CN106389570A - 一种治疗上呼吸道炎症的中药组合物的制备方法 - Google Patents
一种治疗上呼吸道炎症的中药组合物的制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗上呼吸道炎症的中药组合物的制备方法，包括以下步骤：1）以重量份表示，称取昆布，附子，桔梗，枇杷叶，石吊兰，旋覆花，胡颓子叶，鼠曲草，紫苑，海藻；2）将称取好的中药原材料浸泡然后加水煎煮；3）煎煮后进行过滤，然后将滤液进行加热浓缩形成的胶状物，然后加入乙醇进行搅拌，并将搅拌后的液体进行低温冷藏；4）将冷藏后的溶液过滤，然后蒸馏法将乙醇回收；5）向蒸馏后的液体中加入食品防腐剂，最后封装成品并采用巴氏消毒法进行杀菌消毒，即得口服溶液。本发明的制备方法能够有效的利用中药原材料的作用成分，通过高效的浓缩和提取，来提高口服液中的有效成分含量。
Description
技术领域
本发明涉及中医药领域，具体是指一种治疗上呼吸道炎症的中药组合物的制备方法。
背景技术
上呼吸道炎症有70%～80%由病毒引起。包括鼻病毒、冠状病毒、腺病毒、流感和副流感病毒、呼吸道合胞病毒、埃可病毒、柯萨奇病毒等。另有20%～30%的上感由细菌引起。细菌感染可直接感染或继发于病毒感染之后，以溶血性链球菌为最常见，其次为流感嗜血杆菌、肺炎球菌、葡萄球菌等，偶或为革兰阴性细菌。各种导致全身或呼吸道局部防御功能降低的原因，如受凉、淋雨、气候突变、过度疲劳等可使原已存在于上呼吸道的或从外界侵入的病毒或细菌迅速繁殖，从而诱发本病。老幼体弱，免疫功能低下或患有慢性呼吸道疾病的患者易感。治疗上呼吸道炎症应区分炎症类型，采用西药、中药皆可，而中医药用于治疗上呼吸道感染药物，由于具有副作用小、疗效好的特点，故很受人们青睐。
发明内容
本发明的目的在于提供一种能由内而外从根本上有效解决上呼吸道炎症的中药组合物的制备方法。
本发明通过下述技术方案实现：一种治疗上呼吸道炎症的中药组合物的制备方法，包括以下步骤：
（1）以重量份表示，首先称取昆布3-9份，附子5-8份，桔梗4-11份，枇杷叶6-10份，石吊兰5-14份，旋覆花3-7份，胡颓子叶5-13份，鼠曲草2-9份，紫苑6-12份，海藻4-8份；
（2）将称取好的中药原材料浸泡20-25分钟，然后开始加水煎煮；
（3）煎煮后进行过滤得到滤液，然后将滤液进行加热浓缩形成相对密度为0.8-1.1的胶状物，然后加入2-4倍量的92%乙醇进行充分搅拌，并将搅拌后的液体进行30小时的低温冷藏；
（4）将冷藏后的溶液过滤滤除沉淀物，然后蒸馏法将乙醇回收；
（5）向蒸馏后的液体中加入食品防腐剂，最后封装成品并采用巴氏消毒法进行杀菌消毒，即得口服溶液。
进一步地，所述步骤（2）中浸泡和煎煮的具体步骤为：
a、先将称取后的中药原材料清洗干净，清洗后将中药原材料放入清水或纯净水中浸泡20~25分钟，浸泡所需水量为2~3L；
b、然后将浸泡过后的中药原材料及其浸泡液一起转移到煎药罐中，加盖进行煎煮；
c、煎煮时，在未沸腾前先用武火，待煎药罐内的溶液沸腾后将盖取下，并改用文火再煎熬30~60分钟，在整个煎药过程中需要搅拌5~6次；
d、第二次煎煮需加水没过中药原材料2~5cm，然后还是先用武火煮沸，然后用文火煎煮15~23分钟即可。
进一步地，所述步骤（3）中低温冷藏是将加入乙醇后的液体转移到冷库中，在274~276k温度下低温沉淀30小时。
进一步地，所述步骤（3）中浓缩过程采用的是真空减压浓缩罐。
进一步地，所述步骤（5）还添加有阿斯巴甜和蔗糖，所述食品添防腐剂为纳他霉素。
本发明所述的一种用于治疗肥厚性胃炎的中药组合物的原料药药理：
昆布：性寒，味咸。归肝经、胃经、肾经。软坚散结、消痰、利水。属化痰止咳平喘药下属分类的止咳平喘药。
附子：性温，味辛。有毒。归胃经、肝经。祛风痰、定惊搐、解毒、散结、止痛。属化痰止咳平喘药下属分类的温化寒痰药。
桔梗：性平，味苦、辛。归肺经。宣肺祛痰、利咽排脓。属化痰止咳平喘药下分类的清化热痰药。
枇杷叶：味苦，性微寒。归肺经、胃经。清肺止咳、降逆止呕。属化痰止咳平喘药下属中的止咳平喘药。
石吊兰：性温，味苦。归肺经。化痰止咳，软坚散结。属化痰止咳平喘药下属分类的温化寒痰药。
旋覆花：性微温，味苦、辛、咸。归肺经、胃经。降气、消痰、行水、止呕。属化痰止咳平喘药下分类的温化寒痰药。
胡颓子叶：性平，味酸。归肺经。敛肺、平喘、止咳。属化痰止咳平喘药下属分类的止咳平喘药。
鼠曲草：性平，味甘。归肺经。祛痰、止咳平喘、祛风湿。属化痰止咳平喘药下属分类的止咳平喘药。
紫苑：性温，味辛、苦。归肺经。润肺下气、消痰止咳。属化痰止咳平喘药下属分类的止咳平喘药。
海藻：性寒，味苦、咸。归肝经、胃经、肾经。软坚散结、消痰、利水。属化痰止咳平喘药下属分类的清化热痰药。
本发明与现有技术相比，具有以下优点及有益效果：
本发明通过长期研究呼吸道疾病的症状和病因，然后利用中药配方从根本上去解决上呼吸道炎症的问题，相较于西药，中药配方不仅能够缓解炎症带来的咳嗽、咽喉肿痛、吞咽疼痛等症状，而且能够解决病根，防止病症反复发作；与现有的中药配方相比，本发明配方构成明确，制剂的效果明显，适用于多种病因引起的上呼吸道疾病。而且发明的制备方法能够有效的利用中药原材料的作用成分，通过高效的浓缩和提取，来提高口服液中的有效成分含量；然后通过低温沉淀工艺能够进一步提高萃取效果。
具体实施方式
下面详细描述本发明的实施例。
实施例1：
本实施例的一种治疗上呼吸道炎症的中药组合物，所述中药组合物成分包括昆布3-9份，附子5-8份，桔梗4-11份，枇杷叶6-10份，石吊兰5-14份，旋覆花3-7份，胡颓子叶5-13份，鼠曲草2-9份，紫苑6-12份，海藻4-8份。
本发明药物的制备方法，包括以下步骤：
（1）以重量份表示，首先称取昆布3-9份，附子5-8份，桔梗4-11份，枇杷叶6-10份，石吊兰5-14份，旋覆花3-7份，胡颓子叶5-13份，鼠曲草2-9份，紫苑6-12份，海藻4-8份；
（2）将称取好的中药原材料浸泡20-25分钟，然后开始加水煎煮；
（3）煎煮后进行过滤得到滤液，然后将滤液进行加热浓缩形成相对密度为0.8-1.1的胶状物，然后加入2-4倍量的92%乙醇进行充分搅拌，并将搅拌后的液体进行30小时的低温冷藏；
（4）将冷藏后的溶液过滤滤除沉淀物，然后蒸馏法将乙醇回收；
（5）向蒸馏后的液体中加入食品防腐剂，最后封装成品并采用巴氏消毒法进行杀菌消毒，即得口服溶液。
实施例2：
本实施例一种治疗上呼吸道炎症的中药组合物，以重量份表示，所述昆布7份，附子5份，桔梗5份，枇杷叶7份，石吊兰11份，旋覆花4份，胡颓子叶7份，鼠曲草8份，紫苑9份，海藻6份。
实施例3：
本实施例一种治疗上呼吸道炎症的中药组合物，以重量份表示，所述昆布9份，附子7份，桔梗10份，枇杷叶6份，石吊兰5份，旋覆花3份，胡颓子叶6份，鼠曲草3份，紫苑7份，海藻5份。
实施例4：
本实施例一种治疗上呼吸道炎症的中药组合物，以重量份表示，所述昆布3份，附子6份，桔梗8份，枇杷叶9份，石吊兰8份，旋覆花5份，胡颓子叶11份，鼠曲草5份，紫苑6份，海藻7份。
利用本发明药物针对各种上呼吸道炎症病患者的临床统计资料：
经过150例患者的临床使用，其中男患者81，女患者69例，用药年龄对象12~40岁。其中最小13岁，最大39岁，平均年龄22岁；轻度上呼吸道炎症病例74例，中度上呼吸道炎症病例43例，重度上呼吸道炎症病例33例。
其中轻度上呼吸道炎症病患者症状为：患者感到咽部有不适感，且感到喉咙干痒，出现间断性咳嗽，常在傍晚和黎明咳嗽较为频繁；
中度上呼吸道炎症病患者症状为：患者常有咽痛、流泪、味觉减退、呼吸不畅、声嘶等症状，且还伴随有咳嗽、咽干、咽痒或灼热感，鼻后有滴漏感，头痛、发热、畏寒，甚至出现发烧症状；
重度上呼吸道炎症病患者症状为：患者咽喉疼痛难忍，吞咽液体或者口水也会出现剧烈疼痛，且会出现吞咽困难的情况；而且咳嗽不断，痰中带血，发烧，全身无力，鼻、咽、喉明显充血、水肿，颌下淋巴结肿大、压痛。
典型病例：
1、李某，男，31岁，平时经常熬夜加班，作息时间不规律，于2年前无明显诱因出现咽干、咳嗽，咳嗽呈发作性，每次持续数分钟，夜间发作较白天频繁，影响睡眠,伴少量白色泡沫样痰，无发热、寒战、盗汗，无咯血、胸痛、呼吸困，反复在当地医院就诊，予抗感染治疗（具体不详）并服用“甘草片、酮替芬、开瑞坦、博利康尼”等均不能缓解。近半年来闻及油烟、涂料即有咳嗽发作，且夜间咳嗽逐渐加重，呈持续性，不能平卧，需采取坐位，伴胸痛、气喘等症状发生，而采用本发明的中药配方进行治疗，咽干咳嗽等症状明显好转，不再出现持续性咳嗽症状，且夜间胸痛和呼吸困难的症状也逐渐消退，精神状态有明显好转。
2、顾某，男，29岁，5天前无明显诱因下出现发热，体征温度达到38.5℃，伴随咽痛、流清涕，随后咳嗽、咳少量白痰，无胸闷、气促，至医院就诊，诊断为“上呼吸道感染”，予以退热、止咳、化痰、补液、抗感染等对症支持治疗后症状无明显好转；起病以来，无恶心、呕吐，无腹痛、腹泻，乏力，精神睡眠胃纳欠佳，大小便无异常，体重无明显改变，但时长出现持续性咳嗽，并会有呕吐感，而采用本发明中的中药配方进行治疗，服用两个疗程后，咳嗽症状明显减轻，不再出现持续性咳嗽，咽痛感消退，服用四个疗程后，不再出现明显咳嗽症状，且咽部不适感消失。
尽管已经示出和描述了本发明的实施例，本领域的普通技术人员可以理解：在不脱离本发明的原理和宗旨下可以对这些实施例进行多种变化、修改、替换和变型，本发明的范围由权利要求及其等同物限定。
Claims (5)
1.一种治疗上呼吸道炎症的中药组合物的制备方法，其特征为在于，包括以下步骤：
（1）以重量份表示，首先称取昆布3-9份，附子5-8份，桔梗4-11份，枇杷叶6-10份，石吊兰5-14份，旋覆花3-7份，胡颓子叶5-13份，鼠曲草2-9份，紫苑6-12份，海藻4-8份；
（2）将称取好的中药原材料浸泡20-25分钟，然后开始加水煎煮；
（3）煎煮后进行过滤得到滤液，然后将滤液进行加热浓缩形成相对密度为0.8-1.1的胶状物，然后加入2-4倍量的92%乙醇进行充分搅拌，并将搅拌后的液体进行30小时的低温冷藏；
（4）将冷藏后的溶液过滤滤除沉淀物，然后蒸馏法将乙醇回收；
（5）向蒸馏后的液体中加入食品防腐剂，最后封装成品并采用巴氏消毒法进行杀菌消毒，即得口服溶液。
2.根据权利要求1所述的一种治疗上呼吸道炎症的中药组合物的制备方法，其特征为在于，所述步骤（2）中浸泡和煎煮的具体步骤为：
a、先将称取后的中药原材料清洗干净，清洗后将中药原材料放入清水或纯净水中浸泡20~25分钟，浸泡所需水量为2~3L；
b、然后将浸泡过后的中药原材料及其浸泡液一起转移到煎药罐中，加盖进行煎煮；
c、煎煮时，在未沸腾前先用武火，待煎药罐内的溶液沸腾后将盖取下，并改用文火再煎熬30~60分钟，在整个煎药过程中需要搅拌5~6次；
d、第二次煎煮需加水没过中药原材料2~5cm，然后还是先用武火煮沸，然后用文火煎煮15~23分钟即可。
3.根据权利要求1或2所述的一种治疗上呼吸道炎症的中药组合物的制备方法，其特征在于：所述步骤（3）中低温冷藏是将加入乙醇后的液体转移到冷库中，在274~276k温度下低温沉淀30小时。
4.根据权利要求1或2所述的一种治疗上呼吸道炎症的中药组合物的制备方法，其特征在于：所述步骤（3）中浓缩过程采用的是真空减压浓缩罐。
5.根据权利要求1或2所述的一种治疗上呼吸道炎症的中药组合物的制备方法，其特征在于：所述步骤（5）还添加有阿斯巴甜和蔗糖，所述食品添防腐剂为纳他霉素。
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