CN106361839A - Pain-alleviating patch and preparation method thereof - Google Patents

Abstract

The invention provides a pain-alleviating patch, which consists of the following raw materials: radix aconiti kusnezoffii, rhizoma ligustici wallichii, radix angelicae sinensis, radix paeoniae alba, radix angelicae, fructus forsythiae, white poria, roots of three-nerved spicebush, radix aconiti, myrrh, radix sophorae flavescentis and sesame oil; and by virtue of a conventional method, a plaster is prepared. The pain-alleviating patch can be used for effectively treating lumbar spondylosis, cervical spondylosis, rheumatism, rheumatoid disease, ankylosing spondylitis and the like; and the pain-alleviating patch is simple to operate and significant in curative effect, and the pain-alleviating patch is capable of greatly reducing treatment cost.

Description

One kind goes pain patch and preparation method thereof

Technical field

The invention belongs to pharmaceutical technology field is and in particular to one kind goes pain patch and preparation method thereof

Background technology

Clinical statisticses show, the middle-aged and elderly people that the age is more than 50 years old person more than 40% has uncomfortable, different parts pain The situation of pain；Wherein 60% can produce neck, lumbal vertebra, thus disease in pressuring nerve system leads to local pain；About The patient of 10%-15% eventually develops into overall pain, and life is rough to take care of oneself.For this reason, substantial amounts of analgesic drug products arise at the historic moment, The many toxic and side effects of oral pain alleviating medicine are big, unsuitable long-term taking, so needing a kind of Small side effects, and must be advantageously used in auxiliary and control Treat the medicine of pain.

Content of the invention

The invention provides one kind goes pain patch, raw material composition includes Radix Aconiti Kusnezoffii, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Radix Polygoni Ciliinerve, the Radix Angelicae Dahuricae, Fructus Forsythiae, in vain Siberian cocklebur, the Radix Linderae, Radix Aconiti, Myrrha, Radix Sophorae Flavescentiss and Oleum sesami, make Chinese herbs paste by conventional method, by local stick, point-application Etc. mode, make full use of its constant drug effect and improve local microcirculation, play antiinflammatory, detumescence, strengthen metabolism, and pass through local absorption Heat effect after heat and drug effect makes skin temperature raise, thus reaching static physiotherapy, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, wind-dispelling remove Wet, effect of relaxing muscles and tendons and activating QI and blood in the collateral.Can be used for auxiliary treatment traumatic injury, lumbar muscle strain, arthritis, joint numbness pain, scapulohumeral periarthritis, The bone injury ache disease such as hyperosteogeny, bones and muscles pain.

Further, the present invention goes the raw material medicines in portions by weight of pain patch to consist of: 3～5 parts of Radix Aconiti Kusnezoffii, 3～5 parts of Rhizoma Chuanxiong, Radix Angelicae Sinensis 4 ～6 parts, 4～6 parts of Radix Polygoni Ciliinerve, 3～5 parts of the Radix Angelicae Dahuricae, 4～6 parts of Fructus Forsythiae, 4～6 parts of Poria, 4～6 parts of the Radix Linderae, 3～5 parts of Radix Aconiti, Myrrha 1.5～2.5 parts, 2.5～3.5 parts of Radix Sophorae Flavescentiss and 80～120 parts of Oleum sesami.

Further, the present invention goes the raw material medicines in portions by weight of pain patch to consist of: 4 parts of Radix Aconiti Kusnezoffii, 4 parts of Rhizoma Chuanxiong, 5 parts of Radix Angelicae Sinensis, 5 parts of Radix Polygoni Ciliinerve, 4 parts of the Radix Angelicae Dahuricae, 5 parts of Fructus Forsythiae, 5 parts of Poria, 5 parts of the Radix Linderae, 4 parts of Radix Aconiti, 2 parts of Myrrha, 3 parts of Radix Sophorae Flavescentiss and 100 parts of Oleum sesami.

The present invention goes the preparation method of pain patch, comprises the following steps:

(1) extract spice: take true Oleum Sesami to put in container, heating, put into other crude drug after slight fever, stir, until spice To surface dark brown, internal sallow, remove medicinal residues, obtain medicine oil standby；

(2) refine oil: take step (1) gained medicine oil to continue to temper, treat that oil temperature rises to 320 degree, use moderate heat instead, refine to Drip beading；

(3) pilling and pasting: after medicine oil is smelt, from Huo Xiadan, agitate by adding, stir into mastic；

(4) releasing fire-toxin: mastic is put into cold water, soaks, change a water each day, continuous 7 days；

(5) become patch: take cream body is placed in container, fusing, stir evenly, take a certain amount of mastic to be coated in medicated plaster cloth, obtain final product.This Inventing the technique effect reaching has:

1. prescription of the present invention includes Radix Aconiti Kusnezoffii, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Radix Polygoni Ciliinerve, the Radix Angelicae Dahuricae, Fructus Forsythiae, Poria, the Radix Linderae, Radix Aconiti, Myrrha, hardship Ginseng and Oleum sesami, compatibility is precise and appropriate, Radix Aconiti and Radix Aconiti Kusnezoffii be medicine to being monarch drug altogether, be used together the effect playing expelling wind and removing dampness altogether, alleviate complete Body pain；The Radix Angelicae Dahuricae, the Radix Linderae, Myrrha, Radix Sophorae Flavescentiss are ministerial drug, and auxiliary plays alleviating pain, and dehumidifying of stimulating the menstrual flow, the auxiliary disease for the treatment of, Radix Angelicae Sinensis, red Medicine, Fructus Forsythiae, Poria are adjuvant drug, blood circulation promoting and blood stasis dispelling, dredging the meridian, no pain by smooth breath；Rhizoma Chuanxiong is to make, inducting the medicines into affected channel.All medicines share, its effect Concentrate one's efforts grand, permeate space between skin and muscles, through focus, have special effect to unreasonable scrofula symptom.

2. the present invention follows strictly orthodox school's Gu method of black plaster and is boiled, that is, so-called " red two oil, plaster is in thick, and three Under upper three, endure withered remove slag, beading of dripping, from Huo Xiadan, red ripe good fortune, cold water underground." plaster that is smelt with this method, its shape is black Like painting, heat is then soft, and cool then hard, that pastes glues, and that pulls out rises.

Specific embodiment

Embodiment 1

One kind goes pain patch, raw material composition include Radix Aconiti Kusnezoffii, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Radix Polygoni Ciliinerve, the Radix Angelicae Dahuricae, Fructus Forsythiae, Poria, the Radix Linderae, Radix Aconiti, Myrrha, Radix Sophorae Flavescentiss and Oleum sesami, its preparation method is as follows:

(1) extract spice: take Oleum sesami to put in container, heating, put into other crude drug after slight fever, stir, until spice To surface dark brown, internal sallow, remove medicinal residues, obtain medicine oil standby；

(2) refine oil: take step (1) gained medicine oil to continue to temper, treat that oil temperature rises to 320 degree, use moderate heat instead, refine to Drip beading；

(3) pilling and pasting: after medicine oil is smelt, from Huo Xiadan, agitate by adding, stir into mastic；

(4) releasing fire-toxin: mastic is put into cold water, soaks, change a water each day, continuous 7 days；

(5) become patch: take cream body is placed in container, fusing, stir evenly, take a certain amount of mastic to be coated in medicated plaster cloth, obtain final product.

Embodiment 2

One kind goes pain patch, and raw material medicines in portions by weight consists of: 3～5 parts of Radix Aconiti Kusnezoffii, 3～5 parts of Rhizoma Chuanxiong, 4～6 parts of Radix Angelicae Sinensis, Radix Polygoni Ciliinerve 4 ～6 parts, 3～5 parts of the Radix Angelicae Dahuricae, 4～6 parts of Fructus Forsythiae, 4～6 parts of Poria, 4～6 parts of the Radix Linderae, 3～5 parts of Radix Aconiti, 1.5～2.5 parts of Myrrha, 2.5～3.5 parts of Radix Sophorae Flavescentiss and 80～120 parts of Oleum sesami.Its preparation method is as follows:

(1) extract spice: take Oleum sesami to put in container, heating, put into other crude drug after slight fever, stir, until spice To surface dark brown, internal sallow, remove medicinal residues, obtain medicine oil standby；

(2) refine oil: take step (1) gained medicine oil to continue to temper, treat that oil temperature rises to 320 degree, use moderate heat instead, refine to Drip beading；

(3) pilling and pasting: after medicine oil is smelt, from Huo Xiadan, agitate by adding, stir into mastic；

(4) releasing fire-toxin: mastic is put into cold water, soaks, change a water each day, continuous 7 days；

(5) become patch: take cream body is placed in container, fusing, stir evenly, take a certain amount of mastic to be coated in medicated plaster cloth, obtain final product.

Embodiment 3

One kind goes pain patch, and raw material medicines in portions by weight consists of: 4 parts of Radix Aconiti Kusnezoffii, 4 parts of Rhizoma Chuanxiong, 5 parts of Radix Angelicae Sinensis, 5 parts of Radix Polygoni Ciliinerve, the Radix Angelicae Dahuricae 4 Part, 5 parts of Fructus Forsythiae, 5 parts of Poria, 5 parts of the Radix Linderae, 4 parts of Radix Aconiti, 2 parts of Myrrha, 3 parts of Radix Sophorae Flavescentiss and 100 parts of Oleum sesami.Its preparation method is such as Under:

(1) extract spice: take Oleum sesami to put in container, heating, put into other crude drug after slight fever, stir, until spice To surface dark brown, internal sallow, remove medicinal residues, obtain medicine oil standby；

(2) refine oil: take step (1) gained medicine oil to continue to temper, treat that oil temperature rises to 320 degree, use moderate heat instead, refine to Drip beading；

(3) pilling and pasting: after medicine oil is smelt, from Huo Xiadan, agitate by adding, stir into mastic；

(4) releasing fire-toxin: mastic is put into cold water, soaks, change a water each day, continuous 7 days；

(5) become patch: take cream body is placed in container, fusing, stir evenly, take a certain amount of mastic to be coated in medicated plaster cloth, obtain final product.

Embodiment 4

One kind goes pain patch, and raw material medicines in portions by weight consists of: 3 parts of Radix Aconiti Kusnezoffii, 5 parts of Rhizoma Chuanxiong, 4 parts of Radix Angelicae Sinensis, 6 parts of Radix Polygoni Ciliinerve, the Radix Angelicae Dahuricae 3 Part, 4 parts of Fructus Forsythiae, 6 parts of Poria, 4 parts of the Radix Linderae, 5 parts of Radix Aconiti, 1.5 parts of Myrrha, 3.5 parts of Radix Sophorae Flavescentiss and 80 parts of Oleum sesami.Its preparation method As follows:

(1) extract spice: take Oleum sesami to put in container, heating, put into other crude drug after slight fever, stir, until spice To surface dark brown, internal sallow, remove medicinal residues, obtain medicine oil standby；

(2) refine oil: take step (1) gained medicine oil to continue to temper, treat that oil temperature rises to 320 degree, use moderate heat instead, refine to Drip beading；

(3) pilling and pasting: after medicine oil is smelt, from Huo Xiadan, agitate by adding, stir into mastic；

(4) releasing fire-toxin: mastic is put into cold water, soaks, change a water each day, continuous 7 days；

(5) become patch: take cream body is placed in container, fusing, stir evenly, take a certain amount of mastic to be coated in medicated plaster cloth, obtain final product.

Embodiment 5

One kind goes pain patch, and raw material medicines in portions by weight consists of: 5 parts of Radix Aconiti Kusnezoffii, 5 parts of Rhizoma Chuanxiong, 4 parts of Radix Angelicae Sinensis, 6 parts of Radix Polygoni Ciliinerve, the Radix Angelicae Dahuricae 3 Part, 6 parts of Fructus Forsythiae, 4 parts of Poria, 6 parts of the Radix Linderae, 3 parts of Radix Aconiti, 1.5 parts of Myrrha, 3.5 parts of Radix Sophorae Flavescentiss and 120 parts of Oleum sesami.Its preparation side Method is as follows:

(1) extract spice: take Oleum sesami to put in container, heating, put into other crude drug after slight fever, stir, until spice To surface dark brown, internal sallow, remove medicinal residues, obtain medicine oil standby；

(2) refine oil: take step (1) gained medicine oil to continue to temper, treat that oil temperature rises to 320 degree, use moderate heat instead, refine to Drip beading；

(3) pilling and pasting: after medicine oil is smelt, from Huo Xiadan, agitate by adding, stir into mastic；

(4) releasing fire-toxin: mastic is put into cold water, soaks, change a water each day, continuous 7 days；

(5) become patch: take cream body is placed in container, fusing, stir evenly, take a certain amount of mastic to be coated in medicated plaster cloth, obtain final product.

Test case

Case one

Mutually certain, female, 46 years old, teacher, symptoms include headache is stiff tired 15 days with neck and shoulder part.Patient is because bowing for a long time, head in fatigue Bitterly, with the aching and tired pain of back head substantially, stiff tired with neck and shoulder part, not with nausea, vomiting.Meet rotary head, bow, tired when above-mentioned disease Shape can increase.After prostration rest, symptom can have been alleviated.Since morbidity diet can, night not can, defecation is all normal.The past body constitution Typically, row Cholecystectomy in 2005, post-operative recovery is good.

Main physical signs: cervical curvature exists, cervical vertebra the 2nd spinous process is skewed to the left.Neck 2-3,3-4,4-5,5-6,6-7 spine Between tenderness (+), neck 2-3, the other tenderness of 3-4,4-5,5-6,6-7 spine left (+), right (+)；A rotation neck provocative test left side (-), right (-)；Head Neck separation test (-)；A brachial plexus nerve distraction test left side (-), right (-)；Last item test (-)；Cervical region mobility: anteflexion 30 °, after stretch 20 °, curved 30 ° of left side, 30 ° of right lateral bend.

After going pain patch one week using the embodiment of the present invention three gained, headache and the stiff tired symptom of cervical region disappear substantially.

Case two

Lee, man, 59 years old, peasant, main suit's flank pain 1 year, before 1 year, flank pain in the no obvious inducement of patient, with In the middle of waist, aching and tired pain is obvious.Without intermittent claudication, powerless without double lower limb.On bending over, sitting, long station, under During crouching, above-mentioned symptom increases, and after prostration rest, symptom has been alleviated.Since morbidity diet can, night not can, defecation is all normal.Both It is good for toward body, " hypertension " medical history 10 years.

Main physical signs: spinal column physiological camber exists, lumbar vertebra 3.4.5 spinous process offsets to the right, waist 3-4, waist 4-5, waist 5- sacrum 1 Between spine, the other tenderness of spine (+), piriformis tenderness left (+) right (+), femoral nerve test left (-) right (-), double lower limb straight legs are tested: left 60 degree (-), right 60 degree (-), very abdomen test of lying on the back (-) " 4 " word experiment left (-) right (-), thumb dorsiflexion test left (-) right side (-).

After going pain patch ten days using the embodiment of the present invention four gained, flank pain symptom disappears substantially.

Case three

Cao, male, 67 years old, teacher, the stiff tired companion of main suit's cervical region is dizzy, Nausea and vomiting January, the no obvious inducement of patient before January The stiff tired discomfort of cervical region occurs, with dizzy, with nausea, occasionally has vomiting, vomitus is gastric content, not with regarding thing rotation, not with double Upper extremity pain is numb, does not step on cotton sense with double lower limb.On rotary head, bow, tired when above-mentioned symptom can increase.Disease after prostration rest Shape has no alleviation, and once in local hospital " Neurology Department " with " cerebral infarction " hospitalization, symptom is improved inconspicuous.Drink since morbidity Food can, night not can, defecation is all normal.The past body constitution is general, has " chronic atrophic gastritis disease " medical history 8 years；Once went before 4 years " cholecystectomy ", postoperative general status are good；There is " chronic obstructive disease of lung " medical history 2 years；In " cerebral infarction disease " medical history January, the state of an illness is steady.

Training checks: cervical curvature straightens, neck 2-3, tenderness between 3-4,4-5,5-6,6-7 spine (+), the other tenderness of spine is left (+), right (+)；A rotation neck provocative test left side (+), right (+)；Head and neck separation test (+)；A brachial plexus nerve distraction test left side (-), right (-)；Last item test (-)；Cervical region mobility: anteflexion 25 °, after stretch 25 °, curved 25 ° of left side, 25 ° of right lateral bend, double upper extremity strength are just Often.

After going pain patch ten days using the embodiment of the present invention five gained, the stiff tired companion of cervical region is dizzy, Nausea and vomiting symptom disappears substantially Lose.

Case four

Qiu, female, 31 years old, General Office Clerk, main suit flank pain companion lower-left acroanesthesia 1 year, the long-term sitting of patient before 1 year After flank pain occurs, with pain on the left of waist substantially, in intermittent attack.With lower-left acroanesthesia, more than left lower extremity shank Numb obvious.On bending over, sitting, above-mentioned symptom increases when squatting down, and after prostration rest, symptom has been alleviated.Once in local hospital After row massage, physical therapy treatment, the state of an illness has taken a turn for the better.Since morbidity diet can, night not can, defecation is all normal.

Main physical signs: spinal column physiological camber exists, neck 2-3, neck 5-6, a neck 6-7 spine other tenderness left side (+) right (-), waist 4-5, On waist 5- sacrum 1 spine, tenderness between spine (+), the other tenderness of spine left (+) right (-), double lower limb straight-leg raising test: left 70 degree, 70 degree of the right side, Strengthen test left (+) right (-), piriformis tenderness left (+) right (+), femoral nerve stretching test left (-) right (-), the test of " 4 " word is left (-) the right side (-), a thumb dorsiflexion test left side (-) right (-) very abdomen test of lying on the back (-), pick-up test (-).

Go after pain patch first quarter moon using the embodiment of the present invention three gained, flank pain symptom disappears substantially.

Case five

Meng, man, 55 years old, peasant, main suit's left upper extremity pain 1 year, patient is because bowing for a long time, left upper extremity pain in fatigue Bitterly, not with nausea, vomiting.Meet rotary head, bow, tired when above-mentioned symptom can increase.After prostration rest, symptom can have been alleviated.In To our hospital before today.Since morbidity diet can, night not can, defecation is all normal.The past body constitution is poor；Have that " hole is aroused in interest Too slow " medical history.There is " hypertension " medical history 1 year, maximal blood pressure value 140/100mmhg oral drugs, controlling of blood pressure is preferable.2004 Year, row lumbar vertebra vertebral plate started decompression, and post-operative recovery is good.

Main physical signs: cervical curvature exists, cervical vertebra the 2nd spinous process is skewed to the left. neck 2-3.3-4.4-5.5-6.6-7 spine Between tenderness (+), the other tenderness of spine left (+), right (+)；A rotation neck provocative test left side (-), right (-)；Head and neck separation test (-)；Brachial plexus god Through distraction test left (-), right (-)；Last item test (-)；Cervical region mobility: anteflexion 30 °, after stretch 20 °, curved 30 ° of left side, right lateral bend 30°.

After going pain patch ten days using the embodiment of the present invention four gained, left upper extremity pain symptom disappears substantially.

Case six

High certain, man, 39 years old, driver, main suit's flank pain 5 years, before half a year, flank pain in patient's no obvious inducement, Obvious with pain on the left of waist；Pain on front side of left lower extremity thigh in these last few days.On long-time walking, tired, suffer from cold when Above-mentioned symptom increases, and after prostration, symptom is alleviated earlier above is not apparent.Since morbidity diet can, night not can, defecation is all normal.

Main physical signs: lumbar lateral curvature, waist 4.5 Vertebral rotation misplaces.Tenderness between waist 4-5, waist 5- sacrum 1 spine, on spine (+) by spine Tenderness left (+) right (+), double lower limb straight-leg raising test: left 40 degree, right 70 degree, strengthen a test left side (-) right side (-), piriformis tenderness Left (-) right (-).Femoral nerve stretching test left (-) right (-) " 4 " word test left (+) right (-), thumb dorsiflexion test left (-) right (-) Lie on the back very abdomen test (+), pick-up test (+).

After going pain patch one week using the embodiment of the present invention five gained, flank pain symptom disappears substantially.

Claims (4)

1. one kind goes pain patch it is characterised in that including following crude drug:

Radix Aconiti Kusnezoffii, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Radix Polygoni Ciliinerve, the Radix Angelicae Dahuricae, Fructus Forsythiae, Poria, the Radix Linderae, Radix Aconiti, Myrrha, Radix Sophorae Flavescentiss and Oleum sesami.

2. a kind of according to claim 1 go pain patch it is characterised in that the weight portion of described crude drug is as follows:

3～5 parts of Radix Aconiti Kusnezoffii, 3～5 parts of Rhizoma Chuanxiong, 4～6 parts of Radix Angelicae Sinensis, 4～6 parts of Radix Polygoni Ciliinerve, 3～5 parts of the Radix Angelicae Dahuricae, 4～6 parts of Fructus Forsythiae, Poria 4～ 6 parts, 4～6 parts of the Radix Linderae, 3～5 parts of Radix Aconiti, 1.5～2.5 parts of Myrrha, 2.5～3.5 parts of Radix Sophorae Flavescentiss and 80～120 parts of Oleum sesami.

3. a kind of according to claim 1 go pain patch it is characterised in that the weight portion of described crude drug is as follows:

4 parts of Radix Aconiti Kusnezoffii, 4 parts of Rhizoma Chuanxiong, 5 parts of Radix Angelicae Sinensis, 5 parts of Radix Polygoni Ciliinerve, 4 parts of the Radix Angelicae Dahuricae, 5 parts of Fructus Forsythiae, 5 parts of Poria, 5 parts of the Radix Linderae, 4 parts of Radix Aconiti, 2 parts of Myrrha, 3 parts of Radix Sophorae Flavescentiss and 100 parts of Oleum sesami.

4. according to a kind of arbitrary described preparation method going pain patch of claim 1-3 it is characterised in that comprising the following steps:

(1) extract spice: take Oleum sesami to put in container, heating, put into other crude drug, stirring after slight fever, until spice is to table Face dark brown, internal sallow, remove medicinal residues, obtain medicine oil standby；

(2) refine oil: take step (1) gained medicine oil to continue to temper, treat that oil temperature rises to 320 degree, use moderate heat instead, refine to dripping Beading；

(3) pilling and pasting: after medicine oil is smelt, from Huo Xiadan, agitate by adding, stir into mastic；

(4) releasing fire-toxin: mastic is put into cold water, soaks, change a water each day, continuous 7 days；

(5) become patch: take cream body is placed in container, fusing, stir evenly, take a certain amount of mastic to be coated in medicated plaster cloth, obtain final product.