CN106290545A - A kind of method and device detecting trace compound - Google Patents
A kind of method and device detecting trace compound Download PDFInfo
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Abstract
The invention discloses a kind of method and device detecting trace compound, including: step one, sample is carried out ionizing；Step 2, carries out the square wave frequency signal modulation that dutycycle is 50% to continuous print ion stream；Step 3, the ion after described step after-treatment flows into moving apparatus and carries out ion migration separation；Step 4, utilizes Chirp Z transform to rebuild ion mobility spectrometry.Highly sensitive, the utilization rate of ion can be brought up to 50% by the method that the present invention provides, and relatively traditional method sensitivity improves 3～10 times, and compared with conventional Fourier transform, sensitivity can improve 12 times.Resolution is high.The phenomenons such as common tailing peak, the peak that sticks out one's tongue can be eliminated compared with conventional method by the method that the present invention provides, thus improves resolution, and then improves mass spectrum database and quantitative effect.
Description
Technical field
The present invention relates to technical field of analytical instruments, particularly relate to a kind of method and device detecting trace compound.
Background technology
Ion mobility spectrometry (Ion Mobility Spectrometry, IMS) technology is the one occurred the seventies in last century
Novel sharp separation detection technique.Can under atmospheric pressure carry out owing to separating, it is not necessary to vacuum, with traditional mass spectrometer phase
Ratio has simple in construction, highly sensitive, analyzes speed fast, the feature of reliable results.Meanwhile, the separating rate of ion mobility spectrometry is non-
Often fast, just can complete once to analyze in usual a few tens of milliseconds, just can be given in several seconds to tens seconds analysis as a result, it is possible to
In atmospheric environment detecting trace level chemical substance, instrument is particularly suitable for onsite application.At present, ion mobility spectrometry on airport,
The safety check occasions such as station, the detection of precursor chemicals, the method such as detection of chemical warfare agent is widely applied, in tradition
Security fields have uniqueness effect.Ion mobility spectrometry is generally by ion source, ion gate, transport district and detector group
Become.Solid, liquid phase or gaseous sample ionize generation ion in an ion source, and ion is opened by periodicity under the ordering about of electric field
Ion gate enter drift region, and with adverse current neutral drift gas molecule constantly collide during, due to these ions
Each migration rate is different in the electric field so that different ions obtains separating and successively arrive collector and is detected.Therefore lead to
Cross measurement migration time and just can determine that the existence analyzing target substance, and apply peak area or peak height to can determine that the dense of respective substance
Degree.
The ratio of the migration time after said process intermediate ion door opening time and ion entrance migration area is referred to as dutycycle
(Duty Cycle, DC), DC determines signal to noise ratio and the sensitivity of instrument, also contributes to the resolution analyzed simultaneously.Compare biography
The periodicity single door opening method of system, dutycycle can be brought up to 50% by the Hadamard alternative approach proposed in recent years, with
Conventional method is compared and can be improved decades of times.This mode is considered as a kind of encoding-decoding process to ion signal, whole application
Process can divide 3 stages.1st stage was design pseudo-random binary sequence.2nd stage was to enter in the generation stage of ion signal
Row Signal coding, replaces tradition recurrent pulses to control ion gate switch by pseudo-random sequence and produces ion signal.3rd stage
It is ion signal processing stage, carry out signal decoding, uses the corresponding Hadamard inverse matrix of sequence that controls as deconvolution
Core, becomes ion migration spectrum signal by deconvoluting by coding signals revivification.
Similar with Hadamard conversion also has a kind of Fourier transform ion mobility spectrometry (Fourier Transform
Ion Mobility Spectrometry), do not use pseudo-random binary sequence unlike Hadamard conversion, and make
With the gate-control signal of different frequency, ion gate is modulated.Traditional Fourier transformation ion mobility spectrometry uses two synchronizations to open
The ion gate closed, thus receive interference signal at detector, after gathering signal, frequency-region signal is converted to time-domain signal, work again
The dutycycle made is 25%.Both signal modulating methods the most significantly increase the dutycycle of ion migration analysis of spectrum, so that
Sensitivity increases.Fourier transform is due to only sensitive to the ion signal that mobility is fixing, thus resolution has carried
High.
In recent years, carry out being combined by ion mobility spectrometry and mass spectrograph and become the Disciplinary Frontiers that each apparatus manufacture competitively develops.
Although mass spectrometric resolution is the highest, the mass resolution such as novel time of-flight mass spectrometer can reach more than 10,000.But
It is, when analyzing with weight compound, even if mass resolution > 1000000, still possibly these isomers cannot be separated
Identify.Mass spectrograph for isomers more advanced is the most helpless.But, ion mobility spectrometry just can be at knot
Mass spectrum is well supplemented by the qualification aspect of structure isomer.On the other hand, for the complexity containing multiple compounds type
For the analysis of mixture, separating power is particularly important.Depth analysis to be carried out, single chromatographic isolation is the most helpless,
Because several compounds that flow out altogether being eluted out from a liquid chromatograph peak cannot be characterized by it.It addition, high-resolution
Mass spectrum is likely to be limited to MS scanning speed, separates without effective front end, can not obtain allization in sample
The data of compound.For chromatograph effluent altogether, if retention time is variant, mass spectrum can utilize to deconvolute rebuilds mass spectrum
Figure.But, if chromatographic peak is completely overlapped, chromatograph-mas spectrometer also cannot effectively identify, thus causes mistake quantitatively occur
Difference, the identification to compound encounters difficulties.The speed (millisecond) that ion mobility spectrometry separates is between HPLC (second) and mass spectrum (microsecond)
Time range in, system can the trace compound that cannot separate of separation chromatography.Research shows, uses ion mobility spectrometry mass spectrum
Combined system can make total coverage rate of lipid improve about 5 times, in proteomics research, uses ion mobility spectrometry mass spectrum connection
It is used alone LC/MS with the quantity ratio of the peptide and protein identified out and analyzes increase by 3 times.If by chromatograph, ion migration
Separating power and the mass spectrometric mass resolution of spectrum combine, and can obtain the highest peak capacity, to complicated chemical combination
The separation of thing is particularly useful.
But, it is limited by the separation principle of ion mobility spectrometry at present, the resolution of ion mobility spectrometry and the spirit of mass spectral analysis
Sensitivity has become the parameter conditioned each other a pair.Resolution to be improved, just must shorten the time of ion implanting as far as possible, the most again can
Reduce the quantity injecting ion, thus sacrifice sensitivity.For solving this problem, Hadamard conversion and Fourier transform are same
Also having used in ion mobility spectrometry-GC-MS, but problem is the most prominent, new problem served by the most also band, as
Hadamard conversion can produce some this non-existent ghost peaks, qualitative and mistake quantitatively occur.Work due to two ion gates
Waveform is all square wave, and Fourier transformation also can produce ghost peak, and spectrum analysis brings extra difficulty.Further, since it is traditional
B-N ion gate has the strongest discrimination effect to the ion of different mass-to-charge ratioes, so that the ion-sensitive degree of high mass-to-charge ratio reduces,
When using two ion gates, this phenomenon becomes more serious, and the sensitivity of Fourier transformation improves very limited, best
In the case of also only less than 3 times signal to noise ratio improve.Because the consequent ion migration spectrogram of fast Fourier transform
Temporal resolution is relevant with sweep velocity, and the work that sweep velocity is limited by detector type (such as mass spectrograph) and ion gate is former
Reason, thus the temporal resolution of the ion migration spectrogram produced is the lowest, thus the qualitative analysis to compound brings difficulty.
On the instrument of some commercializations, improve sensitivity for improving ion implanting efficiency, ion migration separation quilt
It is placed under low pressure and carries out, use the mode of trap collection capture ion and continuous ionic circulation is turned to ion pulse simultaneously.This
The structure of a little instruments becomes extremely complex, and volume is the biggest, and instrument price is expensive.Meanwhile, due under low pressure ion with in
The collision frequency of property gas molecule is greatly reduced, thus the resolution of ion mobility spectrometry is very limited, such as low pressure under uniform electric field
Ion migration spectral resolution be usually less than 60, and the resolution of row ripple ion mobility spectrometry is usually less than 40.
Summary of the invention
The purpose of the present invention is contemplated to solve the problems referred to above, it is provided that a kind of method and device detecting trace compound,
Detect trace compound under atmospheric pressure and there is high sensitivity, high-resolution feature.
To achieve these goals, the present invention adopts the following technical scheme that
A kind of method detecting trace compound, including:
Step one, carries out ionizing by sample；
Step 2, is set the square wave frequency signal modulation of dutycycle to continuous print ion stream；
Step 3, the ion after described step after-treatment flows into moving apparatus and carries out ion migration separation；
Step 4, utilizes Chirp Z transform to rebuild ion mobility spectrometry.
In described step 2, continuous print ion stream is carried out the square wave frequency signal modulation that dutycycle is 50%, modulation
Mode uses mode that frequency raises or the mode that frequency reduces, and the method for frequency shift is linear frequency modulation, modulation range be 0～
10K Hz。
In described step 3, being passed through setting pressure and the neutral gas of flow velocity in moving apparatus, described neutral gas is nitrogen
Gas, air, helium or carbon dioxide.
Also include that the continuous ionic stream of the ion mobility information that includes after step 3 being processed is directly through faraday
Dish detector detects, and is AD converted to import computer and obtains ion versus time curve or import through interface
Mass spectrograph, the ionic strength versus time curve of the different mass-to-charge ratio of record.
The change curve of record is carried out Mathematical treatment, and the way of concrete process is: use and square wave in described step 2
Frequency signal homophase and anti-phase sinusoidal Chirp signal and square wave Chirp signal with from faraday dish or mass spectrometric from
Sub-intensity variation curve is correlated with respectively, gained signal carries out Chirp Z transform respectively, and compares the result of twice conversion
Relatively, ghost peak and the noise that conversion produces is filtered.
In described step one, before sample is carried out ionizing process: utilize capillary electric chromatogram, gas chromatogram, liquid
Phase chromatograph or means of capillary electrophoresis carry out pre-separation to sample, or straight after dilution, enrichment, purification, remove impurity pretreatment
Connect and import in ion source with syringe pump.
The ionized mode of described step one includes electron spray, Atmosphere Pressure Chemical Ionization (APCI), atmospheric pressure photoionization, radioactive source
Ionization or Direct Analysis in Real Time ionization source.
Described step 2 is modulated and is realized by following device: B-N ion gate or TYNDALL ion gate.
A kind of device using a kind of described method detecting trace compound, including ion source, described ion source is the most right
The ion gate of migration tube one end, the other end of described migration tube is provided with detector；Described ion gate is provided with ion gate controller.
The gas chromatograph that also includes being connected with described ion source, chromatograph of liquid, capillary electrophoresis apparatus, ion chromatograph
Or supercritical fluid chromatograph.
Beneficial effects of the present invention:
The most highly sensitive.The utilization rate of ion can be brought up to 50% by the method that the present invention provides, sensitive compared with traditional method
Degree improves 3～10 times, and compared with conventional Fourier transform, sensitivity can improve 1-2 times.
2. resolution is high.The present invention provide method compared with conventional method can by common tailing peak, stick out one's tongue peak
Eliminate etc. phenomenon, thus improve resolution, and then improve mass spectrum database and quantitative effect.
The simplest.The method that the present invention provides can i.e. may be used on existing ion directly or through little transformation and move
Move spectrometer, ion mobility spectrometry-GC-MS, gas chromatogram-ion mobility spectrometry combined instrument, liquid chromatograph-ion mobility spectrometry connection
With on instrument, and its performance is greatly improved.
4. multidimensional separates.Utilize the method that the present invention provides, in that context it may be convenient to by ion mobility spectrometry-GC-MS and gas
Chromatography, chromatograph of liquid, capillary electrophoresis apparatus, ion chromatograph, supercritical fluid chromatograph etc. are combined, and are not damaging
The ion migration providing extra dimension in the case of the separating degree of eclipsed spectrum, mass spectrographic sensitivity separates, thus is greatly improved and determines
Property analyze and the efficiency of quantitative analysis and accuracy.
5. the temporal resolution of spectrogram is high.By regulation relevant parameter, when Chirp Z transform can be made to concentrate on ion migration
Between position, thus reach the highest temporal resolution, and it be fast to calculate speed, utilizes present mainstream computer to reach
To real-time transform.
6. eliminate Hadamard conversion and the ghost peak of Fourier transformation generation, so that chemical combination Physical Property Analysis divides with quantitative
It is more accurate to analyse.
Accompanying drawing explanation
Fig. 1 is embodiment one ion mobility spectrometry-GC-MS schematic diagram；
Fig. 2 (a) is that conventional ion migrates spectrogram, and Fig. 2 (b) is Chirp Z transform ion migration spectrogram；
Fig. 3 (a) is that conventional transformation method produces ghost peak at 3 times of migration timies, and Fig. 3 (b) is that the method for the present invention can have
Effect removes the ghost peak that conversion produces；
Fig. 4 is the present invention selection chromatography of ions figure as gas chromatography detector；
Fig. 5 (a) is conventional Fourier transform ion mobility spectrometry, and Fig. 5 (b) is the Chirp Z transform ion mobility spectrometry of the present invention.
Wherein, 1. ion source, 2. high voltage power supply, 3. ion gate controller, 4. ion gate, 5. migrate gas entrance, 6. migrate
Pipe, 7. detector.
Detailed description of the invention
The invention will be further described with embodiment below in conjunction with the accompanying drawings.
A kind of method detecting trace compound, specifically comprises the following steps that
(1) sample is carried out ionizing；The mode of described ionizing includes electron spray, Atmosphere Pressure Chemical Ionization (APCI), atmospheric pressure
Photo-ionisation, radioactive source ionization or Direct Analysis in Real Time ionization source, ionizing is the most uninterruptedly carried out.According to the sample analyzed, electricity
From can in the positive-ion mode or carry out under negative ion mode.
(2) continuous print ion flows to line frequency modulation, and frequency modulation(PFM) can use the method for raising frequency or frequency reducing, according to institute
The noise when sampling rate needed, can select modulation period between 200ms to 10s, and ion mobility spectrometry obtains frequency accordingly
Rate is 0.1～5Hz, can adapt with the acquisition speed of HPLC or GC.The highest frequency of modulation is 10K Hz, lowest frequency
Rate is 0Hz.
(3) the ion stream after modulating is incorporated in moving apparatus under electric field action and carries out ion isolation, described migration
Leading in fixation pressure, the neutral gas of the antikinesis of fixed flow rate in device, described neutral gas is nitrogen, air, helium
Or carbon dioxide.
(4) continuous ionic including ion mobility information after step (3) being processed flows through the detection of faraday dish
Device detects, and is converted into digital signal, or imports mass spectrograph through interface, record the ionic strength of variant mass-to-charge ratio after amplification
Versus time curve.
(5) by frequency modulated signal, relevant to the digital signal from (4) including square-wave signal and sinusoidal signal, relevant
Phase place identical with former square wave Chrip signal.Signal after Xiang Guan carries out multiplying window, and window function can be Welch function, Hann
Window function, Gaussian function, Hamm window function etc..
(6) signal after windowing is carried out Chirp Z transform, and compare the signal after conversion to filter conversion generation
Ghost peak, noise etc..
(7) can be using above Chirp Z transform ion mobility spectrometry as gas chromatogram or the detector of liquid chromatograph, thus to multiple
Miscellaneous system carries out two dimensional separation, and obtains the qualitative and quantitative informations such as retention time, the migration time of ion and intensity simultaneously.
(8) above Chirp Z transform ion mobility spectrometry can be connected different types of mass detector, and connect gas chromatogram
Or liquid chromatograph, thus complex system is carried out three-dimensional separation, and obtain retention time, the migration time of ion, matter lotus simultaneously
When intensity etc. are qualitative and quantitative information.
Before sample is carried out ionizing process: to complicated sample, utilize capillary electric chromatogram, gas chromatogram, liquid
Phase chromatograph or means of capillary electrophoresis carry out pre-separation to sample, or straight after dilution, enrichment, purification, remove impurity pretreatment
Connect and import in ion source with syringe pump.
In described step (2), modulation is realized by following device: B-N ion gate, TYNDALL ion gate or other ion grid
Lattice.
As it is shown in figure 1, use the device of a kind of described method detecting trace compound: sequentially include ion source 1, ion
Door 4, migration tube 6, detector 7, ion gate 4 is connected with ion gate controller 3, and modulator approach makes the dutycycle of ion stream reach
50%, warbled mode can use frequency to raise or frequency reduces, or combination.Migration tube 6 is provided with migration
Gas entrance 5, and migration tube 6 is connected with high voltage power supply 6.
The gas chromatograph that also includes being connected with ion source 1, chromatograph of liquid, capillary electrophoresis apparatus, ion chromatograph or
Supercritical fluid chromatograph, or by mass spectrograph associated with atmospheric pressure interface and ion mobility spectrometry phase.
Chromatograph-ion mobility spectrometry and ion mobility spectrometry-GC-MS are being analyzed or detection proteomics, metabolism group
Application in, lipidomics, food safety, natural product and environmental contaminants and drugs, explosive, chemical warfare agent,
Application in the detection such as outburst surroundings accident.
Embodiment one
The structure of the ionic migration spectrometer used in the present embodiment is as it is shown in figure 1, ion mobility spectrometry is operated in atmospheric pressure
Under, ion source is63Ni radiation ionization source, the temperature of ion mobility spectrometry is 150 DEG C, and migration gas is nitrogen, and flow velocity is
900mL.min-1, the total length moving pipe is called 12.8 centimetres, a B-N type ion gate separating is two regions, front end be from
Zi Hua district, a length of 2.8 centimetres, rear end is migration area, a length of 10.2 centimetres.Migration area is followed by a faraday dish detector.
The present invention can be greatly improved the performance of spectrometric system, if traditional ionic migration spectrometer is at the ion of 50ms
Migrating in spectrogram, for reaching good separating effect, the opening time of ion gate is 0.25ms, then the utilization ratio of ion is:
0.25/50=0.5%
In the present embodiment: in the ion migration spectrogram of 50ms, it is to utilize accounting for of B-N ion gate by warbled mode
Empty ratio is 50%, from the utilization ratio of ion and the multiple of raising it can be seen that the present invention is to ion mobility spectrometry-GC-MS
Role and its significant superiority.The present embodiment brings 2.4-lutidine into ion source by carrier gas, and flow velocity is
300mL.min-1.
2 are extracted respectively, the legacy migration spectrogram of 4-lutiddine and the Chirp Z transform of the present invention according to the cycle of 50ms
Spectrogram, by Fig. 2 (a)-Fig. 2 (b) it can be seen that ion migration spectrogram of the present invention migrates spectrogram signal to noise ratio than conventional ion proposes raising
5.27 times, eliminate the phenomenon of baseline drift simultaneously.
Fig. 3 (a) is that Fig. 3 (b) is the spectrogram eliminating ghost peak without the spectrogram removing ghost peak.The two compares can be clear
The superiority of the display present invention, i.e. can remove the interference ghost peak brought by conversion.
Fig. 4 is the present invention selection chromatography of ions figure as gas chromatography detector.
Fig. 5 (b) is the Chirp Z transform spectrogram of the present invention, and Fig. 5 (a) is traditional Fourier transformation spectrogram, it can be seen that this
Bright spectrogram migration time is accurate, and resolution is high, and performance improves clearly compared with tradition spectrogram.
The present invention relates to from carry out colliding by gas ion and neutral gas molecule and according to the electric charge of gas ion, matter
Amount, collision cross-section separate, and improve its resolution and the control of sensitivity and measuring method.With usual ion mobility spectrometry
Measuring method unlike, this method carries out frequency modulation(PFM) to coming from ionogenic continuous ion beam, the dutycycle of modulation
It is 50%, then iontophoresis is separated in migration parts.Ion after separation obtains original by detector detection
Spectrogram, or enter into mass spectrograph through interface and carry out quality analysis, and from mass spectrograph, obtain the intensity of each ion and measure
Its ionic strength over time, passes through mound after this spectrogram is the most relevant to square wave Chirp signal and sinusoidal wave Chirp signal
General transform rebuilds ion mobility spectrometry, and filters ghost peak and the noise that conversion produces, and obtains the migration time of each ion.The present invention
Simple to operate, the utilization ratio of ion is high, and the signal to noise ratio of quantitative analysis can improve 3～10 times with common compared with quasi-instrument.
Meanwhile, the resolution of ion mobility spectrometry also effectively improves, thus contributes to preferably compound being carried out qualitative point
Analysis.The present invention can also be applied in existing ion mobility spectrometry-GC-MS, thus improves sensitivity and the resolution of analysis
Rate.The invention is particularly suited to high performance liquid chromatography, Ultra Performance Liquid Chromatography, gas chromatogram, capillary electrophoresis, capillary tube electricity color
Spectrum wait other separation means combination, thus in common analysis increase a dimension but do not lose sensitivity, make the effect of separation
The accuracy of rate and qualitative analysis is greatly improved.
It is an object of the invention to be to make full use of from ionogenic ion beam, by the most iontophoresis to ion
Migrate in parts and separate.Meanwhile, the ion after migration enters mass spectrograph through interface, and carries out according to the mass-to-charge ratio of ion
Analyze.The signal that mass spectrograph obtains includes ionic strength signal versus time curve.Owing to ionic availability reaches
50%, the sensitivity of analysis is greatly improved.Meanwhile, after Chirp Z transform, tailing peak and the peak that sticks out one's tongue etc. are eliminated existing
As so that the resolution of ion mobility spectrometry is also improved, and in normal circumstances, is about 500 for a mass-to-charge ratio
Ion, the resolution of ion mobility spectrometry is the highest can reach more than 100, thus than existing method be greatly improved separating power and
Sensitivity for analysis, for the analysis such as proteomics, metabolism group of complex sample, lipidomics, food safety, natural product
The analysis of the sample such as thing, environmental contaminants is most important.The invention is particularly suited to connect chromatograph, ion mobility spectrometry and mass spectrum
Constitute dimensional analytic system together.
Although the detailed description of the invention of the present invention is described by the above-mentioned accompanying drawing that combines, but not the present invention is protected model
The restriction enclosed, one of ordinary skill in the art should be understood that on the basis of technical scheme, and those skilled in the art are not
Need to pay various amendments or deformation that creative work can make still within protection scope of the present invention.
Claims (10)
1. the method detecting trace compound, is characterized in that, including:
Step one, carries out ionizing by sample；
Step 2, is set the square wave frequency signal modulation of dutycycle to continuous print ion stream；
Step 3, the ion after described step after-treatment flows into moving apparatus and carries out ion migration separation；
Step 4, utilizes Chirp Z transform to rebuild ion mobility spectrometry.
A kind of method detecting trace compound the most as claimed in claim 1, is characterized in that, in described step 2, to continuous print
Ion stream carries out the modulation of square wave frequency signal that dutycycle is 50%, and the mode of modulation uses mode that frequency raises or frequency to drop
Low mode, the method for frequency shift is linear frequency modulation, and modulation range is 0～10K Hz.
A kind of method detecting trace compound the most as claimed in claim 1, is characterized in that, in described step 3, and moving apparatus
In be passed through setting pressure and the neutral gas of flow velocity, described neutral gas is nitrogen, air, helium or carbon dioxide.
A kind of method detecting trace compound the most as claimed in claim 1, is characterized in that, after also including processing step 3
The continuous ionic stream including ion mobility information directly detects through faraday dish detector, and is AD converted to import
Computer or import mass spectrograph, the ionic strength versus time curve of the different mass-to-charge ratio of record through interface.
A kind of method detecting trace compound the most as claimed in claim 4, is characterized in that, the change curve number to record
Process, and the way of concrete process is: uses and square wave frequency signal homophase in described step 2 and anti-phase sinusoidal Chirp letter
Number and square wave Chirp signal the most relevant to the ionic strength change curve from faraday dish or from matter instrument, to gained believe
Number carry out Chirp Z transform respectively, and the result of twice conversion is compared, filter ghost peak and noise that conversion produces.
A kind of method detecting trace compound the most as claimed in claim 1, is characterized in that, in described step one, to sample
Before carrying out ionizing process: utilize capillary electric chromatogram, gas chromatogram, liquid chromatograph or means of capillary electrophoresis that sample is entered
Row pre-separation, or after dilution, enrichment, purification, remove impurity pretreatment, direct syringe pump imports in ion source.
A kind of method detecting trace compound the most as claimed in claim 1, is characterized in that: the side that described step one is ionized
Formula includes the ionization of electron spray, Atmosphere Pressure Chemical Ionization (APCI), atmospheric pressure photoionization, radioactive source or Direct Analysis in Real Time ionization source.
A kind of method detecting trace compound the most as claimed in claim 1, is characterized in that: described step 2 is modulated by with
Lower device realizes: B-N ion gate or TYNDALL ion gate.
9. use a device for a kind of method detecting trace compound described in claim 1, it is characterized in that: include ion
Source, described ion source just ion gate to migration tube one end, the other end of described migration tube is provided with detector；Described ion gate sets
There is ion gate controller.
10. device as claimed in claim 9, is characterized in that, also include gas chromatograph, the liquid phase being connected with described ion source
Chromatograph, capillary electrophoresis apparatus, ion chromatograph or supercritical fluid chromatograph.
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Cited By (7)
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| CN107219294A (en) * | 2017-05-05 | 2017-09-29 | 塔里木大学 | It is a kind of to improve ionic migration spectrometer resolution ratio and the method for sensitivity |
| CN107478710A (en) * | 2017-09-14 | 2017-12-15 | 安徽理工大学 | One kind eliminates Hadamard ion mobility spectrometry baseline drift distortion methods |
| CN110108778A (en) * | 2019-04-19 | 2019-08-09 | 中国科学院合肥物质科学研究院 | A kind of UV-FAIMS quantitative detecting method of volatile organic matter |
| CN110146585A (en) * | 2019-06-22 | 2019-08-20 | 湘潭大学 | Prediction and the method for eliminating hadamard transformation Ion transfer spectral transformation ghost peak |
| CN110730906A (en) * | 2017-06-21 | 2020-01-24 | 株式会社日立制作所 | Method for inspecting deposit |
| CN111868519A (en) * | 2017-11-15 | 2020-10-30 | 机械解析有限公司 | Method and apparatus for analyzing gas chromatography elution peaks |
| CN114388333A (en) * | 2022-01-13 | 2022-04-22 | 湘潭大学 | Method for improving signal-to-noise ratio of ion mobility spectrometer and ion mobility spectrometer |
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| CN110146585B (en) * | 2019-06-22 | 2021-08-17 | 湘潭大学 | Method for predicting and eliminating Hadamard transform ion mobility spectrometry transform false peak |
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