CN106405607A - Cherenkov single event detection method and apparatus - Google Patents
Cherenkov single event detection method and apparatus Download PDFInfo
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- CN106405607A CN106405607A CN201510802927.1A CN201510802927A CN106405607A CN 106405607 A CN106405607 A CN 106405607A CN 201510802927 A CN201510802927 A CN 201510802927A CN 106405607 A CN106405607 A CN 106405607A
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Abstract
The invention provides a Cherenkov single event detection method. The method includes obtaining a porous substrate by given machining; extending or pasting a set of avalanche multiplication photosensitive device arrays operating under the Geiger mode on a porous substrate; through the experiment and simulation, obtaining the system response matrix of the photosensitive device for each pixel (or voxel) in the field of view; and reconstructing the time and the incident angle information of the Cherenkov single event from the high-speed signal output from the photosensitive device arrays. Provided is a Cherenkov single event detection apparatus including a hole-like substrate mechanical module, a light-sensitive array module, a system response matrix calculation module, and a single event reconstruction module. The Cherenkov single event detection method and apparatus can effectively improve the device spatial resolution, time resolution, device sensitivity and imaging signal to noise ratio for the Cherenkov event detection, and are especially suitable for the application of Cherenkov radiation events in high energy physics and medical imaging.
Description
Technical field
The present invention relates to Digital Signal Processing, Photoelectric Signal Processing and nuclear detection field, the detection method of Cherenkov's single event of more particularly, to a kind of Single Photon Time Resolved Spectrometer and device.
Background technology
The detection of Cherenkov's single event is a kind of optical imaging method being launched visible ray and near infrared light photons by Cerenkov effect.Radiosiotope with Cerenkov radiation by participating in the various physiology of organism and biochemical process, can may make up a kind of new imaging method, have a wide range of applications in optical imagery and multimode medical imaging as the probe of imaging in vivo.(the J. such as U.S. Alessandro Ruggiero in 2010
Nucl. Med.2010,51:1123-1130) confirm that the high speed charged particle with the radiosiotope transmitting of α or β decay can launch Cerenkov radiation in media as well using the observation of haplopia minus lens, and the photon radiating has certain ability penetrating tissue.Optical imaging device can be carried out in body medical imaging to these radiosiotope.This means in addition to single photon emission tomographic imaging, positron emission tomography, the detection of Cherenkov's single event also can develop into a kind of typical molecular image imaging mode.
On the detection method of Cherenkov's single event, existing technology adds scientific grade CCD camera for lens.And it is true that Cherenkov's single event duration is shorter, the photosignal persistent period of CCD device output is oversize.Under most situations, the fast-changing composition of the signal collected is submerged in the middle of the integration of electric current.
Therefore, for above-mentioned technical problem it is necessary to for the single photon temporal information that can obtain, provide a kind of new detection method of Cherenkov's single event and device, to overcome drawbacks described above.The temporal information of reacquisition Cherenkov's single event.
Content of the invention
In view of this, it is an object of the invention to provide a kind of detection method of Cherenkov's single event and device, the method and device can read the signal of telecommunication sample of multiple photons of Cherenkov's event effectively, met by the multi-photon time, reject self-luminous event, very big must maintain the information original appearance related to Cerenkov effect.
For achieving the above object, the present invention provides following technical scheme：
A kind of detection method of Cherenkov's single event, it includes step：
S1：By given ground machining, obtain cavernous substrate；
S2：On cavernous substrate, extension or paste one group of avalanche multiplication photosensor array being operated under Geiger mode angular position digitizer；
S3：By testing and emulating, obtain light-sensitive device for each pixel in field range（Or voxel）System response matrix；
S4：Rebuild the time of Cherenkov's single event and inject angle information from the high speed signal of photosensor array output.
Preferably, in the detection method of above-mentioned Cherenkov's single event, described Cherenkov's single event refers to that single radiosiotope atomic nucleus transmitting charged particle occurs Cerenkov effect in media as well.
Preferably, in the detection method of above-mentioned Cherenkov's single event, described monochromatic light subevent refers to that single visible ray that organism sent by self-luminous or Cherenkov's event or soft ultraviolet light photons hit the absorbed event of photoelectric device.
Preferably, in the detection method of above-mentioned Cherenkov's single event, the described time meets and refers to multiple single photons（No less than 10）Event is in a short period of time（Such as 10 ns）Occur, that is, think that these monochromatic light subevents belong to Cherenkov's single event.
Preferably, in the detection method of above-mentioned Cherenkov's single event, the described avalanche multiplication photosensor array being operated under Geiger mode angular position digitizer refers to the array that the avalanche photodide being operated under Geiger mode angular position digitizer forms, and it is very fast to the response time of photon.
Preferably, in the detection method of above-mentioned Cherenkov's single event, described Cherenkov's events incident angle refers to beam direction in organism for nucleic during nucleic transmitting charged particle, and the relative position that different directions inject the photographic hole of detector is different.
A kind of detection device of Cherenkov's single event, rebuilds module including poroid substrate mechanical module, light-sensitive array module, system response matrix computing module, single event, wherein,
Poroid substrate mechanical module, for supporting light-sensitive array module, has cavernous structure；
Light-sensitive array module, for realizing the detection to Cherenkov's photon in the way of various visual angles.Light-sensitive array module be designed with the electronics design faster of poroid detection geometry and single photon response time, in order to obtain the temporal information of single photon, typically using the avalanche multiplication photodiode array being operated under Geiger mode angular position digitizer；
System response matrix computing module, for calculating the system response matrix in the hole light-sensitive device for each voxel in visual field；
Single event rebuilds module, for the single photon meeting information reconstruction becomes the attribute of Cherenkov's event.
From technique scheme it can be seen that, by detection method and the device of the Cherenkov's single event using the present invention, the imaging signal to noise ratio of device can be effectively improved, resist biological tissue's self-luminous impact, be particularly suitable for the less demanding living imaging of imaging depth such as toy or clinical superficial.
Compared with prior art, the invention has the beneficial effects as follows：
（1）The detector design of the full 3D of various visual angles, single pass can obtain Cherenkov's photon information at countless visual angles simultaneously；
（2）Resist bias light and the organism self luminous time meets design, advantageously reduce the background noise of imaging；
（3）High speed optoelectronic Design of Signal, can lift response speed, the temporal information of capture single photon pulses using the avalanche multiplication photodiode being operated under Geiger mode angular position digitizer, remain the varying information of Cherenkov's single event.
Brief description
In order to be illustrated more clearly that the embodiment of the present invention or technical scheme of the prior art, the accompanying drawing of required use in embodiment or description of the prior art will be briefly described below, apparently, accompanying drawing for the present invention in describing below is only some embodiments of the present invention, for those of ordinary skill in the art, on the premise of not paying creative work, can also obtain other accompanying drawings according to these accompanying drawings.
Fig. 1 is the flow chart of the detection method of Cherenkov's single event of the present invention；
Fig. 2 is the structure drawing of device of the detection device of Cherenkov's single event of the present invention；
Fig. 3 is the dead time cascade schematic diagram of each photon in Cherenkov's single event of the present invention；
Fig. 4 is the schematic diagram in the radiated photons direction of Cherenkov's single event of the present invention；
Fig. 5 is the system block diagram of the detection device of the present invention typical Cherenkov single event；
Fig. 6 is that the time difference of the detection photon of the present invention typical Cherenkov single event calculates；
Fig. 7 projects the light pulse of Cherenkov's single event that kinetic energy is 17.05keV for the present invention；
Fig. 8 projects the light pulse of Cherenkov's single event that kinetic energy is 6.32keV for the present invention；
Fig. 9 is the front domain that Cherenkov's single event of the present invention reads front-end circuit；
Figure 10 is the back side domain that Cherenkov's single event of the present invention reads front-end circuit.
Specific embodiment
The invention discloses a kind of detection method of Cherenkov's single event of Single Photon Time Resolved Spectrometer and device, the method and device can be effectively realized the labelling of the event time of advent, the temporal resolution of hoisting module and device.
Below in conjunction with the accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is described in detail it is clear that described embodiment is only a part of embodiment of the present invention, rather than whole embodiments.Based on the embodiment in the present invention, the every other embodiment that those of ordinary skill in the art are obtained on the premise of not making creative work, broadly fall into the scope of protection of the invention.
As shown in Figure 1, the detection method of Cherenkov's single event of Single Photon Time Resolved Spectrometer disclosed by the invention and device pass through to gather single photon signal with the data mode of event, the recycling time meets the position screening out Cherenkov's event with estimation theory, and specific method and step is：
S1：By given ground machining, obtain cavernous substrate；
S2：On cavernous substrate, extension or paste one group of avalanche multiplication photosensor array being operated under Geiger mode angular position digitizer；
S3：By testing and emulating, obtain light-sensitive device for each pixel in field range（Or voxel）System response matrix；
S4：Rebuild the time of Cherenkov's single event and inject angle information from the high speed signal of photosensor array output.
In the detection device of Cherenkov's single event of above Single Photon Time Resolved Spectrometer, described Cherenkov's single event refers to that single radiosiotope atomic nucleus transmitting charged particle occurs Cerenkov effect in media as well.
In the detection device of Cherenkov's single event of above Single Photon Time Resolved Spectrometer, described monochromatic light subevent refers to that single visible ray that organism sent by self-luminous or Cherenkov's event or soft ultraviolet light photons hit the absorbed event of photoelectric device.
In the detection device of Cherenkov's single event of above Single Photon Time Resolved Spectrometer, the described time meets and refers to multiple single photons（No less than 10）Event is in a short period of time（Such as 10 ns）Occur, that is, think that these monochromatic light subevents belong to Cherenkov's single event.
In the detection device of Cherenkov's single event of above Single Photon Time Resolved Spectrometer, the described avalanche multiplication photosensor array being operated under Geiger mode angular position digitizer refers to the array that the avalanche photodide being operated under Geiger mode angular position digitizer forms, and it is very fast to the response time of photon.
In the detection device of Cherenkov's single event of above Single Photon Time Resolved Spectrometer, described Cherenkov's events incident angle refers to beam direction in organism for nucleic during nucleic transmitting charged particle, and the relative position that different directions inject the photographic hole of detector is different.
As shown in Fig. 2 a kind of detection device of Cherenkov's single event disclosed by the invention, rebuild module 400 including poroid substrate mechanical module 100, light-sensitive array module 200, system response matrix computing module 300, single event, wherein,
Poroid substrate mechanical module 100, for supporting light-sensitive array module, has cavernous structure；
Light-sensitive array module 200, for realizing the detection to Cherenkov's photon in the way of various visual angles.Light-sensitive array module be designed with the electronics design faster of poroid detection geometry and single photon response time, in order to obtain the temporal information of single photon, typically using the avalanche multiplication photodiode array being operated under Geiger mode angular position digitizer；
System response matrix computing module 300, for calculating the system response matrix in the hole light-sensitive device for each voxel in visual field；
Single event rebuilds module 400, for the single photon meeting information reconstruction becomes the attribute of Cherenkov's event.
Fig. 3 is the dead time cascade schematic diagram of each photon in Cherenkov's single event of the present invention；Fig. 4 is the schematic diagram in the radiated photons direction of Cherenkov's single event of the present invention；Fig. 5 is the system block diagram of the detection device of the present invention typical Cherenkov single event；Fig. 6 is that the time difference of the detection photon of the present invention typical Cherenkov single event calculates；Fig. 7 projects the light pulse of Cherenkov's single event that kinetic energy is 17.05keV for the present invention；Fig. 8 projects the light pulse of Cherenkov's single event that kinetic energy is 6.32keV for the present invention；Fig. 9 is the front domain that Cherenkov's single event of the present invention reads front-end circuit；Figure 10 is the back side domain that Cherenkov's single event of the present invention reads front-end circuit.In conjunction with Fig. 3, Fig. 4 and Figure 10, by several specific embodiments, the detection method of Cherenkov's single event of Single Photon Time Resolved Spectrometer of the present invention is described further with device.The detection method of Cherenkov's single event of Single Photon Time Resolved Spectrometer proposed by the present invention and device, the parameter that it is related to, wave filter design, the time meets process needs and is adjusted to reach good Cerenkov radiation resolution performance and shorter pulse duration according to the feature obtaining data.List the parameter of involved Application Example processing data herein.
Example 1：
List the parameter of the present embodiment processing data herein：
Step（1）Actual device used is the cylinder cover of every layer of 360 2mm square holes composition, floor height 2mm, totally 50 layers；
Step（2）Using the enhanced silicon planner technology of HONGGUANG, wave filter adopts 5 rank Butterworth filters to obtain the duration impulse time for 20 ns；
Step（3）System response matrix adopts the Monte Carlo simulation of off-line type to calculate, and voxel grid covers entire field, and voxel size is 0.1
mm；
Step（4）Using Cherenkov's event reconstruction method of parsing, directly draw the time of Cherenkov and inject angle.
Example 2：
List the parameter of this application example 2 processing data herein：
Step（1）Actual device used is the multilamellar spherical shell of 0.5m for radius, aperture 2mm, totally 5 layers；
Step（2）Using gallium arsenide semiconductor technique, wave filter adopts 8 rank Chebyshev filters to obtain the duration impulse time for 22 ns；
Step（3）By the way of experiment plus directly calculating, voxel grid covers entire field to system response matrix, and voxel size is 1 mm；
Step（4）Using Cherenkov's event reconstruction method of iteration, draw the time of Cherenkov hand to hand and inject angle, iterationses are 100 times.
Methods and apparatus of the present invention can be used for radiating the nuclear technology of charged corpuscle, including nuclear detection, kernel analysis, Nuclear medical instruments.
In the detection method of Cherenkov's single event that the present invention provides.Met by the time, reject self-luminous and the bias light of organism.Judge the time of Cherenkov's event and inject angle in the relative position of in the hole by monochromatic light subevent, the good imaging quality of the Cherenkov's imaging method reading than the single-view in background technology or current charge, Cherenkov's photon of capture is many.
In the detection method of Cherenkov's single event disclosed by the invention, the isotope that injection can launch charged particle can be used for the biochemistry in labelling organism and physiological process；Read charged particle and send the photon counting of Cherenkov's photon directive detector module and the time of each counting；The time of carrying out time read is met；The position that Cherenkov's event occurs is estimated in the relative position of in the hole by photon；The position and time of the Cherenkov estimating is rebuild, obtains the distribution of nucleic.
Be can be seen that by contrast, by detection method and the device of the Cherenkov's single event using the present invention, the imaging signal to noise ratio of device can be effectively improved, resist biological tissue's self-luminous impact, be particularly suitable for the less demanding living imaging of imaging depth such as toy or clinical superficial.
Compared with prior art, the invention has the beneficial effects as follows：
（1）The detector design of the full 3D of various visual angles, single pass can obtain Cherenkov's photon information at countless visual angles simultaneously；
（2）Resist bias light and the organism self luminous time meets design, advantageously reduce the background noise of imaging；
（3）High speed optoelectronic Design of Signal, can lift response speed, the temporal information of capture single photon pulses using the avalanche multiplication photodiode being operated under Geiger mode angular position digitizer, remain the varying information of Cherenkov's single event.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, and without departing from the spirit or essential characteristics of the present invention, the present invention can be realized in other specific forms.Therefore, no matter from the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is limited by claims rather than described above, it is intended that all changes in the implication and scope of the equivalency of claim that fall are included in the present invention.Any reference in claim should not be considered as limiting involved claim.
In addition, it should be understood that, although this specification is been described by according to embodiment, but not each embodiment only comprises an independent technical scheme, this narrating mode of description is only for clarity, those skilled in the art should using description as an entirety, the technical scheme in each embodiment can also through appropriately combined, formed it will be appreciated by those skilled in the art that other embodiment.
Claims (7)
1. a kind of detection method of Cherenkov's single event it is characterised in that：Including step：
S1：By given ground machining, obtain cavernous substrate；
S2：On cavernous substrate, extension or paste one group of avalanche multiplication photosensor array being operated under Geiger mode angular position digitizer；
S3：By testing and emulating, obtain light-sensitive device for each pixel in field range（Or voxel）System response matrix；
S4：Rebuild the time of Cherenkov's single event and inject angle information from the high speed signal of photosensor array output.
2. a kind of Cherenkov's single event according to claim 1 detection method it is characterised in that：Single probe unit impulse smaple of the monochromatic light subevent obtaining is the multidimensional property set with single photon event correlation.
3. a kind of Cherenkov's single event according to claim 1 detection method it is characterised in that：By given ground machining, obtain cavernous substrate.
4. Cherenkov's single event according to claim 1 detection method it is characterised in that：On cavernous substrate, extension or paste one group of avalanche multiplication photosensor array being operated under Geiger mode angular position digitizer.
5. Cherenkov's single event according to claim 1 detection method it is characterised in that：By testing and emulating, obtain light-sensitive device for each pixel in field range（Or voxel）System response matrix.
6. Cherenkov's single event according to claim 1 detection method it is characterised in that：Rebuild the time of Cherenkov's single event and inject angle information from the high speed signal of photosensor array output.
7. a kind of detection device of Cherenkov's single event it is characterised in that：Poroid substrate mechanical module, light-sensitive array module, system response matrix computing module, single event rebuild module, wherein：
Poroid substrate mechanical module, for supporting light-sensitive array module, has cavernous structure；
Light-sensitive array module, for realizing the detection to Cherenkov's photon in the way of various visual angles；
The electronics design being designed with poroid detection geometry and nanosecond single photon response time of light-sensitive array module, in order to obtain the temporal information of single photon, typically using the avalanche multiplication photodiode array being operated under Geiger mode angular position digitizer；
System response matrix computing module, for calculating the system response matrix in the hole light-sensitive device for each voxel in visual field；
Single event rebuilds module, for the single photon meeting information reconstruction becomes the attribute of Cherenkov's event.
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