CN106370493A - Liquid metal artificial cell and preparation method thereof - Google Patents
Liquid metal artificial cell and preparation method thereof Download PDFInfo
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- CN106370493A CN106370493A CN201610875644.4A CN201610875644A CN106370493A CN 106370493 A CN106370493 A CN 106370493A CN 201610875644 A CN201610875644 A CN 201610875644A CN 106370493 A CN106370493 A CN 106370493A
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- liquid metal
- semipermeable membrane
- artificial cell
- electrolyte
- cell
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- 229910001338 liquidmetal Inorganic materials 0.000 title claims abstract description 78
- 239000000592 Artificial Cell Substances 0.000 title claims abstract description 41
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 239000012528 membrane Substances 0.000 claims abstract description 48
- 239000003792 electrolyte Substances 0.000 claims abstract description 19
- 239000008151 electrolyte solution Substances 0.000 claims abstract description 11
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical group [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 15
- 239000000463 material Substances 0.000 claims description 15
- GYHNNYVSQQEPJS-UHFFFAOYSA-N Gallium Chemical compound [Ga] GYHNNYVSQQEPJS-UHFFFAOYSA-N 0.000 claims description 14
- 229910052733 gallium Inorganic materials 0.000 claims description 14
- 239000000654 additive Substances 0.000 claims description 13
- 230000000996 additive effect Effects 0.000 claims description 13
- 238000002347 injection Methods 0.000 claims description 12
- 239000007924 injection Substances 0.000 claims description 12
- 239000010408 film Substances 0.000 claims description 10
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims description 8
- 229910052751 metal Inorganic materials 0.000 claims description 8
- 239000002184 metal Substances 0.000 claims description 8
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 7
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 claims description 7
- 229910052709 silver Inorganic materials 0.000 claims description 7
- 239000004332 silver Substances 0.000 claims description 7
- 239000000243 solution Substances 0.000 claims description 7
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical group [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 6
- 229910045601 alloy Inorganic materials 0.000 claims description 6
- 239000000956 alloy Substances 0.000 claims description 6
- 229910052738 indium Inorganic materials 0.000 claims description 6
- APFVFJFRJDLVQX-UHFFFAOYSA-N indium atom Chemical compound [In] APFVFJFRJDLVQX-UHFFFAOYSA-N 0.000 claims description 6
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 5
- 229910052802 copper Inorganic materials 0.000 claims description 5
- 239000010949 copper Substances 0.000 claims description 5
- 239000000284 extract Substances 0.000 claims description 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 4
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 4
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 4
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 4
- 229910017052 cobalt Inorganic materials 0.000 claims description 4
- 239000010941 cobalt Substances 0.000 claims description 4
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims description 4
- 239000008187 granular material Substances 0.000 claims description 4
- 229910021389 graphene Inorganic materials 0.000 claims description 4
- 239000011777 magnesium Substances 0.000 claims description 4
- 229910052749 magnesium Inorganic materials 0.000 claims description 4
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 229910052759 nickel Inorganic materials 0.000 claims description 4
- 239000000725 suspension Substances 0.000 claims description 4
- 229910002058 ternary alloy Inorganic materials 0.000 claims description 4
- 229910052725 zinc Inorganic materials 0.000 claims description 4
- 239000011701 zinc Substances 0.000 claims description 4
- 229910052782 aluminium Inorganic materials 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 229910052710 silicon Inorganic materials 0.000 claims description 3
- 239000010703 silicon Substances 0.000 claims description 3
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 2
- 239000011260 aqueous acid Substances 0.000 claims description 2
- 229940012466 egg shell membrane Drugs 0.000 claims description 2
- 239000013536 elastomeric material Substances 0.000 claims description 2
- VXNZUUAINFGPBY-UHFFFAOYSA-N ethyl ethylene Natural products CCC=C VXNZUUAINFGPBY-UHFFFAOYSA-N 0.000 claims description 2
- 239000003292 glue Substances 0.000 claims description 2
- 229910002804 graphite Inorganic materials 0.000 claims description 2
- 239000010439 graphite Substances 0.000 claims description 2
- RHZWSUVWRRXEJF-UHFFFAOYSA-N indium tin Chemical compound [In].[Sn] RHZWSUVWRRXEJF-UHFFFAOYSA-N 0.000 claims description 2
- NJWNEWQMQCGRDO-UHFFFAOYSA-N indium zinc Chemical compound [Zn].[In] NJWNEWQMQCGRDO-UHFFFAOYSA-N 0.000 claims description 2
- 229910052755 nonmetal Inorganic materials 0.000 claims description 2
- 239000011088 parchment paper Substances 0.000 claims description 2
- 239000004033 plastic Substances 0.000 claims description 2
- 229920003023 plastic Polymers 0.000 claims description 2
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 claims description 2
- 239000011780 sodium chloride Substances 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims description 2
- 239000001117 sulphuric acid Substances 0.000 claims description 2
- 235000011149 sulphuric acid Nutrition 0.000 claims description 2
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 claims description 2
- 239000010409 thin film Substances 0.000 claims description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 2
- 229910001369 Brass Inorganic materials 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 239000010951 brass Substances 0.000 claims 1
- 239000002238 carbon nanotube film Substances 0.000 claims 1
- 238000005868 electrolysis reaction Methods 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- CHWRSCGUEQEHOH-UHFFFAOYSA-N potassium oxide Chemical compound [O-2].[K+].[K+] CHWRSCGUEQEHOH-UHFFFAOYSA-N 0.000 claims 1
- 229910001950 potassium oxide Inorganic materials 0.000 claims 1
- 239000000377 silicon dioxide Substances 0.000 claims 1
- 235000012239 silicon dioxide Nutrition 0.000 claims 1
- 230000006870 function Effects 0.000 abstract description 7
- 239000002131 composite material Substances 0.000 abstract description 4
- 230000003915 cell function Effects 0.000 abstract description 3
- 239000008204 material by function Substances 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 description 26
- 239000007788 liquid Substances 0.000 description 9
- 238000000034 method Methods 0.000 description 8
- 230000000694 effects Effects 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 238000004088 simulation Methods 0.000 description 6
- 241000196324 Embryophyta Species 0.000 description 4
- 210000000170 cell membrane Anatomy 0.000 description 4
- 210000003743 erythrocyte Anatomy 0.000 description 4
- 230000007246 mechanism Effects 0.000 description 4
- 241000894007 species Species 0.000 description 4
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 229910001128 Sn alloy Inorganic materials 0.000 description 3
- 210000002569 neuron Anatomy 0.000 description 3
- 210000000287 oocyte Anatomy 0.000 description 3
- 210000000578 peripheral nerve Anatomy 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- 238000004026 adhesive bonding Methods 0.000 description 2
- 230000002567 autonomic effect Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000005611 electricity Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 235000001968 nicotinic acid Nutrition 0.000 description 2
- 210000003463 organelle Anatomy 0.000 description 2
- 210000004681 ovum Anatomy 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000005316 response function Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 108010022579 ATP dependent 26S protease Proteins 0.000 description 1
- 108010077544 Chromatin Proteins 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 239000000232 Lipid Bilayer Substances 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 102000002151 Microfilament Proteins Human genes 0.000 description 1
- 108010040897 Microfilament Proteins Proteins 0.000 description 1
- 241000237852 Mollusca Species 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 240000005373 Panax quinquefolius Species 0.000 description 1
- 229920006266 Vinyl film Polymers 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 230000003592 biomimetic effect Effects 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 230000002925 chemical effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 210000003483 chromatin Anatomy 0.000 description 1
- 238000002485 combustion reaction Methods 0.000 description 1
- 230000002153 concerted effect Effects 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 210000002472 endoplasmic reticulum Anatomy 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 229920006335 epoxy glue Polymers 0.000 description 1
- 229920002313 fluoropolymer Polymers 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000000446 fuel Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 238000011005 laboratory method Methods 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 230000007102 metabolic function Effects 0.000 description 1
- 210000003632 microfilament Anatomy 0.000 description 1
- 210000003470 mitochondria Anatomy 0.000 description 1
- 239000007777 multifunctional material Substances 0.000 description 1
- 239000002071 nanotube Substances 0.000 description 1
- 210000000633 nuclear envelope Anatomy 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 239000000123 paper Substances 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 229950000845 politef Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Molecular Biology (AREA)
- Prostheses (AREA)
Abstract
The invention provides a liquid metal artificial cell, which comprises a semipermeable membrane, liquid metal and electrolyte; the semi-permeable membrane encloses a closed cavity, and the liquid metal and the electrolyte are located in the cavity. The invention also provides a preparation method of the liquid metal artificial cell. The invention introduces the technical concept of liquid metal artificial cells for the first time, creates a composite device system integrating semipermeable membranes, liquid metal, electrolyte solution and even more functional materials, obviously expands the existing knowledge of the artificial cells and the liquid metal, can partially simulate the cell function of the nature, and can be further used for assembling artificial machines with more complex functions.
Description
Technical field
The invention belongs to bionics techniques field and in particular to a kind of can partial simulation biocellular conditions response function liquid
State metal artificial's cell and preparation method thereof.
Background technology
No matter plant or animal, for the object on the whole earth or even celestial body, organism is all the most complicated
Material.After the evolution of billions of years, organism surmounted in the most basic being that in its activity of every other material.We know
Road, constitutes one of most basic key element of organism and is that cell.Cell is the elementary cell of life 26S Proteasome Structure and Function.Such as people
Body there are about cell between 10 20 microns for 40,000,000,000,000 60 trillion average diameters altogether, and species is various, such as the one-tenth of maximum
Ripe ovum, diameter is in 200 microns；Minimum is platelet, only about 2 microns of diameter, and other also have leukocyte, red thin
Born of the same parents, neurocyte.Mammal in addition to ripe erythrocyte and platelet, all at least one cell of all of cell
Core is it is intended to adjust cell activities.Some cell sizes are far longer than above-mentioned, as unfertilized egg to a certain extent
A cell can simply be look at.And from unlike zooblast, there is cell wall in plant cell, organelles and group inside other
Divide and all there is certain difference.But regardless of difference, say from the general extent, constitute animal body or the cell of plant has substantially
Identical structural system and ergasia.Much important organelle and cellularity, such as cell membrane, nuclear membrane, chromatin, core
Core, mitochondrion, Golgi body, endoplasmic reticulum, ribosome, micro-pipe and microfilament etc., not only morphosiss and composition in different cells
Identical, function is same.It can be said that exactly these basic cellularity, tissue and function constitute on the earth one fresh and alive
The abundant world.Undoubtedly, if the cell of certain function can be produced by laboratory techniques, human machine will be realized and manufacture and structure
The breakthrough built.Obviously, cell structure the most classical is made up of cell membrane and content, and this combinative structure is for bionical
Have great enlightenment.So far, cell also cannot be realized by the approach of pure synthetic, can manually produce now simplest
Lipid bilayer membranes, but also far apart from real cell membrane, and the manual simulation for other mechanisms intracellular there is also class
Like bottleneck.But, in current technological phase, though bionics fail all to reappear the biological function of nature, in certain journey
Can partly close and simulation biological world on degree.
In recent years, with the discovery of some basic effects, liquid metal obtains remarkable progress in terms of realizing flexible machine.
Such as, this team at the beginning of 2015 3 months, " advanced material " has been delivered entitled " bionic-type self-driven liquid metal software move
Research paper (j.zhang, y.y.yao, l.sheng, j.liu, the self-fueled biomimetic liquid of thing "
Metal mollusk, advanced materials, vol.27, pp.2648-2655,2015), reported first in the world
A kind of unique phenomenon of exception and mechanism, that is, liquid metal such as gallio liquid alloy can be in a small amount of material such as " absorption " aluminum work of eating
For after fuel with the long-time high-speed motion of deformable machine form it is achieved that autonomic movement without external power, liquid metal
A series of simple software of unusual habit of machine some natures fairly close is biological, such as: " can eat " food (combustion
Material), autonomic movement, deformable, possess certain metabolic function (chemical reaction), therefore we are named as liquid metal software
Animal.One of mechanism of these deformation and motion is caused to be the electric double layer effect on liquid metal and water body interface.However,
This machine is actually also mainly an alloy fluid, does not still possess the basic function that the most basic unit of organism is cell,
Such as there are certain perception and sensing to external world.In view of the electric double layer effect on liquid metal and water body interface it is easy to right
The electricity in the external world, magnetic, sound, light, heat or even chemical effect produce response, thus can develop certain intelligent response object.For this reason,
It is contemplated that by this mechanism provide structurally and functionally can partial simulation biological cell liquid metal artificial cell and
Its manufacture method.
Content of the invention
Based on the discovery to liquid metal basis effect, the purpose of the present invention is from a kind of brand-new technical standpoint, provides
Can partial simulation biological cell function liquid metal artificial cell.
It is a further object of the present invention to provide a kind of preparation method of liquid metal artificial cell.
The technical scheme realizing the object of the invention is:
A kind of liquid metal artificial cell, including semipermeable membrane, liquid metal and electrolyte；Described semipermeable membrane surrounds closing
Cavity, liquid metal and electrolyte are within the cavity.
Wherein, the material of described semipermeable membrane is biological cell membrane, pericystium, parchment paper, eggshell membrane, graphene film, carbon
In nano-tube film, polyfluortetraethyleventilated ventilated membrane, the collodion thin film of ethylethylene film, oxirane film and artificial system one
Kind；Being shaped as of the cavity that described semipermeable membrane surrounds is spherical, oblate, oval spherical or elongated cylindrical, and the size of cavity is 10 μ
M～2cm.
Wherein, described liquid metal is one or more of metal simple-substance gallium, bianry alloy, ternary alloy three-partalloy, wherein institute
Stating bianry alloy is one or more of gallium indium, gallium stannum, gallium kirsite, and described ternary alloy three-partalloy is gallium indium tin, gallium indium zinc, gallium stannum
One or more of kirsite.
Wherein, described electrolyte is one of sodium hydroxide, potassium hydroxide, sodium chloride, sulphuric acid and nitre aqueous acid,
The concentration of solution is 0.1～5mol/l.
Further, also contain additive in the cavity of described semipermeable membrane, described additive is size in 10nm to 1000 μ
The granule of one or more of the copper between m, indium, stannum, zinc, silver, ferrum, nickel, manganese, cobalt, magnesium, aluminum metal；Or be silicon, titanium dioxide
The granule of one or more of silicon, graphite, Graphene, plastics, elastomeric material, the quality of additive accounts for the 1 of electrolyte quality
～20%.
Further, the particle surface of described metal has copper, indium, stannum, zinc, silver, ferrum, nickel, manganese, cobalt, magnesium, aluminum wherein one
Plant or several clads, or have nonmetal-coated layer.
The preparation method of described liquid metal artificial cell, including step:
1) take semipermeable membrane material, curve the mode that spherical blend compounds glue, sew or tighten and be fabricated to closing chamber, that is, obtain envelope
The semipermeable membrane space closed；
2) adopt injection needle, extract electrolyte solution, pierce through semipermeable membrane afterwards, electrolyte is injected；
3) prepare liquid metal, using injection needle, pierce through semipermeable membrane after extracting liquid metal, liquid metal is injected.
The volume of electrolyte and liquid metal accounts for the 20～90% of the space of semi-transparent membrane closure.
The needle diameter of described injection needle is 1～500 micron.Needle diameter in 1 micron～50 microns of micron pin, and
100～500 microns of syringe needle is all commercially available.
The preparation method of described liquid metal artificial cell, further comprises the steps of:
4) extract, with injection needle, the electrolyte suspension including additive, pierce through semipermeable membrane afterwards, suspension is injected.It is thus
Obtain being closed with the liquid metal artificial cell of corresponding composite fluid material.
Further, the preparation method of described liquid metal artificial cell, the artificial cell preparing is stacked simultaneously
It is fixedly assembled, obtain aggregative cell assembly.
Application in biosensor, bionical element for the liquid metal artificial cell of the present invention.
The beneficial effects of the present invention is:
The present invention has been firstly introduced the technological concept of liquid metal artificial cell, creates a kind of collection semipermeable membrane, liquid gold
Genus, electrolyte solution or even more multifunctional material, in the multiple device system of one, significantly extend artificial cell and liquid gold
Belong to be both recognized, can partial simulation nature cell function, be further useful for assembling the more complicated Manual machine of function
Device.So far, there is not yet realize the research report of artificial cell using liquid metal in domestic and foreign literature.The present invention provides first
And establish a kind of technical system building liquid metal artificial cell.
Brief description
Fig. 1 is the structural representation of the spherical liquid metal artificial cell of the embodiment of the present invention 1 one species oocyte；
Fig. 2 is the structural representation of the flat liquid metal artificial cell of the embodiment of the present invention 2 one species erythrocyte；
Fig. 3 is the structural representation of the major axis shape liquid metal artificial cell of the embodiment of the present invention 3 one species neuron；
Fig. 4 is a kind of cell composite unit structure schematic diagram of the embodiment of the present invention 4；
Fig. 5 is a kind of cell composite unit structure schematic diagram comprising additive of the embodiment of the present invention 6.
In figure: 1 is semipermeable membrane；2 is liquid metal；3 is additive；4 is electrolyte solution.
Specific embodiment
Hereinafter technical solution of the present invention is further illustrated with specific embodiment.Those skilled in the art are it is to be understood that reality
Apply example and be merely to illustrate the present invention, be not used in restriction the scope of the present invention.
In embodiment, if no special instructions, technological means used are this area conventional technique means.
Embodiment 1:
Fig. 1 is the structural representation of the liquid metal artificial cell of one embodiment of the present invention；Described liquid metal people
Work cell includes: semipermeable membrane 1, liquid metal 2 and electrolyte solution 4；
Described semipermeable membrane 1 is closed cavity structure, and inside is contained with liquid metal 2 and electrolyte solution 4, is achieved in class
The environmental response function of biological cell.
The membrane material politef that described semipermeable membrane 2 does not allow solute to pass through for only allowing hydrone to pass through is breathed freely
Film.Semipermeable membrane 1 described in the present embodiment is designed as spherical, diameter 2cm, in order to simulate oocyte Shape closed cavity.For ensureing
Described liquid metal 2 is in liquid, described liquid metal 2 adopt low-melting-point metal that is to say, that described liquid metal 2 molten
Point is less than 100 DEG C.
In the present embodiment implements, the quality of described liquid metal 2 is 2g, is the gallium-indium-tin alloy of 11 DEG C of fusing point,
Electrolyte 4 is the sodium hydroxide solution of 0.5mol/l, and volume is 2ml；It will be appreciated that the gallium-indium-tin alloy due to 11 DEG C of fusing point
It is liquid under normal temperature state, so, need not carry out heating can achieve.
Preparation process is:
1) take semipermeable membrane material, curve the viscous mode of spherical blend compounds and be fabricated to closing chamber, gluing process is: polytetrafluoro
Vinyl film processes 10min with surface conditioning agent (my morning twilight fluoroplastics factory), uses epoxy glue bonding, that is, obtain after being cleaned with acetone
The semipermeable membrane space of closing；
2) adopt injection needle (2 microns of diameter, purchased from Shenzhen concerted effort micro-nano), extract electrolyte solution, pierce through semi-transparent afterwards
Film, electrolyte is injected；
3) prepare liquid metal, using injection needle, pierce through semipermeable membrane after extracting liquid metal, liquid metal is injected.
Embodiment 2:
Fig. 2 is the structural representation of the liquid metal artificial cell of one embodiment of the present invention.The present embodiment artificial
Cell shape assumes flat-disk shape erythrocyte, and electrolyte solution 4 used is the sodium hydroxide solution of 0.3mol/l for concentration.Its
Remaining component is consistent with embodiment 1 with manufacture method.Here, the semi-transparent membrane structure of flat-disk shape, mainly mould why are adopted
Intend erythrocyte.
Embodiment 3:
Fig. 3 is the structural representation of the liquid metal artificial cell of one embodiment of the present invention.The present embodiment is except shape
Shape is in outside major axis shape, and remaining component and manufacture method are completely the same with embodiment 1.Here, why adopt the half of long shape shaft
The structure of permeable membrane structure, mainly imictron.Further, also can dendritic structure be set, not shown here.
Embodiment 4:
Fig. 4 is the structural representation of the liquid metal artificial cell of one embodiment of the present invention.The present embodiment is multiple
The assembly of cell, the component of its individual cells and manufacture method are completely the same with embodiment 1.
Embodiment 5:
The present embodiment is the assembly (figure is not drawn into) of multiple cells, basically identical with embodiment 4, but uses reality
Apply the class neuronal cell assembly that example 3 obtains, calculate in order to analog neuron.
Embodiment 6:
Fig. 5 is the structural representation of the liquid metal artificial cell of one embodiment of the present invention.The present embodiment is in shape
Completely the same with embodiment 1, but slightly distinguish with embodiment 1 in component and manufacture method.Here, also added in semipermeable membrane and add
Plus thing 3 such as diameter is in the copper of 500nm or alumina particles, the quality of additive accounts for the 10% of electrolyte solution quality, to realize more
Multi-functional and behavior.Additive 3 can be loaded in electrolyte 4 environment in semipermeable membrane 1 or liquid metal 2 according to actual needs
Interior.
Embodiment 7:
The present embodiment is basically identical with embodiment 4, and simply additive 3 is filament, such as diameter 500nm, length 1cm
Copper wire.
Embodiment 8:
Semipermeable membrane 2 is polyfluortetraethyleventilated ventilated membrane.Semipermeable membrane 1 described in the present embodiment is designed as spherical, diameter 1cm, uses
To simulate oocyte Shape closed cavity.The quality of described liquid metal 2 is 0.2g, is the gallium-indium-tin alloy of 11 DEG C of fusing point, electricity
Solution liquid 4 is the sodium hydroxide solution of 0.2mol/l, and volume is 0.3ml.
Preparation process is:
1) take semipermeable membrane material, curve spherical, become closing chamber with thin nylon tow, obtain spherical semipermeable membrane space；
2) adopt injection needle (4# syringe needle) to extract electrolyte solution, pierce through semi-transparent perineurium mouth afterwards, electrolyte is injected；
3) prepare liquid metal, using injection needle (4# syringe needle), after extracting liquid metal, pierce through semi-transparent perineurium mouth, by liquid
State metal injects.
Filamentary silver as the working electrode of all insulation of remaining surface in addition to end, the exposed 0.3mm of filamentary silver of its end, after use
Polytetrafluoroethylmaterial material coats, and is inserted in liquid metal by semi-transparent perineurium mouth, then tightens semipermeable membrane；Another filamentary silver be
To electrode, it is attached to semi-transparent film outer surface, working electrode and electrode is connected with electrochemical workstation, constitute two electrode systems, inspection
Survey the response to the signal of telecommunication for this liquid metal artificial cell.
Above embodiment is only that the specific embodiment to the present invention is described, and not the scope of the present invention is entered
Row limits, and those skilled in the art also can do numerous modifications and variations on the basis of existing technology, set without departing from the present invention
On the premise of meter spirit, various modifications and improvement that this area ordinary skill technical staff makes to technical scheme,
All should fall in the protection domain of claims of the present invention determination.
Claims (10)
1. a kind of liquid metal artificial cell is it is characterised in that include semipermeable membrane, liquid metal and electrolyte；Described semipermeable membrane
Surround the cavity of closing, liquid metal and electrolyte are within the cavity.
2. liquid metal artificial cell according to claim 1 is it is characterised in that the material of described semipermeable membrane is biological thin
After birth, pericystium, parchment paper, eggshell membrane, graphene film, carbon nano-tube film, polyfluortetraethyleventilated ventilated membrane, ethylethylene
One of collodion thin film of film, oxirane film and artificial system；Being shaped as of the cavity that described semipermeable membrane surrounds is spherical, flat
Circular, oval spherical or elongated cylindrical, the size of cavity is 10 μm～2cm.
3. liquid metal artificial cell according to claim 1 is it is characterised in that described liquid metal is metal simple-substance
One or more of gallium, bianry alloy, ternary alloy three-partalloy, wherein said bianry alloy is gallium indium, gallium stannum, in gallium kirsite one
Plant or several, described ternary alloy three-partalloy is one or more of gallium indium tin, gallium indium zinc, gallium red brass.
4. liquid metal artificial cell according to claim 1 is it is characterised in that described electrolyte is sodium hydroxide, hydrogen
One of potassium oxide, sodium chloride, sulphuric acid and nitre aqueous acid, the concentration of solution is 0.1～5mol/l.
5. the liquid metal artificial cell according to any one of Claims 1 to 4 is it is characterised in that the chamber of described semipermeable membrane
Also contain additive in vivo, described additive is copper between 10nm to 1000 μm for the size, indium, stannum, zinc, silver, ferrum, nickel, manganese,
The granule of one or more of cobalt, magnesium, aluminum metal；Or in silicon, silicon dioxide, graphite, Graphene, plastics, elastomeric material
One or more of granule, the quality of additive accounts for the 1～20% of electrolyte quality.
6. liquid metal artificial cell according to claim 5 it is characterised in that the particle surface of described metal have copper,
Indium, stannum, zinc, silver, ferrum, nickel, manganese, cobalt, magnesium, aluminum one of which or several clads, or have nonmetal-coated layer.
7. the preparation method of the arbitrary described liquid metal artificial cell of claim 1～6 is it is characterised in that include step:
1) take semipermeable membrane material, curve the mode that spherical blend compounds glue, sew or tighten and be fabricated to closing chamber, that is, obtain closing
Semipermeable membrane space；
2) adopt injection needle, extract electrolyte solution, pierce through semipermeable membrane afterwards, electrolyte is injected；
3) prepare liquid metal, using injection needle, pierce through semipermeable membrane after extracting liquid metal, liquid metal is injected, electrolysis
The volume of matter and liquid metal accounts for the 20～90% of the space of semi-transparent membrane closure；
The needle diameter of described injection needle is 1～500 micron.
8. the preparation method of liquid metal artificial cell according to claim 7 is it is characterised in that further comprise the steps of:
4) extract, with injection needle, the electrolyte suspension including additive, pierce through semipermeable membrane afterwards, suspension is injected.
9. the preparation method of the liquid metal artificial cell according to claim 7 or 8 will be it is characterised in that will prepare
Artificial cell stack and be fixedly assembled, obtain aggregative cell assembly.
10. application in biosensor, bionical element for the arbitrary described liquid metal artificial cell of claim 1～6.
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| CN109605356A (en) * | 2018-11-16 | 2019-04-12 | 中国科学院理化技术研究所 | A kind of liquid metal flexible machine that imitative serpentine locomotion can be carried out from driving |
| CN111198052A (en) * | 2020-01-14 | 2020-05-26 | 清华大学 | Deformable liquid sensor |
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| CN106370493B (en) | 2018-10-16 |
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