CN106419853B - Closed loop OCT conduit automatic returning methods and its device - Google Patents
Closed loop OCT conduit automatic returning methods and its device Download PDFInfo
- Publication number
- CN106419853B CN106419853B CN201611092711.1A CN201611092711A CN106419853B CN 106419853 B CN106419853 B CN 106419853B CN 201611092711 A CN201611092711 A CN 201611092711A CN 106419853 B CN106419853 B CN 106419853B
- Authority
- CN
- China
- Prior art keywords
- threshold value
- signal strength
- light signal
- value
- rotary speed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000034 method Methods 0.000 title abstract description 35
- 238000003384 imaging method Methods 0.000 claims abstract description 102
- 230000003287 optical effect Effects 0.000 claims abstract description 26
- 238000011088 calibration curve Methods 0.000 claims description 56
- 238000012544 monitoring process Methods 0.000 claims description 20
- 230000005693 optoelectronics Effects 0.000 claims description 15
- 230000011664 signaling Effects 0.000 claims description 6
- 210000001367 artery Anatomy 0.000 claims 2
- 210000003462 vein Anatomy 0.000 claims 2
- 230000005540 biological transmission Effects 0.000 abstract description 7
- 238000012014 optical coherence tomography Methods 0.000 description 58
- 238000010586 diagram Methods 0.000 description 6
- 230000003902 lesion Effects 0.000 description 6
- 238000012545 processing Methods 0.000 description 6
- 230000000747 cardiac effect Effects 0.000 description 4
- 208000029078 coronary artery disease Diseases 0.000 description 4
- 238000006073 displacement reaction Methods 0.000 description 4
- 238000013146 percutaneous coronary intervention Methods 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 239000000835 fiber Substances 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 238000011017 operating method Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000005070 sampling Methods 0.000 description 3
- 206010002383 Angina Pectoris Diseases 0.000 description 2
- 101000624382 Homo sapiens Protein MON2 homolog Proteins 0.000 description 2
- 101150098959 MON1 gene Proteins 0.000 description 2
- 101100291875 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) apg-13 gene Proteins 0.000 description 2
- 102100023396 Protein MON2 homolog Human genes 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000005611 electricity Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- 208000037260 Atherosclerotic Plaque Diseases 0.000 description 1
- 238000012274 Preoperative evaluation Methods 0.000 description 1
- 206010049418 Sudden Cardiac Death Diseases 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- 239000013307 optical fiber Substances 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 208000008918 voyeurism Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0062—Arrangements for scanning
- A61B5/0066—Optical coherence imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/02007—Evaluating blood vessel condition, e.g. elasticity, compliance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6852—Catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6867—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive specially adapted to be attached or implanted in a specific body part
- A61B5/6876—Blood vessel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
- A61B2560/02—Operational features
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Physiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Endoscopes (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
The invention discloses a kind of closed loop OCT conduits automatic returning method, comprise the following steps：The motor rotary speed that the optical signal and scanning monitor that reception photodetector gathers in real time obtain；Judge whether current light signal strength value is more than default light signal strength threshold value and whether current rotational speed values are more than default rotary speed threshold value；Such as current light signal strength value is more than default light signal strength threshold value or current rotational speed values are more than default rotary speed threshold value, and withdraw stop signal to scanning monitor transmission imaging catheter is withdrawn with stopping imaging catheter；Such as current light signal strength value not less than default light signal strength threshold value and current rotational speed values not less than default rotary speed threshold value, the working condition of scanning monitor and laser is monitored.Invention additionally discloses a kind of closed loop OCT conduits automatic returning device.Closed loop OCT conduits automatic returning method proposed by the present invention, reduce the risk of conduit injure patient during imaging is withdrawn.
Description
Technical field
The present invention relates to peeping detection technique field in medical treatment, more particularly to a kind of closed loop OCT conduit automatic returning methods and
Its device.
Background technology
Coronary artery disease is the No.1 reason that the whole world causes death.Due to the accumulating of atherosclerotic plaque, break
Split and thrombus, coronary artery disease can cause pectoralgia（Angina pectoris）, myocardial ischemia and sudden cardiac death.Do not died suddenly for those
Or having the patient of chronic angina symptom, the treatment of suitable patch includes PCI（Percutaneous Coronary
Intervention, percutaneous coronary intervention operation）.Cardiac interventional expert is performed the operation by PCI places support processing lesion, but
Many results of study think that cardiac stent is abused in recent years, or at least excessively using many disputes are triggered, doctor is considering only
Using more with caution and fastidious during support.Additionally due to lower-cost drug therapy has been introduced in market, research finds it
And it is effective.When treating the patients with coronary heart disease of stable disease we have seen that the gentle decline of stent endoprosthesis.
These factors, along with increasing public opinion, three kinds of new blood vessel imaging/measuring apparatus and consumptive material：1）It is intravascular super
Sound, 2）OCT（Optical Coherence Tomography, optical coherence tomography）With 3）Blood flow reserve fraction technology energy
Help doctor is that each patient's preoperative evaluation whether insert and postoperative evaluation by support exactly, played in coronary disease lesion examining
More and more important effect.
Referring to Figures 1 and 2, in existing OCT image equipment, conduit includes outer tube 2 and collection tube 1, and collection tube 1 includes leading
Pipe optical fiber 4 and fibre-optical probe 5, the outside of catheter fiber 4 are provided with torque drive sleeve 3；The fiber end face of fibre-optical probe 5 is provided with globe lens
And prism（Or gradual index lenses）.The both ends of conduit are the near-end and accurate miniature medical plastic expects pipe of band connection joint respectively
Distally, near-end is connected with scanning monitor, is distally imaged through guide seal wire into tissue.Existing intravascular OCT products
Imaging process be that imaging catheter is sent to the distal end of vessel inner lesion along seal wire, beyond extent of disease about more than 5mm, then
Automatic returning is opened, imaging catheter withdraws retrogressing, whole lesion region is imaged.This process of automatic returning is usually 3-
7 seconds, distance was 50-150mm.Outer tube 2 of imaging catheter is motionless during this, servomotor (the i.e. electric rotating of scanning monitor
Machine) and linear electric motors（That is stepper motor）Control the inside collection tube 1 of imaging catheter to retreat while high speed rotates to withdraw, it is right
Intravascular tissue carries out spiral spot scan, gathers the scattering return optical signal of tissue each point, and collection tube 1 backs to the production of setting
When product withdraw distance such as 50mm, two motors stop, and the end of scan, main frame is believed according to each point scattering return light detected
Number, generate complete vascular tissue's lesion image.Whole automatic returning process is the open loop do not fed back：Once withdrawing,
Linear electric motors go to 50mm from 0 just to be stopped.This way has potential risk：If imaging catheter in the blood vessels by cardiac stent or
Person's lesion or other object are seized, and because resolution ratio is inadequate, doctor does not see this situation from X-ray, starts as usual
Automatic returning, the outer tube 2 blocked are possible to be driven by the collection tube 1 that inside attempts to retreat, also attempt to retreat by force, so as to draw
To the objects such as its cardiac stent or patch are blocked, can be damaged to patient.
The content of the invention
It is a primary object of the present invention to provide a kind of closed loop OCT conduit automatic returning methods and its device, it is intended to reduce
The risk of conduit injure patient during imaging is withdrawn.
To achieve the above object, the present invention provides a kind of closed loop OCT conduits automatic returning method, comprises the following steps：
The motor rotary speed that the optical signal and scanning monitor that reception photodetector gathers in real time obtain；
Judge whether current light signal strength value is more than default light signal strength threshold value and whether current rotational speed values are big
In default rotary speed threshold value；
As current light signal strength value is more than default light signal strength threshold value or current rotational speed values more than default rotation
Threshold speed, withdraw stop signal to scanning monitor transmission imaging catheter and withdrawn with stopping imaging catheter；
Such as current light signal strength value is not less than default light signal strength threshold value and current rotational speed values are not less than default
Rotary speed threshold value, monitor the working condition of scanning monitor and laser.
Preferably, the motor rotation that the optical signal and scanning monitor that the reception photodetector gathers in real time obtain
Also include before the step of speed：
Calibration curve when imaging catheter does not block is obtained, calibration curve includes the light letter of collection tube feedback in imaging catheter
The gap periods T0 for the pulse signal that optoelectronic switch on number intensity level M0 and corresponding time t and electric rotating machine is sent is corresponding
Time t.
Preferably, light signal strength threshold value M'(t is preset)=M0 (t) -3dB, preset rotary speed threshold value T'(z)=1.5T0
(t), wherein, M0 (t) is light signal strength value corresponding to time t in calibration curve, and T0 (t) is that time t is corresponding in calibration curve
Pulse signal gap periods.
Preferably, also include after the step of working condition of the monitoring scanning monitor and laser：
Judge whether scanning monitor and laser are not turned off；
When scanning monitor and laser are not turned off, the light that the reception photodetector gathers in real time is continued executing with
The step of motor rotary speed that signal and scanning monitor obtain, is until scanning monitor and laser are turned off.
The present invention also proposes a kind of closed loop OCT conduits automatic returning device, including：
First receiving module, for receiving the optical signal that photodetector gathers in real time and the electricity that scanning monitor obtains
Machine rotary speed；
First judge module, for judging whether current light signal strength value is more than default light signal strength threshold value and current
Whether rotational speed values are more than default rotary speed threshold value；
First conduit withdraws control module, for being more than default light signal strength threshold value in current light signal strength value or working as
When preceding rotational speed values are more than default rotary speed threshold value, send imaging catheter to scanning monitor and withdraw stop signal to stop
Imaging catheter is withdrawn；
First scanning monitor and laser monitoring module, in current light signal strength value not less than default optical signal
Intensity threshold and when current rotary speed is not less than default rotary speed threshold value, monitors the work shape of scanning monitor and laser
State.
The present invention also proposes a kind of closed loop OCT conduits automatic returning method, comprises the following steps：
The motor rotary speed and straight line that the optical signal and scanning monitor that reception photodetector gathers in real time obtain
Motor position signal；
It is strong to judge whether current light signal strength value, current rotational speed values and positional value exceed default optical signal respectively
Spend threshold value, default rotary speed threshold value and predeterminated position threshold value；
The threshold value as corresponding to current light signal strength value, current rotational speed values and positional value have one of them to exceed,
Stop signal is withdrawn to scanning monitor transmission imaging catheter to withdraw to stop imaging catheter；
If current light signal strength value, current rotational speed values and positional value three are not less than corresponding threshold value, prison
Control the working condition of scanning monitor and laser.
Preferably, the motor rotation that the optical signal and scanning monitor that the reception photodetector gathers in real time obtain
Also include before the step of speed：
Calibration curve when imaging catheter does not block is obtained, calibration curve includes the light letter of collection tube feedback in imaging catheter
The gap periods T0 for the pulse signal that optoelectronic switch on number intensity level M0 and corresponding time t, electric rotating machine is sent and correspondingly
Time t and motor positional value z0 and corresponding time t.
Preferably, light signal strength threshold value M'(t is preset)=MO (t) -3dB, preset rotary speed threshold value T'(z)=1.5T0
(t), predeterminated position threshold value z'(t)=0.7z0 (t), wherein, M0 (t) is light signal strength value corresponding to time t in calibration curve,
T0 (t) is the gap periods of pulse signal corresponding to time t in calibration curve, and z0 (t) is position corresponding to time t in calibration curve
Put value.
Preferably, also include after the step of working condition of the monitoring scanning monitor and laser：
Judge whether scanning monitor and laser are not turned off；
When scanning monitor and laser are not turned off, the light that the reception photodetector gathers in real time is continued executing with
The step of motor rotary speed and linear electric motors position signalling that signal and scanning monitor obtain until scanning monitor and
Laser is turned off.
The present invention also proposes a kind of closed loop OCT conduits automatic returning device, including：
Second receiving module, for receiving the optical signal that photodetector gathers in real time and the electricity that scanning monitor obtains
Machine rotary speed and linear electric motors position signalling；
Second judge module, for judging whether current light signal strength value, current rotational speed values and positional value divide
Light signal strength threshold value, default rotary speed threshold value and predeterminated position threshold value Chao Guo not preset；
Second conduit withdraws control module, in current light signal strength value, current rotational speed values and positional value
When having one of them more than corresponding threshold value, send imaging catheter to scanning monitor and withdraw stop signal to stop imaging catheter
Withdraw；
Second scanning monitor and laser monitoring module, in current light signal strength value, current rotational speed values
And positional value three not less than corresponding threshold value when, monitor the working condition of scanning monitor and laser.
Closed loop OCT conduits automatic returning method proposed by the present invention, forms the closed-loop control that imaging catheter is withdrawn, effectively
Ground prevents the generation that imaging catheter is withdrawn by force, and thus improvement improves imaging catheter and withdraws this conventional manifold OCT image
The security of operating procedure is intelligent, significantly reduces the risk of imaging catheter injure patient during imaging is withdrawn.
Brief description of the drawings
Fig. 1 is the structural representation of imaging catheter in the prior art；
Fig. 2 is the structural representation of collection tube in the prior art；
Fig. 3 is the schematic flow sheet of closed loop OCT conduits automatic returning method first embodiment of the present invention；
Fig. 4 is that imaging catheter does not block optical signal and the corresponding relation schematic diagram of time；
Fig. 5 is that imaging catheter blocks optical signal and the corresponding relation schematic diagram of time；
Fig. 6 is the pulse signal and the corresponding relation schematic diagram of time that optoelectronic switch is sent when imaging catheter does not block；
The pulse signal and the corresponding relation schematic diagram of time that optoelectronic switch is sent when Fig. 7 blocks for imaging catheter；
Fig. 8 is the schematic flow sheet of closed loop OCT conduits automatic returning method second embodiment of the present invention；
Fig. 9 is the schematic flow sheet of closed loop OCT conduits automatic returning method 3rd embodiment of the present invention；
Figure 10 is the structural representation of closed loop OCT conduits automatic returning method fourth embodiment of the present invention；
Figure 11 is linear electric motors displacement and the corresponding relation schematic diagram of time when imaging catheter does not block；
The corresponding relation schematic diagram of linear electric motors displacement and time when Figure 12 blocks for imaging catheter；
Figure 13 is the schematic flow sheet of the embodiment of closed loop OCT conduit automatic returnings method the 5th of the present invention；
Figure 14 is the schematic flow sheet of closed loop OCT conduits automatic returning method sixth embodiment of the present invention；
Figure 15 is the structural representation of closed loop OCT conduits automatic returning device first embodiment of the present invention；
Figure 16 is the hardware configuration signal that closed loop OCT conduit automatic returnings device of the present invention is applied in OCT image equipment
Figure；
Figure 17 is the structural representation of closed loop OCT conduits automatic returning device second embodiment of the present invention.
In figure, 1- collection tubes, 2- outer tubes, 3- torque drive sleeves, 4- catheter fibers, 5- fibre-optical probes, 10- first receives
Module, the judge modules of 20- first, the conduits of 30- first withdraw control module, the scanning monitors of 40- first and laser monitoring mould
Block, 50- the first calibration curve acquisition modules, 70- imaging catheters, 80- scanning monitors, 90- main frames, 91- lasers, 92- light
Electric explorer, 93- optical interferometers, 94- delay lines, 95-GPU displays, 96- signal processing units, 961- conduit Stateful Inspections
Module, 962- imaging main frames, 963- sampling cards, the receiving modules of 100- second, the judge modules of 200- second, the conduits of 300- second return
Remove control module, the scanning monitors of 400- second and laser monitoring module, 500- the second calibration curve acquisition modules.
The realization, functional characteristics and advantage of the object of the invention will be described further referring to the drawings in conjunction with the embodiments.
Embodiment
It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not intended to limit the present invention.
The present invention proposes a kind of closed loop OCT conduits automatic returning method.
Reference picture 3, Fig. 3 are the schematic flow sheet of closed loop OCT conduits automatic returning method first embodiment of the present invention.
The present invention proposes a kind of first embodiment of closed loop OCT conduits automatic returning method.In the present embodiment, closed loop OCT
Conduit automatic returning method comprises the following steps：
Step S10, the motor rotation speed that the optical signal and scanning monitor that reception photodetector gathers in real time obtain
Degree；
Step S20, judges whether current light signal strength value is more than default light signal strength threshold value and current rotary speed
Whether value is more than default rotary speed threshold value；
As current light signal strength value is more than default light signal strength threshold value or current rotational speed values more than default rotation
Threshold speed, perform step S30；If current light signal strength value is not less than default light signal strength threshold value and current rotary speed
Value performs step S40 not less than default rotary speed threshold value；
Step S30, withdraw stop signal to scanning monitor transmission imaging catheter and withdrawn with stopping imaging catheter；
Step S40, monitor the working condition of scanning monitor and laser.
In step S10, motor rotary speed refers to the rotary speed of servomotor.In the present embodiment, light signal strength is preset
Whether threshold value and current rotational speed values are more than default light signal strength threshold value and default rotary speed threshold value can be by lookup pair
The calibration curve answered determines concrete numerical value corresponding to current time t.Calibration curve can be pre-stored in hardware for subsequently making
Used time calls default light signal strength threshold value and default rotary speed threshold value, can also be given birth to again by user's calibration in each use
Into a calibration curve.Calibration curve include imaging catheter in collection tube feedback light signal strength value M0 and corresponding time t with
And time t corresponding to the gap periods T0 of pulse signal that sends of the optoelectronic switch on electric rotating machine.Calibration curve is led for imaging
Experiment curv when Guan Wei is blocked.In the present embodiment, light signal strength threshold value M'(t is preset)=M0 (t) -3dB, presets rotary speed
Threshold value T'(z)=1.5T0 (t), wherein, M0 (t) is light signal strength value corresponding to time t in calibration curve, and T0 (t) is calibration
The gap periods of pulse signal corresponding to time t in curve.Warning message can be also generated after step S30 to prompt user.
Now, it is because imaging catheter is stuck rather than other that user can know that current imaging catheter stops withdrawing according to warning message
Hardware fault.Warning message can be in the form of sound, word, indicator lamp etc..
It is by judging whether current light signal strength value is more than default light signal strength threshold value and current rotational speed values
It is no to be more than default rotary speed threshold value, so as to understand whether imaging catheter blocks.Exceed corresponding threshold value when there is one in both
Or both exceed corresponding threshold value, then be illustrated as conduit blocks, imaging catheter is withdrawn to be stopped at once.The optical signal of conduit comes
The two test side MON1 and MON2, light signal strength M'(t of auto-balanced detection device)=(MON1+MON2)/2.
Reference picture 4 and Fig. 5, when imaging catheter clip is lived, light signal strength changes over time curve and has change before, because
This, when light signal strength changes, by may know that imaging catheter blocks to light signal strength monitoring.Equally, the He of reference picture 6
Fig. 7, the pulse signal that optoelectronic switch is sent is monitored and may know that whether imaging catheter blocks.
The closed loop OCT conduit automatic returning methods that the present embodiment proposes, effectively prevent what imaging catheter was withdrawn by force
Occur, thus improve improve imaging catheter withdraw this conventional manifold OCT image operating procedure security it is intelligent, greatly
Ground reduces the risk of imaging catheter injure patient during imaging is withdrawn.
Reference picture 8, Fig. 8 are the schematic flow sheet of closed loop OCT conduits automatic returning method second embodiment of the present invention.
The present invention proposes the second embodiment of closed loop OCT conduit automatic returning methods, and the present embodiment is implemented with above-mentioned first
Unlike example, also include before step S10：
Step S01, obtain calibration curve when imaging catheter does not block.
Calibration curve includes the light signal strength value M0 of collection tube feedback and corresponding time t and rotation in imaging catheter
Time t corresponding to the gap periods T0 for the pulse signal that optoelectronic switch on motor is sent.
User can generate calibration curve according to use demand when using OCT image equipment every time, to improve imaging catheter
Withdraw precision.
Reference picture 9, Fig. 9 are the schematic flow sheet of closed loop OCT conduits automatic returning method 3rd embodiment of the present invention.
The present invention proposes the 3rd embodiment of closed loop OCT conduit automatic returning methods, and the present embodiment is implemented with above-mentioned first
Unlike example, also include after step S30：
Step S50, judges whether scanning monitor and laser are not turned off；When scanning monitor and laser do not close
When closing, step S10 is continued executing with until scanning monitor and laser are turned off.
After scanning monitor and laser are turned off, illustrate that current image forming job finishes, at this point it is possible to stop monitoring into
As the state of conduit.
Reference picture 10, Figure 10 are the structural representation of closed loop OCT conduits automatic returning method fourth embodiment of the present invention.
Closed loop OCT conduits automatic returning method proposed by the present invention comprises the following steps：
Step S100, the motor rotation speed that the optical signal and scanning monitor that reception photodetector gathers in real time obtain
Degree and linear electric motors position signalling；
Step S200, it is pre- to judge whether current light signal strength value, current rotational speed values and positional value exceed respectively
If light signal strength threshold value, default rotary speed threshold value and predeterminated position threshold value；Such as current light signal strength value, current rotation
Velocity amplitude and positional value have one of them to exceed corresponding threshold value, perform step S300；Such as current light signal strength value, currently
Rotational speed values and positional value three perform step S400 not less than corresponding threshold value；
Step S300, withdraw stop signal to scanning monitor transmission imaging catheter and withdrawn with stopping imaging catheter；
Step S400, monitor the working condition of scanning monitor and laser.
In the present embodiment, whether current light signal strength value, current rotational speed values and positional value are more than corresponding threshold value
It can be determined by calibration curve corresponding to lookup.Calibration curve can be pre-stored in hardware for being called during follow-up use,
A calibration curve can be regenerated by user's calibration in each use.Calibration curve includes collection tube feedback in imaging catheter
The gap periods T0 for the pulse signal that optoelectronic switch on light signal strength value M0 and corresponding time t, electric rotating machine is sent and
Corresponding time t and motor positional value z0 and corresponding time t.Calibration curve is that measurement is bent when imaging catheter does not block
Line.In the present embodiment, light signal strength threshold value M'(t is preset)=MO (t) -3dB, preset rotary speed threshold value T'(z)=1.5T0
(t), predeterminated position threshold value z'(t)=0.7z0 (t), wherein, M0 (t) is light signal strength value corresponding to time t in calibration curve,
T0 (t) is the gap periods of pulse signal corresponding to time t in calibration curve, and z0 (t) is position corresponding to time t in calibration curve
Put value.
Warning message can be also generated after step S300 to prompt user.Now, user can know according to warning message
It is because imaging catheter is stuck rather than other hardware faults that current imaging catheter, which stops withdrawing,.Warning message can be with sound
The forms such as sound, word, indicator lamp.
When there is one to exceed corresponding threshold value in three, then it is illustrated as conduit blocks, imaging catheter is withdrawn to be stopped at once.
The present embodiment is unlike above-mentioned first embodiment, and the present embodiment monitoring is three signals, when there is one in three signals
More than corresponding threshold value, then control conduit to withdraw, make the coverage of this closed loop OCT conduit automatic returning methods wider.Reference
Figure 11 and Figure 12, linear electric motors displacement is monitored, when its displacement exception, you can illustrate that imaging catheter is stuck.
The closed loop OCT conduit automatic returning methods that the present embodiment proposes, effectively prevent what imaging catheter was withdrawn by force
Occur, thus improve improve imaging catheter withdraw this conventional manifold OCT image operating procedure security it is intelligent, greatly
Ground reduces the risk of imaging catheter injure patient during imaging is withdrawn.
Reference picture 13, Figure 13 are the schematic flow sheet of the embodiment of closed loop OCT conduit automatic returnings method the 5th of the present invention.
The present invention proposes the 5th embodiment of closed loop OCT conduit automatic returning methods, and the present embodiment is implemented with the above-mentioned 4th
Unlike example, also include before step S100：
Step S001, obtain calibration curve when imaging catheter does not block.
Calibration curve includes the light signal strength value M0 and corresponding time t, electric rotating of collection tube feedback in imaging catheter
The gap periods T0 for the pulse signal that optoelectronic switch on machine the is sent and positional value z0 of corresponding time t and motor with it is corresponding
Time t.
User can generate calibration curve according to use demand when using OCT image equipment every time, to improve imaging catheter
Withdraw precision.
Reference picture 14, Figure 14 are the schematic flow sheet of closed loop OCT conduits automatic returning method sixth embodiment of the present invention.
The present invention proposes the sixth embodiment of closed loop OCT conduit automatic returning methods, and the present embodiment is implemented with the above-mentioned 4th
Unlike example, also include after step S300：
Step S500, judges whether scanning monitor and laser are not turned off；When scanning monitor and laser not
During closing, step S100 is continued executing with until scanning monitor and laser are turned off.
After scanning monitor and laser are turned off, illustrate that current image forming job finishes, at this point it is possible to stop monitoring into
As the state of conduit.
A kind of present invention further propose that closed loop OCT conduits automatic returning device.
Reference picture 15, Figure 15 are the structural representation of closed loop OCT conduits automatic returning device first embodiment of the present invention.
Closed loop OCT conduits automatic returning device proposed by the present invention, including：
First receiving module 10, for receiving optical signal that photodetector gathers in real time and scanning monitor obtains
Motor rotary speed；
First judge module 20, for judging whether current light signal strength value is more than default light signal strength threshold value and works as
Whether preceding rotational speed values are more than default rotary speed threshold value；
First conduit withdraws control module 30, for current light signal strength value be more than default light signal strength threshold value or
When current rotational speed values are more than default rotary speed threshold value, send imaging catheter to scanning monitor and withdraw stop signal to stop
Only imaging catheter is withdrawn；
First scanning monitor and laser monitoring module 40, for believing in current light signal strength value not less than default light
Number intensity threshold and when current rotary speed is not less than default rotary speed threshold value, monitors the work of scanning monitor and laser
State.
Further, this closed loop OCT conduits automatic returning device also includes the first calibration curve acquisition module 50, and this first
Calibration curve acquisition module 50 is used to obtain calibration curve when imaging catheter does not block, and calibration curve includes adopting in imaging catheter
The pulse signal that optoelectronic switch on the light signal strength value M0 and corresponding time t and electric rotating machine of collector feedback is sent
Gap periods T0 and corresponding time t.
First judge module 20 is additionally operable to judge whether scanning monitor and laser are not turned off, when scanning monitor and
When laser is not turned off, the first receiving module 10 continues to optical signal and the scan control that photodetector gathers in real time
The motor rotary speed that device obtains is until scanning monitor and laser are turned off.
Specifically within hardware, reference picture 16, OCT image equipment in the specific implementation, can use following hardware configuration.Existing
One conduit state monitoring module 961 of increase inside signal processing unit, gives in scanning monitor 80 in some OCT image equipment
Electric rotating machine adds an optoelectronic switch.
The hardware configuration of OCT image equipment includes imaging catheter 70, scanning monitor 80 and the main frame 90 being sequentially connected.Sweep
Retouch controller 80 to be used to control the torque drive sleeve in imaging catheter 70, to drive fibre-optical probe by laser to human vas group
Knit scanning, collection vascular tissue scattered light signal, finally, return to send scattered light signal to main frame 90 and be imaged.Main frame
90 include laser 91, photodetector 92, optical interferometer 93, delay line 94, GPU (Graphics Processing Unit,
Graphics processor) display 95 and signal processing unit 96, wherein, signal processing unit 96 includes conduit state monitoring module
961st, main frame 962 and sampling card 963 are imaged.Conduit state monitoring module 961 with scanning monitor 80, photodetector 92,
Sampling card 963 and imaging main frame 962 electrically connect.
Conduit state monitoring module 961 is used to receive optical signal and scanning monitor that photodetector 92 gathers in real time
The 80 motor rotary speeies obtained（This motor is electric rotating machine）, conduit state monitoring module 961 judges current light signal strength
Whether value is more than default light signal strength threshold value and whether current rotational speed values are more than default rotary speed threshold value；Such as current light
Signal strength values are more than default light signal strength threshold value or current rotational speed values are more than default rotary speed threshold value, conduit state
Monitoring module 961 withdraws stop signal to the transmission imaging catheter of scanning monitor 80 and withdrawn with stopping imaging catheter 70.
In the present embodiment, preset light signal strength threshold value and whether current rotational speed values are more than default light signal strength threshold
Value and default rotary speed threshold value can determine concrete numerical value corresponding to current time t by calibration curve corresponding to lookup.School
Directrix curve can be pre-stored in hardware for calling default light signal strength threshold value and default rotary speed threshold value during follow-up use,
Also a calibration curve can be regenerated by user's calibration in each use.Calibration curve includes collection tube feedback in imaging catheter
Light signal strength value M and corresponding time t and electric rotating machine on the gap periods of pulse signal that send of optoelectronic switch
Time t corresponding to T0.Calibration curve is experiment curv when imaging catheter does not block.In the present embodiment, light signal strength threshold is preset
Value M'(t)=M0 (t) -3dB, preset rotary speed threshold value T'(z)=1.5T0 (t), wherein, M0 (t) is time t in calibration curve
Corresponding light signal strength value, T0 (t) are the gap periods of pulse signal corresponding to time t in calibration curve.
It is by judging whether current light signal strength value is more than default light signal strength threshold value and current rotational speed values
It is no to be more than default rotary speed threshold value, so as to understand whether imaging catheter blocks.Exceed corresponding threshold value when there is one in both
Or both exceed corresponding threshold value, then be illustrated as conduit blocks, imaging catheter is withdrawn to be stopped at once.
The closed loop OCT conduit automatic returning devices that the present embodiment proposes, form the closed-loop control that imaging catheter is withdrawn, have
The generation that imaging catheter is withdrawn by force is prevented to effect, thus improvement improves conduit and withdraws this conventional manifold OCT image behaviour
Make that the security of step is intelligent, significantly reduce the risk of imaging catheter injure patient during imaging is withdrawn.
Reference picture 17, Figure 17 are the structural representation of closed loop OCT conduits automatic returning device second embodiment of the present invention.
In the present embodiment, a kind of closed loop OCT conduits automatic returning device, including：
Second receiving module 100, for receiving optical signal and the scanning monitor acquisition that photodetector gathers in real time
Motor rotary speed and linear electric motors position signalling；
Second judge module 200, for whether judging current light signal strength value, current rotational speed values and positional value
Exceed default light signal strength threshold value, default rotary speed threshold value and predeterminated position threshold value respectively；
Second conduit withdraws control module 300, in current light signal strength value, current rotational speed values and position
When value has one of them more than corresponding threshold value, withdraw stop signal to scanning monitor transmission imaging catheter and led with stopping imaging
Pipe is withdrawn；
Second scanning monitor and laser monitoring module 400, in current light signal strength value, current rotary speed
When value and positional value three are not less than corresponding threshold value, the working condition of scanning monitor and laser is monitored.
Further, this closed loop OCT conduits automatic returning device also includes the second calibration curve acquisition module 500, and this
Two calibration curve acquisition modules 500 are used to obtain calibration curve when imaging catheter does not block, and calibration curve includes imaging catheter
The pulse signal that optoelectronic switch on the light signal strength value M0 and corresponding time t, electric rotating machine of interior collection tube feedback is sent
Gap periods T0 and the positional value z0 of corresponding time t and motor and corresponding time t.
Second judge module 200 is additionally operable to judge whether scanning monitor and laser are not turned off.Work as scanning monitor
When being not turned off with laser, the first receiving module 100 continues to optical signal and the scanning that photodetector gathers in real time
Motor rotary speed and the linear electric motors position signalling that controller obtains are until scanning monitor and laser are turned off.
The closed loop OCT conduit automatic returning devices that the present embodiment proposes, form the closed-loop control that imaging catheter is withdrawn, have
The generation that imaging catheter is withdrawn by force is prevented to effect, thus improvement improves conduit and withdraws this conventional manifold OCT image behaviour
Make that the security of step is intelligent, significantly reduce the risk of imaging catheter injure patient during imaging is withdrawn.
The preferred embodiments of the present invention are these are only, are not intended to limit the scope of the invention, it is every to utilize this hair
The equivalent structure transformation that bright specification and accompanying drawing content are made, or other related technical areas are directly or indirectly used in,
Similarly it is included within the scope of the present invention.
Claims (6)
- A kind of 1. closed loop OCT conduits automatic returning device, it is characterised in that including：First receiving module, for receiving the optical signal that photodetector gathers in real time and the motor rotation that scanning monitor obtains Rotary speed；First judge module, for judging whether current light signal strength value is more than default light signal strength threshold value and current rotation Whether velocity amplitude is more than default rotary speed threshold value；First conduit withdraws control module, for being more than default light signal strength threshold value or current rotation in current light signal strength value When spin speed value is more than default rotary speed threshold value, sends imaging catheter to scanning monitor and withdraw stop signal to stop being imaged Conduit is withdrawn；First scanning monitor and laser monitoring module, in current light signal strength value not less than default light signal strength Threshold value and when current rotary speed is not less than default rotary speed threshold value, monitors the working condition of scanning monitor and laser；First calibration curve acquisition module, it receives the optical signal that gathers in real time of photodetector in the first receiving module and swept Calibration curve when imaging catheter does not block is obtained before retouching the motor rotary speed of controller acquisition, calibration curve includes imaging The arteries and veins that the optoelectronic switch on light signal strength value M0 and corresponding time t and electric rotating machine that collection tube feeds back in conduit is sent Rush time t corresponding to the gap periods T0 of signal.
- 2. closed loop OCT conduits automatic returning device as claimed in claim 1, preset light signal strength threshold value M'(t)=M0 (t) -3dB, rotary speed threshold value T'(z is preset)=1.5T0 (t), wherein, M0 (t) is that light corresponding to time t is believed in calibration curve Number intensity level, T0 (t) are the gap periods of pulse signal corresponding to time t in calibration curve.
- 3. closed loop OCT conduits automatic returning device as claimed in claim 1 or 2, first judge module are additionally operable to judge Whether scanning monitor and laser are not turned off.
- A kind of 4. closed loop OCT conduits automatic returning device, it is characterised in that including：Second receiving module, for receiving the optical signal that photodetector gathers in real time and the motor rotation that scanning monitor obtains Rotary speed and linear electric motors position signalling；Second judge module, for judging whether current light signal strength value, current rotational speed values and positional value surpass respectively Cross default light signal strength threshold value, default rotary speed threshold value and predeterminated position threshold value；Second conduit withdraws control module, for having it in current light signal strength value, current rotational speed values and positional value One of when exceeding corresponding threshold value, send imaging catheter to scanning monitor and withdraw stop signal and returned with stopping imaging catheter Remove；Second scanning monitor and laser monitoring module, for current light signal strength value, current rotational speed values and When positional value three is not less than corresponding threshold value, the working condition of scanning monitor and laser is monitored；Second calibration curve acquisition module, it receives the optical signal that gathers in real time of photodetector in the second receiving module and swept Calibration curve when imaging catheter does not block is obtained before retouching the motor rotary speed of controller acquisition, calibration curve includes imaging The pulse that the optoelectronic switch on light signal strength value M0 and corresponding time t, electric rotating machine that collection tube feeds back in conduit is sent The positional value z0 of time t and motor corresponding to the gap periods T0 of signal and corresponding time t.
- 5. closed loop OCT conduits automatic returning device as claimed in claim 4, it is characterised in that default light signal strength threshold value M'(t)=M0 (t) -3dB, rotary speed threshold value T'(z is preset)=1.5T0 (t), predeterminated position threshold value z'(t)=0.7z0 (t), Wherein, M0 (t) is light signal strength value corresponding to time t in calibration curve, and T0 (t) is arteries and veins corresponding to time t in calibration curve The gap periods of signal are rushed, z0 (t) is positional value corresponding to time t in calibration curve.
- 6. the closed loop OCT conduit automatic returning devices as described in claim 4 or 5, second judge module are additionally operable to judge Whether scanning monitor and laser are not turned off.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611092711.1A CN106419853B (en) | 2016-11-30 | 2016-11-30 | Closed loop OCT conduit automatic returning methods and its device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611092711.1A CN106419853B (en) | 2016-11-30 | 2016-11-30 | Closed loop OCT conduit automatic returning methods and its device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106419853A CN106419853A (en) | 2017-02-22 |
| CN106419853B true CN106419853B (en) | 2018-03-30 |
Family
ID=58223382
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611092711.1A Active CN106419853B (en) | 2016-11-30 | 2016-11-30 | Closed loop OCT conduit automatic returning methods and its device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106419853B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107550443A (en) * | 2017-08-25 | 2018-01-09 | 广州永士达医疗科技有限责任公司 | A kind of OCT catheter interiors pumpback device |
| WO2019107581A1 (en) * | 2017-11-28 | 2019-06-06 | 오리오스메디칼 주식회사 | Optical coherence tomography system |
| CN212346515U (en) * | 2019-12-31 | 2021-01-15 | 深圳北芯生命科技有限公司 | Intravascular pressure measurement system |
| CN111419146A (en) * | 2020-04-24 | 2020-07-17 | 天津恒宇医疗科技有限公司 | Endoscopic OCT (optical coherence tomography) withdrawing control system and control method |
| CN112043242B (en) * | 2020-08-31 | 2022-11-11 | 中国科学院苏州生物医学工程技术研究所 | Signal processing method and system for OCT imaging, and storage medium |
| CN117598792A (en) * | 2023-07-28 | 2024-02-27 | 北京万思医疗器械有限公司 | Interventional consumable control method for vascular interventional operation robot |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101365375A (en) * | 2005-09-29 | 2009-02-11 | 通用医疗公司 | Method and apparatus for optical imaging via spectral encoding |
| WO2015116986A2 (en) * | 2014-01-31 | 2015-08-06 | The General Hospital Corporation | System and method for facilitating manual and/or automatic volumetric imaging with real-time tension or force feedback using a tethered imaging device |
| CN105188833A (en) * | 2013-05-21 | 2015-12-23 | 泰尔茂株式会社 | Catheter |
| WO2016007172A1 (en) * | 2014-07-11 | 2016-01-14 | Acist Medical Systems, Inc. | Intravascular imaging |
| CN205306957U (en) * | 2015-11-25 | 2016-06-15 | 深圳大学 | OCT formation of image probe in machinery rotation type blood vessel |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007268133A (en) * | 2006-03-31 | 2007-10-18 | Terumo Corp | Catheter device |
-
2016
- 2016-11-30 CN CN201611092711.1A patent/CN106419853B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101365375A (en) * | 2005-09-29 | 2009-02-11 | 通用医疗公司 | Method and apparatus for optical imaging via spectral encoding |
| CN105188833A (en) * | 2013-05-21 | 2015-12-23 | 泰尔茂株式会社 | Catheter |
| WO2015116986A2 (en) * | 2014-01-31 | 2015-08-06 | The General Hospital Corporation | System and method for facilitating manual and/or automatic volumetric imaging with real-time tension or force feedback using a tethered imaging device |
| WO2016007172A1 (en) * | 2014-07-11 | 2016-01-14 | Acist Medical Systems, Inc. | Intravascular imaging |
| CN205306957U (en) * | 2015-11-25 | 2016-06-15 | 深圳大学 | OCT formation of image probe in machinery rotation type blood vessel |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106419853A (en) | 2017-02-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106419853B (en) | Closed loop OCT conduit automatic returning methods and its device | |
| JP6371421B2 (en) | Method for controlling the operation of an imaging system | |
| CN104739377B (en) | It is intravascular while carry out OCT image and device for pressure measurement, system and method | |
| JP5164309B2 (en) | Catheter device | |
| US9084562B2 (en) | Control device, control method and control program for optical coherence tomographic image-generating apparatuses | |
| CN109893099B (en) | MLA-OCT imaging catheter, MLA-OCT imaging system and MLA-OCT imaging method | |
| CN108042125B (en) | High-speed endoscopic optical coherent blood flow imaging system | |
| JP6158936B2 (en) | Ultrasound data visualization device | |
| CN108463156A (en) | Optical guidance formula surgery device | |
| US20090076375A1 (en) | Myocardial tissue ablation device for treatment of cardiac arrhythmias by ablation of myocardial tissue in a patient as well as associated catheter and associated method | |
| CN207286036U (en) | A kind of angiocarpy three-dimensional optical coherent video system | |
| CN206651820U (en) | OCT image equipment with automatic returning defencive function | |
| WO2018161384A1 (en) | Oct system for respiratory tract | |
| CN108014408A (en) | A kind of coronary vein guidance system | |
| JP2011189020A (en) | Computing device and computing method | |
| CN203208005U (en) | Novel ophthalmological medical detection equipment | |
| CN106691373A (en) | OCT (optical coherence tomography) probe for small cavity and blood vessel endoscope imaging | |
| KR20170110478A (en) | Pullback system for image processing | |
| CN206424059U (en) | A kind of OCT probe being imaged for tiny cavity and blood vessel endoscope | |
| JP2003088527A (en) | Ultrasonic diagnostic device | |
| WO2018212249A1 (en) | Image display device and image display device set | |
| WO2022033151A1 (en) | Fluorescent camera based on indocyanine green, and use thereof | |
| CN102697440A (en) | Doppler laser OCT (optical coherence tomography) hysteroscopy system | |
| CN111528915A (en) | Portable multi-probe ophthalmic ultrasonic diagnosis device | |
| CN210249923U (en) | Neural scope and video system with monitoring function |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP03 | Change of name, title or address |
Address after: Unit 401, Building 2, Biopharmaceutical Industrial Park, No. 218 Sangtian Street, Suzhou Industrial Park, Jiangsu Province, China, 215123 Patentee after: Suzhou minimally invasive Argus Medical Technology Co.,Ltd. Address before: Unit E180, North Block, Building A1, Bionano Park, No. 218 Xinghu Street, Suzhou Industrial Park, Suzhou City, Jiangsu Province, 215534 Patentee before: SUZHOU ARGUS MEDICAL TECHNOLOGY Corp.,Ltd. |
|
| CP03 | Change of name, title or address |