CN106266382A - A kind of Chinese medicine composition treating fracture, bone does not connect - Google Patents
A kind of Chinese medicine composition treating fracture, bone does not connect Download PDFInfo
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- CN106266382A CN106266382A CN201610735745.1A CN201610735745A CN106266382A CN 106266382 A CN106266382 A CN 106266382A CN 201610735745 A CN201610735745 A CN 201610735745A CN 106266382 A CN106266382 A CN 106266382A
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- 239000003814 drug Substances 0.000 title claims abstract description 45
- 239000000203 mixture Substances 0.000 title claims abstract description 29
- 210000000988 bone and bone Anatomy 0.000 title claims abstract description 22
- 239000000843 powder Substances 0.000 claims abstract description 23
- 239000009286 sanguis draxonis Substances 0.000 claims abstract description 11
- 210000004373 mandible Anatomy 0.000 claims abstract description 9
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims abstract description 9
- 241000371997 Eriocheir sinensis Species 0.000 claims abstract description 8
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- 241001664510 Saussurea costus Species 0.000 claims abstract description 8
- 235000006784 Saussurea lappa Nutrition 0.000 claims abstract description 8
- 235000003143 Panax notoginseng Nutrition 0.000 claims abstract description 7
- 241000180649 Panax notoginseng Species 0.000 claims abstract description 7
- 229940079593 drug Drugs 0.000 claims abstract description 7
- 241000628997 Flos Species 0.000 claims abstract description 6
- 210000000582 semen Anatomy 0.000 claims abstract description 6
- 241001057584 Myrrha Species 0.000 claims abstract description 5
- 238000002360 preparation method Methods 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 239000012567 medical material Substances 0.000 claims description 3
- 238000010298 pulverizing process Methods 0.000 claims description 3
- 239000002994 raw material Substances 0.000 claims 1
- 206010017076 Fracture Diseases 0.000 description 23
- 208000010392 Bone Fractures Diseases 0.000 description 22
- 230000000694 effects Effects 0.000 description 16
- 208000007875 Femur Head Necrosis Diseases 0.000 description 15
- 230000003203 everyday effect Effects 0.000 description 9
- 201000010099 disease Diseases 0.000 description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 241001484259 Lacuna Species 0.000 description 6
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- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 5
- 239000011575 calcium Substances 0.000 description 5
- 229910052791 calcium Inorganic materials 0.000 description 5
- 241000283973 Oryctolagus cuniculus Species 0.000 description 4
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- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical group [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
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- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
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- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000007012 clinical effect Effects 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
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- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 1
- 235000005282 vitamin D3 Nutrition 0.000 description 1
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Abstract
The invention provides a kind of Chinese medicine composition treating fracture, bone does not connect, it is made up of the crude drug of following weight portion: the Radix Paeoniae Alba 20 50, Sanguis Draxonis 10 30, Saussurea lappa Clarke 10 30, Radix et Rhizoma Rhei (processed) 30 40, Eupolyphaga Seu Steleophaga 10 30, Radix Angelicae Sinensis 30 40, Cortex Albiziae 20 30, Radix Dipsaci 20 40, Myrrha (processed) 10 20, Pyritum (calcined) 10 20, Semen Nelumbinis 40 60, CARAPAX ET PIASTRUM TESTUDINIS PREPARATA 20 40, Radix Notoginseng 10 20, Carapax Eriocheir sinensis powder 60 80, dog mandible bone 60 80, Flos Carthami 10 30.
Description
One technical field
The present invention relates to the field of Chinese medicines, specifically, the present invention relates to a kind of Chinese medicine composition treating fracture, bone does not connect
Thing.
Two background technologies
Fracture be the integrity of phalanges or seriality caused by destroying, with pain, swelling, livid purple, dysfunction,
Deformity and bony crepitus etc. are the disease of main performance.Fracture is a kind of commonly encountered diseases, is orthopaedic trauma clinic frequently-occurring disease, owing to it is sick
Journey is long, and serious infringement social labor power also affects orthobiosis.At present, doctor trained in Western medicine is when treatment fracture, it is common that by patient part
Position of bone righting, then use medical apparatus and instruments to be carried out interior fixing, or carry out extenal fixation, slowly with Gypsum Fibrosum, binder, clamping plate etc.
Rest, be aided with medicine of replenishing the calcium (if calcium Er Qihuishi pharmacy effective ingredient is calcium carbonate and vitamin D3) if desired, unspecial
Promote the medicine that fracture is recovered.Although the Chinese medicine for the treatment of fracture is a lot of, (such as GUZHE CUOSHANG JIAONANG Harbin, Hua Yu pharmacy group has
The main components such as limit company include Os Sus domestica, Pyritum (calcined), Flos Carthami, Radix Et Rhizoma Rhei, Radix Angelicae Sinensis, Olibanum (processed with vinegar), Myrrha (processed with vinegar), Sanguis Draxonis, Eupolyphaga Seu Steleophaga etc.,
Gukang capsule Guizhou Wei Kang Zi Fan Pharmaceutical limited company main component includes Radix Musae, Fructus Psoraleae, Radix Dipsaci, Radix Notoginseng etc.), but
Majority also exist uncertain therapeutic efficacy cut, the dissatisfactory shortcoming of the length course for the treatment of, effect.
Femur head necrosis be femoral head blood supply impaired or interrupt cause femoral head structural change, subside, function of joint barrier
Hinder disease.Its course of disease length, disability rate are high, have a strong impact on work and life.Femur head necrosis can be caused by wound or use hormone,
The concrete cause of disease is unclear.Western medical treatment femur head necrosis substantially use various operation to improve blood supply or replacement joint, to early
Phase is slight, and femur head necrosis there is no simple and effective treatment means.The traditional Chinese medical science is not also treated the Chinese patent medicine of femur head necrosis,
The prescription of some the treatment femur head necrosiss provided there is also uncertain therapeutic efficacy and cuts, and take effect problem slowly.
Three summary of the invention
For the problems referred to above, applicant is at the base of the common drug such as Sanguis Draxonis, Radix Dipsaci, Pyritum (calcined) etc. for the treatment of skeletal diseases
On plinth, creative is equipped with the compositions such as dog mandible bone, CARAPAX ET PIASTRUM TESTUDINIS PREPARATA, Eupolyphaga Seu Steleophaga, passes through scientific compatibility, it is provided that one treats bone
Folding, the Chinese medicine composition of bone does not connect, it is all definite to union of fracture curative effect, can individually or auxiliary this disease for the treatment of.Additionally, from
Pharmacologically speculating, this medicine improves blood circulation, promotes that the effect of bone growth should also have certain curative effect to femur head necrosis,
Clinical practice tentatively shows, this medicine may be used for palliative treatment or the auxiliary treatment of femur head necrosis.
On the one hand, the invention provides a kind of Chinese medicine composition treating fracture, bone does not connect, former including following weight portion
Material: Radix Paeoniae Alba 20-50, Sanguis Draxonis 10-30, Saussurea lappa Clarke 10-30, Carapax Eriocheir sinensis powder 60-80, Pyritum (calcined) 10-20.
Further aspect, treatment fracture that the present invention provides, the Chinese medicine composition of bone does not connect, former by following weight portion
Material medicine is made: Radix Paeoniae Alba 20-50, Sanguis Draxonis 10-30, Saussurea lappa Clarke 10-30, Radix et Rhizoma Rhei (processed) 30-40, Eupolyphaga Seu Steleophaga 10-30, Radix Angelicae Sinensis 30-40, conjunction
Joyous skin 20-30, Radix Dipsaci 20-40, Myrrha (processed) 10-20, Pyritum (calcined) 10-20, Semen Nelumbinis 40-60, CARAPAX ET PIASTRUM TESTUDINIS PREPARATA 20-40, Radix Notoginseng 10-
20, Carapax Eriocheir sinensis powder 60-80, dog mandible bone 60-80, Flos Carthami 10-30.
Further aspect, treatment fracture that the present invention provides, the Chinese medicine composition of bone does not connect, former by following weight portion
Material medicine is made: the Radix Paeoniae Alba 20, Sanguis Draxonis 15, Saussurea lappa Clarke 10, Radix et Rhizoma Rhei (processed) 30, Eupolyphaga Seu Steleophaga 20, Radix Angelicae Sinensis 30, Cortex Albiziae 20, Radix Dipsaci 20, system are not
Medicine 10, Pyritum (calcined) 10, Semen Nelumbinis 40, CARAPAX ET PIASTRUM TESTUDINIS PREPARATA 30, Radix Notoginseng 10, Carapax Eriocheir sinensis powder 60, dog mandible bone 60, Flos Carthami 10.
Further aspect, treatment fracture, the Chinese medicine composition of bone does not connect that the present invention provides are powder agent.
On the other hand, the invention provides the preparation method of the Chinese medicine composition of above-mentioned treatment fracture, bone does not connect, including step
Rapid: to weigh various medical material by weight；
Being smashed by dog mandible bone, stewing is deoiled；
Pulverizing medicinal materials is become fine powder, mix homogeneously, crosses 120 mesh sieves, obtain powder agent.
Four detailed description of the invention
The preparation of embodiment 1 Chinese medicine composition of the present invention
Weigh various medical material by weight:
The Radix Paeoniae Alba 20, Sanguis Draxonis 15, Saussurea lappa Clarke 10, Radix et Rhizoma Rhei (processed) 30, Eupolyphaga Seu Steleophaga 20, Radix Angelicae Sinensis 30, Cortex Albiziae 20, Radix Dipsaci 20, system are not
Medicine 10, Pyritum (calcined) 10, Semen Nelumbinis 40, CARAPAX ET PIASTRUM TESTUDINIS PREPARATA 30, Radix Notoginseng 10, Carapax Eriocheir sinensis powder 60, dog mandible bone 60, Flos Carthami 10；
Being smashed by dog mandible bone, stewing is deoiled；
Pulverizing medicinal materials is become fine powder, mix homogeneously, crosses 120 mesh sieves, obtain powder agent.
The embodiment 2 Chinese medicine composition of the present invention effect to rabbit fracture model
Choose the healthy male rabbit 40 of body weight 2-2.5kg, be equally divided into 4 groups, with 3% Nembutal sodium solution according to
After the anesthesia of 1ml/kg dose intravenous, both sides forelimb cropping, 75% alcohol disinfecting, aseptically exist by medical operation dental burr
In the radius of both sides, epimere 1/3 intersection is horizontal is drilled to wide about 3mm, gos deep into medullary cavity and forms bone injury, skin suture.
Second day after operation starts gastric infusion:
Group 1: the medicated powder 0.5g of embodiment 1 preparation is dissolved in normal saline 2ml, every day 1 time；
Group 2: GUZHE CUOSHANG JIAONANG (Huayu Pharmaceutical Group Corp., Ltd., Harbin) powder 0.5g is dissolved in normal saline 2ml,
Every day 1 time；
Group 3: Gukang capsule (Guizhou Wei Kang Zi Fan Pharmaceutical limited company) powder 0.5g is dissolved in normal saline 2ml, often
Day 1 time；
Group 4: strange (Hui Shi pharmacy) the powder 20mg of calcium that is dissolved in normal saline 2ml, every day 1 time；
Successive administration 4 weeks, the 2nd, 4 weekends often organized 5 animals of execution and take injury region (containing upper-lower section) radius with LUNAR bone
Density Measuring Instrument measures bone density.
Experimental result:
| Group | 2 weekend bone density g/cm3 | 4 weekend bone density g/cm3 |
| Group 1 | 0.271±0.030 | 0.372±0.022 |
| Group 2 | 0.237±0.028 | 0.335±0.048 |
| Group 3 | 0.211±0.054 | 0.329±0.071 |
| Group 4 | 0.185±0.026 | 0.260±0.041 |
Result shows to the Chinese medicine composition organizing 3, organizing 1 promotes that the effect of knitting all exceedes the Western medicine method replenished the calcium merely,
Organize 1 bone density value added significantly beyond group 2 and group 3.The Chinese medicine composition of the present invention can effectively accelerate bone ore deposit sedimentation rate, improves
Bone density, promotes fracture site healing.
The embodiment 3 Chinese medicine composition of the present invention effect to rabbits model of femoral head necrosis
Choose the healthy male rabbit 20 of body weight 2-2.5kg, be equally divided into 2 groups, with 3% Nembutal sodium solution according to
After the anesthesia of 1ml/kg dose intravenous, both sides hind leg cropping, 75% alcohol disinfecting, cuts off round ligament of femur circuit, cotton swab dipping liquid
Nitrogen 3 rewarming degree of 3 freezings, sew up round ligament and skin.
Post operation starts to be administered on the 2nd day:
Group 1: the medicated powder 0.5g of embodiment 1 preparation is dissolved in normal saline 2ml, every day 1 time；
Group 2: (main component includes the Radix Paeoniae Alba, Sanguis Draxonis, forges nature the Chinese medicine decoction prepared according to ZL201410507063
Copper, Radix Angelicae Sinensis etc.), 20ml, every day 1 time；
Group 3: normal saline 2ml, every day 1 time.
Continuously treatment 4 weeks, the 2nd, often organize and put to death 5 animals and take left femoral head 4 weekends, and 4% paraformaldehyde is fixed, salt
Acid formic acid solution decalcification, gradient alcohol dehydration, conventional section, dyeing is observed.For each sample, select at random under 200 times of visuals field
Select 16 visuals field, add up the bone lacuna number of the bone lacuna number under each visual field and vacancy, obtain the hundreds of proportion by subtraction of vacancy bone lacuna.
Experimental result:
| Group | 2 weekend the hundreds of proportion by subtraction of vacancy bone lacuna | 4 weekend the hundreds of proportion by subtraction of vacancy bone lacuna |
| Group 1 | 35.5±3.6 | 42.7±2.8 |
| Group 2 | 39.1±3.7 | 45.1±3.9 |
| Group 3 | 38.5±2.2 | 47.2±5.8 |
Result shows, although the not up to standard of statistically significant, but the traditional Chinese medicine composition for treating femoral head of the present invention is bad
Extremely should there is certain effect, compare comparison and conscientiously reduce the most important mark-sky bone lacuna rate (about 10%) of femur head necrosis, and
The Chinese medicine composition effect claiming to treat osteonecrosis in ZL201410507063 has essentially no difference (second week compared with the control
Slightly higher 3%, 4th week lower slightly 5%).The Chinese medicine of the present invention can appease or assist the selection for the treatment of as femur head necrosis, and
And have the pathogensis for femur head necrosis to adjust further, improve the potentiality of curative effect.
Embodiment 4 traditional Chinese medicine composition for treating of the present invention fracture and the actual clinical effect of femur head necrosis
Disclosure is not done for privacy confidentiality reasons, case concrete condition and source hospital.
Fracture case selection:
Get rid of the pathologisch Bruch caused by osteopathia, choose male's fracture of upper limb case 60 example that situation is similar, age 20-40
In year, it is equally divided into 3 groups.
Therapeutic scheme:
Group 1: the medicated powder of embodiment 1 preparation, each 7g, every day 2 times；
Group 2: GUZHE CUOSHANG JIAONANG (Huayu Pharmaceutical Group Corp., Ltd., Harbin), each 5, three times a day；
Group 3: calcium that is strange (Hui Shi pharmacy), each 1, every day 1 time.
Treatment 4 weeks continuously.
Observation of curative effect:
Clinical union of bone standard: fractures is without tenderness, without longitudinal percussion pain；Fracture site is the most alive without bony crepitus and exception
Dynamic；X-ray film display fracture line obscures, and has seriality callus to pass through fracture line；In the case of releasing extenal fixation, upper limb can put down act
1kg weight reaches 1 minute.Observe above-mentioned phenomenon and realize above-mentioned functions within first day, be clinical union of bone day.
The average clinical healing day (37.8) of group 1 is significantly shorter than group 2 (39.9) and group 3 (43.2), it was demonstrated that in the present invention
Drug composition treatment curative effect of fracture is definite and is better than existing Chinese patent medicine.
Femur head necrosis case selects:
Choose femur head necrosis case 30 example of clinical definite, be equally divided into 2 groups.
Group 1: the medicated powder of embodiment 1 preparation, each 7g, every day 2 times；
Group 2: do not use medicine, only with control activity, the palliative treatment of diet.
Treatment 2 months continuously
Curative effect scoring uses the percentage assessment method that skeleton branch of Chinese Medical Association formulates in nineteen ninety-five, and wherein clinical evaluation accounts for
60 points, in clinical evaluation, pain accounts for 25 points, and function accounts for 18 points, and range of motion accounts for 17 points and (refers to the femoral heads such as Wang Yan lack
Courageous and upright downright bad treatment and therapeutic evaluation method PLA's medical journal volume 23 the 1st phase 77-78 page in 1998).Divide before and after treatment
Do not mark, calculate each group of average score and improve.
Result shows that the average score organizing 1 is improved (3.9) and is better than group 2 (-1.3), although amplitude is the highest, but the most provable
The Chinese medicine composition of invention has the curative effect for the treatment of femur head necrosis.
Claims (5)
1. treat a Chinese medicine composition for fracture, bone does not connect, including the raw material of following weight portion: Radix Paeoniae Alba 20-50, Sanguis Draxonis 10-
30, Saussurea lappa Clarke 10-30, Carapax Eriocheir sinensis powder 60-80, Pyritum (calcined) 10-20.
2. the Chinese medicine composition described in claim 1, is made up of the crude drug of following weight portion: Radix Paeoniae Alba 20-50, Sanguis Draxonis 10-30,
Saussurea lappa Clarke 10-30, Radix et Rhizoma Rhei (processed) 30-40, Eupolyphaga Seu Steleophaga 10-30, Radix Angelicae Sinensis 30-40, Cortex Albiziae 20-30, Radix Dipsaci 20-40, Myrrha (processed) 10-
20, Pyritum (calcined) 10-20, Semen Nelumbinis 40-60, CARAPAX ET PIASTRUM TESTUDINIS PREPARATA 20-40, Radix Notoginseng 10-20, Carapax Eriocheir sinensis powder 60-80, dog mandible bone 60-80, red
Flower 10-30.
3. the Chinese medicine composition described in claim 2, is made up of the crude drug of following weight portion: the Radix Paeoniae Alba 20, Sanguis Draxonis 15, Saussurea lappa Clarke
10, Radix et Rhizoma Rhei (processed) 30, Eupolyphaga Seu Steleophaga 20, Radix Angelicae Sinensis 30, Cortex Albiziae 20, Radix Dipsaci 20, Myrrha (processed) 10, Pyritum (calcined) 10, Semen Nelumbinis 40, CARAPAX ET PIASTRUM TESTUDINIS PREPARATA
30, Radix Notoginseng 10, Carapax Eriocheir sinensis powder 60, dog mandible bone 60, Flos Carthami 10.
4. the Chinese medicine composition of any one of claim 1-3, it is powder agent.
5. the preparation method of the Chinese medicine composition of claim 4, including step:
Weigh various medical material by weight；
Pulverizing medicinal materials is become fine powder, mix homogeneously, crosses 120 mesh sieves, obtain powder agent.
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