CN106226211A - The method of particulate matter content detection in the purposes of fluorine-containing alkane and silicone oil and/or weight silicone oil - Google Patents
The method of particulate matter content detection in the purposes of fluorine-containing alkane and silicone oil and/or weight silicone oil Download PDFInfo
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- CN106226211A CN106226211A CN201610710936.2A CN201610710936A CN106226211A CN 106226211 A CN106226211 A CN 106226211A CN 201610710936 A CN201610710936 A CN 201610710936A CN 106226211 A CN106226211 A CN 106226211A
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- 229920002545 silicone oil Polymers 0.000 title claims abstract description 86
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 title claims abstract description 44
- 150000001335 aliphatic alkanes Chemical class 0.000 title claims abstract description 44
- 229910052731 fluorine Inorganic materials 0.000 title claims abstract description 43
- 239000011737 fluorine Substances 0.000 title claims abstract description 43
- 239000013618 particulate matter Substances 0.000 title claims abstract description 41
- 238000001514 detection method Methods 0.000 title claims abstract description 36
- 238000000034 method Methods 0.000 title claims description 46
- 239000004531 microgranule Substances 0.000 claims description 11
- 238000001914 filtration Methods 0.000 claims description 10
- 239000012982 microporous membrane Substances 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 4
- 229910052799 carbon Inorganic materials 0.000 claims description 4
- 239000003921 oil Substances 0.000 claims description 4
- 229910052710 silicon Inorganic materials 0.000 claims description 4
- 239000010703 silicon Substances 0.000 claims description 4
- 239000011259 mixed solution Substances 0.000 claims description 3
- 239000002904 solvent Substances 0.000 abstract description 17
- 239000012895 dilution Substances 0.000 abstract description 14
- 238000010790 dilution Methods 0.000 abstract description 14
- 238000012360 testing method Methods 0.000 description 12
- 239000012528 membrane Substances 0.000 description 11
- 238000007689 inspection Methods 0.000 description 10
- 239000000243 solution Substances 0.000 description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 9
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 8
- 238000005070 sampling Methods 0.000 description 8
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 239000011859 microparticle Substances 0.000 description 6
- 238000004140 cleaning Methods 0.000 description 4
- -1 dimethyl siloxane Chemical class 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 239000004215 Carbon black (E152) Substances 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 230000001186 cumulative effect Effects 0.000 description 3
- 238000007872 degassing Methods 0.000 description 3
- 229960003132 halothane Drugs 0.000 description 3
- 229930195733 hydrocarbon Natural products 0.000 description 3
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000007943 implant Substances 0.000 description 2
- VLKZOEOYAKHREP-UHFFFAOYSA-N methyl pentane Natural products CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 210000004127 vitreous body Anatomy 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 208000017442 Retinal disease Diseases 0.000 description 1
- 230000003466 anti-cipated effect Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 210000005252 bulbus oculi Anatomy 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000001508 eye Anatomy 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 239000003978 infusion fluid Substances 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/06—Investigating concentration of particle suspensions
- G01N15/0606—Investigating concentration of particle suspensions by collecting particles on a support
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/06—Investigating concentration of particle suspensions
- G01N15/075—Investigating concentration of particle suspensions by optical means
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- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
The invention provides the application in silicone oil and/or weight silicone oil in particulate matter content detection of a kind of fluorine-containing alkane.Compared with prior art, the present invention for solvent dilution silicone oil and/or weighs silicone oil in order to detect the content of particulate matter with fluorine-containing alkane, fluorine-containing alkane can dissolve each other with silicone oil or weight silicone oil, and therefore the particulate determination for silicone oil and weight silicone oil provides condition easily.
Description
Technical field
The invention belongs to technical field of organic chemistry, particularly relate to purposes and the silicone oil of a kind of fluorine-containing alkane and/or weigh silicon
The method of particulate matter content detection in oil.
Background technology
Silicone oil belongs to dimethyl siloxane series, its stable chemical nature, and optical transparence is good, and surface tension is relatively big and raw
Thing better tolerance, as a kind of important vitreous substitute, is widely used to vitreoretinal diseases and need to fill for a long time
Fill out to maintain the ophthalmic diseases of eyeball profile.
Weight silicone oil is silicone oil and liquid fluorinated alkane is mixed to form with special ratio.Weight silicone oil has the spy of silicone oil
Property, there is again the oxygen combining power that characteristic such as water white transparency, proportion are high, viscosity is low, boiling point is high, the strongest of fluor alkaline simultaneously, and
In vitreous body, do not affect the observation on optical fundus, water insoluble, can and infusion liquid between form an interface, it is simple to observe, therefore weigh
Silicone oil is widely used as vitreous body implant, is applied to complexity retinal diseases.
Particulate matter inspection technique (" Chinese Pharmacopoeia " 2015 version four 0903) is to check intravenous injection (solution
Type injection, injectable sterile powder, concentrated solution for injection) and injection for intravenous sterile bulk drug in particulate matter big
Little and quantity, for the injection that viscosity is higher can be suitable solvent dilution after measure.Wherein, light blockage method is to work as certain volume
Test liquid by a narrow detection zone time, flow to vertical incident illumination with liquid, owing to being stopped by the microgranule in test liquid
And weaken, the signal therefore exported by sensor reduces, and this signal intensity is relevant to the sectional area size of microgranule, further according to logical
Cross the volume of detection zone test liquid, calculate in every 1ml test liquid containing more than 10 μm (>=10 μm) and containing more than 25 μm (>=25 μ
M) particulate matter number.
According to " YY0862-2011 opticianry Ocular tamponades " standard, microgranule in Ocular tamponades reply production process
Potential pollution or the stroke of microgranule, Product transport, storage time anticipated conditions and product use and harm of being correlated with carries out wind
Danger assessment, therefore the technology of implant needs to detect particulate matter item in requiring within the eye.Owing to current laboratory is at detection silicone oil
And conventional solvent difficulty is dissolved each other the most completely during the particulate matter of weight silicone oil, according to " Chinese Pharmacopoeia " version in 2015 four 0903
Particulate matter inspection technique, can detect with method one light blockage method and method two microscopic method, but micro-due to light blockage method
Grain counts more science, the most convenient, therefore preferentially uses light blockage method.But owing to silicone oil and weight silicon oil viscosity are relatively big, need to adopt
Measure again after releasing with solvent dilution, but silicone oil and weight the extremely difficult laboratory that is dissolved in of silicone oil commonly use chemical solvent, as petroleum ether, ethanol,
Isopropanol, dichloromethane, benzene, dimethylbenzene etc., although during the particulate determination of at present silicone oil and weight silicone oil, use benzene or two
Toluene is solvent, but dissolubility is the least, very inconvenient.
Summary of the invention
In view of this, the technical problem to be solved in the present invention is to provide a kind of fluorine-containing alkane at silicone oil and/or weight silicone oil
Application in middle particulate matter content detection.
The invention provides a kind of fluorine-containing alkane answering in particulate matter content detection in silicone oil and/or weight silicone oil
With.
Preferably, shown in described fluorine-containing alkane such as formula (I):
CF3(CF2)m(CH2)nCH3(I)；
Wherein, described m is 1～10, and n is 1～10.
Preferably, the carbon number of described fluorine-containing alkane is 5～20.
Preferably, the carbon number of described fluorine-containing alkane is 6～15.
Preferably, described fluorine-containing alkane is CF3(CF2)3(CH2)4CH3、CF3(CF2)5(CH2)5CH3With CF3(CF2)5(CH2)7CH3In one or more.
Preferably, fluorine-containing alkane and silicone oil and/or the weight mixed motion of silicone oil in described particulate matter content detection
Viscosity is 0.5～500mm2/s。
Preferably, fluorine-containing alkane and silicone oil and/or the weight mixed motion of silicone oil in described particulate matter content detection
Viscosity is 1～350mm2/s。
Preferably, the method for described particulate matter content detection is light blockage method.
Present invention also offers a kind of method of particulate matter content detection in silicone oil and/or weight silicone oil, including:
By fluorine-containing alkane filtering with microporous membrane, then with silicone oil and/or weight silicone oil mix, in mixed solution not
The content of dissolubility microgranule detects.
Preferably, 10ml every after fluorine-containing alkane filtering with microporous membrane will contain the particulate matter of more than 10 μm at 10
Hereinafter, containing particulate matters more than 25 μm below 5.
The invention provides a kind of fluorine-containing alkane answering in particulate matter content detection in silicone oil and/or weight silicone oil
With.Compared with prior art, the present invention for solvent dilution silicone oil and/or weighs silicone oil in order to detect particulate matter with fluorine-containing alkane
Content, fluorine-containing alkane can with silicone oil or weight silicone oil dissolve each other, therefore for silicone oil and weight silicone oil particulate determination provide
Condition easily.
From experiment, fluorine-containing alkane can dissolve each other completely with silicone oil or weight silicone oil.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described,
Obviously, described embodiment is only a part of embodiment of the present invention rather than whole embodiments.Based in the present invention
Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under not making creative work premise, all
Belong to the scope of protection of the invention.
The invention provides the application in silicone oil/or weight silicone oil in particulate matter content detection of a kind of fluorine-containing alkane.
Wherein, the fluorine-containing alkane that described fluorine-containing alkane is well known to those skilled in the art, there is no special restriction, this
In invention preferably as shown in formula (I):
CF3(CF2)m(CH2)nCH3(I)；
Wherein, described m is 1～10, preferably 1～8, more preferably 2～8, is further preferably 3～5；There is provided in the present invention
In some embodiments, described m is preferably 3；In other embodiments that the present invention provides, described m is preferably 5；Described n is 1
～10, preferably 2～9, more preferably 3～8, be further preferably 4～7；In some embodiments that the present invention provides, described n is excellent
Elect 4 as；In some embodiments that the present invention provides, described n is preferably 5；In other embodiments that the present invention provides, institute
State n and be preferably 7.
According to the present invention, described fluorine-containing alkane is more specifically preferably CF3(CF2)3(CH2)4CH3、CF3(CF2)5(CH2)5CH3
With CF3(CF2)5(CH2)7CH3In one or more.
In particulate matter content detection, fluorine-containing alkane need to be mixed with silicone oil and/or weight silicone oil, then examine
Surveying, mixed kinematic viscosity is preferably 0.5～500mm2/ s, more preferably 1～350mm2/s。
The detection method that the method for described particulate matter content detection is well known to those skilled in the art, there is no spy
Different restriction, preferably utilizes light blockage method to detect in the present invention.
The present invention with fluorine-containing alkane for solvent dilution silicone oil and/or weight silicone oil in order to detect the content of particulate matter, contain
Halothane hydrocarbon can dissolve each other with silicone oil or weight silicone oil, and therefore the particulate determination for silicone oil and weight silicone oil provides bar easily
Part.
Present invention also offers a kind of method of particulate matter content detection in silicone oil and/or weight silicone oil, including: will contain
Halothane hydrocarbon filtering with microporous membrane, then mixes with silicone oil and/or weight silicone oil, contains particulate matter in mixed solution
Amount detects.
Wherein, described fluorine-containing alkane is same as above, does not repeats them here.Described microporous filter membrane is that those skilled in the art are ripe
The microporous filter membrane known, there is no special restriction, is preferably the microporous filter membrane that aperture is 0.2～1 μm, more preferably in the present invention
For the microporous filter membrane that aperture is 0.3～0.6 μm, be further preferably the microporous filter membrane of 0.4～0.6 μm, most preferably aperture 0.4～
The microporous filter membrane of 0.65 μm.
By fluorine-containing alkane filtering with microporous membrane, after preferably filtering, the particulate matter in fluorine-containing alkane is detected,
More preferably utilize light blockage method that the particulate matter content in the fluorine-containing alkane after filtering is detected；After filtration, fluorine-containing alkane is excellent
Select in every 10ml containing particulate matters more than 10 μm below 10, containing particulate matters more than 25 μm below 5.
Then with the fluorine-containing alkane dilution silicone oil after filtration and/or weight silicone oil；The consumption of described fluorine-containing alkane preferably makes to contain
The kinematic viscosity of the solution of halothane hydrocarbon dilution silicone oil and/or weight silicone oil is 0.5～500mm2/ s, more preferably 1～350mm2/s。
Finally the content of the particulate matter in the solution obtained after dilution is detected, carry out preferably by light blockage method
Detection.This detection is carried out under ambient temperature and moisture atmospheric pressure environment.In the present invention, detection is more preferably followed the steps below: will
Solution after dilution is placed in sampling cup, stands degassing, is subsequently placed on sampler, opens stirring, makes solution mixing (avoid gas
Bubble produces), measure at least 4 times according to the light blockage method in pharmacopeia, every sub-sampling is no less than 5ml, and data are disregarded for the first time, take follow-up
The meansigma methods of measurement result, according to the sign loading amount volume of sample volume Yu each container, calculates in each container insoluble micro-
The content of grain.
In order to further illustrate the present invention, the purposes of a kind of fluorine-containing alkane present invention provided below in conjunction with embodiment and
In silicone oil and/or weight silicone oil, the method for particulate matter content detection is described in detail.
Reagent used in following example is commercially available.
Embodiment 1
Take 50ml perfluoro butyl pentane CF3(CF2)3(CH2)4CH3(for the solvent of microparticles), through microporous filter membrane (hole
Footpath is 0.45 μm) filter, it is placed in the appropriate vessel of cleaning, rotates and make microgranule that may be present uniform, stand and treat bubble collapse.
By the inspection technique inspection under light blockage method item, containing more than 10 μm 3 in every 10ml, (require in every 10ml containing 10 containing more than 25 μm 1
The more than μm particulate matter of (>=10 μm) should be below 10, should be at 5 containing the more than 25 μm particulate matter of (>=25 μm)
Below).
Ophthalmic silicone oil 10ml (dynamic viscosity 2000mPas) of flying dragon company of Germany, removes outer package, afterwards according to medicine
In allusion quotation, regulation carries out light blockage method detection.On laminar flow station, the careful content merging at least 4 test samples (makes cumulative volume not
Less than 25ml), it is placed in sampling cup, the solvent dilution for microparticles required by above-mentioned ready coincidence detection,
Observing dissolving situation during this, perfluor base octane is quick and complete with ophthalmic silicone oil to dissolve each other, not stratified.Stand 2min or suitable
Deaerate when the time, be placed on sampler, open stirring, make solution mix (avoiding bubble to produce), measure at least 4 times, often in accordance with the law
Sub-sampling should be no less than 5ml.Data are disregarded for the first time, take the meansigma methods of subsequent measurements result, according to sample volume and each appearance
The sign loading amount volume of device, calculates the particle number contained by each container.Testing result: containing more than 10 μm 5, containing more than 25 μm 1
Grain.
Embodiment 2
Take 50ml perfluor base hexane CF3(CF2)5(CH2)5CH3(for the solvent of microparticles), through microporous filter membrane (hole
Footpath is 0.45 μm) filter, it is placed in the appropriate vessel of cleaning, rotates and make microgranule that may be present uniform, stand and treat bubble collapse.
By the inspection technique inspection under light blockage method item, containing more than 10 μm 4 in every 10ml, containing more than 25 μm 1.
Ophthalmic silicone oil 10ml (dynamic viscosity 1000mPas) of U.S.'s Baushe & Lomb, removes outer package,
Light blockage method detection is carried out afterwards according to regulation in pharmacopeia.At least 4 test samples of careful merging on laminar flow station
Content (making cumulative volume be no less than 25ml), be placed in sampling cup, with above-mentioned ready coincidence detection require for micro-
The solvent dilution that grain checks, observes dissolving situation in the process, and perfluor base octane is quick and complete with ophthalmic silicone oil to dissolve each other,
Not stratified.Stand 2min or appropriate time degassing, be placed on sampler, open stirring, make solution mix (avoiding bubble to produce),
Measuring at least 4 times, every sub-sampling should be no less than 5ml in accordance with the law.Data are disregarded for the first time, take the meansigma methods of subsequent measurements result, root
According to the sign loading amount volume of sample volume Yu each container, calculate the particle number contained by each container.Testing result: containing 10 μm with
Upper 2, containing more than 25 μm 0.
Embodiment 3
Take 100ml perfluor base octane CF3(CF2)5(CH2)7CH3(for the solvent of microparticles), through microporous filter membrane (hole
Footpath is 0.45 μm) filter, it is placed in the appropriate vessel of cleaning, rotates and make microgranule that may be present uniform, stand and treat bubble collapse.
By the inspection technique inspection under light blockage method item, containing more than 10 μm 2 in every 10ml, containing more than 25 μm 0.
Ophthalmic silicone oil 10ml (dynamic viscosity 5000mPas) of Zeiss, Germany company, removes outer package,
Light blockage method detection is carried out afterwards according to regulation in pharmacopeia.At least 4 test samples of careful merging on laminar flow station
Content (making cumulative volume be no less than 25ml), be placed in sampling cup, with above-mentioned ready coincidence detection require for micro-
The solvent dilution that grain checks, observes dissolving situation in the process, and perfluor base octane is quick and complete with ophthalmic silicone oil to dissolve each other,
Not stratified.Stand 2min or appropriate time degassing, be placed on sampler, open stirring, make solution mix (avoiding bubble to produce),
Measuring at least 4 times, every sub-sampling should be no less than 5ml in accordance with the law.Data are disregarded for the first time, take the meansigma methods of subsequent measurements result, root
According to the sign loading amount volume of sample volume Yu each container, calculate the particle number contained by each container.Testing result: containing 10 μm with
Upper 7, containing more than 25 μm 1.
Comparative example 1
Take 50ml ethanol (for the solvent of microparticles), filter through microporous filter membrane (aperture is 0.45 μm), be placed in cleaning
Appropriate vessel in, rotate and make microgranule that may be present uniform, stand and treat bubble collapse.Examine by the inspection technique under light blockage method item
Look into, it is desirable in every 10ml, the particulate matter containing more than 10 μm (>=10 μm) should be below 10, containing more than 25 μm (>=25 μm)
Particulate matter should be below 5.
Baushe & Lomb ophthalmic silicone oil (test sample), remove outer package, and on laminar flow station, careful merging at least 4 is for examination
The content of product, and the ethanol dilution required by above-mentioned coincidence detection, rinse well container outer wall, put in appropriate experimental environment
Standby.Dissolving situation is observed in perusal hereinto, at once observes, ethanol and the extremely difficult solvent of ophthalmic silicone oil, has distinguishable
Two-phase interface, after a period of time (2h), perusal is without significant change.
Comparative example 2
Take 50ml dimethylbenzene (for the solvent of microparticles), filter through microporous filter membrane (aperture is 0.45 μm), be placed in clean
In clean appropriate vessel, rotate and make microgranule that may be present uniform, stand and treat bubble collapse.Examine by the inspection technique under light blockage method item
Look into, it is desirable in every 10ml, the particulate matter containing more than 10 μm (>=10 μm) should be below 10, containing more than 25 μm (>=25 μm)
Particulate matter should be below 5.
Baushe & Lomb ophthalmic silicone oil (test sample), remove outer package, and on laminar flow station, careful merging at least 4 is for examination
The content of product, and with the dimethylbenzene dilution that above-mentioned coincidence detection requires, container outer wall is rinsed well, puts appropriate experimental environment
In standby.Situation is dissolved in perusal in the process, at once observes, dimethylbenzene and ophthalmic silicone oil relatively indissoluble solution, has and can divide
The two-phase interface (having certain dissolubility, two-phase interface is curved surface) distinguished, after a period of time (2h), perusal is without substantially becoming
Change.
Claims (10)
1. fluorine-containing alkane application in particulate matter content detection in silicone oil and/or weight silicone oil.
Application the most according to claim 1, it is characterised in that shown in described fluorine-containing alkane such as formula (I):
CF3(CF2)m(CH2)nCH3(I)；
Wherein, described m is 1～10, and n is 1～10.
Application the most according to claim 1, it is characterised in that the carbon number of described fluorine-containing alkane is 5～20.
Application the most according to claim 1, it is characterised in that the carbon number of described fluorine-containing alkane is 6～15.
Application the most according to claim 1, it is characterised in that described fluorine-containing alkane is CF3(CF2)3(CH2)4CH3、CF3
(CF2)5(CH2)5CH3With CF3(CF2)5(CH2)7CH3In one or more.
Application the most according to claim 1, it is characterised in that fluorine-containing alkane and silicon in described particulate matter content detection
Oil and/or the mixed kinematic viscosity of weight silicone oil are 0.5～500mm2/s。
Application the most according to claim 1, it is characterised in that fluorine-containing alkane and silicon in described particulate matter content detection
Oil and/or the mixed kinematic viscosity of weight silicone oil are 1～350mm2/s。
Application the most according to claim 1, it is characterised in that the method for described particulate matter content detection is photoresistance
Method.
9. the method for particulate matter content detection in a silicone oil and/or weight silicone oil, it is characterised in that including:
By fluorine-containing alkane filtering with microporous membrane, then mix, to insoluble in mixed solution with silicone oil and/or weight silicone oil
The content of microgranule detects.
Method the most according to claim 9, it is characterised in that by 10ml every after fluorine-containing alkane filtering with microporous membrane
Containing particulate matters more than 10 μm below 10, containing particulate matters more than 25 μm below 5.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107677615A (en) * | 2017-09-19 | 2018-02-09 | 上海杰视医疗科技有限公司 | The detection method of particulate matter content in a kind of fluorine-containing alkane |
| CN108507941A (en) * | 2018-03-27 | 2018-09-07 | 苏州桓晨医疗科技有限公司 | A kind of detection method of polymeric coating layer fastness |
| CN108645857A (en) * | 2018-05-31 | 2018-10-12 | 宜昌兴越新材料有限公司 | High boiling point silicon oil sample detection method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108507941A (en) * | 2018-03-27 | 2018-09-07 | 苏州桓晨医疗科技有限公司 | A kind of detection method of polymeric coating layer fastness |
| CN108645857A (en) * | 2018-05-31 | 2018-10-12 | 宜昌兴越新材料有限公司 | High boiling point silicon oil sample detection method |
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