CN106245153A - Medical fiber mixed by gelatin and bamboo fiber and preparation method thereof - Google Patents
Medical fiber mixed by gelatin and bamboo fiber and preparation method thereof Download PDFInfo
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- CN106245153A CN106245153A CN201610603141.1A CN201610603141A CN106245153A CN 106245153 A CN106245153 A CN 106245153A CN 201610603141 A CN201610603141 A CN 201610603141A CN 106245153 A CN106245153 A CN 106245153A
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- gelatin
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F8/00—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof
- D01F8/02—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof from cellulose, cellulose derivatives, or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F1/00—General methods for the manufacture of artificial filaments or the like
- D01F1/02—Addition of substances to the spinning solution or to the melt
- D01F1/10—Other agents for modifying properties
- D01F1/103—Agents inhibiting growth of microorganisms
Abstract
The invention discloses a medical fiber mixed by gelatin and bamboo fiber and a preparation method thereof, wherein the medical fiber is prepared by taking a bio-based material as a raw material, and the weight percentage of each part of the raw material is as follows: gelatin: bamboo fiber = 1-3: 7-9, preparing a gelatin solution by using an enzyme method, decomposing leather by using neutral protease, and performing a sol process to obtain the gelatin solution. Adopting wet fiber-making technology, using saturated sodium chloride solution as coagulating bath, selecting nozzle with aperture of 0.08 and number of holes of 100, and spinning to obtain gelatin and bamboo fiber product. Can be made into medical dressing such as medical hemostatic gauze, etc., and has hemostatic, natural antibacterial and bacteriostatic effects. The method has scientific and reasonable steps, mature technology and low production threshold, and can be popularized and used in a large scale.
Description
Technical field
The present invention relates to the preparation method of the medical fibre of a kind of bio-based, belong to field of medical materials.
Background technology
Gelatin is a kind of fat free high protein preparation, and without cholesterol, is the food thickening of a kind of native trophism
Agent, meanwhile, gelatin medically also has effect of hemostasis, is medical good material, but gelatin is generally used for the shell of capsule,
It is rarely used in medical fibre.
Bamboo fibre is the good material of medical fibre, and it has good breathability, a water absorption, and stronger wearability is natural
Antibacterial, antibacterial, moreover it is possible to deodorant.If joined by gelatin in bamboo fibre, fiber has just possessed effect of hemostasis, may be used for doctor
In treatment, as hemostatic gauze etc., but existing technology does not the most accomplish this step.
Therefore, those skilled in the art is devoted to develop a kind of medical dressing merging gelatin and bamboo fibre advantage.
Summary of the invention
Because the drawbacks described above of prior art, the technical problem to be solved is by gelatin and bamboo fibre
Mixing prepares the medical fiber material with multi-efficiency.
For achieving the above object, the invention provides a kind of gelatin, the medical fibre of bamboo fibre mixing, be former with bio-based
Material is made, and wherein the percentage by weight of each several part raw material is:
Gelatin: bamboo fibre=1-3:7-9.
Preferably, making with bio-based for raw material, wherein the percentage by weight of each several part raw material is:
Gelatin: bamboo fibre=2:8.
The preparation method of the medical fibre of a kind of gelatin, bamboo fibre mixing, comprises the following steps:
Selected leather leftover pieces 3000-5000 weight portion, add neutral protease 6-10 weight portion, control temperature at 35-40 DEG C,
Intermittent stirring 8-10h, initial p H is adjusted to 4；
Then carrying out collosol craft, temperature is transferred to 70-90 DEG C, PH is adjusted to 5, intermittent stirring about 9h；
Then soak one day with lime cream, neutralize with the hydrochloric acid of 10%-12% afterwards, start to add water and endure glue, obtain gelatin solution；
The raw healthy and strong tall and straight high-quality QINGZHU 10000-20000 weight portion of selected 3-4, by high temperature steaming and stirring, until system
Become bamboo pulp；
The solution of above-mentioned preparation is mixed, stirs 50-100min so that it is mix homogeneously is consistent, filter, be dried；
Use wet method fiber, use saturated nacl aqueous solution as coagulating bath, nitrogen pressure 0.1-0.2MPa, temperature 45-55
In the environment of DEG C, carry out spray webbing, select shower nozzle aperture 0.08, hole count 100, carry out spray webbing, it is thus achieved that gelatin and bamboo fiber products.
Further, these leather leftover pieces are Corii Sus domestica.
Technique effect: the present invention is by a kind of medical fibre made altogether after gelatin solution and bamboo fibre mixing, can make doctor
Use with medical dressing such as hemostatic gauzes, there is hemostasis, effect that natural antibacterial is antibacterial.Use preparation of gelatin with enzyme solution, logical
Cross the neutral protease decomposition to leather, then carry out sol-process, obtain gelatin solution.Use wet method fibre technology, saturated
Sodium chloride solution, as coagulating bath, is selected shower nozzle aperture 0.08, hole count 100, is carried out spray webbing, it is thus achieved that gelatin and bamboo fiber products.
Step science, rationally, technology maturation, produce threshold low, can use with large-scale promotion.
Detailed description of the invention
Embodiment 1: the medical fibre of a kind of gelatin, bamboo fibre mixing, makes with bio-based for raw material, wherein each several part
The percentage by weight of raw material is:
Gelatin: bamboo fibre=1:9.
The medical fibre using this percentage by weight has good breathability, water absorption, stronger wearability, has good
Good haemostatic effect.
Embodiment 2: the medical fibre of a kind of gelatin, bamboo fibre mixing, makes with bio-based for raw material, wherein each several part
The percentage by weight of raw material is:
Gelatin: bamboo fibre=3:7.
The medical fibre using this percentage by weight has good breathability, water absorption, stronger wearability, has more
Strong haemostatic effect.
Embodiment 3: the medical fibre of a kind of gelatin, bamboo fibre mixing, makes with bio-based for raw material, wherein each several part
The percentage by weight of raw material is:
Gelatin: bamboo fibre=2:8.
This embodiment reasonable mixture ratio, the advantage of two kinds of raw materials is the most substantially the most comprehensive, and the toughness of medical fibre, elasticity
Preferably.
Embodiment 4: the preparation method of the medical fibre of a kind of gelatin, bamboo fibre mixing, comprises the following steps:
Selected Corii Sus domestica leftover pieces 5000 weight portion, adds neutral protease 6 weight portion, and control temperature is at 40 DEG C, and intermittence stirs
8h, initial p H is adjusted to 4；
Then carrying out collosol craft, temperature is transferred to 70 DEG C, PH is adjusted to 5, intermittent stirring about 9h；
Then soak one day with lime cream, neutralize with the hydrochloric acid of 10% afterwards, start to add water and endure glue, obtain gelatin solution；
Raw healthy and strong tall and straight high-quality QINGZHU 20000 weight portion of selected 3-4, by high temperature steaming and stirring, until making bamboo pulp；
The solution of above-mentioned preparation is mixed, stirs 50min so that it is mix homogeneously is consistent, filter, be dried；
Use wet method fiber, use saturated nacl aqueous solution as coagulating bath, nitrogen pressure 0.1MPa, the environment that temperature is 55 DEG C
Under, carry out spray webbing, select shower nozzle aperture 0.08, hole count 100, carry out spray webbing, it is thus achieved that gelatin and bamboo fiber products.
Embodiment 5: the preparation method of the medical fibre of a kind of gelatin, bamboo fibre mixing, comprises the following steps:
Selected Corii Bovis seu Bubali leftover pieces 3000 weight portion, adds neutral protease 10 weight portion, and control temperature is at 35 DEG C, and intermittence stirs
10h, initial p H is adjusted to 4；
Then carrying out collosol craft, temperature is transferred to 90 DEG C, PH is adjusted to 5, intermittent stirring about 9h；
Then soak one day with lime cream, neutralize with the hydrochloric acid of 12% afterwards, start to add water and endure glue, obtain gelatin solution；
Raw healthy and strong tall and straight high-quality QINGZHU 10000 weight portion of selected 3-4, by high temperature steaming and stirring, until making bamboo pulp；
The solution of above-mentioned preparation is mixed, stirs 100min so that it is mix homogeneously is consistent, filter, be dried；
Use wet method fiber, use saturated nacl aqueous solution as coagulating bath, nitrogen pressure 0.2MPa, the environment of temperature 45 C
Under, carry out spray webbing, select shower nozzle aperture 0.08, hole count 100, carry out spray webbing, it is thus achieved that gelatin and bamboo fiber products.Optionally, system
The dressing fibre diameter obtained is 56.34 μm, and fiber number is 563dtex.This structure is finer and close, but keeps again fluffy, water absorption
Good, adhesion inhibiting properties is strong, and medical performance reaches optimal, and through test, under this parameter, water absorption improves more than 35%, and adhesion inhibiting properties has
Significantly improve..
Embodiment 6: the preparation method of the medical fibre of a kind of gelatin, bamboo fibre mixing, comprises the following steps:
Selected Corii Sus domestica leftover pieces 3800 weight portion, adds neutral protease 8 weight portion, and control temperature is at 38 DEG C, and intermittence stirs
9h, initial p H is adjusted to 4；
Then carrying out collosol craft, temperature is transferred to 85 DEG C, PH is adjusted to 5, intermittent stirring about 9h；
Then soak one day with lime cream, neutralize with the hydrochloric acid of 11% afterwards, start to add water and endure glue, obtain gelatin solution；
Raw healthy and strong tall and straight high-quality QINGZHU 15000 weight portion of selected 3-4, by high temperature steaming and stirring, until making bamboo pulp；
The solution of above-mentioned preparation is mixed, stirs 80min so that it is mix homogeneously is consistent, filter, be dried；
Use wet method fiber, use saturated nacl aqueous solution as coagulating bath, nitrogen pressure 0.15MPa, the ring of temperature 50 C
Under border, carry out spray webbing, select shower nozzle aperture 0.08, hole count 100, carry out spray webbing, it is thus achieved that gelatin and bamboo fiber products.
The medical dressing prepared by this method, its stability is preferable, and in storing 6 months, product does not occurs outward appearance, is dried
Weightless change also keeps aseptic condition.
Take the medical dressing that film applicator coating detection embodiment 4,5,6 prepares to staphylococcus aureus and Pseudomonas aeruginosa
Anti-microbial property: by reference culture staphylococcus aureus, Pseudomonas aeruginosa Secondary Culture, be suspended in TSB culture fluid, adopt
It is configured to, by Maxwell turbidimetry, the bacterium solution that concentration is 1.5 × 108 CFU/mL, and takes turns doing 2 10 times of incremental dilutions.Inhale respectively
Take 200 μ L bacterium solution and be seeded in each group of antibacterial surface of test piece (every kind of dressing does five parallel specimen), cover sterilization PE film, cultivate 24
h.Taking out the sample of cultivation after 24h, be separately added into eluent 20mL, the coverlay repeatedly washing each group of given the test agent (presss from both sides with tweezers
Play thin film to rinse), after vortex vibration 1min fully shakes up, take 200 μ l and be inoculated in nutrient agar (NA), (37 scholars
1) clump count CFU is counted after cultivating 24h at DEG C.More than experiment is repeated twice, results averaged.
The detection of the external moisture pick-up properties of medical dressing: weigh sodium chloride and the anhydrous calcium chloride of 0.277 g of 8.3 g, molten
The solution A that British Pharmacopoeia specifies it is configured in the distilled water of 1L.Pick up in the dressing that testing example 4,5,6 prepares
Time, place 24 h after three kinds of dressing are cut into 5 cm × 5 cm sizes respectively, make the regain of fiber reach balance.At this moment measure
The initial mass of dressing is W.Weigh the solution A than dressing weight 40 times, respectively solution and dressing are correspondingly placed at 2 a diameter of
In the culture dish of 9 cm, after placing 30 min at 37 DEG C with tweezers clamp one jiao of dressing aloft, hang after 30s and weigh dressing
Wet quality (W1).The pick up of unit mass dressing=(W1-W)/W (g/g), pick up=4 (W1-W) g/100 of unit are
cm2.Repeat above-mentioned experiment 3 times, seek its meansigma methods.
During test liquid distribution in fiber and between fiber, the dressing (quality is W1) after imbibition with gauze respectively
Packing together after being placed in dewaterer dehydration 15min, measuring the quality of dressing after being dehydrated is W2, and this quality is fiber itself
Dry mass and be absorbed into the summation of liquid quality of fibrous inside.Then the dressing after centrifuge dehydration in 105 DEG C of dry 4h, examination
The dry mass W3 of fiber is recorded after the most permanent quality of sample.W1-W2 is to absorb liquid between the fibers, and W2-W3 is to be absorbed into fibre
Liquid within Wei.(W1-W2)/W3 and (w2-w3)/w3 can calculate the dressing of every gram of dry mass respectively and absorb between fiber
Liquid with fibrous inside.
By the series of standards requirement in country GB/T16886-2008 and IS010993.12-2009, medical to prepare
Dressing carries out cytotoxicity experiment, Acute systemic toxicity experiment, hemolytic experiment, with its biocompatibility of overall merit.
Cytotoxicity experiment: by experimental group ((medical dressing lixiviating solution), negative control group (2% calf serum
RPMI1640) ((dimethyl sulfoxide of 5%) each 3ml, is respectively placed in the Tissue Culture Dish in 6 holes, adds with positive controls
4x104/ml L-929 cell suspension 3ml, 37 DEG C, cultivate 72h under the incubator environment of volume fraction 5%C02 after, observe thin
Born of the same parents' form and growing state.By L-929 cell suspension inoculation that 200ul concentration is 4 × 104/mL in 3 piece of 96 well culture plate,
Cultivating 24 h in same incubator, cell attachment grows, and is separately added into experimental group, negative control group (2% calf after abandoning stock solution
Serum RPMI1640) and each 200 μ l of positive controls (dimethyl sulfoxide of 5%), every kind of extracting solution repeats 4 holes/plate, incubator
After cultivating 72h, observation of cell form and growing state.And use MTT colorimetric method for determining L-929 cell to cultivate the relative increasing of 72h
Grow rate (RGR), evaluate the cytotoxicity of material.
By three kinds of lixiviating solution of experimental group respectively with RPMI1640 culture fluid by volume mark 75% of 2% calf serum,
50%, 25%, 10%, 1% gradient dilution, take the dilution of the respective various concentration of experimental group lixiviating solution of 200 μ L the most respectively
Liquid repeats above experiment, same use 2% calf serum RPMI1640 be negative control group with 5% dimethyl sulfoxide be the positive
Matched group, uses MTT colorimetric method for determining L-929 cell to cultivate the relative rate of increase (RGR) of 72h, after evaluation material is diluted
Cytotoxicity changes.
Acute systemic toxicity is tested: by 50ml/kg Dose standard, by medical dressing lixiviating solution injection testing under aseptic condition
In group mouse peritoneal, negative control group saline injection, positive controls injects phenol.Within after administration continuous 7 days, observe mice,
Record mouse breathing, take food, ordinary circumstance, toxic reaction, body weight change or the death such as motion.
Hemolytic experiment: take 10ml given the test agent lixiviating solution (medical dressing lixiviating solution), 10ml normal saline (negative control
Group), 10ml distilled water (positive controls), be separately added into 0.2ml fresh anticoagulant dilution Sanguis Leporis seu oryctolagi, it is bright whether perusal occurs
Aobvious haemolysis;Microplate reader detects the absorbance of each sample supernatant, evaluates the extracorporeal blood compatibility of subject material.
By scanning electron microscope, observe the Medical coating that sterilized embodiment 4,5,6 is prepared by the microstructure of medical dressing
Material is cut into 1cm × 1cm size square respectively, with the double fixed preparation of glutaraldehyde and osmic acid after autoclaving.
The laboratory sample being cut into 1cm × 1cm size is put into respectively instilled 0.2 mL concentration be 1.5 ×
In the pancreas peptone soybean broth culture medium (TSB) of staphylococcus aureus (ATCC29213) bacterium solution of 106cfu/mL, then
Sterilizing culture test tube is placed on (37 scholar 1) DEG C, relative humidity more than 90% under the conditions of cultivate 24h.Take with aseptic nipper after 24h
Go out sample dressing, detect antibacterial distribution situation in each dressing.
Result: 1, medical dressing in-vitro antibacterial performance evaluation: medical dressing is to staphylococcus aureus and P. aeruginosa
Bacterium bacteriostasis rate averagely gets off respectively 92.5% and 93.4%.Antimicrobial test 3 kinds of dressing of prompting are to staphylococcus aureus
All have certain bacteriostasis with Pseudomonas aeruginosa, medical dressing is in suppression and kills staphylococcus aureus and Aerugo vacation list
Born of the same parents bacterium has obvious advantage.
2, the evaluation of the external moisture pick-up properties of medical dressing: medical dressing is being centrifuged dehydration and is finding after drying, applying
Material itself has good water absorption, and in the moisture absorbed, most can be retained in fibrous inside, is difficult to by centrifugal
Dehydration is removed.
3, the evaluation of its biocompatibility of medical dressing: cytotoxicity experiment: the cell attachment growth of medical dressing lixiviating solution,
Refractivity is relatively strong, and cell presents fusiformis, the cytopathy situation such as cell detachment, cracking does not occur, and after 72h, RGR is respectively
92.9%, 93.2%, 96.1%, cell-cytotoxic reaction is I grade;Three kinds of medical dressing are pointed out all to have good cytocompatibility
Property, no cytotoxicity.
Acute systemic toxicity is tested: the mice of experimental group, after injection lixiviating solution, is taken food, breathes, movable, excretion is not all sent out
Now abnormal, in the observation period of seven days, Mouse Weight, in the trend increased, does not finds that convulsions, instability of gait, the toxicity such as manic are anti-
Should, death does not the most occur.
Hemolytic experiment: the lixiviating solution of subject material does not cause hemolysis in vitro to react, the hemolysis rate average out to of medical dressing
1.27%.
4, by scanning electron microscope, observe the microstructure of medical dressing, medical dressing only has a small amount of antibacterial and sporadically divides
Cloth is on fiber.
Conclusion: 1, the medical dressing that the technical program prepares.And confirm that this new pattern compress possesses relatively by experiment in vivo and vitro
Strong anti-microbial property, highly hygroscopic gelation and the biocompatibility of excellence.
2, according to QB/T2591-2003 prescribed material, the bacteriostasis rate ＞ 90% of microorganism just can be referred to as anti-biotic material,
Confirm that this medical dressing shows stronger anti-microbial property by plate count experiment.
3, experiment confirms that this medical dressing possesses stronger wettability power (P ＞ 0.05).
4, according to the series standard of GB/T16886-2008 and IS010993-2009, biomaterial biocompatibility is wanted
Asking and detection method, experimental result more fully hereinafter shows the standby medical dressing no cytotoxicity of this project team system, acute without whole body
Toxicity, does not the most cause hemolytic reaction, and this medical dressing has good biocompatibility, is applied to for being further used as antiseptic dressing
Clinic provides strong experimental basis.
The preferred embodiment of the present invention described in detail above.Should be appreciated that those of ordinary skill in the art without
Need creative work just can make many modifications and variations according to the design of the present invention.Therefore, all technology in the art
Personnel are available by logical analysis, reasoning, or a limited experiment the most on the basis of existing technology
Technical scheme, all should be in the protection domain being defined in the patent claims.
Claims (4)
1. gelatin, a medical fibre for bamboo fibre mixing, is characterized in that, make for raw material with bio-based, wherein each several part
The percentage by weight of raw material is:
Gelatin: bamboo fibre=1-3:7-9.
The medical fibre of a kind of gelatin the most as claimed in claim 1, bamboo fibre mixing, is characterized in that, be former material with bio-based
Material is made, and wherein the percentage by weight of each several part raw material is:
Gelatin: bamboo fibre=2:8.
3. a preparation method for the medical fibre of gelatin, bamboo fibre mixing, is characterized in that, comprise the following steps:
Selected leather leftover pieces 3000-5000 weight portion, add neutral protease 6-10 weight portion, control temperature at 35-40 DEG C,
Intermittent stirring 8-10h, initial p H is adjusted to 4；
Then carrying out collosol craft, temperature is transferred to 70-90 DEG C, PH is adjusted to 5, intermittent stirring about 9h；
Then soak one day with lime cream, neutralize with the hydrochloric acid of 10%-12% afterwards, start to add water and endure glue, obtain gelatin solution；
The raw healthy and strong tall and straight high-quality QINGZHU 10000-20000 weight portion of selected 3-4, by high temperature steaming and stirring, until system
Become bamboo pulp；
The solution of above-mentioned preparation is mixed, stirs 50-100min so that it is mix homogeneously is consistent, filter, be dried；
Use wet method fiber, use saturated nacl aqueous solution as coagulating bath, nitrogen pressure 0.1-0.2MPa, temperature 45-55
In the environment of DEG C, carry out spray webbing, select shower nozzle aperture 0.08, hole count 100, carry out spray webbing, it is thus achieved that gelatin and bamboo fiber products.
The preparation method of the medical fibre of a kind of gelatin the most according to claim 3, bamboo fibre mixing, is characterized in that, skin
Leather leftover pieces are Corii Sus domestica.
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Cited By (1)
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