CN106279714A - A kind of Tricyclohexyltin 2,2 ' biphenyl dicarboxylic acid ester coordination polymer and preparation method and application - Google Patents

A kind of Tricyclohexyltin 2,2 ' biphenyl dicarboxylic acid ester coordination polymer and preparation method and application Download PDF

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CN106279714A
CN106279714A CN201610667585.1A CN201610667585A CN106279714A CN 106279714 A CN106279714 A CN 106279714A CN 201610667585 A CN201610667585 A CN 201610667585A CN 106279714 A CN106279714 A CN 106279714A
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dicarboxylic acid
biphenyl dicarboxylic
tricyclohexyltin
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朱小明
成英杰
黄修辉
何哲超
蒋伍玖
庾江喜
张复兴
冯泳兰
邝代治
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Hengyang Normal University
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Abstract

A kind of Tricyclohexyltin 2,2 ' biphenyl dicarboxylic acid ester coordination polymer disclosed by the invention and preparation method and application, for the coordination polymer of following structure formula (I).The invention also discloses the preparation method of Tricyclohexyltin 2,2 ' biphenyl dicarboxylic acid ester coordination polymer and the application in preparing antitumor drug.

Description

A kind of Tricyclohexyltin 2,2 '-biphenyl dicarboxylic acid ester coordination polymer and preparation side thereof Method and application
Technical field
The present invention relates to a kind of Tricyclohexyltin 2,2 '-biphenyl dicarboxylic acid ester coordination polymer, and preparation method thereof, and This coordination polymer Tricyclohexyltin 2,2 '-biphenyl dicarboxylic acid ester application in preparing antitumor drug.
Background technology
Organotin is the metallo-organic compound that a class contains Sn-C key, has higher biological activity, in sterilization, kills Worm, cancer therapy drug the field such as are prepared and are had a wide range of applications.Existing research shows, the alkyl R in organotin is to determine The principal element of compound anti-cancering activity height, e.g., the active anticancer of cyclohexyl, normal-butyl and phenyltin compound is relatively strong, second Base takes second place, and methyl is then almost without active anticancer.The structure of part is to the active anticancer of coordination compound and the wide spectrum of killing cancerous cell Property also plays an important role, it is demonstrated experimentally that the biological activity of organotin carboxylate coordination compound is often than corresponding organotin Compound is high.
Chinese patent CN 103396437B discloses Tricyclohexyltin carboxylate preparation treatment cervical cancer, breast carcinoma, liver The medicine of cancer, colon cancer and pulmonary carcinoma is applied.
Chinese patent CN 103087325B discloses controlling in preparation containing ferrocenyl Tricyclohexyltin carboxylate polymer Treat in the medicine of hepatocarcinoma, nasopharyngeal carcinoma, breast carcinoma, colon cancer and pulmonary carcinoma and apply.
Being to the experiment proved that to have preferable bioactive material based on tin tricyclohexylhydroxide, the present invention selects three rings Hexyl stannic hydroxide, with part 2,2 '-biphenyl dicarboxylic acid, reacts under certain condition, and synthesis has obtained NCI-H460(people's lung Cancerous cell), MCF7(people's breast adenocarcinoma cell), HEPG2(human liver cancer cell) the stronger compound of inhibitory activity, anti-for exploitation Cancer drug provides new way.
Summary of the invention
The problem existed for above-mentioned prior art, the first object of the present invention there is provided a kind of Tricyclohexyltin 2, 2 '-biphenyl dicarboxylic acid ester coordination polymer.
The second object of the present invention is to provide the preparation of above-mentioned Tricyclohexyltin 2,2 '-biphenyl dicarboxylic acid ester coordination polymer Method.
It is anti-in preparation that 3rd mesh of the present invention is to provide above-mentioned Tricyclohexyltin 2,2 '-biphenyl dicarboxylic acid ester coordination polymer Application in cancer drug.
As a kind of Tricyclohexyltin 2 of first aspect present invention, 2 '-biphenyl dicarboxylic acid ester coordination polymer, it is such as The coordination polymer of lower structure formula (I):
(I)。
Tricyclohexyltin 2,2 '-biphenyl dicarboxylic acid ester coordination polymer of the present invention through elementary analysis, infrared spectrum analysis, Nuclear magnetic resoance spectrum and x-ray crystal structure analysis, result is as follows:
Elementary analysis (C32H41O4Sn): theoretical value: C, 63.18；H, 6.79.Measured value: C, 63.22；H, 6.15.
IR(KBr, v/cm-1): 3059, 3022, 2916, 2845 v(C-H), 1636 vas(COO-), 1333 vs (COO-), 552 v(Sn-C), 418 v(Sn-O)。
1H NMR(CDCl3, 500 MHz), δ (ppm): 8.04-7.10 (m, 8H, Ph-H), 1.73-1.23 (m, 33H, Cy-H).
13C NMR(CDCl3, 125 MHz), δ (ppm): 26.83,28.91,30.84,33.45 (Cy), 126.30, 129.75,130.21,130.84,131.41,144.47 (Ph), 172.73 (COO).
119Sn NMR(CDCl3, 186 MHz), δ(ppm): 13.06。
The Tricyclohexyltin 2 of the present invention, 2 '-biphenyl dicarboxylic acid ester coordination polymer is crystal structure, its crystallographic data: Crystal belongs to monoclinic system, space groupP21/n,a=1.83736 (11) nm,b=1.63243 (10) nm,c=2.14853(13) Nm,α=90 °,β=109.3940 (10) °,γ=90 °,Z=8, V=6.0786 (6) nm3,Dc=1.329Mg·m-3,μ (MoKa)=0.763mm-1,F(000)=2520,1.60 ° of ＜θ＜ 25.10 °, crystalline size: 0. 28 × 0.21 × 0.19mm,R=0.0391,wR=0.0988。
Being structurally characterized in that of Tricyclohexyltin 2,2 '-biphenyl dicarboxylic acid ester coordination polymer of the present invention: in molecule Heart stannum and coordination atom constitute pentacoordinate distortion double angles third hand tap configuration, and, tin atom passes through bridge ligand 2,2 '-biphenyl diformazan Acid coordination defines one-dimensional chain polymer..
Preparation side as a kind of Tricyclohexyltin 2,2 '-biphenyl dicarboxylic acid ester coordination polymer of second aspect present invention Method, is sequentially added into 2 in reaction vessel in order, and 2 '-biphenyl dicarboxylic acid, tin tricyclohexylhydroxide and etoh solvent, in temperature Degree reacts 8～24h under conditions of being 50 ~ 65 DEG C；Cooling, filters, and controls solvent volatilization crystallization under conditions of 20 ~ 35 DEG C, Colourless transparent crystal, is Tricyclohexyltin 2,2 '-biphenyl dicarboxylic acid ester coordination polymer.
In a preferred embodiment of the invention, described 2,2 '-biphenyl dicarboxylic acid, both tin tricyclohexylhydroxides The amount of material is than for 1:(1 ~ 1.05).
In a preferred embodiment of the invention, described etoh solvent consumption is every mM of tin tricyclohexylhydroxide Add 20 ~ 35 milliliters.
A kind of Tricyclohexyltin 2,2 '-biphenyl dicarboxylic acid ester coordination polymer as third aspect present invention is anti-in preparation Application in cancer drug.
Applicant has carried out anti tumor activity in vitro and has confirmed research above-mentioned coordination polymer, confirms that this coordination polymer has There is certain anti-tumor biological, say, that the purposes of above-mentioned coordination polymer is answering in preparing antitumor drug With, it is exactly specifically the application in preparing anti-human lung-cancer medicament, human breast carcinoma, people's liver-cancer medicine.
Tricyclohexyltin 2,2 '-biphenyl dicarboxylic acid ester coordination polymer of the present invention is to people's lung-cancer medicament, human breast carcinoma, people Liver-cancer medicines etc. demonstrate good active anticancer, can prepare anti-lung cancer, anti-breast cancer, medicines resistant to liver cancer with it for raw material.With The platinum-containing anticancer drug commonly used at present is compared, the Tricyclohexyltin 2 of the present invention, 2 '-biphenyl dicarboxylic acid ester coordination polymer There is the features such as active anticancer height, low cost, preparation method are simple, provide new way for exploitation cancer therapy drug.
Accompanying drawing explanation
Fig. 1 is the crystal molecular structure figure of Tricyclohexyltin 2,2 '-biphenyl dicarboxylic acid ester coordination polymer.
Fig. 2 is the IR spectrogram of Tricyclohexyltin 2,2 '-biphenyl dicarboxylic acid ester coordination polymer.
Fig. 3 is Tricyclohexyltin 2,2 '-biphenyl dicarboxylic acid ester coordination polymer1H NMR spectra.
Fig. 4 is Tricyclohexyltin 2,2 '-biphenyl dicarboxylic acid ester coordination polymer13C NMR spectra.
Fig. 5 is Tricyclohexyltin 2,2 '-biphenyl dicarboxylic acid ester coordination polymer119Sn NMR spectra.
Fig. 6 is the TG-DTG curve of Tricyclohexyltin 2,2 '-biphenyl dicarboxylic acid ester coordination polymer.
Detailed description of the invention
Further describe the present invention by following example, but it should be noted that the scope of the present invention is not implemented by these Any restriction of example.
Embodiment 1:
The preparation of Tricyclohexyltin 2,2 '-biphenyl dicarboxylic acid ester coordination polymer:
2,2 '-biphenyl dicarboxylic acid 0.2424g (1mmol), thricyclohexyl hydrogen-oxygen it is sequentially added in order in 100ml round-bottomed flask Change stannum 0.3845g (1mmol), etoh solvent 20mL, under conditions of temperature is 50 ~ 65 DEG C, reacts 8h；Cooling, filters, 20 ~ Controlling solvent volatilization crystallization under conditions of 35 DEG C, obtain colourless transparent crystal, be Tricyclohexyltin 2,2 '-biphenyl dicarboxylic acid ester is joined Position polymer.Productivity: 67%, fusing point: 147-148 DEG C.
Elementary analysis (C32H41O4Sn): theoretical value: C, 63.18；H, 6.79.Measured value: C, 63.22；H, 6.15.
IR(KBr, v/cm-1): 3059, 3022, 2916, 2845 v(C-H), 1636 vas(COO-), 1333 vs (COO-), 552 v(Sn-C), 418 v(Sn-O)。
1H NMR(CDCl3, 500 MHz), δ (ppm): 8.04-7.10 (m, 8H, Ph-H), 1.73-1.23 (m, 33H, Cy-H).
13C NMR(CDCl3, 125 MHz), δ (ppm): 26.83,28.91,30.84,33.45 (Cy), 126.30, 129.75,130.21,130.84,131.41,144.47 (Ph), 172.73 (COO).
119Sn NMR(CDCl3, 186 MHz), δ (ppm): 13.06。
Its crystallographic data: crystal belongs to monoclinic system, space groupP21/n,a=1.83736 (11) nm,b=1.63243 (10) nm,c=2.14853 (13) nm,α=90 °,β=109.3940 (10) °,γ=90 °,Z=8, V=6.0786 (6) nm3,Dc=1.329Mg·m-3,μ(MoKa)=0.763mm-1,F(000)=2520,1.60 ° of ＜θ＜ 25.10 °, crystal chi It is very little: 0. 28 × 0.21 × 0.19mm,R=0.0391,wR=0.0988。
Embodiment 2:
The preparation of Tricyclohexyltin 2,2 '-biphenyl dicarboxylic acid ester coordination polymer:
2,2 '-biphenyl dicarboxylic acid 0.2416g (1mmol), thricyclohexyl hydrogen-oxygen it is sequentially added in order in 100ml round-bottomed flask Change stannum 0.4049g (1.05mmol), etoh solvent 37mL, under conditions of temperature is 50 ~ 65 DEG C, reacts 11h；Cooling, filters, Under conditions of 20 ~ 35 DEG C, control solvent volatilization crystallization, obtain colourless transparent crystal, be Tricyclohexyltin 2,2 '-biphenyl diformazan Acid esters coordination polymer.Productivity: 69%, fusing point: 147-148 DEG C.
Elementary analysis (C32H41O4Sn): theoretical value: C, 63.18；H, 6.79.Measured value: C, 63.22；H, 6.15.
IR(KBr, v/cm-1): 3059, 3022, 2916, 2845 v(C-H), 1636 vas(COO-), 1333 vs (COO-), 552 v(Sn-C), 418 v(Sn-O)。
1H NMR(CDCl3, 500 MHz), δ (ppm): 8.04-7.10 (m, 8H, Ph-H), 1.73-1.23 (m, 33H, Cy-H).
13C NMR(CDCl3, 125 MHz), δ (ppm): 26.83,28.91,30.84,33.45 (Cy), 126.30, 129.75,130.21,130.84,131.41,144.47 (Ph), 172.73 (COO).
119Sn NMR(CDCl3, 186 MHz), δ(ppm): 13.06。
Its crystallographic data: crystal belongs to monoclinic system, space groupP 21/n,a=1.83736 (11) nm,b =1.63243 (10) nm,c=2.14853 (13) nm,α=90 °,β=109.3940 (10) °,γ=90 °,Z=8, V=6.0786 (6) nm3,D c=1.329Mg·m-3,μ (MoKa)=0.763mm-1,F(000)=2520,1.60 ° of ＜θ＜ 25.10 °, crystal chi It is very little: 0. 28 × 0.21 × 0.19mm,R=0.0391,w R =0.0988。
Embodiment 3:
The preparation of Tricyclohexyltin 2,2 '-biphenyl dicarboxylic acid ester coordination polymer:
2,2 '-biphenyl dicarboxylic acid 0.4818g (2mmol), thricyclohexyl hydrogen-oxygen it is sequentially added in order in 100ml round-bottomed flask Change stannum 0.7894g (2.05mmol), etoh solvent 45mL, under conditions of temperature is 50 ~ 65 DEG C, reacts 15h；Cooling, filters, Under conditions of 20 ~ 35 DEG C, control solvent volatilization crystallization, obtain colourless transparent crystal, be Tricyclohexyltin 2,2 '-biphenyl diformazan Acid esters coordination polymer.Productivity: 67%, fusing point: 147-148 DEG C.
Elementary analysis (C32H41O4Sn): theoretical value: C, 63.18；H, 6.79.Measured value: C, 63.22；H, 6.15.
IR(KBr, v/cm-1): 3059, 3022, 2916, 2845 v(C-H), 1636 vas(COO-), 1333 vs (COO-), 552 v(Sn-C), 418 v(Sn-O)。
1H NMR(CDCl3, 500 MHz), δ (ppm): 8.04-7.10 (m, 8H, Ph-H), 1.73-1.23 (m, 33H, Cy-H).
13C NMR(CDCl3, 125 MHz), δ (ppm): 26.83,28.91,30.84,33.45 (Cy), 126.30, 129.75,130.21,130.84,131.41,144.47 (Ph), 172.73 (COO).
119Sn NMR(CDCl3, 186 MHz), δ(ppm): 13.06。
Its crystallographic data: crystal belongs to monoclinic system, space groupP 21/n,a=1.83736 (11) nm,b =1.63243 (10) nm,c=2.14853 (13) nm,α=90 °,β=109.3940 (10) °,γ=90 °,Z=8, V=6.0786 (6) nm3,D c=1.329Mg·m-3,μ (MoKa)=0.763mm-1,F(000)=2520,1.60 ° of ＜θ＜ 25.10 °, crystal chi It is very little: 0.28 × 0.21 × 0.19mm,R=0.0391,w R =0.0988。
Embodiment 4:
The preparation of Tricyclohexyltin 2,2 '-biphenyl dicarboxylic acid ester coordination polymer:
2,2 '-biphenyl dicarboxylic acid 0.7262g (3mmol), thricyclohexyl hydrogen-oxygen it is sequentially added in order in 100ml round-bottomed flask Change stannum 1.2136g (3.15mmol), etoh solvent 70mL, under conditions of temperature is 50 ~ 65 DEG C, reacts 24h；Cooling, filters, Under conditions of 20 ~ 35 DEG C, control solvent volatilization crystallization, obtain colourless transparent crystal, be Tricyclohexyltin 2,2 '-biphenyl diformazan Acid esters coordination polymer.Productivity: 68%, fusing point: 147-148 DEG C.
Elementary analysis (C32H41O4Sn): theoretical value: C, 63.18；H, 6.79.Measured value: C, 63.22；H, 6.15.
IR(KBr, v/cm-1): 3059, 3022, 2916, 2845 v(C-H), 1636 vas(COO-), 1333 vs (COO-), 552 v(Sn-C), 418 v(Sn-O)。
1H NMR(CDCl3, 500 MHz), δ (ppm): 8.04-7.10 (m, 8H, Ph-H), 1.73-1.23 (m, 33H, Cy-H).
13C NMR(CDCl3, 125 MHz), δ (ppm): 26.83,28.91,30.84,33.45 (Cy), 126.30, 129.75,130.21,130.84,131.41,144.47 (Ph), 172.73 (COO).
119Sn NMR(CDCl3, 186 MHz), δ (ppm): 13.06。
Its crystallographic data: crystal belongs to monoclinic system, space groupP 21/n,a=1.83736 (11) nm,b =1.63243 (10) nm,c=2.14853 (13) nm,α=90 °,β=109.3940 (10) °,γ=90 °,Z=8, V=6.0786 (6) nm3,D c=1.329Mg·m-3,μ (MoKa)=0.763mm-1,F(000)=2520,1.60 ° of ＜θ＜ 25.10 °, crystal chi It is very little: 0. 28 × 0.21 × 0.19mm,R=0.0391,w R =0.0988。
Embodiment 5:
The preparation of Tricyclohexyltin 2,2 '-biphenyl dicarboxylic acid ester coordination polymer:
2,2 '-biphenyl dicarboxylic acid 0.726g (3mmol), thricyclohexyl hydrogen-oxygen it is sequentially added in order in 100ml round-bottomed flask Change stannum 1.1548g (3mmol), etoh solvent 70mL, under conditions of temperature is 50 ~ 65 DEG C, reacts 24h；Cooling, filters, 20 Control solvent volatilization crystallization under conditions of ~ 35 DEG C, obtain colourless transparent crystal, be Tricyclohexyltin 2,2 '-biphenyl dicarboxylic acid ester Coordination polymer.Productivity: 67%, fusing point: 147-148 DEG C.
Elementary analysis (C32H41O4Sn): theoretical value: C, 63.18；H, 6.79.Measured value: C, 63.22；H, 6.15.
IR(KBr, v/cm-1): 3059, 3022, 2916, 2845 v(C-H), 1636 vas(COO-), 1333 vs (COO-), 552 v(Sn-C), 418 v(Sn-O)。
1H NMR(CDCl3, 500 MHz), δ (ppm): 8.04-7.10 (m, 8H, Ph-H), 1.73-1.23 (m, 33H, Cy-H).
13C NMR(CDCl3, 125 MHz), δ (ppm): 26.83,28.91,30.84,33.45 (Cy), 126.30, 129.75,130.21,130.84,131.41,144.47 (Ph), 172.73 (COO).
119Sn NMR(CDCl3, 186 MHz), δ(ppm): 13.06。
Its crystallographic data: crystal belongs to monoclinic system, space groupP 21/n,a=1.83736 (11) nm,b =1.63243 (10) nm,c=2.14853 (13) nm,α=90 °,β=109.3940 (10) °,γ=90 °,Z=8, V=6.0786 (6) nm3,D c=1.329Mg·m-3,μ (MoKa)=0.763mm-1,F(000)=2520,1.60 ° of ＜θ＜ 25.10 °, crystal chi It is very little: 0. 28 × 0.21 × 0.19mm,R=0.0391,w R =0.0988。
Test example:
The Tricyclohexyltin 2 of the present invention, 2 '-biphenyl dicarboxylic acid ester coordination polymer, it is to pass through MTT that its Anticancer Activity in vitro measures Experimental technique realizes.
MTT analyses method:
With metabolism reduction 3-(4,5-Dimethylthiazol-2-yl)-2,5-diArenyltetrazolium bromide it is Basis.Succinate dehydrogenase in living cells mitochondrion can make exogenous MTT be reduced to water-insoluble bluish violet crystallization first a ceremonial jade-ladle, used in libation (Formazan) and be deposited in cell, and dead cell is without this function.Dimethyl sulfoxide (DMSO) can dissolve the first a ceremonial jade-ladle, used in libation in cell, Measure the optical density of characteristic wavelength by microplate reader, can indirectly reflect living cells quantity.
Mtt assay is used to measure Tricyclohexyltin 2,2 '-biphenyl dicarboxylic acid ester coordination polymer of embodiment 1 preparation to people Lung carcinoma cell (NCI-H460), human breast cancer cell (MCF7), the inhibitory activity of human liver cancer cell (HepG2).
Cell strain and cultivating system: NCI-H460, MCF7 and HepG2 cell strain takes from American. tissue incubator (ATCC). By RPMI1640 (GIBICO company) culture medium containing 10% hyclone, at 5% (volume fraction) CO2, 37 DEG C of saturated humidity trainings In vitro culture is carried out in supporting case.
Test process: test medicinal liquid (0.1nM-10 μM) is added separately in each hole according to the Concentraton gradient of concentration, Each concentration sets 3 parallel holes.Experiment is divided into drug test group (being separately added into the test medicine of variable concentrations), matched group (only to add Culture fluid and cell, be not added with testing medicine) and blank group (only adding culture fluid, be not added with cell and test medicine).By the orifice plate after dosing It is placed in 37 DEG C, 5%CO2Incubator is cultivated 72h.The activity of control drug measures according to the method for test sample.Cultivating In orifice plate after 72h, every hole adds MTT40uL (being made into 4mg/mL with D-Hanks buffer).After placing 4h at 37 DEG C, remove Clear liquid.Every hole adds 150uL DMSO, and vibrate 5min, makes Formazan crystallization dissolve.Finally, utilize automatic microplate reader at 570nm The optical density in each hole is detected at wavelength.
Data process: data process and use GraAr Pad Prism version5.0 program, compound IC50Pass through program In there is the nonlinear regression model (NLRM) of S-shaped dose response be fitted obtaining.
With MTT analytic process to human lung carcinoma cell (NCI-H460) cell strain, human breast cancer cell (MCF7) cell strain, people liver Cancerous cell (HepG2) cell strain is analyzed, and measures its IC50Value, result is as shown in table 1, and conclusion is: from data in table, The Tricyclohexyltin 2 of the present invention, 2 '-biphenyl dicarboxylic acid ester coordination polymer as cancer therapy drug, to people's pulmonary carcinoma, human breast carcinoma, People's hepatocarcinoma active anticancer is higher, can be as the candidate compound of cancer therapy drug.
Table 1 Tricyclohexyltin 2,2 '-biphenyl dicarboxylic acid ester coordination polymer cancer therapy drug external activity test data.
Human lung carcinoma cell Human breast cancer cell Human liver cancer cell
Cell strain NCI-H460 MC-7 HEPG2
IC50 μM 4.66 3.31 3.27
Tricyclohexyltin 2,2 '-biphenyl dicarboxylic acid ester coordination polymer prepared by remaining embodiment with mtt assay to people's pulmonary carcinoma The active anticancer method of testing of cell (NCI-H460), human liver cancer cell (HepG2) and human breast cancer cell (MCF7) is with test Example, test result is essentially identical with table 1.

Claims (9)

1. a Tricyclohexyltin 2,2 '-biphenyl dicarboxylic acid ester coordination polymer, for the coordination polymer of following structure formula (I):
(I)。
2. as claimed in claim 1 containing a kind of Tricyclohexyltin 2,2 '-biphenyl dicarboxylic acid ester coordination polymer, its infrared light Modal data: FT-IR (KBr, v/cm-1): 3059, 3022, 2916, 2845 v(C-H), 1636 vas(COO-), 1333 vs(COO-), 552 v(Sn-C), 418 v(Sn-O)；Its nuclear-magnetism modal data:1H NMR(CDCl3, 500 MHz), δ (ppm): 8.04-7.10 (m, 8H, Ph-H), 1.73-1.23 (m, 33H, Cy-H)；13C NMR(CDCl3, 125 MHz), δ (ppm): 26.83,28.91,30.84,33.45 (Cy), 126.30,129.75,130.21,130.84,131.41, 144.47(Ph), 172.73(COO)；119Sn NMR(CDCl3, 186 MHz), δ(ppm): 13.06。
3. Tricyclohexyltin 2 as claimed in claim 1,2 '-biphenyl dicarboxylic acid ester coordination polymer, wherein, three described rings Hexyl stannum 2,2 '-biphenyl dicarboxylic acid ester coordination polymer is crystal structure, and its crystallographic data is as follows: monoclinic system, space groupP21/n,a=1.83736 (11) nm,b=1.63243 (10) nm,c=2.14853 (13) nm,α=90 °,β= 109.3940 (10) °,γ=90 °,Z=8, V=6.0786 (6) nm3；Center stannum in molecule constitutes pentacoordinate with coordination atom Distortion double angles third hand tap configuration, and, tin atom passes through bridge ligand 2, and the coordination of 2 '-biphenyl dicarboxylic acid defines one-dimensional chain polymerization Thing.
4. the Tricyclohexyltin 2 described in claim 1, the preparation method of 2 '-biphenyl dicarboxylic acid ester coordination polymer, its feature exists In, reaction vessel is sequentially added into 2 in order, 2 '-biphenyl dicarboxylic acid, tin tricyclohexylhydroxide and etoh solvent, in temperature Degree reacts 8～24h under conditions of being 50 ~ 65 DEG C；Cooling, filters, and controls solvent volatilization crystallization under conditions of 20 ~ 35 DEG C, Colourless transparent crystal, is Tricyclohexyltin 2,2 '-biphenyl dicarboxylic acid ester coordination polymer.
5. preparation method as claimed in claim 4, it is characterised in that described 2,2 '-biphenyl dicarboxylic acid, double [three (2-methyl- 2-phenyl propyl) stannum] amount of material of both oxides is than for 1:(1 ~ 1.05).
6. preparation method as claimed in claim 4, it is characterised in that described etoh solvent consumption is every mM of thricyclohexyl Stannic hydroxide adds 20 ~ and 35 milliliters.
7. the Tricyclohexyltin 2,2 '-biphenyl dicarboxylic acid ester coordination polymer described in claim 1 has certain thermally-stabilised model Enclose, can stable existence below 155 DEG C.
8. the answering in preparing cancer therapy drug of Tricyclohexyltin 2,2 '-biphenyl dicarboxylic acid ester coordination polymer described in claim 1 With.
9. the application described in claim 8, wherein said cancerous cell is pulmonary carcinoma, breast carcinoma, hepatocarcinoma.
CN201610667585.1A 2016-08-15 2016-08-15 A kind of 2,2 '-biphenyl dicarboxylic acid of Tricyclohexyltin ester coordination polymer and the preparation method and application thereof Active CN106279714B (en)

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