CN106316954B - The method for preparing optical voidness (+)-or (-)-N- demethyl meptazinol - Google Patents

The method for preparing optical voidness (+)-or (-)-N- demethyl meptazinol Download PDF

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CN106316954B
CN106316954B CN201510354529.8A CN201510354529A CN106316954B CN 106316954 B CN106316954 B CN 106316954B CN 201510354529 A CN201510354529 A CN 201510354529A CN 106316954 B CN106316954 B CN 106316954B
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meptazinol
demethyl
formula
reaction
glacial acetic
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CN106316954A (en
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郑伟
程少冰
陈建兴
陈良康
余丽宁
黄婷
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Shanghai Institute of biomedical technology
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Shanghai Institute of Planned Parenthood Research
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/04—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with only hydrogen atoms, halogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Abstract

The present invention relates to the methods for preparing optical voidness (+)-or (-)-N- demethyl meptazinol, include (a) in atent solvent, in the presence of alkali, make optics pure monomer meptazinol and chloro-carbonic acid -2,2, the reaction of 2- trichloro ethyl ester, then the mixed solvent and zinc powder of glacial acetic acid and water is added, optically pure (+)-or (-)-N- demethyl meptazinol is made in reaction.Compared with method in the prior art, the resulting midbody compound of step (a) is not required to purify preparation method of the invention, directly can react to obtain target product through an one-step hydrolysis.Which shorten reaction steps, simplify post-processing operation；Overall yield of reaction (being increased to 80% or more from original 40~51%) is greatly improved, production cost is considerably reduced.

Description

The method for preparing optical voidness (+)-or (-)-N- demethyl meptazinol
Technical field
The present invention relates to the preparation methods of N- demethyl meptazinol, in particular to prepare optical voidness (+)-N- demethyl beauty The method of his general phenol or (-)-N- demethyl meptazinol.
Background technique
Meptazinol (Meptazinol), molecular formula C15H23NO, the entitled 3- (3- ethyl -1- methyl-1 H- hexahydro nitrogen of chemistry Miscellaneous Zhuo -3- base) phenol is the analgesic of listing in 1986, analgesic activities and pentazocine, meperidine and Dextropoxypheene phase When, but it is slightly weaker than morphine, compared with other opium kind analgesics, respiration inhibition and additive equal side effects are extremely low, therefore do not belong to " anaesthetic " management area.Known meptazinol is applicable to Acute or chronic pain, such as wound, postoperative, obstetrics and pain caused by cancer, especially uses It is safe and effective in inhibiting pain in parturition, neonatal health is not influenced.Clinical efficacy is reliable after listing, receives in 1998 for British Pharmacopoeia It carries.
The racemic modification for clinically using meptazinol hydrochloride, there is research, with optically pure tartaric acid or its derivative Object is resolving agent, carries out chemical resolution to racemic meptazinol and obtains optical voidness meptazinol or its esters, through capillary electricity Swimming method confirms e.e. value > 99%, by single crystal X diffraction determined the absolute configuration of levo form for (3S), d-isomer it is absolute It is configured as (3R).It is measured through mouse brain inhibiting activity of acetylcholinesterase, (-)-meptazinol of acquisition has acetylcholine ester The pharmacological activity of enzyme inhibition.
The Chinese patent ZL201110033828.3 and ZL201110153195.X of the applicant discloses the left-handed beauty of series His general amphyl has the purposes for the treatment of alzheimer's disease.(-)-N- demethyl meptazinol is to synthesize these compounds most Important intermediate." new nanomole grade anticholinesterase dinor- meptazinol has height to β-starch peptide aggregation Imitate inhibiting effect " (Xie Qiong etc., J.Med.Chem.2008,51,2027-2036) and Chinese patent application CN101037430A public affairs The preparation method of the compound is opened：Left-handed meptazinol and haloformate react in the presence of alkali and (-) are made in atent solvent N, O- dialkoxy formoxyl-N- remove first meptazinol, then intermediate (-)-N- alcoxyl is made in hydrolysis under weak basic condition Formoxyl-N- removes first meptazinol, and (-)-N- demethyl meptazinol finally is made again by hydrolysis.The inertia is molten Agent is selected from tetrahydrofuran (THF), chloroform, methylene chloride, benzene, toluene, n,N-Dimethylformamide (DMF) or above-mentioned solvent In mixture；The haloformate is selected from ethyl chloroformate, three chloroethene of chloromethane vinyl acetate, phenyl chloroformate or chloro-carbonic acid Ester；The alkali is selected from saleratus or sodium；The final step hydrolysis can in aqueous sulfuric acid or hydrazine hydrate solution or It is carried out under the conditions of aqueous tetrahydrofuran solution.Its total recovery reacted is generally 40-51% or so.
The art is highly desirable to obtain a kind of novel preparation method (+)-N- demethyl meptazinol is prepared Or (-)-N- demethyl meptazinol, the total recovery of total recovery preparation method compared with the existing technology are greatly improved, Operating procedure is simplified, general so as to which optical voidness (+)-N- demethyl meptazinol or (-)-N- demethyl U.S. is greatly lowered The preparation cost of his phenol.
Summary of the invention
It is an object of the present invention to provide optical voidness (+)-N- demethyl meptazinol at low cost, high income or (-)- The preparation method of N- demethyl meptazinol.
The purpose of the present invention is what is realized by following design：
The preparation method of the optically pure lower formula (I) of one kind or (II) compound,
Include (a) in atent solvent, in the presence of alkali, makes optics pure monomer meptazinol (III) and chloro-carbonic acid -2,2,2- Trichloro ethyl ester (IV) reaction,
Obtain the carbamates intermediate of formula (V)
(b) glacial acetic acid and water mixed solvent and zinc powder are added into the resulting formula of step (a) (V) intermediate, reaction is made Optically pure formula (I) or formula (II) compound.
In one embodiment, optics pure monomer meptazinol (III) and chloro-carbonic acid -2,2,2- trichloro ethyl ester (IV) Molar ratio is 1:7.5.
In another embodiment, the zinc powder is the zinc powder of activation, and activation method uses dilute salt known in the art Sour processing method (Synthesis 2005,17,2838-2844), dosage and chloro-carbonic acid-2,2,2- trichloro ethyl ester (IV) etc. are worked as Amount.
In a further embodiment, the atent solvent is selected from tetrahydrofuran (THF), chloroform, methylene chloride, benzene, first Or mixtures thereof benzene, n,N-Dimethylformamide (DMF)；The alkali is selected from saleratus or sodium.
In preferred embodiments, in glacial acetic acid and water mixed solvent described in step (b), the weight of glacial acetic acid and water Than being 2:1~6:1, preferred weight ratio is 4:1.
Preferably, step (a) is carried out in the case where being heated to reflux；Step (b) carries out under ice cooling, 4.
The reaction process is as follows：
In one embodiment, what the method for the present invention was prepared is (-)-N- demethyl meptazinol.
In another embodiment, preparation is (+)-N- demethyl meptazinol.
Specific embodiment
The present invention is further illustrated with preparation embodiment below, but does not limit the present invention.
Embodiment 1
By (-) meptazinol (5.0g, 21.4 mMs), anhydrous K HCO3(37.5g, 364.9 mMs) and 130mL chlorine Imitative mixing, heating stirring are completely dissolved meptazinol, continue to be heated to flowing back, and chloro-carbonic acid -2,2, tri- chloroethene of 2- are added dropwise rapidly Ester (34.1g, 160.5 mMs) continues back flow reaction 1 hour, TLC monitoring reaction (DCM:MeOH=25:1), anti-to substrate Should be completely cooling, it filters, concentration obtains light yellow oil 27.5g (theoretical value 12.2g), is dissolved in 20mL water and 80mL Divide the 3-4 batches of zinc powders (10.5g, 160.5 mMs) that activation is added in glacial acetic acid, under ice bath, is stirred to react 2 hours, TLC monitoring It after fully reacting, filters, concentration, addition 200mL DCM and 150mL water, with ammonium hydroxide tune pH to 9~10 under ice bath.It separates organic Layer, water layer extract (200mL × 3) with DCM, merge DCM layers of solution, and washed three times with saturation NaCl aqueous solution, through anhydrous slufuric acid Sodium is dry.Filtering, concentration, obtains brown oil 10.2g, is purified by silica gel column chromatography (eluant, eluent：DCM:MeOH:NH3H2O= 50:1:0.1), finally obtain (-)-N- demethyl meptazinol 4.0g (for yellow oil).Total recovery is 85.3% (with original Expect (-)-meptazinol meter).MS(ESI):220.1[M+H]+。
Above-mentioned yellow oil is dissolved in anhydrous ether, filters out insoluble matter, and anhydrous HCl- diethyl ether solution is added dropwise and adjusts pH To 4, white powder is precipitated.Filtering, vacuum drying, obtains (-)-N- demethyl meptazinol hydrochloride.Fusing point：73-75℃； [α]D=-7.12 ° (c=0.30, MeOH)；1HNMR(DMSO-d6):9.42(s,H,Ar-OH),8.82(br s,1/2H,NH+, Heavy water exchange disappears), 8.24 (br s, 1/2H, NH+, heavy water exchange disappearance) and 7.16 (t, H, J=7.8Hz, ArH), 6.74- 6.65 (m, 3H, ArH), 3.49 (d, H, J=14.1Hz, N-CH2), 3.21 (d, H, J=14.5Hz, N-CH2),3.08-3.00 (m,2H,N-CH2),2.14(m,H,CH2),1.77-1.55(m,7H,CH2), 0.49 (t, 3H, J=7.4Hz, CH3)。
Embodiment 2
By (+) meptazinol (5.0g, 21.4 mMs), anhydrous K HCO3(37.5g, 364.9 mMs) and 130mL chlorine Imitative mixing, heating stirring are completely dissolved meptazinol, continue to be heated to flowing back, and chloro-carbonic acid -2,2, tri- chloroethene of 2- are added dropwise rapidly Ester (34.1g, 160.5 mMs) continues back flow reaction 1 hour, TLC monitoring reaction (DCM:MeOH=25:1), anti-to substrate Should be completely cooling, it filters, concentration obtains light yellow oil 26.2g (theoretical value 12.2g), is dissolved in 20mL water and 80mL Divide the 3-4 batches of zinc powders (10.5g, 160.5 mMs) that activation is added in glacial acetic acid, under ice bath, is stirred to react 2 hours, TLC monitoring It after fully reacting, filters, concentration, addition 200mL DCM and 150mL water, with ammonium hydroxide tune pH to 9~10 under ice bath.It separates organic Layer, water layer extract (200mL × 3) with DCM, merge DCM layers of solution, and washed three times with saturation NaCl aqueous solution, through anhydrous slufuric acid Sodium is dry.Filtering, concentration, obtains brown oil 10.2g, is purified by silica gel column chromatography (eluant, eluent：DCM:MeOH:NH3H2O =50:1:0.1), finally obtain (+)-N- demethyl meptazinol 3.8g (for light brown grease).Total recovery is 81.0% (in terms of raw material (+)-meptazinol).MS(ESI):220.1[M+H]+。
Comparative example 1：
Left-handed meptazinol (20.9g, 90 mMs) and phenyl chloroformate (97 milliliters, 770 mMs) are in chloroform, carbon It is reacted in the presence of potassium hydrogen phthalate and intermediate (-)-N, O- hexichol oxygen formoxyl-N- demethyl meptazinol (yellow oil) is made. Above-mentioned grease is dissolved in methanol/water solution again, hydrolysis in the presence of potassium carbonate, crude product brown oil 34g is made, It is purified by silica gel column chromatography (elution of E-C solution gradient), obtains (-)-N- benzene oxygen formoxyl-N- demethyl meptazinol 29g, light yellow oil, yield：95%.Then (-)-N- benzene oxygen formoxyl-N- demethyl meptazinol and 85% hydrazine hydrate Mixing, (-)-N- demethyl meptazinol 8.0g (for yellow oil), yield 43% is made in hydrolysis again.MS(ESI): 220.1[M+H]+。
Above-mentioned overall yield of reaction 41%.
Comparative example 2：
Left-handed meptazinol (9.83g, 42.2 mMs) and ethyl chloroformate (34.8g, 320 mMs) in chloroform, It is reacted in the presence of saleratus and intermediate (-)-N, O- diethoxy formoxyl-N- demethyl meptazinol (yellow oily is made Object).Above-mentioned grease is dissolved in methanol/water solution again, hydrolysis in the presence of potassium carbonate, (-)-N- ethoxycarbonyl is made Base-N- demethyl meptazinol 11.17g, yield：95%.Then 50% aqueous sulfuric acid is added, reaction system is hydrolyzed again Obtain (-)-N- demethyl meptazinol 4.58g (for yellow oil), yield 54%.MS(ESI):220.1[M+H]+。
Above-mentioned overall yield of reaction 51%.
In anhydrous HCl- diethyl ether solution, at salt, (-)-N- demethyl meptazinol salt is prepared in above-mentioned yellow oil Hydrochlorate.Fusing point：73-75℃；[α]D=-7.10 ° (c=0.286, MeOH)；1HNMR(DMSO-d6):9.42(s,H,Ar-OH), 8.82(br s,1/2H,NH+, heavy water exchange disappearance), 8.24 (br s, 1/2H, NH+, heavy water exchange disappearance) and 7.16 (t, H, J= 7.8Hz, ArH), 6.74-6.65 (m, 3H, ArH), 3.49 (d, H, J=14.1Hz, N-CH2), 3.21 (d, H, J=14.5Hz, N-CH2),3.08-3.00(m,2H,N-CH2),2.14(m,H,CH2),1.77-1.55(m,7H,CH2), 0.49 (t, 3H, J= 7.4Hz,CH3)。
(i.e. meptazinol first reacts again with haloformate through two-step hydrolysis preparation method of the invention with art methods Reaction) it compares, the resulting formate ester intermediate of step (a) is not required to purify, and can directly react to obtain target production through an one-step hydrolysis Object.Which shorten reaction steps, simplify post-processing operation；Overall yield of reaction is greatly improved (from original 40~51% It is increased to 80% or more), considerably reduce production cost.

Claims (9)

1. a kind of preparation method of optically pure lower formula (I) compound,
The method includes：
(a) in atent solvent, in the presence of alkali, make optics pure monomer (+)-meptazinol (III) and chloro-carbonic acid -2,2,2- trichlorine Ethyl ester (IV) reaction,
Obtain the carbamates intermediate of formula (V)
(b) glacial acetic acid and water mixed solvent and zinc powder are added into the resulting formula of step (a) (V) intermediate, reacts and optics is made Pure formula (I) compound.
2. a kind of preparation method of optically pure lower formula (II) compound,
The method includes：
(a) in atent solvent, in the presence of alkali, make optics pure monomer (-)-meptazinol (III ') and chloro-carbonic acid -2,2,2- tri- Chloroethene ester (IV) reaction,
ClCO2CH2CCl3 (IV)
Obtain the carbamates intermediate of formula (V ')
(b) glacial acetic acid and water mixed solvent and zinc powder are added into the resulting formula of step (a) (V ') intermediate, reacts and optics is made Pure formula (II) compound.
3. method according to claim 1 or 2, which is characterized in that the atent solvent is selected from tetrahydrofuran, chloroform, dichloro Or mixtures thereof methane, benzene, toluene, n,N-Dimethylformamide (DMF).
4. method according to claim 1 or 2, which is characterized in that the alkali is selected from saleratus or sodium.
5. method according to claim 1 or 2, which is characterized in that in glacial acetic acid and water mixed solvent described in step (b), The weight ratio of glacial acetic acid and water is 2:1~6:1.
6. method as claimed in claim 5, which is characterized in that the weight ratio of glacial acetic acid and water is 4:1.
7. method according to claim 1 or 2, which is characterized in that the zinc powder is the zinc powder of activation.
8. the method for claim 7, which is characterized in that the dosage of the zinc powder is 3~8 equivalents.
9. method according to claim 1 or 2, which is characterized in that the step (a) carries out in the case where being heated to reflux；It is described Step (b) carries out under ice cooling, 4.
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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1974558A (en) * 2006-12-20 2007-06-06 复旦大学 (+)-Meptazinol diligand derivative and/or its salt and the prepn process
CN101037430A (en) * 2006-07-27 2007-09-19 复旦大学 (-)-meptazinol double-ligand derivative and/or its salt and preparation method and usage

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101037430A (en) * 2006-07-27 2007-09-19 复旦大学 (-)-meptazinol double-ligand derivative and/or its salt and preparation method and usage
CN1974558A (en) * 2006-12-20 2007-06-06 复旦大学 (+)-Meptazinol diligand derivative and/or its salt and the prepn process

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Bis-(?)-nor-meptazinols as Novel Nanomolar Cholinesterase Inhibitors with High Inhibitory Potency on Amyloid-β Aggregation;Qiong Xie ET AL;《Journal of Medicinal Chemistry》;20080312;第51卷(第7期);2027-2036 *

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