CN106267323A - A kind of preparation method of degradable medicine carrying poly (lactic acid-glycolic acid) operation suture thread - Google Patents
A kind of preparation method of degradable medicine carrying poly (lactic acid-glycolic acid) operation suture thread Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/14—Post-treatment to improve physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/005—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters containing a biologically active substance, e.g. a medicament or a biocide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
- A61L17/12—Homopolymers or copolymers of glycolic acid or lactic acid
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- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
- C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
- C08G63/08—Lactones or lactides
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F1/00—General methods for the manufacture of artificial filaments or the like
- D01F1/02—Addition of substances to the spinning solution or to the melt
- D01F1/10—Other agents for modifying properties
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F6/00—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof
- D01F6/88—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from mixtures of polycondensation products as major constituent with other polymers or low-molecular-weight compounds
- D01F6/92—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from mixtures of polycondensation products as major constituent with other polymers or low-molecular-weight compounds of polyesters
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
- A61L2300/622—Microcapsules
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Abstract
The present invention relates to the preparation method of a kind of degradable medicine carrying poly (lactic acid-glycolic acid) operation suture thread, the hollow silica sub-micron ball loading medicine is dispersed in the aqueous solution of degradable poly y, makes degradable medicine carrying poly (lactic acid-glycolic acid) operation suture thread operation suture thread by using spinning process to be embedded in degradable poly y fiber by the hollow silica sub-micron ball loading medicine；The preparation process of described degradable poly y includes: be 1) raw material by technical grade lactic acid aqueous solution and glycolic, carries out dehydration under vacuum refined, obtains y oligomer；2) by step 1) the y oligomer that obtains mixes with catalyst, adds in reaction vessel, under vacuum, and reacting by heating, obtain poly (lactic acid-glycolic acid) intermediate product；3) in step 2) in reaction vessel in add chain extender MDI, under vacuum, reacting by heating, obtain poly-lactic acid in high molecular weight glycolic.
Description
Technical field
The present invention relates to biomedicine field, concrete, relate to a kind of degradable medicine carrying poly (lactic acid-glycolic acid) operation stitching
The preparation method of line.
Background technology
The most domestic surgical sewing thread used clinically mainly divides nonabsorable stitching thread and absorbable suture
Two kinds.Nonabsorable stitching thread has nylon wire, polypropylene line, formal wire etc..These materials, as surgical sewing thread, are opened
Force intensity is high, and tissue reaction is low, but a disadvantage is that knotting difficulty, the most de-knot, it is impossible to degraded and absorbed, needs to take out stitches.Absorbable seam
Zygonema has cashmere line, polyglycolide, chitin, collagen fiber etc..Advanced absorbable suture should have stronger tension force
Intensity, good operating characteristics, material is homogeneous, stable, and no antigen, tissue reaction is low, is better than nonabsorable stitching thread.At present
The absorbable suture of China is also faced with three big problems: (1) preparation technology is limited, and Mechanical Properties of Products is the most as one wishes.(2) more
Advanced absorbable suture is the most expensive；(3) need to improve intensity and the solution of the polymer as absorbable suture
Certainly implant untoward reaction and the complication etc. in human body later stage.Due to these reasons, absorbable suture China clinically should
With also comparing limitation.
Summary of the invention
The technical problem to be solved is to provide a kind of degradable medicine carrying poly (lactic acid-glycolic acid) operation suture thread
Preparation method.
The technical scheme is that a kind of degradable medicine carrying poly (lactic acid-glycolic acid) operation seam
The preparation method of zygonema, is dispersed in the water-soluble of degradable poly y by the hollow silica sub-micron ball loading medicine
In liquid, by using spinning process that the hollow silica sub-micron ball loading medicine is embedded in degradable poly y
Fiber is made degradable medicine carrying poly (lactic acid-glycolic acid) operation suture thread operation suture thread；
The preparation process of described degradable poly y includes:
1) it is raw material by technical grade lactic acid aqueous solution and glycolic, carries out dehydration under vacuum refined, obtain lactic acid
Glycolic acid oligomer；
2) by step 1) the y oligomer that obtains mixes with catalyst, adds in reaction vessel, at vacuum bar
Under part, reacting by heating, obtain poly (lactic acid-glycolic acid) intermediate product；
3) in step 2) in reaction vessel in add chain extender MDI, under vacuum, reacting by heating, obtain high score
Son amount poly (lactic acid-glycolic acid).
Further, step 1) in vacuum be 2-4kPa, dewatering time is 0.5-10 hour, dehydration temperaturre scope 45-
100 DEG C, described lactic acid is 1:1-3 with the mol ratio of glycolic.
Further, step 2) in vacuum be 0.5-2kPa, range of reaction temperature 150-180 DEG C, the response time is 2-5
Hour, with mechanical agitation during reaction.
Further, step 2) in catalyst be two or three in stannous chloride, stannous octoate, p-methyl benzenesulfonic acid
Mixture, its gross mass is the 0.5%～1% of y oligomer quality.
Further, step 3) in vacuum be 1-3kPa, range of reaction temperature 130-160 DEG C, the response time is that 1-4 is little
Time, with mechanical agitation during reaction.
Further, step 3) in the 0.5%-that quality is poly (lactic acid-glycolic acid) intermediate product quality expanding even agent MDI
1.3%.
Further, step 3) in the adding method of chain extender, be to be directly added into reaction system, after melting mixing, then occur
Chain extending reaction.
Further, step 3) in the adding method of chain extender, be chain extender to be dissolved in solvent injection add, mixed process
In, solvent is discharged by vacuum system.
Further, the described hollow silica sub-micron ball preparation method loading medicine is: by hollow silica
Sub-micron ball is immersed in the aqueous solution of water soluble drug, stirs 1 day～4 days, be then 4 DEG C in temperature at temperature is 4 DEG C
Lower centrifugal, clean gained solid product, lyophilization with deionized water, obtain being loaded with the hollow silica of water soluble drug
Sub-micron ball；Or hollow silica sub-micron ball is immersed in the organic solvent of fat-soluble medicine, stir at temperature is 4 DEG C
Mix 1 day～4 days, then centrifugal at temperature is 4 DEG C, clean gained solid product, lyophilization with deionized water, loaded
The hollow silica sub-micron ball of fat-soluble medicine.
Further, described curative drug selected from neomycin, ribostamycin, micronomicin, A Si mycin, tetracycline,
Oxytetracycline, chlortetracycline, doxycycline, chloromycetin, thiamphenicol, erythromycin, albomycin, erythromycin ethylsuccinate, azithromycin, acetyl
Spiramycin, midecamycin, josamycin, lincomycin, clindamycin, vancomycin, bacitracin, polymyxin, phosphorus are mould
Element, ciramycin, cycloserine, griseofulvin, mitomycin, bleomycin, ciclosporin, metronidazole, penicillin, penicillin sodium,
One in benzylpenicillin potassium, ampicillin, amoxicillin, piperacillin, benzylpenicillin potassium or more than more than one；Or selected from upper
State the one in the derivant of curative drug or more than more than one；Or selected from above-mentioned curative drug and above-mentioned therapeutic medicine
A kind of in the derivant of thing or more than more than one mixture.
The invention has the beneficial effects as follows: obtain that a kind of molecular weight is high, hot strength is good, degradable and be mounted with medicine
Poly (lactic acid-glycolic acid) operation suture thread.
Detailed description of the invention
Principle and feature to the present invention are described below, and example is served only for explaining the present invention, is not intended to limit
Determine the scope of the present invention.
Embodiment 1
The preparation method of a kind of degradable medicine carrying poly (lactic acid-glycolic acid) operation suture thread, will load the hollow titanium dioxide of medicine
Silicon sub-micron ball is dispersed in the aqueous solution of degradable poly y, by using spinning process will to load the hollow of medicine
Silicon dioxide sub-micron sphere is embedded in degradable poly y fiber makes the operation of degradable medicine carrying poly (lactic acid-glycolic acid)
Stitching thread operation suture thread；
The preparation process of described degradable poly y includes:
1) it is raw material by technical grade lactic acid aqueous solution and glycolic, carries out dehydration under vacuum refined, obtain lactic acid
Glycolic acid oligomer；
2) by step 1) the y oligomer that obtains mixes with catalyst, adds in reaction vessel, at vacuum bar
Under part, reacting by heating, obtain poly (lactic acid-glycolic acid) intermediate product；
3) in step 2) in reaction vessel in add chain extender MDI, under vacuum, reacting by heating, obtain high score
Son amount poly (lactic acid-glycolic acid).
Step 1) in vacuum be 4kPa, dewatering time is 10 hours, dehydration temperaturre scope 100 DEG C, described lactic acid with
The mol ratio of glycolic is 1:3.
Step 2) in vacuum be 2kPa, range of reaction temperature 180 DEG C, the response time is 5 hours, with machine during reaction
Tool stirs.
Step 2) in catalyst be in stannous chloride, stannous octoate, p-methyl benzenesulfonic acid two or three mixture,
Its gross mass is the 1% of y oligomer quality.
Step 3) in vacuum be 3kPa, range of reaction temperature 160 DEG C, the response time is 4 hours, with machine during reaction
Tool stirs.
Step 3) in expand quality is poly (lactic acid-glycolic acid) intermediate product quality the 1.3% of even agent MDI.
Step 3) in the adding method of chain extender, be to be directly added into reaction system, after melting mixing, then occur chain extension anti-
Should.
Further, the described hollow silica sub-micron ball preparation method loading medicine is: by hollow silica
Sub-micron ball is immersed in the aqueous solution of water soluble drug, stirs 1 day～4 days, be then 4 DEG C in temperature at temperature is 4 DEG C
Lower centrifugal, clean gained solid product, lyophilization with deionized water, obtain being loaded with the hollow silica of water soluble drug
Sub-micron ball；Or hollow silica sub-micron ball is immersed in the organic solvent of fat-soluble medicine, stir at temperature is 4 DEG C
Mix 1 day～4 days, then centrifugal at temperature is 4 DEG C, clean gained solid product, lyophilization with deionized water, loaded
The hollow silica sub-micron ball of fat-soluble medicine.
Further, described curative drug selected from neomycin, ribostamycin, micronomicin, A Si mycin, tetracycline,
Oxytetracycline, chlortetracycline, doxycycline, chloromycetin, thiamphenicol, erythromycin, albomycin, erythromycin ethylsuccinate, azithromycin, acetyl
Spiramycin, midecamycin, josamycin, lincomycin, clindamycin, vancomycin, bacitracin, polymyxin, phosphorus are mould
Element, ciramycin, cycloserine, griseofulvin, mitomycin, bleomycin, ciclosporin, metronidazole, penicillin, penicillin sodium,
One in benzylpenicillin potassium, ampicillin, amoxicillin, piperacillin, benzylpenicillin potassium or more than more than one；Or selected from upper
State the one in the derivant of curative drug or more than more than one；Or selected from above-mentioned curative drug and above-mentioned therapeutic medicine
A kind of in the derivant of thing or more than more than one mixture.
Embodiment 2
The preparation method of a kind of degradable medicine carrying poly (lactic acid-glycolic acid) operation suture thread, will load the hollow titanium dioxide of medicine
Silicon sub-micron ball is dispersed in the aqueous solution of degradable poly y, by using spinning process will to load the hollow of medicine
Silicon dioxide sub-micron sphere is embedded in degradable poly y fiber makes the operation of degradable medicine carrying poly (lactic acid-glycolic acid)
Stitching thread operation suture thread；
The preparation process of described degradable poly y includes:
1) it is raw material by technical grade lactic acid aqueous solution and glycolic, carries out dehydration under vacuum refined, obtain lactic acid
Glycolic acid oligomer；
2) by step 1) the y oligomer that obtains mixes with catalyst, adds in reaction vessel, at vacuum bar
Under part, reacting by heating, obtain poly (lactic acid-glycolic acid) intermediate product；
3) in step 2) in reaction vessel in add chain extender MDI, under vacuum, reacting by heating, obtain high score
Son amount poly (lactic acid-glycolic acid).
Step 1) in vacuum be 2kPa, dewatering time is 0.5 hour, dehydration temperaturre scope 45 DEG C, described lactic acid with
The mol ratio of glycolic is 1:1.
Step 2) in vacuum be 0.5kPa, range of reaction temperature 130 DEG C, the response time is 2 hours, adjoint during reaction
Mechanical agitation.
Step 2) in catalyst be in stannous chloride, stannous octoate, p-methyl benzenesulfonic acid two or three mixture,
Its gross mass is the 0.5% of y oligomer quality.
Step 3) in vacuum be 1kPa, range of reaction temperature 130 DEG C, the response time is 1 hour, with machine during reaction
Tool stirs.
Step 3) in expand quality is poly (lactic acid-glycolic acid) intermediate product quality the 0.5% of even agent MDI.
Step 3) in the adding method of chain extender, be chain extender to be dissolved in solvent injection add, in mixed process, solvent
Discharged by vacuum system.
Further, the described hollow silica sub-micron ball preparation method loading medicine is: by hollow silica
Sub-micron ball is immersed in the aqueous solution of water soluble drug, stirs 1 day～4 days, be then 4 DEG C in temperature at temperature is 4 DEG C
Lower centrifugal, clean gained solid product, lyophilization with deionized water, obtain being loaded with the hollow silica of water soluble drug
Sub-micron ball；Or hollow silica sub-micron ball is immersed in the organic solvent of fat-soluble medicine, stir at temperature is 4 DEG C
Mix 1 day～4 days, then centrifugal at temperature is 4 DEG C, clean gained solid product, lyophilization with deionized water, loaded
The hollow silica sub-micron ball of fat-soluble medicine.
Further, described curative drug selected from neomycin, ribostamycin, micronomicin, A Si mycin, tetracycline,
Oxytetracycline, chlortetracycline, doxycycline, chloromycetin, thiamphenicol, erythromycin, albomycin, erythromycin ethylsuccinate, azithromycin, acetyl
Spiramycin, midecamycin, josamycin, lincomycin, clindamycin, vancomycin, bacitracin, polymyxin, phosphorus are mould
Element, ciramycin, cycloserine, griseofulvin, mitomycin, bleomycin, ciclosporin, metronidazole, penicillin, penicillin sodium,
One in benzylpenicillin potassium, ampicillin, amoxicillin, piperacillin, benzylpenicillin potassium or more than more than one；Or selected from upper
State the one in the derivant of curative drug or more than more than one；Or selected from above-mentioned curative drug and above-mentioned therapeutic medicine
A kind of in the derivant of thing or more than more than one mixture.
Embodiment 3
The preparation method of a kind of degradable medicine carrying poly (lactic acid-glycolic acid) operation suture thread, will load the hollow titanium dioxide of medicine
Silicon sub-micron ball is dispersed in the aqueous solution of degradable poly y, by using spinning process will to load the hollow of medicine
Silicon dioxide sub-micron sphere is embedded in degradable poly y fiber makes the operation of degradable medicine carrying poly (lactic acid-glycolic acid)
Stitching thread operation suture thread；
The preparation process of described degradable poly y includes:
1) it is raw material by technical grade lactic acid aqueous solution and glycolic, carries out dehydration under vacuum refined, obtain lactic acid
Glycolic acid oligomer；
2) by step 1) the y oligomer that obtains mixes with catalyst, adds in reaction vessel, at vacuum bar
Under part, reacting by heating, obtain poly (lactic acid-glycolic acid) intermediate product；
3) in step 2) in reaction vessel in add chain extender MDI, under vacuum, reacting by heating, obtain high score
Son amount poly (lactic acid-glycolic acid).
Step 1) in vacuum be 2.5kPa, dewatering time is 4 hours, dehydration temperaturre scope 80 DEG C, described lactic acid with
The mol ratio of glycolic is 1:1.5.
Step 2) in vacuum be 2kPa, range of reaction temperature 150 DEG C, the response time is 4 hours, with machine during reaction
Tool stirs.
Step 2) in catalyst be in stannous chloride, stannous octoate, p-methyl benzenesulfonic acid two or three mixture,
Its gross mass is the 0.5% of y oligomer quality.
Step 3) in vacuum be 1.2kPa, range of reaction temperature 140 DEG C, the response time is 2 hours, adjoint during reaction
Mechanical agitation.
Step 3) in expand quality is poly (lactic acid-glycolic acid) intermediate product quality the 0.8% of even agent MDI.
Step 3) in the adding method of chain extender, be chain extender to be dissolved in solvent injection add, in mixed process, solvent
Discharged by vacuum system.
Further, the described hollow silica sub-micron ball preparation method loading medicine is: by hollow silica
Sub-micron ball is immersed in the aqueous solution of water soluble drug, stirs 1 day～4 days, be then 4 DEG C in temperature at temperature is 4 DEG C
Lower centrifugal, clean gained solid product, lyophilization with deionized water, obtain being loaded with the hollow silica of water soluble drug
Sub-micron ball；Or hollow silica sub-micron ball is immersed in the organic solvent of fat-soluble medicine, stir at temperature is 4 DEG C
Mix 1 day～4 days, then centrifugal at temperature is 4 DEG C, clean gained solid product, lyophilization with deionized water, loaded
The hollow silica sub-micron ball of fat-soluble medicine.
Further, described curative drug selected from neomycin, ribostamycin, micronomicin, A Si mycin, tetracycline,
Oxytetracycline, chlortetracycline, doxycycline, chloromycetin, thiamphenicol, erythromycin, albomycin, erythromycin ethylsuccinate, azithromycin, acetyl
Spiramycin, midecamycin, josamycin, lincomycin, clindamycin, vancomycin, bacitracin, polymyxin, phosphorus are mould
Element, ciramycin, cycloserine, griseofulvin, mitomycin, bleomycin, ciclosporin, metronidazole, penicillin, penicillin sodium,
One in benzylpenicillin potassium, ampicillin, amoxicillin, piperacillin, benzylpenicillin potassium or more than more than one；Or selected from upper
State the one in the derivant of curative drug or more than more than one；Or selected from above-mentioned curative drug and above-mentioned therapeutic medicine
A kind of in the derivant of thing or more than more than one mixture.
Embodiment 4
The preparation method of a kind of degradable medicine carrying poly (lactic acid-glycolic acid) operation suture thread, will load the hollow titanium dioxide of medicine
Silicon sub-micron ball is dispersed in the aqueous solution of degradable poly y, by using spinning process will to load the hollow of medicine
Silicon dioxide sub-micron sphere is embedded in degradable poly y fiber makes the operation of degradable medicine carrying poly (lactic acid-glycolic acid)
Stitching thread operation suture thread；
The preparation process of described degradable poly y includes:
1) it is raw material by technical grade lactic acid aqueous solution and glycolic, carries out dehydration under vacuum refined, obtain lactic acid
Glycolic acid oligomer；
2) by step 1) the y oligomer that obtains mixes with catalyst, adds in reaction vessel, at vacuum bar
Under part, reacting by heating, obtain poly (lactic acid-glycolic acid) intermediate product；
3) in step 2) in reaction vessel in add chain extender MDI, under vacuum, reacting by heating, obtain high score
Son amount poly (lactic acid-glycolic acid).
Step 1) in vacuum be 2.2kPa, dewatering time is 6 hours, dehydration temperaturre scope 80 DEG C, described lactic acid with
The mol ratio of glycolic is 1:2.
Step 2) in vacuum be 1.2kPa, range of reaction temperature 160 DEG C, the response time is 4 hours, adjoint during reaction
Mechanical agitation.
Step 2) in catalyst be in stannous chloride, stannous octoate, p-methyl benzenesulfonic acid two or three mixture,
Its gross mass is the 1% of y oligomer quality.
Step 3) in vacuum be 1.5kPa, range of reaction temperature 150 DEG C, the response time is 2 hours, adjoint during reaction
Mechanical agitation.
Step 3) in expand quality is poly (lactic acid-glycolic acid) intermediate product quality the 0.7% of even agent MDI.
Step 3) in the adding method of chain extender, be to be directly added into reaction system, after melting mixing, then occur chain extension anti-
Should.
Further, the described hollow silica sub-micron ball preparation method loading medicine is: by hollow silica
Sub-micron ball is immersed in the aqueous solution of water soluble drug, stirs 1 day～4 days, be then 4 DEG C in temperature at temperature is 4 DEG C
Lower centrifugal, clean gained solid product, lyophilization with deionized water, obtain being loaded with the hollow silica of water soluble drug
Sub-micron ball；Or hollow silica sub-micron ball is immersed in the organic solvent of fat-soluble medicine, stir at temperature is 4 DEG C
Mix 1 day～4 days, then centrifugal at temperature is 4 DEG C, clean gained solid product, lyophilization with deionized water, loaded
The hollow silica sub-micron ball of fat-soluble medicine.
Further, described curative drug selected from neomycin, ribostamycin, micronomicin, A Si mycin, tetracycline,
Oxytetracycline, chlortetracycline, doxycycline, chloromycetin, thiamphenicol, erythromycin, albomycin, erythromycin ethylsuccinate, azithromycin, acetyl
Spiramycin, midecamycin, josamycin, lincomycin, clindamycin, vancomycin, bacitracin, polymyxin, phosphorus are mould
Element, ciramycin, cycloserine, griseofulvin, mitomycin, bleomycin, ciclosporin, metronidazole, penicillin, penicillin sodium,
One in benzylpenicillin potassium, ampicillin, amoxicillin, piperacillin, benzylpenicillin potassium or more than more than one；Or selected from upper
State the one in the derivant of curative drug or more than more than one；Or selected from above-mentioned curative drug and above-mentioned therapeutic medicine
A kind of in the derivant of thing or more than more than one mixture.
Comparative example 1
Commercially available poly (lactic acid-glycolic acid) operation suture thread.
Respectively the sample 1-4 obtained in embodiment 1-4 is carried out the test of molecular weight, hot strength and degradation property, its
Data see table:
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all spirit in the present invention and
Within principle, any modification, equivalent substitution and improvement etc. made, should be included within the scope of the present invention.
Claims (10)
1. the preparation method of a degradable medicine carrying poly (lactic acid-glycolic acid) operation suture thread, it is characterised in that medicine will be loaded
Hollow silica sub-micron ball is dispersed in the aqueous solution of degradable poly y, by using spinning process to load
The hollow silica sub-micron ball of medicine is embedded in degradable poly y fiber makes degradable medicine carrying polylactic acid
Glycolic operation suture thread operation suture thread；
The preparation process of described degradable poly y includes:
1) it is raw material by technical grade lactic acid aqueous solution and glycolic, carries out dehydration under vacuum refined, obtain lactic acid ethanol
Acid oligomer；
2) by step 1) the y oligomer that obtains mixes with catalyst, adds in reaction vessel, under vacuum,
Reacting by heating, obtains poly (lactic acid-glycolic acid) intermediate product；
3) in step 2) in reaction vessel in add chain extender MDI, under vacuum, reacting by heating, obtain high molecular
Poly (lactic acid-glycolic acid).
A kind of preparation method of degradable medicine carrying poly (lactic acid-glycolic acid) operation suture thread, its feature
Be, step 1) in vacuum be 2-4kPa, dewatering time is 0.5-10 hour, and dehydration temperaturre scope 45-100 DEG C is described
Lactic acid is 1:1-3 with the mol ratio of glycolic.
A kind of preparation method of degradable medicine carrying poly (lactic acid-glycolic acid) operation suture thread, its feature
Be, step 2) in vacuum be 0.5-2kPa, range of reaction temperature 150-180 DEG C, the response time is 2-5 hour, reaction
Time with mechanical agitation.
The preparation method of a kind of degradable medicine carrying poly (lactic acid-glycolic acid) operation suture thread the most according to claim 3, it is special
Levy and be, step 2) in catalyst be in stannous chloride, stannous octoate, p-methyl benzenesulfonic acid two or three mixture,
Its gross mass is the 0.5%～1% of y oligomer quality.
A kind of preparation method of degradable medicine carrying poly (lactic acid-glycolic acid) operation suture thread, its feature
Be, step 3) in vacuum be 1-3kPa, range of reaction temperature 130-160 DEG C, the response time is 1-4 hour, during reaction
With mechanical agitation.
A kind of preparation method of degradable medicine carrying poly (lactic acid-glycolic acid) operation suture thread, its feature
Be, step 3) in the 0.5%-1.3% that quality is poly (lactic acid-glycolic acid) intermediate product quality expanding even agent MDI.
7. according to the preparation method of the arbitrary described a kind of degradable medicine carrying poly (lactic acid-glycolic acid) operation suture thread of claim 1-6,
It is characterized in that, step 3) in the adding method of chain extender, be to be directly added into reaction system, after melting mixing, then chain extension occur
Reaction.
8. according to the preparation method of the arbitrary described a kind of degradable medicine carrying poly (lactic acid-glycolic acid) operation suture thread of claim 1-6,
It is characterized in that, step 3) in the adding method of chain extender, be chain extender to be dissolved in solvent injection add, in mixed process,
Solvent is discharged by vacuum system.
9., according to the preparation method of degradable medicine carrying poly (lactic acid-glycolic acid) operation suture thread a kind of described in claim 7 or 8, it is special
Levying and be, the described hollow silica sub-micron ball preparation method loading medicine is: by hollow silica sub-micron ball
It is immersed in the aqueous solution of water soluble drug, stirs at temperature is 4 DEG C 1 day～4 days, then centrifugal at temperature is 4 DEG C, use
Deionized water cleans gained solid product, lyophilization, obtains being loaded with the hollow silica sub-micron ball of water soluble drug；
Or hollow silica sub-micron ball is immersed in the organic solvent of fat-soluble medicine, stir 1 day～4 at temperature is 4 DEG C
My god, then centrifugal at temperature is 4 DEG C, clean gained solid product, lyophilization with deionized water, obtain being loaded with fat-soluble
The hollow silica sub-micron ball of medicine.
10. according to the preparation method of degradable medicine carrying poly (lactic acid-glycolic acid) operation suture thread a kind of described in claim 7 or 8, its
Be characterised by, described curative drug selected from neomycin, ribostamycin, micronomicin, A Si mycin, tetracycline, oxytetracycline,
Chlortetracycline, doxycycline, chloromycetin, thiamphenicol, erythromycin, albomycin, erythromycin ethylsuccinate, azithromycin, acetyl spiral are mould
Element, midecamycin, josamycin, lincomycin, clindamycin, vancomycin, bacitracin, polymyxin, fosfomycin, volume are mould
Element, cycloserine, griseofulvin, mitomycin, bleomycin, ciclosporin, metronidazole, penicillin, penicillin sodium, penicillin
One in potassium, ampicillin, amoxicillin, piperacillin, benzylpenicillin potassium or more than more than one；Or selected from above-mentioned treatment
Property medicine derivant in one or more than more than one；Or spreading out selected from above-mentioned curative drug and above-mentioned curative drug
A kind of in biology or more than more than one mixture.
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Citations (3)
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|---|---|---|---|---|
| CN1624019A (en) * | 2004-10-25 | 2005-06-08 | 安徽中人科技有限责任公司 | Method for preparing poly (L-lactic acid-glycollic acid) |
| CN101721739A (en) * | 2008-10-10 | 2010-06-09 | 陈东 | Polymer composite fiber surgical suture line capable of sustaining and controlling release of therapeutic medicaments and preparation method thereof |
| CN103254411A (en) * | 2013-06-07 | 2013-08-21 | 北京理工大学 | Method for preparing high-molecular-weight polylactic acid through direct polycondensation and chain extension |
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2016
- 2016-08-27 CN CN201610743094.0A patent/CN106267323A/en active Pending
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|---|---|---|---|---|
| CN1624019A (en) * | 2004-10-25 | 2005-06-08 | 安徽中人科技有限责任公司 | Method for preparing poly (L-lactic acid-glycollic acid) |
| CN101721739A (en) * | 2008-10-10 | 2010-06-09 | 陈东 | Polymer composite fiber surgical suture line capable of sustaining and controlling release of therapeutic medicaments and preparation method thereof |
| CN103254411A (en) * | 2013-06-07 | 2013-08-21 | 北京理工大学 | Method for preparing high-molecular-weight polylactic acid through direct polycondensation and chain extension |
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