CN106362811B - A kind of micro-fluidic chip measuring pressure change in the deformable channel of wall surface - Google Patents
A kind of micro-fluidic chip measuring pressure change in the deformable channel of wall surface Download PDFInfo
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- CN106362811B CN106362811B CN201610757833.1A CN201610757833A CN106362811B CN 106362811 B CN106362811 B CN 106362811B CN 201610757833 A CN201610757833 A CN 201610757833A CN 106362811 B CN106362811 B CN 106362811B
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- channel
- pressure
- drop formation
- wall surface
- pressure comparison
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
Abstract
The invention discloses the micro-fluidic chip of pressure change in a kind of deformable channel of measurement wall surface, the present invention indicates that pressure at both sides is poor by comparing the displacement and direction of comparison two channel liquid interface of interface.Since groove structure will be added in the main channel lower wall surface of drop formation in deformable lower wall surface microchannel, and it is limited by precision is made, the width of groove structure is more than the width of microchannel structure main channel, to form complete thin-wall face structure in the width direction of main channel, so the upstream in drop formation channel and pressure comparison channel will separate design to avoid interfering with each other, drop formation channel and pressure comparison channel are 90 ° of fold-line-shapeds.Since pressure signal can gradually be decayed in transmittance process, pressure comparison interface be unable to chaotropic drop cross it is too far at generation.The present invention indicates the pressure change in drop formation channel using the direction of displacement and size at interface, operating method simple, intuitive, and experiment effect is reliable and stable.
Description
Technical field
The present invention relates to one kind being based on the deformable drop formation structure of wall surface, by the side wall for improving drop formation downstream
Face structure increases a flow direction parallel comparison channel and pressure comparison interface, and it is deformable logical to form a kind of measurement wall surface
The comparison structure of pressure change in road.
Background technology
In recent years, it is rapidly developed by the microflow control technique of core of microlayer model technology, the presence of microlayer model brings one
A little outstanding advantages, small, large specific surface area, speed is fast, and flux is high, uniform in size, and system closing etc., these advantages make micro-
Drop technique obtains extensive use in fields such as physics, chemistry, biology and multi-crossed disciplines.
In microlayer model technology, the generation and movement of drop/bubble will produce extra pressure, to the pressure of channel interior and
VELOCITY DISTRIBUTION produces a very large impact, and increases the functionality and complexity of system.Liquid is often utilized in experiment at present and engineering
Extra pressure that drop/bubble generates meets different demands, for example the pressure can carry out control logic as a kind of logical signal
Door or logic switch；The pressure change that multiple emulsion band comes also functions to very important effect in oil exploitation, can be by
Microlayer model technical modelling underground porous environment, and measure the pressure in laboratory level.In addition, two-phase in the presence of drop/bubble
The increased non-linear Laminar Flow situation that can be used for disturbing system under low reynolds number of interface, enhances the mixing effect of continuous phase
Rate.The realizations of these functions it should be understood that under various flox conditions different size droplets/bubbles system pressure is changed it is specific
Action rule.
Have much in the method for the minute yardstick conditioned measurement pressure, most directly a kind of is exactly by the sensor of micromation
It is embedded into the pressure change data that measurement point is obtained in microchannel, but since size sensor is larger, compatibility is unfriendly to be made
System structure is relative complex, measuring position and being restricted causes the pressure drop that can only measure single-phase flow or to measure a distance
The total pressure head of upper multiple drops.This allows for this method and is difficult to preferable insertion on many devices, on the other hand many situations
It is lower that we can be not necessarily to obtain specific numerical value more concerned about the pressure trend under drop different conditions.
Invention content
The present invention is based on the deformable T-type microlayer model generating structure of the wall surface of design, change crosses at generating structure downstream
Side wall surface, increase the flow direction comparison channel and pressure comparison interface parallel with main channel, by comparing comparison interface
The displacements of two channel liquid interfaces and direction indicate that pressure at both sides is poor.
To achieve the above object, the technical solution adopted by the present invention is pressure change in a kind of deformable channel of measurement wall surface
Micro-fluidic chip, entire micro-fluidic chip is made of cover plate 1, film layer 2 and substrate 3, and three parts are made of PDMS material；
In Fig. 1, cover plate 1 is internally provided with microchannel structure 4, and microchannel structure 4 is equipped with open side；Film layer 2 is flat surface；Substrate
3 are internally provided with groove structure 5, and open side also is provided on groove structure 5；In open side and groove structure 5 in microchannel structure 4
Open side and film layer 2 be in direct contact cooperation, cover plate 1, film layer 2 and about 3 substrate cooperatively form micro-fluidic chip successively
Overall structure, as shown in Figure 1.
As shown in Fig. 2, the microchannel structure 4 includes drop formation part and pressure comparison part；
Drop formation part is by 9 groups of discrete phase entrance 8, undyed continuous phase entrance 7, outlet 12 and drop formation channel
At；Pressure comparison part is made of continuous phase entrance 6, pressure comparison channel 10 and the outlet 12 dyed；
The outlet 12 of drop formation part and the 12 same mouth of outlet of pressure comparison part；Drop formation channel 9 it is upper
Trip is connected with discrete phase entrance 8 and undyed continuous phase entrance 7, and the downstream in drop formation channel 9 is communicated with outlet 12；Pressure
The upstream in comparison channel 10 is connected with the continuous phase entrance 6 of dyeing, and the downstream in pressure comparison channel 10 is also communicated with outlet 12；Liquid
Drop generates channel 9 and pressure comparison channel 10 and is connected by pressure comparison interface 11 in the downstream of drop formation；First alignment slot
13 are arranged in microchannel structure 4, and the structure being illustrated in figure 3 on substrate 3, the second alignment slot 14 is arranged on groove structure 5；
First alignment slot 13 is corresponding with the second alignment slot 14, to ensure that cover plate 1, film layer 2 are connected with the bonding of substrate 3.
Since groove structure will be added in the main channel lower wall surface of drop formation in deformable lower wall surface microchannel, and made
Precision is limited, and the width of groove structure is more than the width of 4 main channel of microchannel structure, complete in the width direction of main channel to be formed
Thin-wall face structure, so the upstream in drop formation channel 9 and pressure comparison channel 10 will separate design to avoid interfering with each other,
Drop formation channel 9 and pressure comparison channel 10 are 90 ° of fold-line-shapeds.On the other hand, the meeting in transmittance process due to pressure signal
Gradually decaying, so in order to measure the pressure change during drop formation, pressure comparison interface 11 is unable to chaotropic and drips the life that crosses
It is too far at locating.
The present invention devises pressure comparison channel and pressure comparison interface, is indicated using the direction of displacement and size at interface
The pressure change in drop formation channel, operating method simple, intuitive, experiment effect are reliable and stable.
Description of the drawings
Fig. 1 is a kind of three-dimensional general outline measuring the micro-fluidic chip of pressure change in the deformable channel of wall surface of the present invention
Schematic diagram.
Fig. 2, which is that the present invention is a kind of, measuring in wall surface deformable channel microchannel structure in the micro-fluidic chip of pressure change
Schematic diagram.
Fig. 3, which is that the present invention is a kind of, measuring showing for the micro-fluidic chip concave slot structure of pressure change in wall surface deformable channel
It is intended to.
Fig. 4 be the present invention it is a kind of measure in wall surface deformable channel the microfluidic chip liquid drop generating process of pressure change and
Different moments in motion process, the interface variation diagram of pressure comparison interface.Wherein, (a) is flat for pressure comparison interface pressure at both sides
Surface chart when weighing apparatus is (b) surface chart at drop formation moment, is (c) surface chart of the drop at certain moment of movement.
In figure：1, cover plate, 2, film layer, 3, substrate, 4, microchannel structure, 5, groove structure, 6, the continuous phase of dyeing enters
Mouthful, 7, undyed continuous phase entrance, 8, discrete phase entrance, 9, drop formation channel, 10, pressure comparison channel, 11, pressure pair
Than interface, 12, outlet, the 13, first alignment slot, the 14, second alignment slot.
Note：
1, the microchannel structure in Fig. 1 is schematic diagram, and the pressure comparison structure in experiment is shown in Fig. 2；
2, the experiment condition that the interface variation diagram provided in Fig. 4 measures：Undyed oil phase pressure is 56mbar, dyes
Oil phase pressure is 35mbar, discrete phase pressure is 14-17mbar.
Specific implementation mode
With reference to Structure Figure to inventing the micro-fluidic chip of pressure change in a kind of deformable channel of measurement wall surface
The course of work and function and effect are described in detail.
The specific work process of the present apparatus is as follows：Drop formation part, discrete phase liquid are flowed into from discrete phase entrance 8, not
The continuous phase liquid of dyeing is flowed into from undyed continuous phase entrance 7, the two phase at the structure that crosses in drop formation channel 9
It meets, discrete phase liquid crushing forms drop and with continuous phase toward downstream flow, eventually by 12 outflow chip of outlet.Pressure
Part is compared, the continuous phase liquid of dyeing is flowed into from the continuous phase entrance 6 of dyeing, and outlet is flowed to by pressure comparison channel 10
12.The continuous phase liquid being passed through from the continuous phase entrance 6 and undyed continuous phase entrance 7 of dyeing is same liquid, difference
What is flowed in the channel for being the continuous phase entrance 6 of dyeing is the liquid being colored, so can be with shape at pressure comparison interface 11
At the interface that is clear and stablizing that demarcates, which can be displaced according to the pressure difference in two edge channels.
Adjusting pressure at both sides as shown in Fig. 4 (a), before drop formation makes the interface of pressure comparison interface be in interposition
It sets, in this, as the benchmark of subsequent contrast's experiment.Fig. 4 (b) show drop formation process median surface variation diagram, at this time interface
Displacement downwards；Fig. 4 (c) show liquid drop movement process median surface variation diagram, at this time interface upward displacement.It, can by comparison
To be clearly observed in generation and motion process, the corresponding of displacement is closed up and down with comparison interface interface for droplet flow position
System.
Claims (2)
1. a kind of micro-fluidic chip measuring pressure change in the deformable channel of wall surface, it is characterised in that：Entire micro-fluidic chip
It is made of cover plate (1), film layer (2) and substrate (3), three parts are made of PDMS material；Cover plate (1) is internally provided with microchannel
Structure (4), microchannel structure (4) are equipped with open side；Film layer (2) is flat surface；Substrate (3) is internally provided with groove structure
(5), it also is provided with open side on groove structure (5)；The open side in open side and groove structure (5) in microchannel structure (4)
It is in direct contact cooperation with film layer (2), cover plate (1), film layer (2) and substrate (3) cooperatively form micro-fluidic chip successively up and down
Overall structure；
The microchannel structure (4) includes drop formation part and pressure comparison part；
Drop formation part is by discrete phase entrance (8), undyed continuous phase entrance (7), outlet (12) and drop formation channel
(9) it forms；Pressure comparison part is made of continuous phase entrance (6), pressure comparison channel (10) and the outlet (12) dyed；
The outlet (12) of drop formation part and the outlet (12) of pressure comparison part are the same mouths；Drop formation channel (9)
Upstream be connected with discrete phase entrance (8) and undyed continuous phase entrance (7), the downstream and outlet of drop formation channel (9)
(12) it communicates；The upstream in pressure comparison channel (10) is connected with the continuous phase entrance (6) of dyeing, under pressure comparison channel (10)
Trip is also communicated with outlet (12)；Drop formation channel (9) and pressure comparison channel (10) pass through pressure in the downstream of drop formation
Interface (11) is compared to connect；First alignment slot (13) is arranged in microchannel structure (4), and the second alignment slot (14) is arranged in groove
In structure (5)；First alignment slot (13) is corresponding with the second alignment slot (14), to ensure cover plate (1), film layer (2) and base
The bonding of piece (3) connects.
2. a kind of micro-fluidic chip measuring pressure change in the deformable channel of wall surface according to claim 1, feature
It is：Since groove structure will be added in the main channel lower wall surface of drop formation in deformable lower wall surface microchannel, and it is smart by making
Degree is limited, and the width of groove structure is more than the width of microchannel structure (4) main channel, complete in the width direction of main channel to be formed
Thin-wall face structure, so the upstream of drop formation channel (9) and pressure comparison channel (10) will separate design to avoid mutual
Interference, drop formation channel (9) and pressure comparison channel (10) are 90 ° of fold-line-shapeds；Due to pressure signal meeting in transmittance process
Gradually decaying, so in order to measure the pressure change during drop formation, pressure comparison interface (11) is unable to chaotropic drop and crosses
It is too far at generation.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610757833.1A CN106362811B (en) | 2016-08-29 | 2016-08-29 | A kind of micro-fluidic chip measuring pressure change in the deformable channel of wall surface |
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| CN201610757833.1A CN106362811B (en) | 2016-08-29 | 2016-08-29 | A kind of micro-fluidic chip measuring pressure change in the deformable channel of wall surface |
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| CN106362811B true CN106362811B (en) | 2018-07-13 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107913745B (en) * | 2017-11-16 | 2020-08-07 | 北京工业大学 | Micro-droplet generation chip based on pressure coupling effect of double-layer channel |
| CN107930708B (en) * | 2017-11-16 | 2020-01-10 | 北京工业大学 | Micro-fluidic chip for measuring pressure change in deformable micro-channel on downstream wall surface |
| CN109682574B (en) * | 2019-01-14 | 2020-10-27 | 北京工业大学 | Device and method for measuring flow resistance of micro-droplets/bubbles in motion in channel in real time |
| CN112657565B (en) * | 2020-12-17 | 2022-08-19 | 京东方科技集团股份有限公司 | Microfluidic channel, control method thereof, microfluidic chip and analysis device |
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