CN106212882A - Radix Salviae Miltiorrhizae extract natural feed addictive and preparation method thereof - Google Patents
Radix Salviae Miltiorrhizae extract natural feed addictive and preparation method thereof Download PDFInfo
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- CN106212882A CN106212882A CN201610615406.XA CN201610615406A CN106212882A CN 106212882 A CN106212882 A CN 106212882A CN 201610615406 A CN201610615406 A CN 201610615406A CN 106212882 A CN106212882 A CN 106212882A
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- radix salviae
- salviae miltiorrhizae
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Abstract
The invention provides a kind of Radix Salviae Miltiorrhizae extract natural feed addictive and preparation method thereof, described Radix Salviae Miltiorrhizae extract natural feed addictive includes Radix Salviae Miltiorrhizae extract and carrier；The percentage by weight of described Radix Salviae Miltiorrhizae extract and carrier is 6～8:2～4.The present invention, by improving the preparation method of Radix Salviae Miltiorrhizae extract, is remarkably improved the extraction efficiency of Radix Salviae Miltiorrhizae extract, and the TANSHINONES content obtained may be up to 60.01%；Radix Salviae Miltiorrhizae extract natural feed raw material prepared by the present invention has the effect of anti-stress, free radical resisting, is effectively reduced mortality of animals, improves animal health degree, and extends the service life of feedstuff.
Description
Technical field
The present invention relates to field of fodder, be specifically related to a kind of Radix Salviae Miltiorrhizae extract natural feed addictive and preparation method thereof.
Background technology
Plant extract becomes one of main fodder antibiotics succedaneum, belongs to pure natural substance, has promotion growth of animal,
Strengthen its body constitution, enhance metabolism, improve the effect such as production performance, anti-stress and disease preventing and treating, be in advanced international level.
State is external sees, abroad the requirement to food safety is extremely strict, especially European Union, and European Union is to forbid in the world to use feedstuff antibiosis
Element the earliest, the maximum and the tightest region, European Union successfully disables fodder antibiotics, supporting except having benefited from good feeding and management
Beyond measure, a highly important material measure is to substitute feedstuff antibiotic, in success with plant extract (Chinese herbal medicine)
In disabling fodder antibiotics, Chinese herbal medicine has played important effect.
Along with China's animal husbandry is by the extensive transformation to the intensive production and operation of modernization of tradition, and animality is eaten
The raising day by day that quality requires, with disease-prevention health, promote to grow, have no drug resistance, have no side effect, the advantageous feature such as noresidue
Chinese herbal medicine natural feed raw material substitution fodder antibiotics be development inexorable trend, at home green safety agricultural have it is only
Thick advantage.The sector extensive market, is excavated the most energetically, and therefore market capacity is huge, has a high potential, development space
Huge.
Radix Salviae Miltiorrhizae is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae Salvia miltiorhiza Bage, is clinical painstaking effort
One of the most frequently used Chinese medicine of pipe disease.There is wind-expelling pain-stopping, promoting blood circulation to remove obstruction in the collateral, the effect of the relieving restlessness that clears away heart-fire.The main active of Radix Salviae Miltiorrhizae
For the water soluble ingredient with salvianolic acid B as representative and the tanshinone IIA liposoluble constituent as representative.Liposoluble constituent such as Radix Salviae Miltiorrhizae
Ketone can promote body to the metabolism of oxygen-derived free radicals, reduce Free Radical Level, reduces brain injury.Red sage root water soluble ingredient has anticoagulant
And anti thrombotic action, anti-cardiac-cerebral ischemia effect, hepatoprotective effect, to lung and kidney protection effect.
Value that Radix Salviae Miltiorrhizae uses as feedstuff and the correlational study of effect, have not yet to see report.
Summary of the invention
For defect of the prior art, it is an object of the invention to provide a kind of Radix Salviae Miltiorrhizae extract natural feed addictive and
Its preparation method.
It is an object of the invention to be achieved through the following technical solutions:
The invention provides a kind of unmarried extract natural feed addictive, including Radix Salviae Miltiorrhizae extract and carrier；Described pellet
The weight ratio of conopsea extraction and carrier is: 6～8:2～4.
Preferably, the weight ratio of described Radix Salviae Miltiorrhizae extract and carrier is: 7:3.
Preferably, described carrier includes maltodextrin.
Preferably, the preparation method of described Radix Salviae Miltiorrhizae extract comprises the steps:
A, by Radix Salviae Miltiorrhizae pretreatment, pulverize, add 10 times amount ethanol, extract 4～8h under 65～75 DEG C of steam, obtain the first filtrate
With the first solid residue；Filtrate is through being evaporated under reduced pressure, being concentrated to give the first extractum；
B, in described first solid residue, add 3 times amount water vacuum extraction 2～5h, obtain the second filtrate and the second solid is residual
Slag；Second filtrate is concentrated to give the second extractum；
C, in described second solid residue, add 8 times amount water vacuum extraction 1～3h, obtain the 3rd filtrate and the 3rd solid is residual
Slag；3rd filtrate is concentrated to give the 3rd extractum；
D, by described first, second and third extractum mixing, concentrate, obtain the 4th extractum, more spray-dried process, obtain dry powder.
Preferably, in step A, described steam pressure is 0.5MPa；In step B and C, the pressure of described vacuum extraction is
0.4～0.6MPa.
Preferably, in step A, concretely comprising the following steps of described Radix Salviae Miltiorrhizae pretreatment: after red sage root and cutting shoots ,-30～-15
Lyophilization 12～18h at DEG C.
Preferably, in step A, the weight/mass percentage composition of described ethanol is 80～90%.
Use in the Radix Salviae Miltiorrhizae extract that preparation method of the present invention obtains, after testing, its effective ingredient mainly include TANSHINONES,
Cryptotanshinone, Radix Salviae Miltiorrhizae acid, salvianolic acid, wherein the content of TANSHINONES is up to 60.01%, and this effective ingredient have anti-stress,
Free radical resisting, improving cardio cerebral function, promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, clear away heart-fire relieving restlessness, the effect of calming heart and tranquilizing mind.
Present invention also offers the preparation method of a kind of Radix Salviae Miltiorrhizae extract natural feed addictive wanted as described in 1 such as right,
It is characterized in that, described method is for mix Radix Salviae Miltiorrhizae extract by weight with carrier.
Present invention also offers a kind of animal feed, including aforesaid Radix Salviae Miltiorrhizae extract natural feed addictive.
Preferably, described Radix Salviae Miltiorrhizae extract natural feed addictive accounts for the weight percent content of animal feed gross weight and is
0.5～1%.
Compared with prior art, the present invention has a following beneficial effect:
1, the present invention is by improving the preparation method of Radix Salviae Miltiorrhizae extract, is remarkably improved the extraction efficiency of Radix Salviae Miltiorrhizae extract,
The dry cream rate of prepared Radix Salviae Miltiorrhizae extract is up to 25～35%.
2, use the present invention preparation method obtain Radix Salviae Miltiorrhizae extract in, the content of its effective ingredient TANSHINONES up to
60.01%.
3,3, the Radix Salviae Miltiorrhizae extract natural feed addictive prepared of the present invention there is the effect of anti-stress, free radical resisting, use
Mortality of animals can be reduced in animal feed, improve animal health degree, extend the effect of the service life of feedstuff.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in detail.Following example will assist in the technology of this area
Personnel are further appreciated by the present invention, but limit the present invention the most in any form.It should be pointed out that, the ordinary skill to this area
For personnel, without departing from the inventive concept of the premise, it is also possible to make some deformation and improvement.These broadly fall into the present invention
Protection domain.
Embodiment 1
Present embodiments providing a kind of Radix Salviae Miltiorrhizae extract natural feed raw material, its preparation method is as follows:
Step one, by after red sage root and rhizome cutting ,-30～-15 DEG C at after lyophilization 12～18h, pulverize rapidly, add
Entering 10 times amount weight/mass percentage composition is the ethanol of 80%, 65 DEG C, extract 8h under steam pressure 0.5MPa, obtains the second filtrate and first
Solid residue；Filtrate is through being evaporated under reduced pressure, being concentrated to give the first extractum；
Step 2, adding 3 times amount water in described first solid residue, 0.6MPa vacuum under pressure extracts 5h, obtains second
Filtrate and the second solid residue；Second filtrate is concentrated to give the second extractum；
Step 3, adding 8 times amount water in described first solid residue, 0.5MPa vacuum under pressure extracts 3h, obtains the 3rd
Filtrate and the 3rd solid residue；3rd filtrate is concentrated to give the 3rd extractum；
Step 4, by described first, second and third extracting solution mixing, and be concentrated into D=0.6, obtain the 4th extractum；4th leaching
Cream enters spray dryer, inlet temperature 150 DEG C, leaving air temp 80 DEG C, obtains Radix Salviae Miltiorrhizae extract dry powder；
Step 5, Radix Salviae Miltiorrhizae extract dry powder and carrier maltodextrin are mixed by weight 7:3.
Embodiment 2
Present embodiments providing a kind of Radix Salviae Miltiorrhizae extract natural feed raw material, its preparation method is as follows:
Step one, by after red sage root and rhizome cutting ,-30～-15 DEG C at after lyophilization 12～18h, pulverize rapidly, add
Entering 10 times amount weight/mass percentage composition is the ethanol of 90%, 75 DEG C, extract 4h under steam pressure 0.5MPa, obtains the second filtrate and first
Solid residue；Filtrate is through being evaporated under reduced pressure, being concentrated to give the first extractum；
Step 2, adding 3 times amount water in described first solid residue, 0.5MPa vacuum under pressure extracts 2h, obtains second
Filtrate and the second solid residue；Second filtrate is concentrated to give the second extractum；
Step 3, adding 8 times amount water in described first solid residue, 0.4MPa vacuum under pressure extracts 2h, obtains the 3rd
Filtrate and the 3rd solid residue；3rd filtrate is concentrated to give the 3rd extractum；
Step 4, by described first, second and third extracting solution mixing, and be concentrated into D=0.8, obtain the 4th extractum；4th leaching
Cream enters spray dryer, inlet temperature 150 DEG C, leaving air temp 80 DEG C, obtains Radix Salviae Miltiorrhizae extract dry powder；
Step 5, Radix Salviae Miltiorrhizae extract dry powder and carrier maltodextrin are mixed by weight 8:2.
Embodiment 3
Present embodiments providing a kind of Radix Salviae Miltiorrhizae extract natural feed raw material, its preparation method is as follows:
Step one, by after red sage root and rhizome cutting ,-30～-15 DEG C at after lyophilization 12～18h, pulverize rapidly, add
Entering 10 times amount weight/mass percentage composition is the ethanol of 85%, 70 DEG C, extract 6h under steam pressure 0.5MPa, obtains the second filtrate and first
Solid residue；Filtrate is through being evaporated under reduced pressure, being concentrated to give the first extractum；
Step 2, adding 3 times amount water in described first solid residue, 0.4MPa vacuum under pressure extracts 4h, obtains second
Filtrate and the second solid residue；Second filtrate is concentrated to give the second extractum；
Step 3, adding 8 times amount water in described first solid residue, 0.6MPa vacuum under pressure extracts 1h, obtains the 3rd
Filtrate and the 3rd solid residue；3rd filtrate is concentrated to give the 3rd extractum；
Step 4, by described first, second and third extracting solution mixing, and be concentrated into D=1.2, obtain the 4th extractum；4th leaching
Cream enters spray dryer, inlet temperature 150 DEG C, leaving air temp 80 DEG C, obtains Radix Salviae Miltiorrhizae extract dry powder；
Step 5, Radix Salviae Miltiorrhizae extract dry powder and carrier maltodextrin are mixed by weight 7:3.
Embodiment 4
Present embodiments providing a kind of Radix Salviae Miltiorrhizae extract natural feed raw material, its preparation method is as follows:
Step one, by after red sage root and rhizome cutting ,-30～-15 DEG C at after lyophilization 12～18h, pulverize rapidly, add
Entering 10 times amount weight/mass percentage composition is the ethanol of 80%, 70 DEG C, extract 5h under steam pressure 0.5MPa, obtains the second filtrate and first
Solid residue；Filtrate is through being evaporated under reduced pressure, being concentrated to give the first extractum；
Step 2, adding 3 times amount water in described first solid residue, 0.4MPa vacuum under pressure extracts 3h, obtains second
Filtrate and the second solid residue；Second filtrate is concentrated to give the second extractum；
Step 3, adding 8 times amount water in described first solid residue, 0.4MPa vacuum under pressure extracts 3h, obtains the 3rd
Filtrate and the 3rd solid residue；3rd filtrate is concentrated to give the 3rd extractum；
Step 4, by described first, second and third extracting solution mixing, and be concentrated into D=1.0, obtain the 4th extractum；4th leaching
Cream enters spray dryer, inlet temperature 150 DEG C, leaving air temp 80 DEG C, obtains Radix Salviae Miltiorrhizae extract dry powder；
Step 5, Radix Salviae Miltiorrhizae extract dry powder and carrier maltodextrin are mixed by weight 6:4.
Comparative example 1
This comparative example is identical with the preparation method of embodiment 1, the difference is that only: in step one, uses 8 times amount ethanol
Extract.
Comparative example 2
This comparative example is identical with the preparation method of embodiment 1, the difference is that only: in step one, uses 10 times amount matter
Amount percentage composition is the ethanol extraction of 70%.
Comparative example 3
This comparative example is identical with the preparation method of embodiment 2, the difference is that only: in step one, and the temperature of employing is
80℃。
Comparative example 4
This comparative example is identical with the preparation method of embodiment 2, the difference is that only: in step one, and the temperature of employing is
60℃。
Comparative example 5
This comparative example is identical with the preparation method of embodiment 2, the difference is that only: in step one, the vapour pressure of employing
Power is 0.6MPa.
Comparative example 6
This comparative example is identical with the preparation method of embodiment 2, the difference is that only: in step one, the vapour pressure of employing
Power is 0.4MPa.
Comparative example 7
This comparative example is identical with the preparation method of embodiment 2, the difference is that only: in step 5, and described Radix Salviae Miltiorrhizae extracts
Thing dry powder is 5:5 with the weight ratio of carrier.
Comparative example 8
This comparative example is identical with the preparation method of embodiment 2, the difference is that only: in step 5, and described carrier is pine
Pin powder.
Compliance test result:
The Radix Salviae Miltiorrhizae extract dry cream rate that embodiment 1-4 and comparative example 1-6 are obtained is as shown in table 1:
Dry cream rate measures: above-described embodiment 1-4 and comparative example 1-6 gained first, second and third extracting solution is mixed respectively and concentrates
To 500ml, measure 20ml and put moisture determination instrument carries out moisture determination, calculate the dry cream rate of extract according to moisture content value.
Table 1 dry cream rate measurement result
As shown in Table 1, the dry cream rate of Radix Salviae Miltiorrhizae extract prepared by employing the inventive method is apparently higher than comparative example.
The content of the principle active component TANSHINONES of the Radix Salviae Miltiorrhizae extract that embodiment 1-4 and comparative example 1-6 are obtained uses
Conventional method is measured, and measurement result is as shown in table 2:
Table 2
| Active constituent content | TANSHINONES % |
| Embodiment 1 | 57.8 |
| Embodiment 2 | 60.01 |
| Embodiment 3 | 58.44 |
| Embodiment 4 | 59.21 |
| Comparative example 1 | 50.04 |
| Comparative example 2 | 48.33 |
| Comparative example 3 | 50.7 |
| Comparative example 4 | 51.5 |
| Comparative example 5 | 49.68 |
| Comparative example 6 | 47.31 |
As shown in Table 2, using in the Radix Salviae Miltiorrhizae extract that the preparation method of the present invention is extracted, TANSHINONES content is apparently higher than right
Ratio.
The zoopery of the Radix Salviae Miltiorrhizae extract natural feed addictive described in embodiment 1-4 and comparative example 7-8:
At Shanghai unit henry animal Chinese medicine medicine research center field experiment to embodiment 1,2,3,4 and the Radix Salviae Miltiorrhizae of comparative example 7,8
Extract natural feed addictive carries out contrast test, and experimental animal uses and is bred as later stage DLY ternary pigs, and spice eats, often
Ton feedstuff adds 800g Radix Salviae Miltiorrhizae extract natural feed addictive；Matched group is without Radix Salviae Miltiorrhizae extract natural feed addictive.
Experimental result is as shown in table 3:
Table 3
As shown in Table 3, use the Radix Salviae Miltiorrhizae extract natural feed addictive of carrier of the present invention and specific addition, can be notable
Improve the survival rate of experiment pig, reduce sickness rate.
Above the specific embodiment of the present invention is described.It is to be appreciated that the invention is not limited in above-mentioned
Particular implementation, those skilled in the art can make various deformation or amendment within the scope of the claims, this not shadow
Ring the flesh and blood of the present invention.
Claims (10)
1. a Radix Salviae Miltiorrhizae extract natural feed addictive, it is characterised in that include Radix Salviae Miltiorrhizae extract and carrier；Described Radix Salviae Miltiorrhizae carries
The percentage by weight taking thing and carrier is: 6～8:2～4.
2. Radix Salviae Miltiorrhizae extract natural feed addictive as claimed in claim 1, it is characterised in that described Radix Salviae Miltiorrhizae extract and load
The percentage by weight of body is: 7:3.
3. Radix Salviae Miltiorrhizae extract natural feed addictive as claimed in claim 1 or 2, it is characterised in that described carrier includes wheat
Bud dextrin.
4. Radix Salviae Miltiorrhizae extract natural feed addictive as claimed in claim 1 or 2, it is characterised in that described Radix Salviae Miltiorrhizae extract
Preparation method comprise the steps:
A, by Radix Salviae Miltiorrhizae pretreatment, pulverize, add 10 times amount ethanol, under 65～75 DEG C of steam, extract 4～8h, obtain the first filtrate and the
One solid residue；Filtrate is through being evaporated under reduced pressure, being concentrated to give the first extractum；
B, in described first solid residue, add 3 times amount water vacuum extraction 2～5h, obtain the second filtrate and the second solid residue；
Second filtrate is concentrated to give the second extractum；
C, in described second solid residue, add 8 times amount water vacuum extraction 1～3h, obtain the 3rd filtrate and the 3rd solid residue；
3rd filtrate is concentrated to give the 3rd extractum；
D, by described first, second and third extractum mixing, be concentrated into D=0.6～1.2, obtain the 4th extractum, more spray-dried process,
Obtain dry powder.
5. Radix Salviae Miltiorrhizae extract natural feed addictive as claimed in claim 4, it is characterised in that in step A, described vapour pressure
Power is 0.5MPa；In step B and C, the pressure of described vacuum extraction is 0.4～0.6MPa.
6. Radix Salviae Miltiorrhizae extract natural feed addictive as claimed in claim 4, it is characterised in that in step A, described Radix Salviae Miltiorrhizae is pre-
Process concretely comprise the following steps: after red sage root and cutting shoots ,-30～-15 DEG C at lyophilization 12～18h.
7. Radix Salviae Miltiorrhizae extract natural feed addictive as claimed in claim 4, it is characterised in that in step A, described ethanol
Weight/mass percentage composition is 80～90%.
8. the preparation method of the Radix Salviae Miltiorrhizae extract natural feed addictive wanted such as right as described in 1, it is characterised in that described side
Method is for mix Radix Salviae Miltiorrhizae extract by weight with carrier.
9. an animal feed, it is characterised in that include Radix Salviae Miltiorrhizae extract natural feed addictive as claimed in claim 1.
10. animal feed as claimed in claim 9, it is characterised in that described Radix Salviae Miltiorrhizae extract natural feed addictive accounts for
The weight percent content of thing feedstuff gross weight is 0.5～1%.
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|---|---|---|---|---|
| CN1806655A (en) * | 2006-02-05 | 2006-07-26 | 谭金镜 | Feedstuff with red sage root and preparation method thereof |
| CN103340311A (en) * | 2013-07-11 | 2013-10-09 | 曾勇 | Anti-stress feed regulating agent for cow |
| CN103750071A (en) * | 2014-02-17 | 2014-04-30 | 双胞胎（集团）股份有限公司 | Green feed additive for pigs for increasing lean meat percentage |
| CN103892044A (en) * | 2014-04-16 | 2014-07-02 | 上海朝翔生物技术有限公司 | Rhizoma atractylodis extract feed additive and preparation method thereof |
| US20150297657A1 (en) * | 2014-04-16 | 2015-10-22 | Shanghai Zhao Xiang Biological Technology Co., LTD | Portulaca oleracea L. extract feed additive and preparation method thereof |
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2016
- 2016-07-29 CN CN201610615406.XA patent/CN106212882A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1806655A (en) * | 2006-02-05 | 2006-07-26 | 谭金镜 | Feedstuff with red sage root and preparation method thereof |
| CN103340311A (en) * | 2013-07-11 | 2013-10-09 | 曾勇 | Anti-stress feed regulating agent for cow |
| CN103750071A (en) * | 2014-02-17 | 2014-04-30 | 双胞胎（集团）股份有限公司 | Green feed additive for pigs for increasing lean meat percentage |
| CN103892044A (en) * | 2014-04-16 | 2014-07-02 | 上海朝翔生物技术有限公司 | Rhizoma atractylodis extract feed additive and preparation method thereof |
| US20150297657A1 (en) * | 2014-04-16 | 2015-10-22 | Shanghai Zhao Xiang Biological Technology Co., LTD | Portulaca oleracea L. extract feed additive and preparation method thereof |
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Effective date of registration: 20210507 Address after: 201306 C, 888, west two road, Nanhui new town, Pudong New Area, Shanghai Applicant after: Chaoxiang (Shanghai) Additive Co.,Ltd. Address before: 201609 block a, 18 Yerong Road, Yexie Town, Songjiang District, Shanghai Applicant before: Shanghai Zhao Xiang Biological Technology Co.,Ltd. |
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