CN106248434A - Liquid acquisition device and the method making liquid acquisition device - Google Patents
Liquid acquisition device and the method making liquid acquisition device Download PDFInfo
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- CN106248434A CN106248434A CN201510256759.0A CN201510256759A CN106248434A CN 106248434 A CN106248434 A CN 106248434A CN 201510256759 A CN201510256759 A CN 201510256759A CN 106248434 A CN106248434 A CN 106248434A
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- acquisition device
- space
- liquid acquisition
- gumwater
- resin
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Abstract
The invention discloses a kind of liquid acquisition device, comprise a body, have an opening, this opening connects the space in this body, is wherein coated with arabic gum on an inwall in this space.The present invention additionally discloses a kind of method making liquid acquisition device, first one body is provided, there is an opening, this opening connects the space in this body, then by openings contact one gumwater, make space be full of gumwater, then remove the gumwater of part in space, be finally dried body.
Description
Technical field
The present invention relates to a kind of liquid acquisition device and the method making liquid acquisition device, especially for,
Relate to a kind of liquid acquisition device for gathering blood and be constructed for gathering the liquid acquisition dress of blood
The method put.
Background technology
After capillary microcuvette is used for gathering liquid sample and reacting with reagent, to reaction sample
This or to carry out optical analysis itself as sample.Such as, existing capillary tube is small transparent
After container is used primarily in collection blood sample, its hemoglobin (Hemoglobin) is carried out optical detection.
The principle of capillary tube harvester passes through capillarity, makes liquid lead to gathering sample liquids contact
Cross capillary force to be certainly advanced in the tube wall of capillary tube, to complete the action gathered.Conventional capillary
Pipe harvester is typically made with glass, but due to the restriction of glass technology and use the one-tenth of material
This, make the cost of capillary glass tube remain high.And in other material, not becoming due to technique again
Ripe so that the tube wall in capillary tube cannot form predefined size, therefore cannot improve absorption success rate.
Therefore, it is also desirable to a kind of cost is less, and the harvester drawing success rate can be increased, especially
It it is the harvester being useful in blood sample.
Summary of the invention
The present invention, in being to provide a kind of liquid acquisition device, has height successfully absorption rate.
According to an embodiment of the invention, the invention provides a kind of liquid acquisition device, comprise one
Body, has an opening, and this opening connects the space in this body, wherein on an inwall in this space
It is coated with arabic gum.
According to another one embodiment of the present invention, the present invention provides a kind of side making liquid acquisition device
Method.First providing a body, have an opening, this opening connects the space in this body.Then will
Openings contact one gumwater, makes space be full of gumwater, then removes the portion in space
The gumwater divided.Finally it is dried body.
Liquid acquisition device provided by the present invention, one of them is characterised by coating layer having Arab
Glue, can increase absorption success rate, and has the advantages such as lightweight, low cost, sample requirements be low simultaneously,
It is more suitable for batch production.
Accompanying drawing explanation
Fig. 1 show the one of which embodiment schematic diagram of the present invention a kind of liquid acquisition device.
Fig. 2 show the detailed maps of an embodiment of drawing section of the present invention.
Fig. 3 show the broken line graph of the arabic gum comparison absorption success rate of variable concentrations.
The arabic gum of Fig. 4 to Fig. 8 the most corresponding 0%, 1.25%, 2.5%, 5% and 10% judges to draw
The picture schematic diagram of success rate, wherein fills up space with liquid and is judged as successfully.
Fig. 9 show another embodiment detailed maps of drawing section of the present invention.
Wherein, description of reference numerals is as follows:
300 liquid acquisition device 312 coating layers
302 body 314 openings
304 space, grip parts 316
306 supporting part 316A draw space
308 tapered portion 316B accommodate space
310 drawing sections
Detailed description of the invention
For making those skilled in the art can be further understood that the present invention, hereafter special detailed description is originally
The effect that the constitution content of invention and hope realize.The most disclose enough details and made the technology of this area
Personnel can have to implement.Additionally, the known object structure in some this areas and operating process will no longer
Repeated description.Certainly, other embodiment the most practicable in the present invention, or do not violating described in literary composition
The change in any logicality is made on the premise of embodiment.
The present invention is about a kind of liquid acquisition device, is used to gather liquid sample, is gathered and hold
Receive in harvester, then via after transporting to carrying out being checked or analyzed of liquid at another.First please
With reference to Fig. 1, it show the one of which embodiment schematic diagram of the present invention a kind of liquid acquisition device.As
Shown in Fig. 1, the liquid acquisition device 300 of the present invention comprises a body 302, body 302 by one end to
The other end sequentially comprises grip part 304, supporting part 306, tapered portion 308 and a drawing section
310.Grip part 304 is used for providing operation and the taking of user, preferably presents long handle；Supporting part
306 have bigger caliber compared to grip part 304, to provide the support of drawing section, front end 310；Gradually
Contracting portion 308 is in order to connect supporting part 306 and drawing section 310, and its caliber is tapered towards drawing section 310；And
The drawing section 310 being positioned at end is then to be mainly used to provide the position drawn with accommodate testing liquid.Body
Each position of 302 can use different materials, and preferably for, each position in body 302
It is to be formed by same material and is integrally formed (monolithic), to reach cost-effective purpose.And
And, in order to reach the target of lightweight and batch production, in one embodiment, body 302 is preferably
Made by jetting formation process, and the macromolecule resin, e.g. polypropylene such as material e.g. plastic cement
(Polypropylene, PP), polystyrene (Polystyrene, PS), acrylonitrile-butadiene-styrene (ABS) copolymerization
Resin (Acrylonitrile butadiene styrene, ABS), polyethylene terephthalate
(Polyethylene terephthalate, PET), polyester resin (Polyester, PES), polyamide (Polyamides,
PA), polrvinyl chloride (Polyvinyl chloride, PVC), polyurethane (Polyurethanes, PU), poly-carbonic acid
Ester (Polycarbonate, PC), polyvinyl dichloride (Polyvinylidene chloride, PVDC), polyethylene
(Polyethylene, PE), Merlon/ABS resin (Polycarbonate/Acrylonitrile Butadiene
Styrene, PC/ABS), polymethyl methacrylate (Polymethyl methacrylate, PMMA), poly-four
Fluorothene (Polytetrafluoroethylene, PTFE), polyether-ether-ketone (Polyetheretherketone, PEEK),
PolyEtherImide (Polyetherimide, PEI), phenolic resin (Phenolics, PF), urea-formaldehyde resin
Urea-formaldehyde, UF), melamine formaldehyde resin (Melamine formaldehyde, MF) or
Polylactic resin (Polylactic acid, PLA) etc., but be not limited thereto.In a preferred embodiment, pipe
The material of body 302 is Merlon, polrvinyl chloride or acrylonitrile-butadiene-styrene copolymer resin.Value
It is noted that in body 302 in addition to said elements, it is also possible to there are other and assist sample collecting
Design, or, it is also possible to omit such as supporting part 306 and tapered portion 308 element such as grade, and only retain
Drawing section 310 is arranged on one end of grip part 304.In such embodiments, grip part 304 and suction
The caliber taking portion 310 can be the same or different, and determines with processing technology depending on product design.
Refer to Fig. 2, show the detailed maps of drawing section 310 of the present invention.As in figure 2 it is shown, draw
Being provided with a space 316 in portion 310, this space 316 connects the external world, opening 314 by an opening 314
Being arranged on one end of drawing section 310, the absorption of sample liquids can enter space 316 by opening 314
In, it is received further.In the preferred embodiment of the present invention, liquid acquisition device 300 passes through liquid completely
Surface tension draws testing liquid (i.e. capillary force), therefore in the space 316 of drawing section 310
It is not connected with other openings in addition to opening 314, and will not have the power set phase of suction with other
Even.But in other embodiments of the present invention, liquid acquisition device 300 is likely to and other power set phases
Even, this time space 316 then may have other openings and be connected with described power set.
In order to easy to make, the caliber in space 316 is generally the most identical with opening 314, makes space 316
Present cylindric.And in other embodiments, as described in Figure 9, space 316 is likely to have size not
The caliber of one, the absorption space 316A such as with relatively pipe with small pipe diameter connects opening 314, and relatively Large Diameter Pipeline
Receiving space 316B.In a preferred embodiment of the invention, the capacity in space 316 is less than 5 microlitres
(micro liter, μ l) is main, preferably 0.5 microlitre～2 microlitres, and more preferably 1 microlitre, to realize corpusculum
Long-pending analysis sample, can save the sample size required for analysis.In one embodiment, the pipe in space 316
Footpath is about 300 microns～3000 microns.
As in figure 2 it is shown, one of them of the present invention is characterised by, the inwall in space 316 is coated with one
Coating layer 312.Coating layer 312 preferably can be uniformly coated on whole space 316, but implements at other
In example, coating layer 312 then partly can be coated on default position.As it is shown in figure 9, coating layer 312
Only it is coated on the absorption space 316A of previous embodiment space 316 relatively pipe with small pipe diameter, and is not coated on bigger
The receiving space 316B of caliber.The coating layer 312 of the present invention comprises any natural or passes through by laboratory
The arabic gum of purification, can obtain via various business or non-commercial channel, such as CAS registration number 9000
The product of-01-5.In an embodiment of the invention, the weight percent of arabic gum in coating layer 312
Ratio is 10% to 100%, preferably 30% to 100%, more preferably 50% to 100%.Arabic gum
Can be with water or other suitable liquid as solvent.The present invention forms the method for described coating layer 312 can
To use various common process.In one embodiment, can first provide just like aforementioned liquids harvester 300,
Then opening 314 is contacted a predetermined concentration, in the gumwater of e.g. 1.25% to 10%,
Gumwater can be made to be coated on the inwall in space 316 whole or in part by capillary force
On, follow-up remove unnecessary arabic gum, make on the inwall in space 316, to form very thin coating layer 312.
The embodiment that form coating layer 312 is set forth below.
Embodiment
1. reduce the Parafilm sealed membrane of about 3 centimeters * 9 centimeters, tear off on Parafilm sealed membrane
Protective paper, the side that protective paper contacts with Parafilm upward, is placed in the desktop after alcohol wipe
On.
2. take out the gumwater configured with dropper, drip about 50 μ l on Parafilm.
3. take the liquid acquisition device such as Fig. 1, front opening is contacted with Parafilm, to put point mode up and down
Repeat to allow space be saturated with arabic gum liquid.
4. will be saturated with the opening of the liquid acquisition device of arabic gum, contact is pressed against on a lens paper, can naked eyes
Arabic gum liquid in observation space again after being decreased until disappearance more waits about 1 second, i.e. removes liquid
Harvester.
5. repeat step 3, step 4 twice.
6. put and be dried about 30 minutes at room temperature.
Be there is the coating layer 312, Ke Yiming of arabic gum by formation all or part of in space 316
The aobvious ability promoting fluid present invention harvester 300 collecting sample liquid.In order to confirm the merit of the present invention
Effect, the present invention carries out following experiment:
1. a red pigment water on dripping on Parafilm sealed membrane, volume is more than 100 μ l；
The most then to connect with red pigment water at the opening 314 of liquid acquisition device 300 drawing section 310 of the present invention
Touch, after starting several 5 seconds with timer, remove liquid acquisition device 300；
3. judge to draw success rate, be completely filled with red pigments water in 5 seconds in space 316 and be then judged as successfully.
Table 1 is according to above-mentioned steps, and the Arabic glue-line presenting Different Weight percent solution concentration is drawn
The data of success rate, each concentration carries out three times repeating test, to guarantee the reliability of data.
Molten by the difference drawn according to the result of table 1 please also refer to Fig. 3 and Fig. 4 to Fig. 8, Fig. 3
The broken line graph of success rate is drawn in the arabic gum comparison of liquid concentration.Fig. 4 to Fig. 8 respectively corresponding 0%, 1.25%,
2.5%, the gumwater of 5% and 10% judges to draw the picture schematic diagram of success rate, is wherein with the
Three experiments present for example.As shown in table 1, Fig. 3 Yu Fig. 4, it be not coated with arabic gum (0%)
In the case of, red pigments water can not be made in 5 seconds to be full of the space of 1 microlitre, and the most a little portion
The red pigments water divided can enter in space；But along with the solution concentration of coating arabic gum rises, inhale
The success rate taken also is gradually increasing, and in the arabic gum of proportions (1.25%), has had 10%
Success rate, and have significant success rate at 2.5%, 5% and 10%, it can be verified that with more than 2.5%
Gumwater coating can be obviously improved success rate.
The present invention successfully proposes a kind of liquid acquisition device that can increase and draw success rate, Qi Zhongyi
Individual it is characterised by coating layer having arabic gum, absorption success rate can be increased.Additionally, liquid acquisition dress
Put and be preferably integrally formed with ejection formation, there is macromolecule resin material, compared to conventional glass
Glass capillary tube, the present invention has lightweight and cost-effective advantage.Further, the space of the present invention is preferred
At 5 below μ l, e.g. 1 μ l, in routine technology for be that 1 μ l cannot be inhaled by capillarity
Take sample liquids, and due to the fact that and be provided with coating layer, therefore can simply overcome this problem.
Therefore, to have lightweight, low cost, sample requirements low etc. excellent simultaneously for the liquid acquisition device of the present invention
Point, is more suitable for batch production.The liquid acquisition device of the present invention can be used to gather various treats side liquid,
Preferably gather blood sample.It is can to combine with other set groups (kit) that the liquid acquisition of the present invention is installed on
Or become the part of a set of group, to provide more multiple demands.
The foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, for this
For the technical staff in field, the present invention can have various modifications and variations.All spirit in the present invention and
Within principle, any modification, equivalent substitution and improvement etc. made, should be included in the protection of the present invention
Within the scope of.
Claims (10)
1. a liquid acquisition device, it is characterised in that comprise:
One body, has an opening, and this opening connects the space in this body, on the inwall in this space
It is coated with arabic gum.
Liquid acquisition device the most according to claim 1, it is characterised in that the concentration of this arabic gum
For 10w/w%～100w/w%.
Liquid acquisition device the most according to claim 1, it is characterised in that the capacity in this space is less than 5
Microlitre.
Liquid acquisition device the most according to claim 1, it is characterised in that the capacity in this space is 0.5
To 2 microlitres.
Liquid acquisition device the most according to claim 1, it is characterised in that this space has a caliber
For _ 300 microns～3000 microns.
Liquid acquisition device the most according to claim 1, it is characterised in that the material of this body comprises
Polypropylene, polystyrene, acrylonitrile-butadiene-styrene copolymer resin, polyethylene terephthalate,
Polyester resin, polyamide, polrvinyl chloride, polyurethane, Merlon, polyvinyl dichloride, polyethylene,
Merlon/ABS resin, polymethyl methacrylate, politef, polyether-ether-ketone, polyethers are sub-
Amide, phenolic resin, urea-formaldehyde resin, melamine formaldehyde resin or polylactic resin.
Liquid acquisition device the most according to claim 1, it is characterised in that this liquid acquisition device is
It is used for gathering blood.
8. the method making liquid acquisition device, it is characterised in that comprise:
Thering is provided a body, have an opening, this opening connects the space in this body；
By this openings contact one gumwater, this space is made to be full of this gumwater；
Remove this gumwater of part in this space；And
It is dried this body.
The method of making liquid acquisition device the most according to claim 8, it is characterised in that remove this
In space, the step of this gumwater of part is by this openings contact one lens paper.
The method of making liquid acquisition device the most according to claim 8, it is characterised in that this I
The concentration of primary sol solution is between 2.5w/w%～10w/w%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510256759.0A CN106248434A (en) | 2015-05-19 | 2015-05-19 | Liquid acquisition device and the method making liquid acquisition device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510256759.0A CN106248434A (en) | 2015-05-19 | 2015-05-19 | Liquid acquisition device and the method making liquid acquisition device |
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| Publication Number | Publication Date |
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| CN106248434A true CN106248434A (en) | 2016-12-21 |
Family
ID=57626280
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN201510256759.0A Pending CN106248434A (en) | 2015-05-19 | 2015-05-19 | Liquid acquisition device and the method making liquid acquisition device |
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Citations (8)
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|---|---|---|---|---|
| US4679446A (en) * | 1985-09-09 | 1987-07-14 | Baxter Travenol Laboratories, Inc. | Multi-volume displacement pipette |
| CN1207056A (en) * | 1995-11-13 | 1999-02-03 | 科特克斯(英国)有限公司 | Diagnostic test apparatus |
| JP2003344236A (en) * | 2002-05-31 | 2003-12-03 | Horiba Ltd | Method and device for sampling fixed amount of liquid |
| CN1735370A (en) * | 2002-11-01 | 2006-02-15 | 佩利坎技术公司 | Method and apparatus for body fluid sampling |
| CN201327454Y (en) * | 2008-12-29 | 2009-10-14 | 上海宝钢化工有限公司 | Novel liquid sampler |
| CN101726597A (en) * | 2008-10-27 | 2010-06-09 | 中国科学院动物研究所 | Test paper for detecting avian influenza virus and preparation method thereof |
| CN102764133A (en) * | 2012-08-10 | 2012-11-07 | 上海科华检验医学产品有限公司 | Vacuum blood collection tube and method thereof capable of directly separating blood plasma |
| CN103477197A (en) * | 2011-01-21 | 2013-12-25 | 提拉诺斯公司 | Systems and methods for sample use maximization |
-
2015
- 2015-05-19 CN CN201510256759.0A patent/CN106248434A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4679446A (en) * | 1985-09-09 | 1987-07-14 | Baxter Travenol Laboratories, Inc. | Multi-volume displacement pipette |
| CN1207056A (en) * | 1995-11-13 | 1999-02-03 | 科特克斯(英国)有限公司 | Diagnostic test apparatus |
| JP2003344236A (en) * | 2002-05-31 | 2003-12-03 | Horiba Ltd | Method and device for sampling fixed amount of liquid |
| CN1735370A (en) * | 2002-11-01 | 2006-02-15 | 佩利坎技术公司 | Method and apparatus for body fluid sampling |
| CN101726597A (en) * | 2008-10-27 | 2010-06-09 | 中国科学院动物研究所 | Test paper for detecting avian influenza virus and preparation method thereof |
| CN201327454Y (en) * | 2008-12-29 | 2009-10-14 | 上海宝钢化工有限公司 | Novel liquid sampler |
| CN103477197A (en) * | 2011-01-21 | 2013-12-25 | 提拉诺斯公司 | Systems and methods for sample use maximization |
| CN102764133A (en) * | 2012-08-10 | 2012-11-07 | 上海科华检验医学产品有限公司 | Vacuum blood collection tube and method thereof capable of directly separating blood plasma |
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Application publication date: 20161221 |
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