CN106338608B - A kind of Gynecological secretion automatic checkout equipment - Google Patents
A kind of Gynecological secretion automatic checkout equipment Download PDFInfo
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- CN106338608B CN106338608B CN201610775311.4A CN201610775311A CN106338608B CN 106338608 B CN106338608 B CN 106338608B CN 201610775311 A CN201610775311 A CN 201610775311A CN 106338608 B CN106338608 B CN 106338608B
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- flow cell
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- gynecological secretion
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
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- Life Sciences & Earth Sciences (AREA)
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Abstract
The invention discloses a kind of Gynecological secretion automatic checkout equipments comprising：Pedestal is set to the flow cell for acquiring original sample and the flat sample flow of boil down on the pedestal；It is set on the pedestal and is used to be imaged positioned at the flow cell side imaging device of sample in flat sample flow；It is set on the pedestal and is used to be imaged the beam condensing unit that sample provides light for the imaging device positioned at the flow cell other side.Gynecological secretion automatic checkout equipment provided by the present invention, as a result of the flow cell for acquiring original sample and the flat sample flow of boil down to, and the imaging device for being imaged sample in flat sample flow, and the beam condensing unit of light is provided for imaging sample, so that the detection of Gynecological secretion can be completed by equipment high speed, and solve the problems, such as that sample is contaminated in detection process, improve the accuracy of Gynecological secretion detection, and the device structure is simple, production and use cost are low.
Description
Technical field
The present invention relates to secretion detection device technical field more particularly to a kind of Gynecological secretion, detection is set automatically
It is standby.
Background technology
Currently, domestic nearly all hospital is still manually performed the microscopy work of Gynecological secretion, when cervical arthroplasty, needs
Manual mixing sample is wanted, is observed further according to the actual conditions of sample, is all human eye subjective judgement, checks that speed is slow, also very
It is possible that the secretion sample of patient is mixed up.
Therefore, the existing technology needs to be improved and developed.
Invention content
In view of above-mentioned deficiencies of the prior art, the purpose of the present invention is to provide a kind of Gynecological secretion, detection is set automatically
Standby, which improves the detection efficiency and detection accuracy of Gynecological secretion detection, and the device structure is simple, reduces inspection
Survey cost.
Technical scheme is as follows：
A kind of Gynecological secretion automatic checkout equipment, wherein the Gynecological secretion automatic checkout equipment includes：Pedestal,
It is set to the flow cell for acquiring original sample and the flat sample flow of boil down on the pedestal；
It is set on the pedestal and is used to be imaged positioned at the flow cell side imaging dress of sample in flat sample flow
It sets；
It is set on the pedestal and is used to be imaged sample for the imaging device positioned at the flow cell other side and provide
The beam condensing unit of light.
Preferably, the Gynecological secretion automatic checkout equipment, wherein the beam condensing unit includes：For providing light
The light source of line,
It is set to the collecting lens for collecting the light emitted line of the light source between the light source and the flow cell；
It is set between the collecting lens and the flow cell and is radiated at the flowing after the collecting lens for controlling
The field stop of the field size of pond glazed thread；
It is set between the field stop and the flow cell for being put for the first time as filament projection in the light source
The aperture diaphragm of image space after big；
It is set between the aperture diaphragm and the flow cell for the filament once amplified projection convergence will to be passed through
Condenser.
Preferably, the Gynecological secretion automatic checkout equipment, wherein the imaging device includes：
Amplify the object lens of sample for the first time using the provided light of the beam condensing unit；
It is set to the attachment objective that the object lens are used to be imaged sample far from the flow cell side；
The attachment objective is set to far from the flow cell side and is connect with computer for receiving imaging sample
Image and the camera for being uploaded to computer to be analyzed.
Preferably, the Gynecological secretion automatic checkout equipment, wherein the Gynecological secretion automatic checkout equipment is also
Including：
It is set to the slide unit for driving the flow cell to be moved left and right along the pedestal on the pedestal；
The flow cell assemblies being connect with the slide unit, the flow cell are connected to the flow cell fixation kit.
Preferably, the Gynecological secretion automatic checkout equipment, wherein the Gynecological secretion automatic checkout equipment is also
Including：
It is set to the measurement part that the pedestal moves size for measuring the slide unit.
Preferably, the Gynecological secretion automatic checkout equipment, wherein the flow cell assemblies include：
The slide unit pinboard being connect with the slide unit；
The pitch regulation plate for adjusting the flow cell pitch angle and deflection angle is connect with the flow cell；
The connection backboard being set between the slide unit pinboard and pitch regulation plate；
And the pitch regulation plate is set to for controlling the pitch regulation plate and the tune of flow cell pitching and deflection
One integral piece.
Preferably, the Gynecological secretion automatic checkout equipment, wherein the Gynecological secretion automatic checkout equipment is also
Including：
It is fixed on the pedestal and connect the control moved left and right along the pedestal for controlling the slide unit with the slide unit
Motor processed.
Preferably, the Gynecological secretion automatic checkout equipment, wherein the Gynecological secretion automatic checkout equipment is also
Including：
It is set in the slide unit for moving left and right the photo-coupler that extreme position is defined to the slide unit.
Preferably, the Gynecological secretion automatic checkout equipment, wherein there are three the photo-coupler settings, three
The photo-coupler is respectively used to limit the initial position of the slide unit, the first extreme position and the second extreme position；
First extreme position is the proximal most position that the slide unit is allowed to the close imaging device；
Second extreme position is the proximal most position that the slide unit is allowed to the close beam condensing unit.
Preferably, Gynecological secretion automatic checkout equipment, wherein the Gynecological secretion automatic checkout equipment further includes：
It is set to the limited block that the pedestal is used to limit the slide unit shift position close to the imaging device.
Gynecological secretion automatic checkout equipment provided by the present invention, as a result of for acquiring original sample and compressing
For the flow cell of flat sample flow, and the imaging device for being imaged sample in flat sample flow, and provide for imaging sample
The beam condensing unit of light so that the detection of Gynecological secretion can be completed by equipment high speed, and be solved in detection process
The contaminated problem of sample improves the accuracy of Gynecological secretion detection, and the device structure is simple, production and use cost
It is low.
Description of the drawings
Fig. 1 is the structural schematic diagram of Gynecological secretion automatic checkout equipment preferred embodiment of the present invention.
Fig. 2 is the sectional view of Gynecological secretion automatic checkout equipment preferred embodiment of the present invention.
Specific implementation mode
The present invention provides a kind of Gynecological secretion automatic checkout equipment, to make the purpose of the present invention, technical solution and effect
It is clearer, clear, referring to the drawings and give an actual example that the present invention is described in more detail.It should be appreciated that described herein
Specific embodiment be only used to explain the present invention, be not intended to limit the present invention.
As shown in Figure 1, the present invention provides a kind of Gynecological secretion automatic checkout equipment, the Gynecological secretion is examined automatically
Measurement equipment includes：Pedestal 100 is set to the stream for acquiring original sample and the flat sample flow of boil down on the pedestal 100
Dynamic pond 200；It is set on the pedestal 100 and positioned at 200 side of the flow cell for being imaged sample in flat sample flow
Imaging device 300；It is set on the pedestal 100 and is used to be the imaging device 300 positioned at 200 other side of the flow cell
It is imaged the beam condensing unit 400 that sample provides light.
As shown in Fig. 2, in the embodiment of the present invention, the pedestal 100 includes that fixed plate is set to the fixed plate with four
The supporting rack of bottom end, the flow cell 200 are in cylindrical type, and bottom is provided with transparent window, is internally provided with for accommodating original
The inner cavity of beginning sample, the flow cell 200 are connected with by the inner cavity and carry original sample into the inner cavity for wrapping up
Liquid sheath, original sample the interior intracavitary by set and high speed compression flow to the position shot to form flat sample
It sets, the inner cavity includes the clamping accent for liquid sheath described in clamping, and for accommodating the original sample brought by the liquid sheath
Accommodating chamber section, and for accommodate flat sample flow in order to the imaging device 300 be imaged sample flat accommodating chamber section.
When it is implemented, the beam condensing unit 400 includes：Light source 410 for providing light, be set to the light source and
Collecting lens 420 between the flow cell for collecting the light emitted line of the light source；It is set to the collecting lens and the stream
Field stop 430 between dynamic pond for controlling the field size for being radiated at the flow cell glazed thread after the collecting lens；
It is set between the field stop and the flow cell for being imaged after amplifying for the first time as filament projection in the light source
The aperture diaphragm 440 of position；It is set between the aperture diaphragm and the flow cell for the filament once amplified will to be passed through
Project the condenser 450 assembled.
The beam condensing unit further includes：For fixing the light source 410, collecting lens 420, field stop 430, aperture respectively
Each shell of diaphragm 440 and condenser 450.
The light source 410, collecting lens 420, field stop 430, aperture diaphragm 440 and condenser 450 form micro- optically focused
System, specially Kohler illumination system, wherein the light source 410 is preferably stroboscopic light source, in order to which the camera is when taking pictures
Between match, reach and set out simultaneously with shooting time, improve the net synchronization capability of the Gynecological secretion automatic checkout equipment, save energy
While source consumes, the detection efficiency of equipment is improved.
The light source 410, collecting lens 420, field stop 430, aperture diaphragm 440 and condenser 450 and the flow cell
200, the object lens, the attachment objective and the camera are installed in same horizontal line.
With the above arrangement, ensure that 410 light emitted line of the light source by the collecting lens 420, field stop
430, after aperture diaphragm 440 and condenser 450 in viewing surface at directional light uniform irradiation to be measured in the flow cell 200
On sample.
The imaging device 300 includes：Amplify the object lens of sample for the first time using 400 provided light of the beam condensing unit
310；It is set to the attachment objective 320 that the object lens 310 are used to be imaged sample far from the flow cell side；It is set to described auxiliary
Object lens 320 are helped to be connect far from 200 side of the flow cell and with computer based on receiving imaging sample image and being uploaded to
Camera 330 of the calculation machine to be analyzed.
The camera 330 is preferably high speed camera, the high speed camera of 80fps or more can be especially preferably shot, to keep away
Cell has trailing phenomenon in sample when exempting from high-speed capture, need to carry out formula calculating first, to be amplified multiplying power and camera frame speed
Matching.
It specifically includes：Camera exposure time calculation formula：
T=e*n*v/m;
v=a/t;
t=1/f;
Wherein, T is the camera longest time for exposure when ensureing shooting picture without hangover；E is the pixel dimension of selected camera；n
When to generate trailing phenomenon, the occupied pixel quantity of same point；M is enlargement ratio；V is motor speed；A is for chip size
Captured photo size；T is the time occupied by every photo of shooting；F is camera capture rate, that is, camera frame number.
Such as：When same point is shown on two pixels simultaneously（n=2）When, that is, generate trailing phenomenon, it is assumed that selected camera picture
Elemental size e is 5.5um, and enlargement ratio m is 40 times；And each second shoots 80 pictures, i.e., is per pictures holding time t1
0.0125s reserves taking for longitudinal movement, is then equivalent to 79fps per second, then every holding time t is 0.0126s at this time,
Assuming that captured photo size a is 11.26mm, then it is 11.26mm/0.0126s=893.6mm/s that can obtain motor speed v, then
It is 5.5um × 2 to require T to the time for exposure of camera（2 pixels）/ 40 times/893.6mm/s=3.1us.
Fps, that is, Frames Per Second refer to the frame number of middle filling image per second (unit is frame/second).
By the way that high speed camera is arranged, the shooting speed and liquid for improving the Gynecological secretion automatic checkout equipment are clapped
The amount of taking the photograph；And by carrying out formula calculating in advance, enlargement ratio is ensure that under the premise of camera blur-free imaging, reaches maximum value,
So that motor when power-off it is also ensured that focus is inconvenient, then exercise the used time without being focused again, simplification
The simplicity of operation of the Gynecological secretion automatic checkout equipment.
After sample to be tested forms laminar flow, the camera 310 is triggered by the light source 410 and carries out high-speed capture, and is being clapped
Captured picture is directly uploaded to by computer by entity connecting line after taking the photograph, to carry out subsequent analysis；And at the same time, it carries out
Line clear, to carry out the detection of next sample.
Gynecological secretion automatic checkout equipment provided by the present invention, as a result of for acquiring original sample and compressing
For the flow cell of flat sample flow, and the imaging device for being imaged sample in flat sample flow, and provide for imaging sample
The beam condensing unit of light so that the detection of Gynecological secretion can be completed by equipment high speed, and be solved in detection process
The contaminated problem of sample improves the accuracy of Gynecological secretion detection, and the device structure is simple, production and use cost
It is low.
Further, the Gynecological secretion automatic checkout equipment further includes：It is set on the pedestal for driving institute
State the slide unit that flow cell is moved left and right along the pedestal；The flow cell assemblies being connect with the slide unit, the flow cell are connected to
The flow cell fixation kit.
Further, the Gynecological secretion automatic checkout equipment further includes：It is described for measuring to be set to the pedestal
Slide unit moves the measurement part of size.
The measurement part is the micrometer of setting on the base.
Further, the flow cell assemblies include：The slide unit pinboard being connect with the slide unit；Connect with the flow cell
Connect the pitch regulation plate for adjusting the flow cell pitch angle and deflection angle；It is set to the slide unit pinboard and pitching
Connection backboard between adjustable plate；And the pitch regulation plate is set to for controlling the pitch regulation plate and flow cell is bowed
The adjustment part faced upward and deflected.
The flow cell assemblies further include the cunning pearl contacted with the pitch regulation plate, and the adjustment part preferably adjusts spiral shell
Line pair can make the pitching adjustment version that angle offset occur along steel ball, described in reaching by rotating the adjustment screw thread pair
Pitch regulation between flow cell 200 and optical axis.
Further, the Gynecological secretion automatic checkout equipment further includes：Be fixed on the pedestal and with the slide unit
Connect the control motor moved left and right along the pedestal for controlling the slide unit.
The slide unit is connect by leading screw with the control motor, improve sensitivity that slide unit is moved along the pedestal and
Accuracy.
Further, the Gynecological secretion automatic checkout equipment further includes：It is set in the slide unit for described
Slide unit moves left and right the photo-coupler that extreme position is defined.
It ensure that the slide unit is limited by optocoupler by the way that the photo-coupler is arranged, protecting the flow cell 200
And while object lens 310, both avoids to collide with and cause liquid splash and the influence to detection result.
Further, there are three the photo-coupler settings, three photo-couplers are respectively used to limit the slide unit
Initial position, the first extreme position and the second extreme position；First extreme position is allowed to for the slide unit close to institute
State the proximal most position of imaging device；Second extreme position is the most peri position that the slide unit is allowed to the close beam condensing unit
It sets.
Further, the Gynecological secretion automatic checkout equipment further includes：Be set to the pedestal close to it is described at
As device is used to limit the limited block of the slide unit shift position.
Make the Gynecological secretion automatic checkout equipment by optocoupler position limitation protection by the way that the limited block is arranged
On the basis of, again by mechanical position limitation, while the further protection flow cell 200 and the object lens 310, avoid
The two, which is collided with, causes liquid splash and the influence to detection result.
It should be understood that the application of the present invention is not limited to the above for those of ordinary skills can
With improvement or transformation based on the above description, such as the flow cell cavity shape, all these modifications and variations should all belong to
In the protection domain of appended claims of the present invention.
Claims (8)
1. a kind of Gynecological secretion automatic checkout equipment, which is characterized in that the Gynecological secretion automatic checkout equipment includes：Bottom
Seat,
It is set to the flow cell for acquiring original sample and the flat sample flow of boil down on the pedestal；
It is set on the pedestal and is used to be imaged positioned at the flow cell side imaging device of sample in flat sample flow；
It is set on the pedestal and is used to be imaged sample for the imaging device positioned at the flow cell other side and light is provided
Beam condensing unit；
The pedestal includes the supporting rack that fixed plate and four are set to the fixed plate bottom end, and the flow cell is in cylindrical type,
Bottom is provided with transparent window, is internally provided with the inner cavity for accommodating original sample, and the flow cell passes through the inner cavity
It is connected with for wrapping up the liquid sheath for carrying original sample and entering the inner cavity, original sample passes through set and height in the interior intracavitary
Ram compression contracting flow to the position shot to form flat sample, and the inner cavity includes the clamping chamber for liquid sheath described in clamping
Mouthful, and the accommodating chamber section for accommodating the original sample brought by the liquid sheath, and for accommodate flat sample flow in order to
The flat accommodating chamber section of the imaging device imaging sample；
The beam condensing unit includes：Light source for providing light, the light source are stroboscopic light source；
It is set to the collecting lens for collecting the light emitted line of the light source between the light source and the flow cell；
It is set between the collecting lens and the flow cell and is radiated at the flow cell after the collecting lens for controlling
The field stop of the field size of light；
After being set between the field stop and the flow cell for amplifying as filament projection first time in the light source
The aperture diaphragm of image space；
It is set to the optically focused assembled between the aperture diaphragm and the flow cell for the filament once amplified projection will to be passed through
Mirror；
The imaging device includes：
Amplify the object lens of sample for the first time using the provided light of the beam condensing unit；
It is set to the attachment objective that the object lens are used to be imaged sample far from the flow cell side；
The attachment objective is set to far from the flow cell side and is connect with computer for receiving imaging sample image
And the camera for being uploaded to computer to be analyzed；The camera is the high speed camera that can shoot 80fps or more；
The light source, collecting lens, field stop, aperture diaphragm and condenser and the flow cell, the object lens, the adminicle
Mirror and the camera are installed in same horizontal line.
2. Gynecological secretion automatic checkout equipment according to claim 1, which is characterized in that the Gynecological secretion is automatic
Detection device further includes：
It is set to the slide unit for driving the flow cell to be moved left and right along the pedestal on the pedestal；
The flow cell assemblies being connect with the slide unit, the flow cell are connected to the flow cell assemblies.
3. Gynecological secretion automatic checkout equipment according to claim 2, which is characterized in that the Gynecological secretion is automatic
Detection device further includes：
It is set to the measurement part that the pedestal moves size for measuring the slide unit.
4. Gynecological secretion automatic checkout equipment according to claim 2, which is characterized in that the flow cell assemblies packet
It includes：
The slide unit pinboard being connect with the slide unit；
The pitch regulation plate for adjusting the flow cell pitch angle and deflection angle is connect with the flow cell；
The connection backboard being set between the slide unit pinboard and pitch regulation plate；
And the pitch regulation plate is set to for controlling the pitch regulation plate and the adjustment part of flow cell pitching and deflection.
5. Gynecological secretion automatic checkout equipment according to claim 2, which is characterized in that the Gynecological secretion is automatic
Detection device further includes：
It is fixed on the pedestal and connect the control electricity moved left and right along the pedestal for controlling the slide unit with the slide unit
Machine.
6. Gynecological secretion automatic checkout equipment according to claim 5, which is characterized in that the Gynecological secretion is automatic
Detection device further includes：
It is set in the slide unit for moving left and right the photo-coupler that extreme position is defined to the slide unit.
7. Gynecological secretion automatic checkout equipment according to claim 6, which is characterized in that the photo-coupler is provided with
Three, three photo-couplers are respectively used to limit the initial position of the slide unit, the first extreme position and the second limit position
It sets；
First extreme position is the proximal most position that the slide unit is allowed to the close imaging device；
Second extreme position is the proximal most position that the slide unit is allowed to the close beam condensing unit.
8. Gynecological secretion automatic checkout equipment according to claim 2, which is characterized in that the Gynecological secretion is automatic
Detection device further includes：
It is set to the limited block that the pedestal is used to limit the slide unit shift position close to the imaging device.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610775311.4A CN106338608B (en) | 2016-08-31 | 2016-08-31 | A kind of Gynecological secretion automatic checkout equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610775311.4A CN106338608B (en) | 2016-08-31 | 2016-08-31 | A kind of Gynecological secretion automatic checkout equipment |
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| Publication Number | Publication Date |
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| CN106338608A CN106338608A (en) | 2017-01-18 |
| CN106338608B true CN106338608B (en) | 2018-08-07 |
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| CN201610775311.4A Active CN106338608B (en) | 2016-08-31 | 2016-08-31 | A kind of Gynecological secretion automatic checkout equipment |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5895762A (en) * | 1996-03-25 | 1999-04-20 | Diasys Corporation | Apparatus and method for handling fluid samples of body materials |
| CN201548542U (en) * | 2009-11-13 | 2010-08-11 | 长春迪瑞实业有限公司 | Flow cell fine-adjustment device |
| CN103245790A (en) * | 2012-02-13 | 2013-08-14 | 北京中生金域诊断技术有限公司 | Analyzer for vaginal secretion |
| CN105675898A (en) * | 2016-03-28 | 2016-06-15 | 深圳市汇研科创生物科技有限公司 | Full-automatic detecting device and genital tract secretion detecting equipment with same |
-
2016
- 2016-08-31 CN CN201610775311.4A patent/CN106338608B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5895762A (en) * | 1996-03-25 | 1999-04-20 | Diasys Corporation | Apparatus and method for handling fluid samples of body materials |
| CN201548542U (en) * | 2009-11-13 | 2010-08-11 | 长春迪瑞实业有限公司 | Flow cell fine-adjustment device |
| CN103245790A (en) * | 2012-02-13 | 2013-08-14 | 北京中生金域诊断技术有限公司 | Analyzer for vaginal secretion |
| CN105675898A (en) * | 2016-03-28 | 2016-06-15 | 深圳市汇研科创生物科技有限公司 | Full-automatic detecting device and genital tract secretion detecting equipment with same |
Non-Patent Citations (1)
| Title |
|---|
| 封闭式流动池阴道分泌物检测方法的建立及临床引用;苏敏等;《国际检验医学杂志》;20080831;743-744页 * |
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| CN106338608A (en) | 2017-01-18 |
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