CN106290333A - A kind of detection method of sacculus product reducing substances - Google Patents
A kind of detection method of sacculus product reducing substances Download PDFInfo
- Publication number
- CN106290333A CN106290333A CN201610613408.5A CN201610613408A CN106290333A CN 106290333 A CN106290333 A CN 106290333A CN 201610613408 A CN201610613408 A CN 201610613408A CN 106290333 A CN106290333 A CN 106290333A
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- solution
- add
- reducing substances
- sodium thiosulfate
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
- G01N31/16—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using titration
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
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- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
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- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plasma & Fusion (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Abstract
The present invention relates to the detection method of reducing substances in a kind of sacculus product, it is characterized in that precision measures product test liquid in right amount, in right amount and dilute sulfuric acid is appropriate to add 0.002mol/L potassium permanganate solution, shake up, boil several minutes, cool down rapidly, add potassium iodide appropriate, several minutes is placed in dark place, being titrated to light brown with 0.01mol/L sodium thiosulfate volumetric solution, add starch and refer to that test solution is appropriate, continuation 0.01mol/L sodium thiosulfate volumetric solution is titrated to colourless, it is terminal, reads to consume volumetric solution volume number.It is measured in the same method blank, calculates by the difference of the volumetric solution volume consumed, to obtain final product.Utilize the amount of the method detection sacculus reducing substances of the present invention, this method of inspection strong operability, reaction is completely, add potassium iodide dark place and place several minutes, control potassium iodide and see the labile character of light, the amount making the reducing substances that the reaction of sodium thiosulfate volumetric solution and iodine draws in this course of reaction is more accurate, result accurately, reliably, have good stability.
Description
Technical field:
The present invention relates to chemical analysis field and pharmaceutical analysis technical field, reducing substances in particularly a kind of sacculus product
Detection method.
Background technology:
All there is reducing substances in more existing sacculus products, is one of instable influence factor of product, in order to more preferably
Control product, therefore should strictly control the amount of product reducing substances.At present GB/T14233.1-2008 medical infusion, transfuse blood, note
The emitter tool method of inspection, Part I: the method assay stability in chemical analysis method is not ideal.
Summary of the invention
The technical problem to be solved is for existing GB/T14233.1-2008 medical infusion, transfuses blood, notes
The emitter tool method of inspection, Part I: the method less-than-ideal problem of assay stability in chemical analysis method and
Thering is provided a kind of easy and simple to handle, quick, testing instruments are the most common, and result accurately, reliable, the sacculus product that has good stability
The detection method of reducing substances.
The technical problem to be solved can be achieved through the following technical solutions:
The detection method of a kind of sacculus product reducing substances, it is characterised in that comprise the steps:
1) need testing solution preparation process
Weighing product appropriate, add water in 0.1g/ml ratio and soak system 24 hours under 37 degrees Celsius of constant temperatures, taking-up shakes up
Obtain need testing solution；
2) blank solution preparation process
Take Purified Water q. s as blank solution；
3) precision measures step 1) the need testing solution 20ml for preparing, add 0.002mol/L potassium permanganate solution 20ml and dilute
Sulphuric acid 2ml, shakes up, and boils 3 minutes, cools down rapidly, adds potassium iodide 0.1g, and dark place is placed 5 minutes, with 0.01mol/L sulfur for sulfur
Acid sodium volumetric solution is titrated to light brown, adds starch and refers to that test solution 5, continuation 0.01mol/L sodium thiosulfate volumetric solution are titrated to
Colourless, it is terminal；Separately take step 2) blank solution, be measured in the same method, by consume volumetric solution volume difference calculate, obtain product
The amount of middle reducing substances.
The present invention is in GB/T14233.1-2008 medical infusion, blood transfusion, the instrument used for injection method of inspection, Part I: change
Analysis method is improved, it is achieved that method is easy and simple to handle, quick, and testing instruments are the most common on the basis of credit analysis method, and
Result accurately, reliable, have good stability.
Detailed description of the invention
The present invention provides a kind of analysis method that can measure reducing substances in sacculus product:
According to GB/T14233.1-2008 medical infusion, blood transfusion, the instrument used for injection method of inspection, Part I: chemical analysis
Method measures
Experimental technique and process:
Instrument and reagent
Analytical balance: BSA224S type (producer: Sai Duolisi)
Test sample: a kind of sacculus product, such as single use cervical dilatation foley's tube, it is known that containing reducing substances.
Need testing solution preparation process
Weighing product 10g, add water in 0.1g/ml ratio and soak system 24 hours under 37 degrees Celsius of constant temperatures, taking-up shakes up
Obtain need testing solution 100ml；
Blank solution preparation process
Take purified water 100ml standby as blank solution；
Precision measures product test liquid 20ml, adds 0.002mol/L potassium permanganate solution 20ml and dilute sulfuric acid 2ml, shakes up,
Boiling 3 minutes, cool down rapidly, add potassium iodide 0.1g, dark place is placed 5 minutes, titrates with 0.01mol/L sodium thiosulfate volumetric solution
To light brown, adding starch and refer to test solution 5, continuation 0.01mol/L sodium thiosulfate volumetric solution is titrated to colourless, is terminal,
Read the volumetric solution volume number consumed.Separately take blank solution, be measured in the same method, calculate by the difference of the volumetric solution volume consumed, obtain ball
The amount of reducing substances in capsule product.
In above-mentioned embodiment, it is 18.80ml that need testing solution consumes the amount of 0.01mol/L sodium thiosulfate volumetric solution,
After titration factor conversion, volume F=1.043 is 19.61ml, and blank solution consumes the amount of 0.01mol/L sodium thiosulfate volumetric solution
For 18.60ml, after titration factor conversion, volume F=1.043 is 19.40ml, and both consume the difference of volumetric solution is 0.21ml.
The principle of the present invention is: potassium permanganate and product test liquid occur reduction reaction in acid condition, and potassium iodide is (i.e.
Oxidizing have again reproducibility, sees that light easily decomposes) and the reaction of unnecessary potassium permanganate, generate elemental iodine, drip with sodium thiosulfate
Determine elemental iodine and be iodimetric titration, calculate the content of reducing substances from the difference of sample with the blank sodium thiosulfate volume consumed
(consuming sodium thiosulfate volumetric solution the most, illustrate that the iodine generated is the most, the potassium permanganate of reaction is the most, and reduzate is described
Matter is few, and this reaction reacts more complete in acid condition).
Described above is not to the restriction invented, and the present invention is also not limited to the example above, the common skill of the art
Art personnel, the change made, retrofit, add or replace in the essential scope of the present invention, also should belong to the protection model of the present invention
Enclose.
Claims (1)
1. the detection method of a sacculus product reducing substances, it is characterised in that comprise the steps:
1) need testing solution preparation process
Weigh product appropriate, add water in 0.1g/ml ratio and soak system 24 hours under 37 degrees Celsius of constant temperatures, take out and shake up and get final product
Need testing solution；
2) blank solution preparation process
Take Purified Water q. s as blank solution；
3) by step 1) concrete grammar of the need testing solution 0.01mol/L sodium thiosulfate volumetric solution prepared titration is: essence
Close measure step 1) the need testing solution 20ml for preparing, add 0.002mol/L potassium permanganate solution 20ml and dilute sulfuric acid 2ml, shake
Even, to boil 3 minutes, cool down rapidly, add potassium iodide 0.1g, dark place is placed 5 minutes, with 0.01mol/L sodium thiosulfate volumetric solution
Being titrated to light brown, add starch and refer to test solution 5, continuation 0.01mol/L sodium thiosulfate volumetric solution is titrated to colourless, is end
Point；Separately take step 2) blank solution, be measured in the same method, by consume volumetric solution volume difference calculate, obtain reducing substances in product
Amount.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610613408.5A CN106290333A (en) | 2016-07-27 | 2016-07-27 | A kind of detection method of sacculus product reducing substances |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610613408.5A CN106290333A (en) | 2016-07-27 | 2016-07-27 | A kind of detection method of sacculus product reducing substances |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106290333A true CN106290333A (en) | 2017-01-04 |
Family
ID=57663207
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610613408.5A Pending CN106290333A (en) | 2016-07-27 | 2016-07-27 | A kind of detection method of sacculus product reducing substances |
Country Status (1)
| Country | Link |
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| CN (1) | CN106290333A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101101286A (en) * | 2006-07-04 | 2008-01-09 | 吴礼龙 | Chlorine dioxide disinfector content detection method |
| CN101907616A (en) * | 2010-08-27 | 2010-12-08 | 长沙兴嘉生物工程股份有限公司 | Method for determining residual quantity of oxidant in inorganic salt |
| CN101929992A (en) * | 2010-08-19 | 2010-12-29 | 重庆市药品检验所 | Method for measuring oxidizable substance of drug packing material with total organic carbon analyser |
| CN102426169A (en) * | 2011-11-09 | 2012-04-25 | 天津市天骄辐射固化材料有限公司 | Method for detecting content of peroxide in polyether polyol |
-
2016
- 2016-07-27 CN CN201610613408.5A patent/CN106290333A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101101286A (en) * | 2006-07-04 | 2008-01-09 | 吴礼龙 | Chlorine dioxide disinfector content detection method |
| CN101929992A (en) * | 2010-08-19 | 2010-12-29 | 重庆市药品检验所 | Method for measuring oxidizable substance of drug packing material with total organic carbon analyser |
| CN101907616A (en) * | 2010-08-27 | 2010-12-08 | 长沙兴嘉生物工程股份有限公司 | Method for determining residual quantity of oxidant in inorganic salt |
| CN102426169A (en) * | 2011-11-09 | 2012-04-25 | 天津市天骄辐射固化材料有限公司 | Method for detecting content of peroxide in polyether polyol |
Non-Patent Citations (3)
| Title |
|---|
| 刘星 等: "医用输液、输血、注射器具中还原物质直接和间接检验方法的差异性比较", 《化学工程与装备》 * |
| 张磊 等: "一次性使用输液器中还原物质含量测定的不确定度分析", 《计量与测试技术》 * |
| 骆红宇 等: "《中华人民共和国国家标准》", 31 March 2009, 中国标准出版社 * |
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Application publication date: 20170104 |