CN106267362A - A kind of bionical medical composite material and application thereof - Google Patents
A kind of bionical medical composite material and application thereof Download PDFInfo
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- CN106267362A CN106267362A CN201610786113.8A CN201610786113A CN106267362A CN 106267362 A CN106267362 A CN 106267362A CN 201610786113 A CN201610786113 A CN 201610786113A CN 106267362 A CN106267362 A CN 106267362A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/10—Ceramics or glasses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
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Abstract
The invention discloses a kind of bionical medical composite material and application thereof, be prepared from by the raw material of following weight portion: tricalcium phosphate, 55 65 parts；Hydroxyapatite, 35 45 parts；Modified glass-fiber, 25 35 parts；Methyl vinyl silicone rubber, 20 30 parts；Sargassum polysaccharides, 10 20 parts；Glycerol, 10 20 parts；Nano-cellulose, 5 15 parts；Deionized water, 6 10 parts；The preparation method of described modified glass-fiber is: is immersed by glass fibre in fiberglass surface modifiers and takes out after 13 hours, with distilled water flushing glass fibre until after after Chong Xiing, liquid is neutrality, glass fibre is put into 15 25h in 75 85 DEG C of baking ovens, takes out, cool down and get final product；Fiberglass surface modifiers is prepared by after the raw material blending of following weight parts: pentaerythritol ester, 79 parts；Polyethylene Glycol, 35 parts；Acrylic acid, 35 parts；Cross-linking agent TAC, 24 parts；Mercaptoethanol, 24 parts.The medical composite material that the present invention provides has higher hot strength and tearing strength, may be used for preparing artificial bone.
Description
Technical field
The invention belongs to field of compound material, be specifically related to a kind of bionical medical composite material and application thereof.
Background technology
Biomimetic material refers to the various features of mimic biology or characteristic and the material developed.Generally copying life system
Operational mode and the structure law of biomaterial of system and the artificial material that manufactures and designs is referred to as biomimetic material.Bionics is at material
Branch in science is referred to as Researches on Biomimetic Materials (biomimetic materials science), and it refers to grind from molecular level
Study carefully the construction features of biomaterial, structure activity relationship, and then develop a new branch of science that is similar or that be better than protozoa material, be
The intersection of the subjects such as chemistry, materialogy, biology, physics.The structure of Bionic Design biological object to be simulated, more wants mould
Intend its function.Material science, life sciences, bionics are combined, for promoting the development of material science to be significant.
One of most important performance of biomimetic material is exactly that requirement has some strength, including hot strength and tearing strength.
Summary of the invention
It is an object of the invention to provide a kind of bionical medical composite material and application thereof.
The above-mentioned purpose of the present invention is achieved by techniques below scheme:
A kind of bionical medical composite material, is prepared from by the raw material of following weight portion: tricalcium phosphate, 55-65 part；Hydroxyl
Base apatite, 35-45 part；Modified glass-fiber, 25-35 part；Methyl vinyl silicone rubber, 20-30 part；Sargassum polysaccharides, 10-20
Part；Glycerol, 10-20 part；Nano-cellulose, 5-15 part；Deionized water, 6-10 part；The preparation side of described modified glass-fiber
Method is: is immersed by glass fibre in fiberglass surface modifiers and to take out after 1-3 hour, with distilled water flushing glass fibre until
After liquid is neutrality after flushing, glass fibre is put into 15-25h in 75-85 DEG C of baking oven, take out, cool down and get final product；Glass fibers dimension table
Face modifying agent is prepared by after the raw material blending of following weight parts: pentaerythritol ester, 7-9 part；Polyethylene Glycol, 3-5 part；Acrylic acid,
3-5 part；Cross-linking agent TAC, 2-4 part；Mercaptoethanol, 2-4 part.
Preferably, the preparation method of described modified glass-fiber is: glass fibre is immersed fiberglass surface modifiers
In after 2 hours take out, with distilled water flushing glass fibre until after liquid is neutrality after Chong Xiing, glass fibre being put into 80 DEG C of bakings
20h in case, takes out, cools down and get final product；Fiberglass surface modifiers is prepared by after the raw material blending of following weight parts: tetramethylolmethane
Ester, 8 parts；Polyethylene Glycol, 4 parts；Acrylic acid, 4 parts；Cross-linking agent TAC, 3 parts；Mercaptoethanol, 3 parts.
Preferably, described bionical medical composite material is prepared from by the raw material of following weight portion: tricalcium phosphate, and 60
Part；Hydroxyapatite, 40 parts；Modified glass-fiber, 30 parts；Methyl vinyl silicone rubber, 25 parts；Sargassum polysaccharides, 15 parts；The third three
Alcohol, 15 parts；Nano-cellulose, 10 parts；Deionized water, 8 parts.
Preferably, described bionical medical composite material is prepared from by the raw material of following weight portion: tricalcium phosphate, and 55
Part；Hydroxyapatite, 35 parts；Modified glass-fiber, 25 parts；Methyl vinyl silicone rubber, 20 parts；Sargassum polysaccharides, 10 parts；The third three
Alcohol, 10 parts；Nano-cellulose, 5 parts；Deionized water, 6 parts.
Preferably, described bionical medical composite material is prepared from by the raw material of following weight portion: tricalcium phosphate, and 65
Part；Hydroxyapatite, 45 parts；Modified glass-fiber, 35 parts；Methyl vinyl silicone rubber, 30 parts；Sargassum polysaccharides, 20 parts；The third three
Alcohol, 20 parts；Nano-cellulose, 15 parts；Deionized water, 10 parts.
The preparation method of above-mentioned bionical medical composite material comprise the steps: first by tricalcium phosphate, hydroxyapatite and
Sargassum polysaccharides mixed grinding, then mix with leftover materials；Melt blending 5-15 minute in extruder is added after mix homogeneously；Finally
Extrude at a temperature of 220-240 DEG C and get final product.
Preferably, in extruder, melt blending is extruded after 10 minutes at a temperature of 230 DEG C.
The application in terms of preparing artificial bone of the above-mentioned bionical medical composite material.
Advantages of the present invention:
The medical composite material that the present invention provides has higher hot strength and tearing strength, may be used for preparation artificial
Bone.
Detailed description of the invention
Further illustrate the essentiality content of the present invention below in conjunction with embodiment, but do not limit the present invention with this and protect model
Enclose.Although the present invention being explained in detail with reference to preferred embodiment, it will be understood by those within the art that, can be right
Technical scheme is modified or equivalent, without deviating from the spirit and scope of technical solution of the present invention.
Embodiment 1: the preparation of bionical medical composite material
Parts by weight of raw materials compares:
Tricalcium phosphate, 60 parts；Hydroxyapatite, 40 parts；Modified glass-fiber, 30 parts；Methyl vinyl silicone rubber, 25
Part；Sargassum polysaccharides, 15 parts；Glycerol, 15 parts；Nano-cellulose, 10 parts；Deionized water, 8 parts.
Wherein, the preparation method of described modified glass-fiber is: glass fibre immerses in fiberglass surface modifiers 2
Take out after hour, with distilled water flushing glass fibre until after liquid is neutrality after Chong Xiing, glass fibre being put into 80 DEG C of baking ovens
Middle 20h, takes out, cools down and get final product；Fiberglass surface modifiers is prepared by after the raw material blending of following weight parts: tetramethylolmethane
Ester, 8 parts；Polyethylene Glycol, 4 parts；Acrylic acid, 4 parts；Cross-linking agent TAC, 3 parts；Mercaptoethanol, 3 parts.
The preparation method of bionical medical composite material:
First by tricalcium phosphate, hydroxyapatite and Sargassum polysaccharides mixed grinding, then mix with leftover materials；After mix homogeneously
Add melt blending 10 minutes in extruder；Finally extrude at a temperature of 230 DEG C and get final product.
Embodiment 2: the preparation of bionical medical composite material
Parts by weight of raw materials compares:
Tricalcium phosphate, 55 parts；Hydroxyapatite, 35 parts；Modified glass-fiber, 25 parts；Methyl vinyl silicone rubber, 20
Part；Sargassum polysaccharides, 10 parts；Glycerol, 10 parts；Nano-cellulose, 5 parts；Deionized water, 6 parts.
Wherein, the preparation method of described modified glass-fiber is: glass fibre immerses in fiberglass surface modifiers 2
Take out after hour, with distilled water flushing glass fibre until after liquid is neutrality after Chong Xiing, glass fibre being put into 80 DEG C of baking ovens
Middle 20h, takes out, cools down and get final product；Fiberglass surface modifiers is prepared by after the raw material blending of following weight parts: tetramethylolmethane
Ester, 8 parts；Polyethylene Glycol, 4 parts；Acrylic acid, 4 parts；Cross-linking agent TAC, 3 parts；Mercaptoethanol, 3 parts.
The preparation method of bionical medical composite material:
First by tricalcium phosphate, hydroxyapatite and Sargassum polysaccharides mixed grinding, then mix with leftover materials；After mix homogeneously
Add melt blending 10 minutes in extruder；Finally extrude at a temperature of 230 DEG C and get final product.
Embodiment 3: the preparation of bionical medical composite material
Parts by weight of raw materials compares:
Tricalcium phosphate, 65 parts；Hydroxyapatite, 45 parts；Modified glass-fiber, 35 parts；Methyl vinyl silicone rubber, 30
Part；Sargassum polysaccharides, 20 parts；Glycerol, 20 parts；Nano-cellulose, 15 parts；Deionized water, 10 parts.
Wherein, the preparation method of described modified glass-fiber is: glass fibre immerses in fiberglass surface modifiers 2
Take out after hour, with distilled water flushing glass fibre until after liquid is neutrality after Chong Xiing, glass fibre being put into 80 DEG C of baking ovens
Middle 20h, takes out, cools down and get final product；Fiberglass surface modifiers is prepared by after the raw material blending of following weight parts: tetramethylolmethane
Ester, 8 parts；Polyethylene Glycol, 4 parts；Acrylic acid, 4 parts；Cross-linking agent TAC, 3 parts；Mercaptoethanol, 3 parts.
The preparation method of bionical medical composite material:
First by tricalcium phosphate, hydroxyapatite and Sargassum polysaccharides mixed grinding, then mix with leftover materials；After mix homogeneously
Add melt blending 10 minutes in extruder；Finally extrude at a temperature of 230 DEG C and get final product.
Embodiment 4: the preparation of bionical medical composite material
Parts by weight of raw materials compares:
Tricalcium phosphate, 60 parts；Hydroxyapatite, 40 parts；Modified glass-fiber, 28 parts；Methyl vinyl silicone rubber, 25
Part；Sargassum polysaccharides, 15 parts；Glycerol, 15 parts；Nano-cellulose, 10 parts；Deionized water, 8 parts.
Wherein, the preparation method of described modified glass-fiber is: glass fibre immerses in fiberglass surface modifiers 2
Take out after hour, with distilled water flushing glass fibre until after liquid is neutrality after Chong Xiing, glass fibre being put into 80 DEG C of baking ovens
Middle 20h, takes out, cools down and get final product；Fiberglass surface modifiers is prepared by after the raw material blending of following weight parts: tetramethylolmethane
Ester, 8 parts；Polyethylene Glycol, 4 parts；Acrylic acid, 4 parts；Cross-linking agent TAC, 3 parts；Mercaptoethanol, 3 parts.
The preparation method of bionical medical composite material:
First by tricalcium phosphate, hydroxyapatite and Sargassum polysaccharides mixed grinding, then mix with leftover materials；After mix homogeneously
Add melt blending 10 minutes in extruder；Finally extrude at a temperature of 230 DEG C and get final product.
Embodiment 5: the preparation of bionical medical composite material
Parts by weight of raw materials compares:
Tricalcium phosphate, 60 parts；Hydroxyapatite, 40 parts；Modified glass-fiber, 32 parts；Methyl vinyl silicone rubber, 25
Part；Sargassum polysaccharides, 15 parts；Glycerol, 15 parts；Nano-cellulose, 10 parts；Deionized water, 8 parts.
Wherein, the preparation method of described modified glass-fiber is: glass fibre immerses in fiberglass surface modifiers 2
Take out after hour, with distilled water flushing glass fibre until after liquid is neutrality after Chong Xiing, glass fibre being put into 80 DEG C of baking ovens
Middle 20h, takes out, cools down and get final product；Fiberglass surface modifiers is prepared by after the raw material blending of following weight parts: tetramethylolmethane
Ester, 8 parts；Polyethylene Glycol, 4 parts；Acrylic acid, 4 parts；Cross-linking agent TAC, 3 parts；Mercaptoethanol, 3 parts.
The preparation method of bionical medical composite material:
First by tricalcium phosphate, hydroxyapatite and Sargassum polysaccharides mixed grinding, then mix with leftover materials；After mix homogeneously
Add melt blending 10 minutes in extruder；Finally extrude at a temperature of 230 DEG C and get final product.
Embodiment 6: comparative example, glass fibre is the most modified
Parts by weight of raw materials compares:
Tricalcium phosphate, 60 parts；Hydroxyapatite, 40 parts；Glass fibre, 30 parts；Methyl vinyl silicone rubber, 25 parts；Sea
Polysaccharides, 15 parts；Glycerol, 15 parts；Nano-cellulose, 10 parts；Deionized water, 8 parts.
The preparation method of bionical medical composite material:
First by tricalcium phosphate, hydroxyapatite and Sargassum polysaccharides mixed grinding, then mix with leftover materials；After mix homogeneously
Add melt blending 10 minutes in extruder；Finally extrude at a temperature of 230 DEG C and get final product.
Embodiment 7: effect example
Testing example 1-6 prepares the intensity of material respectively, result such as following table:
| Hot strength (MPa) | Tearing strength (kN m-1) | |
| Embodiment 1 | 14.2 | 32.9 |
| Embodiment 6 | 7.1 | 22.3 |
Embodiment 2-5 test result is basically identical with embodiment 1, enumerates the most one by one.
Result shows, medical composite material of the present invention has higher hot strength and tearing strength, may be used for preparation
Artificial bone.
The effect of above-described embodiment indicates that the essentiality content of the present invention, but does not limit the protection of the present invention with this
Scope.It will be understood by those within the art that, technical scheme can be modified or equivalent,
Essence and protection domain without deviating from technical solution of the present invention.
Claims (8)
1. a bionical medical composite material, it is characterised in that be prepared from by the raw material of following weight portion: tricalcium phosphate,
55-65 part；Hydroxyapatite, 35-45 part；Modified glass-fiber, 25-35 part；Methyl vinyl silicone rubber, 20-30 part；Sargassum
Polysaccharide, 10-20 part；Glycerol, 10-20 part；Nano-cellulose, 5-15 part；Deionized water, 6-10 part；Described modified glass fibre
The preparation method of dimension is: is immersed by glass fibre in fiberglass surface modifiers and takes out after 1-3 hour, uses distilled water flushing glass
Glass fiber, until after liquid is neutrality after Chong Xiing, glass fibre being put into 15-25h in 75-85 DEG C of baking oven, takes out, cools down and get final product；
Fiberglass surface modifiers is prepared by after the raw material blending of following weight parts: pentaerythritol ester, 7-9 part；Polyethylene Glycol, 3-5
Part；Acrylic acid, 3-5 part；Cross-linking agent TAC, 2-4 part；Mercaptoethanol, 2-4 part.
Bionical medical composite material the most according to claim 1, it is characterised in that the preparation side of described modified glass-fiber
Method is: is immersed by glass fibre in fiberglass surface modifiers and takes out after 2 hours, with distilled water flushing glass fibre until rushing
Wash after rear liquid is neutrality, glass fibre is put into 20h in 80 DEG C of baking ovens, takes out, cool down and get final product；Fiberglass surface modifiers
Prepared by after the raw material blending of following weight parts: pentaerythritol ester, 8 parts；Polyethylene Glycol, 4 parts；Acrylic acid, 4 parts；Cross-linking agent
TAC, 3 parts；Mercaptoethanol, 3 parts.
Bionical medical composite material the most according to claim 1, it is characterised in that prepared by the raw material of following weight portion
Form: tricalcium phosphate, 60 parts；Hydroxyapatite, 40 parts；Modified glass-fiber, 30 parts；Methyl vinyl silicone rubber, 25 parts；Sea
Polysaccharides, 15 parts；Glycerol, 15 parts；Nano-cellulose, 10 parts；Deionized water, 8 parts.
Bionical medical composite material the most according to claim 1, it is characterised in that prepared by the raw material of following weight portion
Form: tricalcium phosphate, 55 parts；Hydroxyapatite, 35 parts；Modified glass-fiber, 25 parts；Methyl vinyl silicone rubber, 20 parts；Sea
Polysaccharides, 10 parts；Glycerol, 10 parts；Nano-cellulose, 5 parts；Deionized water, 6 parts.
Bionical medical composite material the most according to claim 1, it is characterised in that prepared by the raw material of following weight portion
Form: tricalcium phosphate, 65 parts；Hydroxyapatite, 45 parts；Modified glass-fiber, 35 parts；Methyl vinyl silicone rubber, 30 parts；Sea
Polysaccharides, 20 parts；Glycerol, 20 parts；Nano-cellulose, 15 parts；Deionized water, 10 parts.
6. the preparation method of the arbitrary described bionical medical composite material of claim 1-5, it is characterised in that comprise the steps:
First by tricalcium phosphate, hydroxyapatite and Sargassum polysaccharides mixed grinding, then mix with leftover materials；Extrusion is added after mix homogeneously
Melt blending 5-15 minute in machine；Finally extrude at a temperature of 220-240 DEG C and get final product.
Preparation method the most according to claim 6, it is characterised in that: in extruder melt blending after 10 minutes at 230 DEG C
At a temperature of extrude.
8. claim 1-5 arbitrary described bionical medical composite material application in terms of preparing artificial bone.
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| CN201610786113.8A CN106267362A (en) | 2016-08-31 | 2016-08-31 | A kind of bionical medical composite material and application thereof |
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| CN201610786113.8A CN106267362A (en) | 2016-08-31 | 2016-08-31 | A kind of bionical medical composite material and application thereof |
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Citations (6)
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|---|---|---|---|---|
| CN1562390A (en) * | 2004-03-17 | 2005-01-12 | 武汉理工大学 | Method for preparing artificial head bones made from composite material and for modifying surface |
| US20070123604A1 (en) * | 2005-05-26 | 2007-05-31 | Ada Foundation | Dental releasing materials |
| CN103774423A (en) * | 2014-01-09 | 2014-05-07 | 郎溪普瑞泰渔具制造有限公司 | Modified carbon fiber for manufacturing fishing rod |
| CN104399121A (en) * | 2014-11-10 | 2015-03-11 | 苏州维泰生物技术有限公司 | Material for preparing artificial bones and preparation method thereof |
| CN104941006A (en) * | 2015-06-30 | 2015-09-30 | 苏州佑君环境科技有限公司 | Preparation method of composite material for joint prosthesis |
| EP2959882A1 (en) * | 2014-06-27 | 2015-12-30 | Stick Tech OY | A composite material and its uses |
-
2016
- 2016-08-31 CN CN201610786113.8A patent/CN106267362A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1562390A (en) * | 2004-03-17 | 2005-01-12 | 武汉理工大学 | Method for preparing artificial head bones made from composite material and for modifying surface |
| US20070123604A1 (en) * | 2005-05-26 | 2007-05-31 | Ada Foundation | Dental releasing materials |
| CN103774423A (en) * | 2014-01-09 | 2014-05-07 | 郎溪普瑞泰渔具制造有限公司 | Modified carbon fiber for manufacturing fishing rod |
| EP2959882A1 (en) * | 2014-06-27 | 2015-12-30 | Stick Tech OY | A composite material and its uses |
| CN104399121A (en) * | 2014-11-10 | 2015-03-11 | 苏州维泰生物技术有限公司 | Material for preparing artificial bones and preparation method thereof |
| CN104941006A (en) * | 2015-06-30 | 2015-09-30 | 苏州佑君环境科技有限公司 | Preparation method of composite material for joint prosthesis |
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