isocyanate crosslinking
Vinyl pyrrolidone polymer, the coating of preparation possess the excellent effect for persistently playing hydrophilic superslide.
Hydrophilic superslide coating prepared by the present invention is especially suitable for polyvinyl chloride, polyurethane, nylon, acrylate, polyethers
The medical instrument of ether ketone polar materials production, such as catheter, ureter bracket, seal wire, angiography catheter, endoscopy sheath
Pipe, foley's tube, drainage tube, central venous catheter etc..
The technical solution adopted by the present invention is that:
A kind of preparation method of the hydrophilic superslide coating for medical apparatus surface, it is characterised in that include following parts by weight
Raw material: the hydroxyvinyl pyrrolidone polymer of 5~15 mass parts, the isocyanates of 0.5~8 mass parts, 0.2~8 matter
Measure the isocyanate crosslinking of part, the levelling agent of 0.05~0.5 mass parts, 73.5~94.25 mass parts solvent A；Preparation parent
First raw material is uniformly mixed in proportion under room temperature when water superslide coating and coating composition is made after stirring 3~6h, then will
Coating composition is coated on medical apparatus surface using dip-coating or spraying method, and 20~40min system is dried at 50~60 DEG C
Hydrophilic superslide coating is obtained, medical instrument is made to generate the effect of hydrophilic superslide.
Further, the preparation method of the hydroxyvinyl pyrrolidone polymer is as follows, first in the reaction vessel
Pour into the solvent B of 30~60 mass parts, then by the n-vinyl pyrrolidone of 20~50 mass parts, 1~10 mass parts third
Olefin(e) acid ester is uniformly mixed in head tank A；Then the initiator of 0.2~2 mass parts is identical as 11.5~18.8 mass parts
Solvent is uniformly mixed in head tank B；Finally under 60~80 DEG C of reaction temperature, while head tank A and head tank B are opened,
It drops evenly and finishes in 2~4h；After all raw materials are added dropwise, it is poly- that insulation reaction 2h obtains hydroxyvinyl pyrrolidones
Close object.
Further, the solvent A is tetrahydrofuran, methyl lactate, any one in ethyl lactate.
Further, the acrylate has hydroxyl ethyl ester or hydroxypropyl acrylate functional group.
Further, the acrylate hydroxy-ethyl acrylate, hydroxypropyl acrylate, hydroxyethyl methacrylate, methyl
Any one in hydroxypropyl acrylate.
Further, the initiator is preferably azo initiator V-601, azo initiator V-50, azo initiator
Any one in VA-044, its main feature is that not nitrile group-containing, good biocompatibility, efficiency of initiation are high.
Further, the isocyanates is methyl diphenylene diisocyanate MDI, isophorone diisocyanate
IPDI, poly methylene poly phenyl poly isocyanate PAPI, tetramethyl diphenylmethane diisocyanate TMXDI, 1,4- hexamethylene
Diisocyanate CHDI, trimethyl -1,6- hexamethylene diisocyanate TMDI, norbornene alkyl diisocyanate NBDI, diformazan
Any one in base biphenyl diisocyanate TODI, dicyclohexyl methyl hydride diisocyanate H12MDI.
Further, the isocyanate crosslinking be molecular weight 141-5000, degree of functionality 2.2-4 polyether polyol or
Castor oil polyhydric alcohol.
Further, the levelling agent is organic silicon modified by polyether, such as uses BYK Additives&Instruments
Any one in BYK-373, BYK-375, BYK-377, BYK-300, BYK-306 of company.
Further, the solvent A is acetone, butanone, tetrahydrofuran, methyl lactate, ethyl lactate, diisobutyl ketone
In any one.
The beneficial effects of the present invention are:
1. in technical solution of the present invention, hydroxyvinyl pyrrolidone polymer and isocyanates, isocyanate crosslinking
Common reaction, the end of reaction within the time of 3-6h generate the hydrophilic super of the micro- cross-linked structure of three-dimensional network of chemical bonding effect
Sliding coating composition.
2. hydrophilic superslide coating composition prepared by the present invention is coated in inside and outside medical instrument by dip-coating, spraying process
Behind surface, 50-60 DEG C of drying 20-40min can form stable coating in equipment surfaces, realize lasting hydrophilic superslide effect
Fruit.
3. the present invention has, coating processes are simple, medical instrument high production efficiency, inside and outside multi-surface can coat, wet friction
The advantages of coefficient is low, durable, especially suitable for based on polyvinyl chloride, polyurethane, nylon, acrylate, polyether-ether-ketone etc.
The medical instrument of polar material production.
Specific embodiment
In order to be more clearly understood the advantages of making the purpose of the present invention and technical solution, below in conjunction with example, to the present invention
It is further elaborated.
Embodiment 1-5 is the specific synthetic method of hydroxyvinyl pyrrolidone polymer.
Embodiment 1
The tetrahydrofuran of 30 mass parts is poured into the reaction vessel first, then by the N- ethenyl pyrrolidone of 50 mass parts
Ketone, the hydroxy-ethyl acrylate of 1 mass parts are uniformly mixed in head tank A；Then by the initiator V-601 of 0.2 mass parts with
The tetrahydrofuran of 18.8 mass parts is uniformly mixed in head tank B, finally under 60 DEG C of reaction temperature, while opening head tank
A and head tank B, drops evenly in 4h and finishes；After all materials are added dropwise, insulation reaction 2h obtains hydroxyvinyl pyrrole
Pyrrolidone polymer.
Embodiment 2
The methyl lactate of 45 mass parts is poured into the reaction vessel first, then by the N- ethenyl pyrrolidone of 40 mass parts
Ketone, the hydroxypropyl acrylate of 3 mass parts are uniformly mixed in head tank A；Then by the initiator V-50 of 0.5 mass parts and 11.5
The methyl lactate of mass parts in head tank B be uniformly mixed, finally under 70 DEG C of reaction temperature, at the same open head tank A and
Head tank B, drops evenly in 3h and finishes；After all materials are added dropwise, insulation reaction 2h obtains hydroxyvinyl pyrroles
Alkanone polymer.
Embodiment 3
The ethyl lactate of 50 mass parts is poured into the reaction vessel first, then by the N- ethenyl pyrrolidone of 30 mass parts
Ketone, the hydroxyethyl methacrylate of 5 mass parts are uniformly mixed in head tank A；Then by the initiator V-044 of 1 mass parts with
The ethyl lactate of 14 mass parts is uniformly mixed in head tank B, finally under 80 DEG C of reaction temperature, while opening head tank A
With head tank B, drops evenly and finish in 2h；After all materials are added dropwise, insulation reaction 2h obtains hydroxyvinyl pyrrole
Pyrrolidone polymer.
Embodiment 4
The tetrahydrofuran of 60 mass parts is poured into the reaction vessel first, then by the N- ethenyl pyrrolidone of 20 mass parts
Ketone, the hydroxy propyl methacrylate of 7 mass parts are uniformly mixed in head tank A；Then by the initiator V-601 of 1.5 mass parts
It is uniformly mixed in head tank B with the tetrahydrofuran of 11.5 mass parts, finally under 70 DEG C of reaction temperature, while opening a high position
Slot A and head tank B, drops evenly in 3h and finishes；After all materials are added dropwise, insulation reaction 2h obtains hydroxyvinyl
Pyrrolidone polymer.
Embodiment 5
The ethyl lactate of 40 mass parts is poured into the reaction vessel first, then by the N- ethenyl pyrrolidone of 30 mass parts
Ketone, the hydroxy-ethyl acrylate of 10 mass parts are uniformly mixed in head tank A；Then by the initiator V-50 of 2 mass parts and 18 matter
The ethyl lactate for measuring part is uniformly mixed in head tank B, finally under 60 DEG C of reaction temperature, while opening head tank A and height
Position slot B, drops evenly in 4h and finishes；After all materials are added dropwise, insulation reaction 2h obtains hydroxyvinyl pyrrolidines
Ketone polymer.
Embodiment 6-15 is the hydroxyvinyl pyrrolidone polymer prepares coating composition using embodiment 1-5 synthesis
Method.
Embodiment 6
5 mass parts according to embodiment 1 prepare hydroxyvinyl pyrrolidone polymer, 0.5 mass parts diphenyl
Polyether polyol (molecular weight 700, degree of functionality 3, the Voranol of Dow company of methane diisocyanate, 0.2 mass parts
2070)；The BYK-373 of 0.05 mass parts；94.25 the acetone of mass parts；Composition is uniformly mixed and is stirred in proportion under room temperature
Hydrophilic superslide coating composition is obtained after mixing 3h.
Embodiment 7
8 mass parts according to embodiment 2 prepare hydroxyvinyl pyrrolidone polymer, 1 mass parts isophorone
The polyether polyol (molecular weight 1000, degree of functionality 3, the Voranol CP-1055 of Dow company) of diisocyanate, 1 mass parts；
The BYK-375 of 0.1 mass parts；The butanone of 89.9 mass parts；Composition is uniformly mixed in proportion under room temperature and is obtained after stirring 4h
Obtain hydrophilic superslide coating composition.
Embodiment 8
10 mass parts according to embodiment 3 prepare hydroxyvinyl pyrrolidone polymer, 1.5 mass parts more methylenes
Polyether polyol (molecular weight 3000, degree of functionality 3, the Voranol of Dow company of Quito polyphenyl polyisocyanate, 2 mass parts
3010)；The BYK-377 of 0.2 mass parts；The tetrahydrofuran of 86.3 mass parts；Composition is uniformly mixed simultaneously in proportion under room temperature
Hydrophilic superslide coating composition is obtained after stirring 5h.
Embodiment 9
15 mass parts according to embodiment 4 prepare hydroxyvinyl pyrrolidone polymer, 3 mass parts 1.4- hexamethylene
Polyether polyol (molecular weight 5000, degree of functionality 3, the Voranol CP of Dow company of alkane diisocyanate, 5 mass parts
1421)；The BYK-300 of 0.5 mass parts；The ethyl lactate of 76.5 mass parts；Composition is uniformly mixed simultaneously in proportion under room temperature
Hydrophilic superslide coating composition is obtained after stirring 6h.
Embodiment 10
5 mass parts according to embodiment 5 prepare hydroxyvinyl pyrrolidone polymer, 4 mass parts 1.4- hexamethylene
Polyether polyol (molecular weight 5000, degree of functionality 3, the Voranol CP of Dow company of alkane diisocyanate, 8 mass parts
1421)；The BYK-300 of 0.5 mass parts；The ethyl lactate of 82.5 mass parts；Composition is uniformly mixed simultaneously in proportion under room temperature
Hydrophilic superslide coating composition is obtained after stirring 6h.
Embodiment 11
15 mass parts according to embodiment 2 prepare hydroxyvinyl pyrrolidone polymer, 8 mass parts trimethyl-
Polyether polyol (molecular weight 800, degree of functionality 4, the Voranol of Dow company of 1,6- hexamethylene diisocyanate, 3 mass parts
RA-800)；The BYK-375 of 0.5 mass parts；The diisobutyl ketone of 73.5 mass parts；Composition is mixed in proportion under room temperature equal
It is even and obtain hydrophilic superslide coating composition after stirring 6h.
Embodiment 12
10 mass parts according to embodiment 3 prepare hydroxyvinyl pyrrolidone polymer, 5 mass parts norbornane
Castor oil polyhydric alcohol (molecular weight 1085, degree of functionality 2.2, the Vertellus Specialties public affairs of diisocyanate, 1 mass parts
The Polycin GR-50 of department)；The BYK-373 of 0.1 mass parts；The ethyl lactate of 83.9 mass parts；It in proportion will combination under room temperature
Object is uniformly mixed and obtains hydrophilic superslide coating composition after stirring 4h.
Embodiment 13
12 mass parts according to embodiment 4 prepare hydroxyvinyl pyrrolidone polymer, 6 mass parts dicyclohexyl
Castor oil polyhydric alcohol (molecular weight 141, the degree of functionality 3, Vertellus of methane diisocyanate, 0.5 mass parts
The Polycin T-400 of Specialties company)；The BYK-306 of 0.2 mass parts；The tetrahydrofuran of 81.3 mass parts；Room temperature
Under composition be uniformly mixed in proportion and obtain hydrophilic superslide coating composition after stirring 3h.
Effect in order to better illustrate the present invention, referring to the method for embodiment 13, using the polyvinyl of not hydroxyl
Pyrrolidones K90 replaces hydroxyvinyl pyrrolidone polymer, prepares comparative example 1.
Comparative example 1
The Kollidon 90 of 2 mass parts, the dicyclohexyl methyl hydride diisocyanate of 6 mass parts, 0.5 mass
The castor oil polyhydric alcohol (molecular weight 141, degree of functionality 3, the Polycin T-400 of Vertellus Specialties company) of part；
The BYK-306 of 0.2 mass parts；The tetrahydrofuran of 81.3 mass parts；Composition is uniformly mixed in proportion under room temperature and stirs 3h
After obtain hydrophilic superslide coating composition.
Application example
Coating prepared by embodiment 6-13 and comparative example 1 is according to the coating polyvinyl chloride catheter of dip-coating method and outer
Layer is the seal wire of polyurethane casing.The finally dry 20min in 60 DEG C of convection ovens.
Test method: the conduit after applying coating is impregnated into different time in 37 DEG C of physiological saline environment.Then it cleans
Wet friction coefficient, the water contact angle of different soaking times are tested in conduit and drying.
Meanwhile by the method for the drying at room temperature after mold is cast, 0.5mm thickness, 50 × 50mm ruler is made in coating solution
Very little film.It is impregnated into different time in 37 DEG C of physiological saline environment, the matter of different soaking times is tested after dry after cleaning
Amount loss rate.
Related data is shown in that the coating result of the visible embodiment 6-13 preparation of Tables 1 and 2 is substantially better than comparative example, and hydrophilic
Lubricant effect and resistance to wiping are had excellent performance.
1 polyvinyl chloride catheter test comparison data of table
2 outer layer of table is the seal wire test comparison data of polyurethane casing
Claims (9)
1. a kind of preparation method of the hydrophilic superslide coating for medical apparatus surface, it is characterised in that include following parts by weight
Raw material: the hydroxyvinyl pyrrolidone polymer of 5~15 mass parts, the isocyanates of 0.5~8 mass parts, 0.2~8 mass
Part isocyanate crosslinking, the levelling agents of 0.05~0.5 mass parts, 73.5~94.25 mass parts solvent A；It prepares hydrophilic
First raw material is uniformly mixed in proportion under room temperature when superslide coating and coating composition is made after stirring 3~6h, then will be applied
Layer composition is coated on medical apparatus surface using dip-coating or spraying method, and 20~40min is dried at 50~60 DEG C and is made
Hydrophilic superslide coating；
The preparation method of the hydroxyvinyl pyrrolidone polymer is as follows, pours into 30~60 mass in the reaction vessel first
Part solvent B, then by the n-vinyl pyrrolidone of 20~50 mass parts, 1~10 mass parts acrylate in head tank A
In be uniformly mixed；Then by the same solvent of the initiator of 0.2~2 mass parts and 11.5~18.8 mass parts in head tank B
It is uniformly mixed；Finally under 60~80 DEG C of reaction temperature, while head tank A and head tank B are opened, is uniformly dripped in 2~4h
It adds complete；After all raw materials are added dropwise, insulation reaction 2h obtains hydroxyvinyl pyrrolidone polymer.
2. a kind of preparation method of hydrophilic superslide coating for medical apparatus surface according to claim 1, feature
Be: the solvent A is tetrahydrofuran, methyl lactate, any one in ethyl lactate.
3. a kind of preparation method of hydrophilic superslide coating for medical apparatus surface according to claim 1, feature
Be: the acrylate has hydroxyl ethyl ester or hydroxypropyl acrylate functional group.
4. a kind of preparation method of hydrophilic superslide coating for medical apparatus surface according to claim 3, feature
Be: the acrylate is hydroxy-ethyl acrylate, hydroxypropyl acrylate, hydroxyethyl methacrylate, methacrylic acid hydroxypropyl
Any one in ester.
5. a kind of preparation method of hydrophilic superslide coating for medical apparatus surface according to claim 1, feature
Be: the initiator is preferably azo initiator V-601, azo initiator V-50, appointing in azo initiator VA-044
It anticipates one kind.
6. a kind of system of the hydrophilic superslide coating for medical apparatus surface described according to claim 1~any one of 5
Preparation Method, it is characterised in that: the isocyanates is methyl diphenylene diisocyanate, isophorone diisocyanate, mostly Asia
Methyl polyphenyl polyisocyanate, tetramethyl diphenylmethane diisocyanate, 1,4- cyclohexane diisocyanate, trimethyl-
1,6- hexamethylene diisocyanate, norbornene alkyl diisocyanate, dimethyl diphenyl diisocyanate, dicyclohexyl methyl hydride two
Any one in isocyanates.
7. a kind of system of the hydrophilic superslide coating for medical apparatus surface described according to claim 1~any one of 5
Preparation Method, it is characterised in that: the isocyanate crosslinking is the polyether polyol of molecular weight 141-5000, degree of functionality 2.2-4
Or castor oil polyhydric alcohol.
8. a kind of system of the hydrophilic superslide coating for medical apparatus surface described according to claim 1~any one of 5
Preparation Method, it is characterised in that: the levelling agent is organic silicon modified by polyether.
9. a kind of system of the hydrophilic superslide coating for medical apparatus surface described according to claim 1~any one of 5
Preparation Method, it is characterised in that: the solvent B is acetone, butanone, tetrahydrofuran, methyl lactate, ethyl lactate, diisobutyl
Any one in ketone.
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| CN201610861058.4A CN106421934B (en) | 2016-09-29 | 2016-09-29 | A kind of preparation method of the hydrophilic superslide coating for medical apparatus surface |
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| CN108992219A (en) * | 2018-08-25 | 2018-12-14 | 山东瑞安泰医疗技术有限公司 | A kind of overlay film esophageal stents of anti-displacement and preparation method thereof |
| CN109337492B (en) * | 2018-10-16 | 2020-07-03 | 成都德信安创新医疗技术有限公司 | Hydrophilic super-smooth coating and activation-free coating catheter |
| CN110507864B (en) * | 2019-09-29 | 2020-05-19 | 佛山市其右医疗科技有限公司 | Medical guide wire with excellent lubricating property |
| CN111303618A (en) * | 2019-12-20 | 2020-06-19 | 山东一诺威聚氨酯股份有限公司 | Organic silicon modified TPU medical catheter and preparation method thereof |
| CN112891629B (en) * | 2021-03-18 | 2022-07-01 | 成都德信安创新医疗技术有限公司 | Super-lubricating antibacterial medical coating and application method thereof |
| CN117159811A (en) * | 2022-01-30 | 2023-12-05 | 苏州浩微生物医疗科技有限公司 | Surface treatment composition, medical device and preparation method of medical device |
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