CN106214126A - A kind of bilirubinic detection device and detection method - Google Patents
A kind of bilirubinic detection device and detection method Download PDFInfo
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Abstract
The present invention relates to a kind of bilirubinic detection device and detection method, this device includes that housing, enclosure interior are provided with bilirubin sensor, MCU, and bilirubin sensor is connected with MCU；Bilirubin sensor includes blue light harvester and green light harvester；Blue light harvester includes blue-light source that wavelength is 460nm and for gathering the photodiode of blue light, and wavelength is the blue-light source of 460nm and is encapsulation all-in-one-piece for gathering the photodiode of blue light；Green glow harvester includes green light source that wavelength is 550nm and for gathering the photodiode of green glow, and wavelength is the green light source of 550nm and is encapsulation all-in-one-piece for gathering the photodiode of green glow；Blue light harvester and green glow harvester position are parallel or point-blank.The bilirubinic detection device that the present invention provides, uses bilirubin sensor as the core component of bilirubinic detection device, it is not necessary to rely on the Optical devices of specialty, low cost and easy for installation.
Description
Technical field
The present invention relates to bilirubin detection technique field, a kind of bilirubinic detection device and detection method.
Background technology
Jaundice is serum mesobilirubin too high levels, causes the common clinical table of the tissue jaundice such as skin, sclera, mucosa
Existing, detection jaundice is to be judged by the concentration of detection serum mesobilirubin at present.Subcutaneous group of neonatal jaundice patient
Knit the reflected value to the incident illumination that wavelength is 460nm, consistently reduce along with the increase of serum total bilirubin concentration, thus
The hypodermic reflected value at 460nm can be efficiently used and carry out percutaneous mensuration Neonatal total bilirubin concentration.Due to blood
Lactoferrin also has strong absorption value at 460nm, therefore in subcutaneous tissue, hypodermic reflectance spectrum is also had aobvious by hemoglobin
Person affects, and can disturb bilirubinic percutaneous measurement.Because hemoglobin absorption value at 550nm and the absorption at 460nm
It is worth identical, therefore in measuring instrument, eliminates the interference of hemoglobin by the method for the absorption value deducted at 550nm, thus realize
Determination of bilirubin.
According to principles above, as long as measuring the luminous reflectance value of 460nm and 550nm, bilirubinic value can be calculated.
And measure the reflected value of light, mainly realized by optical module.One bilirubinic detection device in the market
Optical detecting module cardinal principle, be illustrated in fig. 1 shown below, the light source of employing is blue-ray LED 11 and green light LED 12, and fibre bundle is
Two-way, the other end at fibre bundle utilizes the two of 500nm to carry out light splitting to a point mirror 13, and the light after light splitting is respectively radiated to blue light
On photodiode 14 and green glow photodiode 15, thus collect the data of needs, it is possible to calculate bilirubinic value.
The optical detecting module cost of this structure is the highest, need rely on specialty Optical devices such as two to divide a mirror, this
A little assembling parts degree of difficulty are the highest.
Summary of the invention
Therefore, the invention provides a kind of bilirubinic detection device, to solve the problems referred to above.
The technical scheme is that a kind of bilirubinic detection device, including housing, described enclosure interior is provided with gallbladder
Red pigment sensor, MCU, described bilirubin sensor is connected with described MCU；Described bilirubin sensor includes blue light harvester
With green light harvester；Described blue light harvester includes blue-light source that wavelength is 460nm and for gathering the photoelectricity two of blue light
Pole is managed, and described wavelength is the blue-light source of 460nm and is encapsulation all-in-one-piece for gathering the photodiode of blue light；Described green
Light collector includes green light source that wavelength is 550nm and for gathering the photodiode of green glow, and described wavelength is 550nm's
Green light source and the photodiode being used for gathering green glow are encapsulation all-in-one-piece；Described blue light harvester and described green glow collection
Device position is parallel or point-blank.Above-mentioned MCU refers to the CPU of computer, RAM, ROM, timer conter and many
Planting I/O Interface integration on one chip, the computer of the chip-scale of formation, is that here is omitted for existing matured product.
Optionally, described photodiode for gathering blue light and for gather the photodiode of green glow be with
The photodiode of nano coating.
Optionally, being provided with bluetooth module in described housing, described bluetooth module is connected with described MCU.
Optionally, power supply, described power supply and described bilirubin sensor, described MCU and institute it are also equipped with in described housing
State bluetooth module to connect.
Optionally, described bilirubinic detection device includes light hole, and described light hole is cased with rubber blanket, described rubber
20-30 times of the area that area is light hole of pad；The one side of the light hole dorsad of described rubber blanket has reflector layer.
Optionally, described bilirubinic detection device includes light hole, and described light hole is provided with plug；Described plug
Including cap, piston part and operating portion, described cap, piston part and operating portion are integrated, and have interval between described cap and piston part,
Projection, described projection is had to be positioned at described interval on described piston part；Described cap and the coupling part of described piston part, described projection
And described operating portion is free chamber respectively；Have in described light hole and the concave surface of described male cooperation.
Present invention also offers a kind of bilirubinic detection method, including, choosing wavelength is the blue-light source of 460nm, ripple
The green light source of a length of 550nm, for gathering the photodiode of blue light and for gathering the photodiode of green glow；Make light
Electricity harvester: by blue-light source that wavelength is 460nm be used for gathering the photodiode of blue light and utilize semiconductor packaging
Molding, forms blue light harvester；By green light source that wavelength is 550nm be used for gathering the photodiode of green glow and utilize half
Conductor encapsulation technology molding, forms green light harvester；By described see blue light harvester parallel with green light harvester or
Point-blank place, connect formation bilirubin sensor；Bilirubin sensor is connected MCU, is placed in light hole
In shell, form bilirubin detecting instrument；Light hole is placed on skin, starts described bilirubin detecting instrument.
Preferably, choose wavelength be the blue-light source of 460nm, wavelength be the green light source of 550nm, for gathering blue light
Photodiode and the photodiode for gathering green glow include, choose blue led light source that wavelength is 460nm, wavelength is
The green LED light source of 550nm, for gather blue light the photodiode with nano coating and for gather green glow with
The photodiode of nano coating.
Preferably, bilirubin sensor is connected MCU, is placed in the shell with light hole, form bilirubin detector
Device also includes, MCU is connected bluetooth module；Described light hole is placed on skin, after starting described bilirubin detecting instrument
Also include, described bluetooth module is connected with mobile phone.
Preferably, bilirubin sensor is connected MCU, is placed in the shell with light hole, form bilirubin detector
After device, described light hole is placed on skin, also includes before starting described bilirubin detecting instrument, choose area for logical light
The rubber blanket of 20-30 times of the area in hole；The one side of described rubber blanket is coated reflector layer；By relative for the one side with reflector layer
Light hole is placed on described light hole.
Preferably, described bilirubin sensor includes isolation current bar, is provided with and sets successively in described isolation current bar
Being equipped with blue light harvester and green light harvester, described bilirubin sensor layer is provided with signal transmission module, isolates electric current
Being provided with insulating course between blue light harvester and green light harvester in bar, described insulating course is provided with partition panel；Described every
OSP layer also it is coated with from the surface of current bar；The bottom of described isolation current bar is additionally provided with base, described base be provided with for
Isolation current bar is hingedly connected on the light hole of described bilirubinic detection device；Described signal transmission module includes circle
Multilayer board, with six elongated strip antennas of its midpoint circumferential array in each multilayer board, described each elongated band
Strip antenna includes the framework of rectangle, each edge of described framework all towards be provided centrally with arc the first arc sub antenna and
Second arc sub antenna；The radius of described second arc sub antenna is more than the first arc sub antenna；Each elongated strip antenna is also
Include from each edge towards centrally disposed go out circular sub antenna, the radius of described circular sub antenna is more than the second arc sky
Line, the width of described circular sub antenna is gradually reduced to center from two ends；Described circular sub antenna is made up of carbofrax material；Institute
The end stating framework is provided with partition band, and described the partition carries the material for non-conducting electric current, and the end of framework is disconnected by it；Justify two-by-two
Being equipped with the 3rd sub antenna between shape sub antenna, one end of described 3rd sub antenna is provided with the annular sub antenna of annular,
Described annular sub antenna is located at the top of framework；The other end of described 3rd sub antenna is provided with the 4th arc sub antenna of arc,
The radius of three the 4th arc sub antennas in described each framework is identical；The center of described framework is provided with a data transmission terminal
Mouthful, described data transmission port electrically connects with three the 4th arc sub antennas respectively；The bottom surface of described multilayer board also is provided with
First connector corresponding with data transmission port；Described 3rd sub antenna is provided with multiple the second connector being placed equidistant；
The outer end of described multilayer board is provided with a circle transmission line, and described transmission line electrically connects with each sub antenna；Multilayer board top
Being provided with a gripper shoe in face, multilayered printed back is provided with axostylus axostyle, and described axostylus axostyle electrically connects with gripper shoe, described axostylus axostyle
Lower end is provided with outside antenna, and described outside antenna includes three outer sub antennas triangular in shape；Described partition panel is a copper billet, described
The connector corresponding with six elongated strip antennas is had with its midpoint circumferential array on partition panel；Described connector is big with framework
Little identical；The quantity of described second connector is N, a length of Lmm of described 3rd sub antenna, the radius of described annular sub antenna
For Kmm, then K=L/N.
Preferably, described photodiode for gathering blue light and all including for gathering the photodiode of green glow:
Time quantum, is connected for setting up with at least one MCU, and carries out acquisition time record；Photochromic detector unit, is used for gathering light
During source data, gather the first light source data, and receive the secondary light source data of collection；Integral unit, for by described
First light source data and secondary light source data carry out the integration of many sessions, obtain multiple light courcess data, and wherein, described integral unit is concrete
Including: do poor unit, for the first light source data started acquisition time and the beginning acquisition time of secondary light source data, ripple
The long absolute value doing the poor difference obtaining the absolute value of difference of time, wavelength；Capture unit, is used for the exhausted of the difference according to the described time
Value is caught the wavelength information of light source data corresponding in described first light source data and secondary light source data；Processing unit, uses
In light source data corresponding in described first light source data and secondary light source data is carried out the process of many sessions, obtain described how light
Source data；Described processing unit includes: process subelement, for by corresponding in described first light source data and secondary light source data
Light source data process according to the arrayed feature of many sessions, obtain the pulse code modulation data of many sessions；Coding is single
Unit, for encoding described pulse code modulation data according to predetermined file format, obtains described multiple light courcess data；Its
In, processing unit contrasts according to the wavelength information of the first light source data and secondary light source data, if the difference of wavelength is absolute
Value more than 10nm, then controls photochromic detector unit and again detects the first light source data and secondary light source data.
The bilirubinic detection device that the present invention provides, uses bilirubin sensor as the core of bilirubinic detection device
Heart parts, it is not necessary to rely on the Optical devices of specialty, low cost and easy for installation.
Using the bilirubinic detection method detection bilirubin that the present invention provides, low cost, accuracy is high.
Accompanying drawing explanation
Fig. 1 is the structural representation of existing a kind of bilirubinic detection device；
Fig. 2 is the structural representation of a kind of bilirubinic detection device that the present invention provides；
Fig. 3 is the concrete structure schematic diagram of a kind of bilirubinic detection device that the present invention provides；
Fig. 4 is a kind of bilirubinic structure of the detecting device schematic diagram with rubber blanket that the present invention provides；
Fig. 5 is the part section structural representation of the plug of a kind of bilirubinic detection device that the present invention provides；
Fig. 6 is the cross-sectional view of the light hole of a kind of bilirubinic detection device that the present invention provides；
Wherein, 11, blue-ray LED；12, green light LED；13, two to a point mirror；14, blue photodiode；15, green glow photoelectricity
Diode；16, housing；17, bilirubin sensor；18、MCU；19, blue light harvester；20, green light harvester；21, wavelength
Blue-light source for 460nm；22, for gathering the photodiode of blue light；23, wavelength is the green light source of 550nm；24, use
In the photodiode gathering green glow；25, bluetooth module；26, power supply；27, light hole；28, rubber blanket；29, reflector layer；30、
Cap；31, piston part；32, operating portion；33, protruding；34, cavity；35, concave surface.
Detailed description of the invention
Below in conjunction with the accompanying drawings technical scheme is described in detail.
The invention provides a kind of bilirubinic detection device, see Fig. 2, including housing 16, described enclosure interior is installed
Bilirubin sensor 17, MCU18, described bilirubin sensor is had to be connected with described MCU；Described bilirubin sensor includes blueness
Light collector 19 and green light harvester 20；Described blue light harvester includes blue-light source 21 that wavelength is 460nm and for adopting
The photodiode 22 of collection blue light, described wavelength is the blue-light source 23 of 460nm and for gathering photoelectricity two pole of described blue light
Pipe 24 is encapsulation all-in-one-piece；Described green glow harvester includes green light source that wavelength is 550nm and for gathering the light of green glow
Electric diode, described wavelength is the green light source of 550nm and for gathering the photodiode of described green glow for being packaged into one
's；Described blue light harvester and described green glow harvester position are parallel or point-blank, concrete can be by indigo plant
Light collector and described green glow harvester are arranged on one piece of circuit board formation bilirubin sensor.Above-mentioned for gathering blue light
Photodiode and for gathering the photodiode of green glow preferably with the photodiode of nano coating, selection can mistake
Leach the photodiode with nano coating of the light of 550nm or 460nm, the interference of veiling glare in light source can be reduced, increase
Adding the accuracy of bilirubinic detection device, veiling glare described herein refers to light source owing to there being error to contain during fabrication
Light in addition to 550nm or 460nm, above-mentioned light source can select LED.Bluetooth module 25 it is also equipped with in housing,
See Fig. 3, bluetooth module is connected with described MCU, the data in MCU can be transmitted in the form of a signal by bluetooth module
To mobile phone, more convenient people check and analyze, and bilirubinic detection device can also be without, with display screen, reducing bilirubinic
The volume of detection device；Of course for being easy to observe, it is also possible to arrange upper display screen according to design requirement.Power for convenience,
Power supply 26, described power supply and described bilirubin sensor, described MCU and described bluetooth module preferably it is also equipped with in described housing
Connect, further, it is also possible to arrange on and off switch, operation switch etc., convenient use.
The bilirubinic detection device that the present invention provides, uses bilirubin sensor as the core of bilirubinic detection device
Heart parts, it is not necessary to relying on the Optical devices of specialty, low cost and easy for installation, accuracy is high.
Bilirubinic detection device to avoid ambient light to disturb to ensure its accuracy, outside preventing in use as far as possible
Boundary's light interference, applicant has also done following design: as shown in Figure 4, and bilirubinic detection device includes light hole 27, described logical light
Being cased with rubber blanket 28 on hole, the area of described rubber blanket is 20-30 times of the area of light hole；Described rubber blanket lead to light dorsad
The one side in hole has reflector layer 29, due to the characteristic of rubber blanket, and itself and contact human skin's relative tight, easy shading, and connect
The most relatively comfortable, after the one side of rubber blanket light hole dorsad coats reflector layer, the luminous reflectance of light hole circumfusion can be fallen,
Thus prevent having ambient light to disturb during detection, affect the accuracy of bilirubinic detection device detection, through test of many times research, rubber
Using effect can be met when the area of rubber cushion is 20-30 times of the area of light hole.
Bilirubinic detection device is owing to there being the light hole for detection, and therefore dust and air enter easily by light hole
Entering inside bilirubinic detection device, dust of long duration is easily piled up, and especially in the environment of there was dampness in the air, is attached to gallbladder
On the inwall of the detection device case of red pigment or sensor components and parts, affect the accuracy of bilirubinic detection device detection, for
This, applicant has done following design: described bilirubinic detection device includes light hole 27, described light hole is provided with stifled
Head, sees Fig. 5, and described plug includes that cap 30, piston part 31 and operating portion 32, described cap 30, piston part 31 and operating portion 32 are
One, there is interval between described cap and piston part, described piston part has protruding 33, described projection is positioned at described interval；Institute
State cap and be free chamber 34 respectively with the coupling part of described piston part, described piston part protruding, described and described operating portion；Described logical light
There is the concave surface 35 with described male cooperation in hole, see Fig. 6, cooperation described herein refers to make convex with convex shape cooperation
Rise and be stuck in concave surface.By use plug dust can be blocked in outside light-transmitting opening, and the dampness in air be also not easy into
Entering light hole, thus effectively protect the use accuracy of bilirubinic detection device, concrete, the cap of plug can block
Living light hole, piston part is further ensured that sealing, operating portion make plug for convenience take off and install in inserting light hole；Piston part
On projection and concave surface in light hole coordinate, be possible to prevent only a few dampness directly to enter with piston part contact surface along light hole
Enter, thus be further ensured that the sealing of plug；Can prevent from taking additionally, the projection on piston part and the concave surface in light hole coordinate
Vibrate the plug that causes during band to loosen and even come off, its sealing of image；Owing to the mobile performance of air is preferable, therefore cover
Cavity and the cavity of piston part between portion and piston part are conducive to piston part to deform when inserting light-transmitting opening, thus are easier to insert；Convex
The cavity risen is conducive to stress bulging deformation, conveniently coordinates with concave surface；The cavity of operating portion is conducive to operating portion to deform, and preferably sets
It is placed in middle part, is convenient for people to pressing and by holding；It addition, described cap and the coupling part of described piston part, described projection, institute
The cavity stating piston part also helps damping in carrying process.
Preferably, described bilirubin sensor includes isolation current bar, is provided with and sets successively in described isolation current bar
Being equipped with blue light harvester and green light harvester, described bilirubin sensor layer is provided with signal transmission module, isolates electric current
Being provided with insulating course between blue light harvester and green light harvester in bar, described insulating course is provided with partition panel；Described every
OSP layer also it is coated with from the surface of current bar；The bottom of described isolation current bar is additionally provided with base, described base be provided with for
Isolation current bar is hingedly connected on the light hole of described bilirubinic detection device；
Described signal transmission module includes the multilayer board of circle, with its midpoint circumferential array in each multilayer board
Six elongated strip antennas, described each elongated strip antenna includes the framework of rectangle, each edge of described framework all towards
It is provided centrally with the first arc sub antenna and the second arc sub antenna of arc；The radius of described second arc sub antenna is more than the
One arc sub antenna；
Each elongated strip antenna also include from each edge towards centrally disposed go out circular sub antenna, described circular son
The radius of antenna is more than the second arc sub antenna, and the width of described circular sub antenna is gradually reduced to center from two ends；Described circle
Shape sub antenna is made up of carbofrax material；The end of described framework is provided with partition band, and described the partition carries the material for non-conducting electric current
Material, the end of framework is disconnected by it；It is equipped with the 3rd sub antenna two-by-two between circular sub antenna, described 3rd sub antenna
One end is provided with the annular sub antenna of annular, and described annular sub antenna is located at the top of framework；Another of described 3rd sub antenna
End is provided with the 4th arc sub antenna of arc, and the radius of three the 4th arc sub antennas in described each framework is identical；Described
The center of framework is provided with a data transmission port, and described data transmission port is electrically connected with three the 4th arc sub antennas respectively
Connect；The bottom surface of described multilayer board also is provided with first connector corresponding with data transmission port；On described 3rd sub antenna
It is provided with multiple the second connector being placed equidistant；The outer end of described multilayer board is provided with a circle transmission line, described transmission line with
Each sub antenna electrically connects；Being provided with a gripper shoe in multilayered printed plate top surface, multilayered printed back is provided with axostylus axostyle, described
Axostylus axostyle electrically connects with gripper shoe, and the lower end of described axostylus axostyle is provided with outside antenna, described outside antenna include three triangular in shape outside
Sub antenna；
Described partition panel is a copper billet, and described partition panel has and six elongated strip antennas pair with its midpoint circumferential array
The connector answered；Described connector is identical with the size of framework；The quantity of described second connector is N, described 3rd sub antenna
A length of Lmm, described annular sub antenna radius be Kmm, then K=L/N.
The present invention can avoid isolating between blue light harvester and the green light harvester in current bar by said structure
The interfering of light collection, thus improve the accuracy of detection.
Preferably, described photodiode for gathering blue light and all including for gathering the photodiode of green glow:
Time quantum, is connected for setting up with at least one MCU, and carries out acquisition time record；
Photochromic detector unit, during being used for gathering light source data, gathers the first light source data, and receives the of collection
Two light source data；
Integral unit, for described first light source data and secondary light source data are carried out the integration of many sessions, obtains how light
Source data, wherein, described integral unit specifically includes:
Do poor unit, for the first light source data started acquisition time and when starting to gather of secondary light source data
Between, wavelength does difference and obtains the absolute value of difference of the absolute value of difference of time, wavelength；
Capture unit, the absolute value for the difference according to the described time catches described first light source data and secondary light source number
Wavelength information according to the light source data of middle correspondence；
Processing unit, for carrying out how light by light source data corresponding in described first light source data and secondary light source data
Road processes, and obtains described multiple light courcess data；
Described processing unit includes: process subelement, for by right in described first light source data and secondary light source data
The light source data answered processes according to the arrayed feature of many sessions, obtains the pulse code modulation data of many sessions；
Coded sub-units, for encoding described pulse code modulation data according to predetermined file format, obtains
Described multiple light courcess data；
Wherein, processing unit contrasts according to the wavelength information of the first light source data and secondary light source data, if wavelength
The absolute value of difference more than 10nm, then control photochromic detector unit and again detect the first light source data and secondary light source data.
The present invention can carry out detecting and identifying wavelength for the light source of multi-frequency, photoenvironment complexity by said apparatus,
Thus identify the blue light in light source and green light so that it is determined that bilirubin, and by the first light source data and secondary light source data
It is integrated into multiple light courcess data, thus two light source information are exported with uniting two into one, save transinformation, for
Data transmission is optimized.
Present invention also offers a kind of bilirubinic detection method, including, choosing wavelength is the blue-light source of 460nm, ripple
The green light source of a length of 550nm, for gathering the photodiode of blue light and for gathering the photodiode of green glow, above-mentioned unit
Device is existing components and parts on market, and people can select to buy as required；Make photoelectric gathering apparatus: by wavelength be
The blue-light source of 460nm and utilize semiconductor packaging molding for gathering the photodiode of blue light, forms blue gloss
Storage；By green light source that wavelength is 550nm be used for gathering the photodiode of green glow and utilize semiconductor packaging molding,
Form green light harvester；Encapsulation technology is so that mature technology, and here is omitted, sees blue light harvester and green by described
Light collector is parallel or point-blank places, connect formation bilirubin sensor；By described see blue light harvester and
Green light harvester is parallel or point-blank places, and can make the ratio of the light of blue light harvester and the collection of green glow harvester
Example is almost consistent, makes measurement more accurate；Bilirubin sensor is connected MCU, is placed in the shell with light hole, form gallbladder red
Element detecting instrument；Light hole is placed on skin, starts described bilirubin detecting instrument, the number that bilirubin detecting instrument will gather
According to storing by process or reach on computer or mobile phone so that people checking.
In order to improve the accuracy of bilirubinic detection further, choosing wavelength is that the blue-light source of 460nm, wavelength are
The green light source of 550nm, for gathering the photodiode of blue light and including for gathering the photodiode of green glow, choose ripple
The blue led light source of a length of 460nm, wavelength be 550nm green LED light source, for gather blue light with nano coating
Photodiode and for gathering the photodiode with nano coating of green glow, LED light source luminous efficiency is high, beneficially photoelectricity
Diode receives, and selects to filter out the photodiode with nano coating of the light of 550nm or 460nm, can reduce
The interference of the veiling glare in light source, increases the accuracy of bilirubinic detection method.
Use for convenience, bilirubin sensor is connected MCU, is placed in the shell with light hole, form bilirubin
Detecting instrument also includes, MCU is connected bluetooth module；Described light hole is placed on skin, starts described bilirubin detector
Also including after device, being connected with mobile phone by described bluetooth module, the data of detection are reached mobile phone by bronze drum bluetooth module, can facilitate
Observation, can also download bilirubin data analysis APP in addition on mobile phone in advance, in time to jaundice prediction, send suggestion.
Preferably, bilirubin sensor is connected MCU, is placed in the shell with light hole, form bilirubin detector
After device, described light hole is placed on skin, also includes before starting described bilirubin detecting instrument, choose area for logical light
The rubber blanket of 20-30 times of the area in hole；The one side of described rubber blanket is coated reflector layer；By relative for the one side with reflector layer
Light hole is placed on described light hole, and so passing through can be with the rubber blanket of reflector layer by the luminous reflectance of light hole circumfusion
Fall, thus prevent having ambient light to disturb during detection, affect the accuracy of bilirubinic detection device detection.
The illustration of above-described embodiment simply invention, should not describe with the exemplary embodiments of description and accompanying drawing and limit specially
The protection domain of economic rights.
Above in conjunction with accompanying drawing, the preferred embodiments of the disclosure and embodiment are explained in detail, but the present invention
It is not limited to the above-described embodiment and examples, in the ken that those skilled in the art are possessed, it is also possible to do not taking off
On the premise of present inventive concept, various changes can be made.
Claims (10)
1. a bilirubinic detection device, it is characterised in that include that housing, described enclosure interior are provided with bilirubin sensing
Device, MCU, described bilirubin sensor is connected with described MCU；
Described bilirubin sensor includes blue light harvester and green light harvester；
Described blue light harvester includes blue-light source that wavelength is 460nm and for gathering the photodiode of blue light, described ripple
The blue-light source of a length of 460nm and be encapsulation all-in-one-piece for gathering the photodiode of blue light；
Described green glow harvester includes green light source that wavelength is 550nm and for gathering the photodiode of green glow, described ripple
The green light source of a length of 550nm and be encapsulation all-in-one-piece for gathering the photodiode of green glow；
Described blue light harvester and described green glow harvester position are parallel or point-blank.
Bilirubinic detection device the most according to claim 1, it is characterised in that the described photoelectricity two for gathering blue light
Pole is managed and is the photodiode with nano coating for gathering the photodiode of green glow.
Bilirubinic detection device the most according to claim 1, it is characterised in that be provided with bluetooth mould in described housing
Block, described bluetooth module is connected with described MCU.
Bilirubinic detection device the most according to claim 1, it is characterised in that be also equipped with power supply in described housing,
Described power supply is connected with described bilirubin sensor, described MCU and described bluetooth module.
5. according to the bilirubinic detection device described in any one of claim 1-4, it is characterised in that described bilirubinic detection
Device includes light hole, and described light hole is cased with rubber blanket, and the area of described rubber blanket is the 20-30 of the area of light hole
Times；
The one side of the light hole dorsad of described rubber blanket has reflector layer.
6. according to the bilirubinic detection device described in any one of claim 1-4, it is characterised in that described bilirubinic detection
Device includes light hole, and described light hole is provided with plug；
Described plug includes that cap, piston part and operating portion, described cap, piston part and operating portion are integrated, described cap and plug
There is interval between portion, described piston part has projection, described projection are positioned at described interval；
Described cap and the coupling part of described piston part, described protruding and described operating portion are free chamber respectively；
Have in described light hole and the concave surface of described male cooperation；
Preferably, described bilirubin sensor includes isolation current bar, is provided with and is disposed with in described isolation current bar
Blue light harvester and green light harvester, described bilirubin sensor layer is provided with signal transmission module, in isolation current bar
Blue light harvester and green light harvester between be provided with insulating course, described insulating course is provided with partition panel；Described isolation electricity
The surface of flow post is also coated with OSP layer；The bottom of described isolation current bar is additionally provided with base, and described base is provided with for will be every
On the light hole that current bar is hingedly connected at described bilirubinic detection device；
Described signal transmission module includes the multilayer board of circle, with its midpoint circumferential array six in each multilayer board
Elongated strip antenna, described each elongated strip antenna includes the framework of rectangle, and each edge of described framework is all towards center
It is provided with the first arc sub antenna and the second arc sub antenna of arc；The radius of described second arc sub antenna is more than the first arc
Shape sub antenna；
Each elongated strip antenna also include from each edge towards centrally disposed go out circular sub antenna, described circular sub antenna
Radius more than the second arc sub antenna, the width of described circular sub antenna is gradually reduced to center from two ends；Described circular son
Antenna is made up of carbofrax material；The end of described framework is provided with partition band, and described the partition carries the material for non-conducting electric current, its
The end of framework is disconnected；It is equipped with the 3rd sub antenna, one end of described 3rd sub antenna two-by-two between circular sub antenna
Being provided with the annular sub antenna of annular, described annular sub antenna is located at the top of framework；The other end of described 3rd sub antenna sets
Having the 4th arc sub antenna of arc, the radius of three the 4th arc sub antennas in described each framework is identical；Described framework
Center be provided with a data transmission port, described data transmission port electrically connects with three the 4th arc sub antennas respectively；Institute
The bottom surface stating multilayer board also is provided with first connector corresponding with data transmission port；Described 3rd sub antenna is provided with many
Individual the second connector being placed equidistant；The outer end of described multilayer board is provided with a circle transmission line, described transmission line and every height
Antenna electric connects；Being provided with a gripper shoe in multilayered printed plate top surface, multilayered printed back is provided with axostylus axostyle, described axostylus axostyle with
Gripper shoe electrically connects, and the lower end of described axostylus axostyle is provided with outside antenna, and described outside antenna includes three outer sub antennas triangular in shape；
Described partition panel is a copper billet, described partition panel has corresponding with six elongated strip antennas with its midpoint circumferential array
Connector；Described connector is identical with the size of framework；The quantity of described second connector is N, the length of described 3rd sub antenna
Degree is Lmm, and the radius of described annular sub antenna is Kmm, then K=L/N；
Preferably, described photodiode for gathering blue light and all including for gathering the photodiode of green glow:
Time quantum, is connected for setting up with at least one MCU, and carries out acquisition time record；
Photochromic detector unit, during being used for gathering light source data, gathers the first light source data, and receives the second light of collection
Source data；
Integral unit, for described first light source data and secondary light source data are carried out the integration of many sessions, obtains multiple light courcess number
According to, wherein, described integral unit specifically includes:
Do poor unit, for the first light source data started acquisition time and the beginning acquisition time of secondary light source data, ripple
The long absolute value doing the poor difference obtaining the absolute value of difference of time, wavelength；
Capture unit, the absolute value for the difference according to the described time catches in described first light source data and secondary light source data
The wavelength information of corresponding light source data；
Processing unit, for carrying out many sessions place by light source data corresponding in described first light source data and secondary light source data
Reason, obtains described multiple light courcess data；
Described processing unit includes: process subelement, for by correspondence in described first light source data and secondary light source data
Light source data processes according to the arrayed feature of many sessions, obtains the pulse code modulation data of many sessions；
Coded sub-units, for encoding described pulse code modulation data according to predetermined file format, obtains described
Multiple light courcess data；
Wherein, processing unit contrasts according to the wavelength information of the first light source data and secondary light source data, if the difference of wavelength
Absolute value more than 10nm, then control photochromic detector unit and again detect the first light source data and secondary light source data.
7. a bilirubinic detection method, it is characterised in that include,
Choose wavelength be the blue-light source of 460nm, wavelength be the green light source of 550nm, for gathering the photodiode of blue light
And for gathering the photodiode of green glow；
Make photoelectric gathering apparatus: by blue-light source that wavelength is 460nm be used for gathering the photodiode of blue light and utilize and partly lead
Body encapsulation technology molding, forms blue light harvester；By green light source that wavelength is 550nm be used for gathering the photoelectricity two of green glow
Pole pipe utilizes semiconductor packaging molding, forms green light harvester；
See that blue light harvester is parallel with green light harvester or point-blank places, connect formation bilirubin by described
Sensor；
Bilirubin sensor is connected MCU, is placed in the shell with light hole, form bilirubin detecting instrument；
Light hole is placed on skin, starts described bilirubin detecting instrument.
Bilirubinic detection method the most according to claim 7, it is characterised in that described in choose the indigo plant that wavelength is 460nm
Color light source, wavelength be the green light source of 550nm, for gathering the photodiode of blue light and for gathering photoelectricity two pole of green glow
Pipe includes,
Choose blue led light source that wavelength is 460nm, wavelength be 550nm green LED light source, for gather blue light with
The photodiode of nano coating and for gathering the photodiode with nano coating of green glow.
Bilirubinic detection method the most according to claim 8, it is characterised in that described by the connection of bilirubin sensor
MCU, is placed in the shell with light hole, forms bilirubin detecting instrument and also includes, MCU is connected bluetooth module；
Described light hole is placed on skin, also includes after starting described bilirubin detecting instrument,
Described bluetooth module is connected with mobile phone.
10. according to the bilirubinic detection method described in any one of claim 7-9, it is characterised in that described by bilirubin biography
Sensor connects MCU, is placed in the shell with light hole, is formed after bilirubin detecting instrument, described light hole is placed in skin
On skin, also include before starting described bilirubin detecting instrument, choose the rubber of 20-30 times of the area that area is light hole
Pad；
The one side of described rubber blanket is coated reflector layer；
One side with reflector layer is placed on described light hole relative to light hole.
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| CN201610587777.1A CN106214126B (en) | 2016-07-22 | 2016-07-22 | A kind of detection device and detection method of bilirubin |
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| CN201610587777.1A CN106214126B (en) | 2016-07-22 | 2016-07-22 | A kind of detection device and detection method of bilirubin |
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| CN107966410A (en) * | 2017-12-20 | 2018-04-27 | 深圳乐普智能医疗器械有限公司 | Bilirubin measuring device |
| WO2018208233A1 (en) * | 2017-05-12 | 2018-11-15 | National University Of Singapore | Noninvasive optical sensor for analyzing a level of a substance in a subject by illuminating the sclera |
| CN110368602A (en) * | 2019-09-04 | 2019-10-25 | 河南科技大学第一附属医院 | A kind of multiple light courcess infant jaundice light exposure treatment equipment |
| CN112971708A (en) * | 2019-12-12 | 2021-06-18 | 上海交通大学 | Bilirubin noninvasive detection device based on skin fluorescence spectrum analysis |
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| US6847835B1 (en) * | 1999-03-31 | 2005-01-25 | Minolta Co., Ltd. | Transcutaneous bilirubin concentration measuring apparatus and a measurement data checking plate for use with the same |
| CN102906559A (en) * | 2010-05-27 | 2013-01-30 | 皇家飞利浦电子股份有限公司 | Apparatus and method for measuring analyte such as bilirubin, using light |
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| BR9606008A (en) * | 1996-12-06 | 1998-09-08 | Cunha Jose Carlos Da | Non-invasive neonatal jaundice analyzer |
| US6847835B1 (en) * | 1999-03-31 | 2005-01-25 | Minolta Co., Ltd. | Transcutaneous bilirubin concentration measuring apparatus and a measurement data checking plate for use with the same |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2018208233A1 (en) * | 2017-05-12 | 2018-11-15 | National University Of Singapore | Noninvasive optical sensor for analyzing a level of a substance in a subject by illuminating the sclera |
| US11744489B2 (en) | 2017-05-12 | 2023-09-05 | National University Of Singapore | Noninvasive optical sensor for analyzing a level of a substance in a subject by illuminating the sclera |
| CN107966410A (en) * | 2017-12-20 | 2018-04-27 | 深圳乐普智能医疗器械有限公司 | Bilirubin measuring device |
| CN110368602A (en) * | 2019-09-04 | 2019-10-25 | 河南科技大学第一附属医院 | A kind of multiple light courcess infant jaundice light exposure treatment equipment |
| CN110368602B (en) * | 2019-09-04 | 2021-01-15 | 河南科技大学第一附属医院 | Infant jaundice phototherapy equipment with multiple light sources |
| CN112971708A (en) * | 2019-12-12 | 2021-06-18 | 上海交通大学 | Bilirubin noninvasive detection device based on skin fluorescence spectrum analysis |
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| Publication number | Publication date |
|---|---|
| CN106214126B (en) | 2019-03-29 |
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