CN106265675A - A kind of antimicrobial form aciclovir eye drop and preparation method thereof - Google Patents
A kind of antimicrobial form aciclovir eye drop and preparation method thereof Download PDFInfo
- Publication number
- CN106265675A CN106265675A CN201610745500.7A CN201610745500A CN106265675A CN 106265675 A CN106265675 A CN 106265675A CN 201610745500 A CN201610745500 A CN 201610745500A CN 106265675 A CN106265675 A CN 106265675A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
Abstract
The invention discloses a kind of antimicrobial form aciclovir eye drop; its raw material is as follows: acyclovir 8 10 grams, 45 grams of chloromycetin, 0.3 0.5 grams of sodium chloride; Macrogol 600 23 grams; vitamin B6 1 1.5 grams, vitamin B12 1 1.3 grams, boric acid 0.5 0.8 grams; thickening agent 0.6 0.8 grams; taurine 0.1 0.2 grams, Borax 0.5 0.7 grams, distilled water 150 170 milliliters.A kind of antimicrobial form aciclovir eye drop that the present invention provides and preparation method thereof, by the mixing of acyclovir with chloromycetin is added so that collyrium has higher antibiotic property, multiple eye inflammation can be eliminated simultaneously, so that the purposes of collyrium is greatly improved, solve various problems.
Description
Technical field
The present invention relates to eye drop technical field, particularly relate to a kind of antimicrobial form aciclovir eye drop and preparation side thereof
Method.
Background technology
Collyrium is the liquid medicine for the treatment of disease of eye, and its composition has numerous species according to the difference of effect, such as steroid, anti-
Raw element, antihistaminic, beta-blocker, non-steroidal anti-inflammatory analgesic etc..Acyclovir (AZV) is sick to I, II type herpes simplex
Poison (HSV) is effective, secondly also effective to varicella zoster virus (AZV), and viral and big and small to EB (Epstein-Barr)
Cellular virus effect is more weak.Acyclovir is owing to AZV can be sick to I, herpes simplex virus type 2 and varicella zoster virus
Thymidine kinase (TK) phosphoric acid of poison coding turns to monophosphate acycloguanosine, the latter again by the catalysis of cellular enzymes formed diphosphonic acid,
Triphosphoric acid acycloguanosine.Triphosphoric acid acycloguanosine is the potent inhibitor of hsv dna polymerase, and it is as viral DNA
The substrate of polymerase is combined with enzyme and mixes in viral DNA, thus terminates the synthesis of viral DNA.Aciclovir eye drop can
Effectively various ocular disease to be controlled, there is good sterilization effect simultaneously.
Summary of the invention
The invention aims to solve shortcoming present in prior art, and a kind of eye drip rifampicin system proposed
Agent and preparation method thereof.
To achieve these goals, present invention employs following technical scheme:
A kind of antimicrobial form aciclovir eye drop, its raw material is as follows: acyclovir 8-10 gram, 4-5 gram of chloromycetin, chlorine
Change 0.3-0.5 gram of sodium, Macrogol 600 2-3 gram, vitamin B6 1-1.5 gram, vitamin B12 1-1.3 gram, boric acid 0.5-
0.8 gram, thickening agent 0.6-0.8 gram, taurine 0.1-0.2 gram, Borax 0.5-0.7 gram, distilled water 150-170 milliliter.
Preferably, described thickening agent is hyaluronic acid sodium.
The preparation method of a kind of antimicrobial form aciclovir eye drop, comprises the steps:
S1: be pre-mixed with chloromycetin by acyclovir, joins in reagent bottle by mixed acyclovir and chloromycetin, adds
The distillation water yield entering 1/4th carries out mix and blend, uses the mode of heating in water bath to heat, and bath temperature controls at 35-
Between 45 degrees Celsius, prepare mixed solution A, solution A is placed standby；
S2: Macrogol 600, vitamin B6, vitamin B12, boric acid, thickening agent, taurine and Borax are mixed in advance,
Join in test tube, in test tube, add four/two-component distilled water, mix, use heating in water bath mode to heat,
Bath temperature controls between 35-45 degree Celsius, it is thus achieved that mixed solution B, solution B is placed standby；
S3: mixed homogeneously in test tube by the distilled water of sodium chloride with remaining 1/4th, uses the mode of heating in water bath to add
Heat, bath temperature controls between 35-45 degree Celsius, it is thus achieved that solution C, solution C is placed standby；
S4: solution A, solution B and solution C are mixed, uses vibrations instrument to carry out vibrations mixing；
S5: the solution that S4 obtains is carried out fine straining process, the impurity in solution can effectively be removed, the filter opening of fine filtering device
Aperture is 1200 mesh；
S6: the solution after essence being considered packs in the vial, should be noted that the sterilization treatment of bottle bottleneck during subpackage.
A kind of antimicrobial form aciclovir eye drop that the present invention provides and preparation method thereof, by mould with chlorine by acyclovir
The mixing of element adds so that collyrium has higher antibiotic property, can eliminate multiple eye inflammation simultaneously, so that
The purposes of collyrium is greatly improved, and solves various problems.
Detailed description of the invention
In order to make the purpose of the present invention, technical scheme and advantage clearer, below in conjunction with specific embodiment, to this
Invention is further elaborated.Should be appreciated that specific embodiment described herein only in order to explain the present invention, not
For limiting the present invention.
Embodiment 1
A kind of antimicrobial form aciclovir eye drop, its raw material is as follows: acyclovir 8 grams, 4 grams of chloromycetin, sodium chloride
0.3 gram, Macrogol 600 2 grams, vitamin B6 1 gram, vitamin B12 1 gram, boric acid 0.5 gram, thickening agent 0.6 gram, taurine
0.1-0. gram, Borax 0.5 gram, distilled water 150 milliliters.
Described thickening agent is hyaluronic acid sodium.
The preparation method of a kind of antimicrobial form aciclovir eye drop, comprises the steps:
S1: be pre-mixed with chloromycetin by acyclovir, joins in reagent bottle by mixed acyclovir and chloromycetin, adds
The distillation water yield entering 1/4th carries out mix and blend, uses the mode of heating in water bath to heat, and bath temperature controls at 35-
Between 45 degrees Celsius, prepare mixed solution A, solution A is placed standby；
S2: Macrogol 600, vitamin B6, vitamin B12, boric acid, thickening agent, taurine and Borax are mixed in advance,
Join in test tube, in test tube, add four/two-component distilled water, mix, use heating in water bath mode to heat,
Bath temperature controls between 35-45 degree Celsius, it is thus achieved that mixed solution B, solution B is placed standby；
S3: mixed homogeneously in test tube by the distilled water of sodium chloride with remaining 1/4th, uses the mode of heating in water bath to add
Heat, bath temperature controls between 35-45 degree Celsius, it is thus achieved that solution C, solution C is placed standby；
S4: solution A, solution B and solution C are mixed, uses vibrations instrument to carry out vibrations mixing；
S5: the solution that S4 obtains is carried out fine straining process, the impurity in solution can effectively be removed, the filter opening of fine filtering device
Aperture is 1200 mesh；
S6: the solution after essence being considered packs in the vial, should be noted that the sterilization treatment of bottle bottleneck during subpackage.
Embodiment 2
A kind of antimicrobial form aciclovir eye drop, its raw material is as follows: acyclovir 9 grams, 4.5 grams of chloromycetin, chlorination
0.4 gram of sodium, Macrogol 600 2.5 grams, vitamin B6 1.3 grams, vitamin B12 1.2 grams, boric acid 0.7 gram, thickening agent 0.7
Gram, taurine 0.15 gram, Borax 0.6 gram, distilled water 160 milliliters.
Described thickening agent is hyaluronic acid sodium.
The preparation method of a kind of antimicrobial form aciclovir eye drop, comprises the steps:
S1: be pre-mixed with chloromycetin by acyclovir, joins in reagent bottle by mixed acyclovir and chloromycetin, adds
The distillation water yield entering 1/4th carries out mix and blend, uses the mode of heating in water bath to heat, and bath temperature controls at 35-
Between 45 degrees Celsius, prepare mixed solution A, solution A is placed standby；
S2: Macrogol 600, vitamin B6, vitamin B12, boric acid, thickening agent, taurine and Borax are mixed in advance,
Join in test tube, in test tube, add four/two-component distilled water, mix, use heating in water bath mode to heat,
Bath temperature controls between 35-45 degree Celsius, it is thus achieved that mixed solution B, solution B is placed standby；
S3: mixed homogeneously in test tube by the distilled water of sodium chloride with remaining 1/4th, uses the mode of heating in water bath to add
Heat, bath temperature controls between 35-45 degree Celsius, it is thus achieved that solution C, solution C is placed standby；
S4: solution A, solution B and solution C are mixed, uses vibrations instrument to carry out vibrations mixing；
S5: the solution that S4 obtains is carried out fine straining process, the impurity in solution can effectively be removed, the filter opening of fine filtering device
Aperture is 1200 mesh；
S6: the solution after essence being considered packs in the vial, should be noted that the sterilization treatment of bottle bottleneck during subpackage.
Embodiment 3
A kind of antimicrobial form aciclovir eye drop, its raw material is as follows: acyclovir 10 grams, 5 grams of chloromycetin, sodium chloride
0.5 gram, Macrogol 600 3 grams, vitamin B6 1.5 grams, vitamin B12 1.3 grams, boric acid 0.8 gram, thickening agent 0.8 gram, cattle
Sulfonic acid 0.2 gram, Borax 0.7 gram, distilled water 170 milliliters.
Described thickening agent is hyaluronic acid sodium.
The preparation method of a kind of antimicrobial form aciclovir eye drop, comprises the steps:
S1: be pre-mixed with chloromycetin by acyclovir, joins in reagent bottle by mixed acyclovir and chloromycetin, adds
The distillation water yield entering 1/4th carries out mix and blend, uses the mode of heating in water bath to heat, and bath temperature controls at 35-
Between 45 degrees Celsius, prepare mixed solution A, solution A is placed standby；
S2: Macrogol 600, vitamin B6, vitamin B12, boric acid, thickening agent, taurine and Borax are mixed in advance,
Join in test tube, in test tube, add four/two-component distilled water, mix, use heating in water bath mode to heat,
Bath temperature controls between 35-45 degree Celsius, it is thus achieved that mixed solution B, solution B is placed standby；
S3: mixed homogeneously in test tube by the distilled water of sodium chloride with remaining 1/4th, uses the mode of heating in water bath to add
Heat, bath temperature controls between 35-45 degree Celsius, it is thus achieved that solution C, solution C is placed standby；
S4: solution A, solution B and solution C are mixed, uses vibrations instrument to carry out vibrations mixing；
S5: the solution that S4 obtains is carried out fine straining process, the impurity in solution can effectively be removed, the filter opening of fine filtering device
Aperture is 1200 mesh；
S6: the solution after essence being considered packs in the vial, should be noted that the sterilization treatment of bottle bottleneck during subpackage.
A kind of antimicrobial form aciclovir eye drop that the present invention provides and preparation method thereof, by mould with chlorine by acyclovir
The mixing of element adds so that collyrium has higher antibiotic property, can eliminate multiple eye inflammation simultaneously, so that
The purposes of collyrium is greatly improved, and solves various problems.
The above, the only present invention preferably detailed description of the invention, but protection scope of the present invention is not limited thereto,
Any those familiar with the art in the technical scope that the invention discloses, according to technical scheme and
Inventive concept equivalent or change in addition, all should contain within protection scope of the present invention.
Claims (3)
1. an antimicrobial form aciclovir eye drop, it is characterised in that: its raw material is as follows: acyclovir 8-10 gram,
4-5 gram of chloromycetin, 0.3-0.5 gram of sodium chloride, Macrogol 600 2-3 gram, vitamin B6 1-1.5 gram, vitamin B12 1-
1.3 grams, boric acid 0.5-0.8 gram, thickening agent 0.6-0.8 gram, taurine 0.1-0.2 gram, Borax 0.5-0.7 gram, distilled water 150-
170 milliliters.
A kind of antimicrobial form aciclovir eye drop the most according to claim 1, it is characterised in that: described thickening agent is glass
Acid sodium.
3. the preparation method of the antimicrobial form aciclovir eye drop described in a claim 1, it is characterised in that: include walking as follows
Rapid:
S1: be pre-mixed with chloromycetin by acyclovir, joins in reagent bottle by mixed acyclovir and chloromycetin, adds
The distillation water yield entering 1/4th carries out mix and blend, uses the mode of heating in water bath to heat, and bath temperature controls at 35-
Between 45 degrees Celsius, prepare mixed solution A, solution A is placed standby；
S2: Macrogol 600, vitamin B6, vitamin B12, boric acid, thickening agent, taurine and Borax are mixed in advance,
Join in test tube, in test tube, add four/two-component distilled water, mix, use heating in water bath mode to heat,
Bath temperature controls between 35-45 degree Celsius, it is thus achieved that mixed solution B, solution B is placed standby；
S3: mixed homogeneously in test tube by the distilled water of sodium chloride with remaining 1/4th, uses the mode of heating in water bath to add
Heat, bath temperature controls between 35-45 degree Celsius, it is thus achieved that solution C, solution C is placed standby；
S4: solution A, solution B and solution C are mixed, uses vibrations instrument to carry out vibrations mixing；
S5: the solution that S4 obtains is carried out fine straining process, the impurity in solution can effectively be removed, the filter opening of fine filtering device
Aperture is 1200 mesh；
S6: the solution after essence being considered packs in the vial, should be noted that the sterilization treatment of bottle bottleneck during subpackage.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610745500.7A CN106265675A (en) | 2016-08-29 | 2016-08-29 | A kind of antimicrobial form aciclovir eye drop and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610745500.7A CN106265675A (en) | 2016-08-29 | 2016-08-29 | A kind of antimicrobial form aciclovir eye drop and preparation method thereof |
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| CN106265675A true CN106265675A (en) | 2017-01-04 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201610745500.7A Pending CN106265675A (en) | 2016-08-29 | 2016-08-29 | A kind of antimicrobial form aciclovir eye drop and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107440975A (en) * | 2017-09-18 | 2017-12-08 | 江苏天眼医药科技股份有限公司 | A kind of composition for eye-care |
| CN111840421A (en) * | 2020-08-20 | 2020-10-30 | 安徽艾珂尔制药有限公司 | Antibacterial ribavirin eye drops and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1183302A (en) * | 1996-11-22 | 1998-06-03 | 凌沛学 | Eye drops contg. sodium hyaluronate and preparing method thereof |
| CN1383383A (en) * | 2000-06-29 | 2002-12-04 | 老笃制药株式会社 | Oxygen-contg. ophthalmic compsn. |
| CN101455639A (en) * | 2009-01-06 | 2009-06-17 | 河北科技大学 | Acyclovir eye drops without bacteria inhibitor and preparation method thereof |
| CN101461775A (en) * | 2009-01-06 | 2009-06-24 | 河北科技大学 | Chloromycetin eyedrops without bacteriostatic agent and preparation method thereof |
| WO2010004594A1 (en) * | 2008-07-08 | 2010-01-14 | S.I.F.I. Societa' Industria Farmaceutica Italiana S.P.A. | Ophthalmic compositions for treating pathologies of the posterior segment of the eye |
-
2016
- 2016-08-29 CN CN201610745500.7A patent/CN106265675A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1183302A (en) * | 1996-11-22 | 1998-06-03 | 凌沛学 | Eye drops contg. sodium hyaluronate and preparing method thereof |
| CN1383383A (en) * | 2000-06-29 | 2002-12-04 | 老笃制药株式会社 | Oxygen-contg. ophthalmic compsn. |
| WO2010004594A1 (en) * | 2008-07-08 | 2010-01-14 | S.I.F.I. Societa' Industria Farmaceutica Italiana S.P.A. | Ophthalmic compositions for treating pathologies of the posterior segment of the eye |
| CN101455639A (en) * | 2009-01-06 | 2009-06-17 | 河北科技大学 | Acyclovir eye drops without bacteria inhibitor and preparation method thereof |
| CN101461775A (en) * | 2009-01-06 | 2009-06-24 | 河北科技大学 | Chloromycetin eyedrops without bacteriostatic agent and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 孟胜男: "《药剂学》", 31 January 2012 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107440975A (en) * | 2017-09-18 | 2017-12-08 | 江苏天眼医药科技股份有限公司 | A kind of composition for eye-care |
| CN111840421A (en) * | 2020-08-20 | 2020-10-30 | 安徽艾珂尔制药有限公司 | Antibacterial ribavirin eye drops and preparation method thereof |
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Application publication date: 20170104 |