CN106198707A - A kind of mass spectrum sampling device and Mass Spectrometer Method equipment - Google Patents
A kind of mass spectrum sampling device and Mass Spectrometer Method equipment Download PDFInfo
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- CN106198707A CN106198707A CN201610541432.2A CN201610541432A CN106198707A CN 106198707 A CN106198707 A CN 106198707A CN 201610541432 A CN201610541432 A CN 201610541432A CN 106198707 A CN106198707 A CN 106198707A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
Abstract
nullA kind of mass spectrum sampling device and the Mass Spectrometer Method equipment with this mass spectrum sampling device，This mass spectrum sampling device includes sprayer unit、Seal cavity、Gas-carrier pipeline、Transfer conduit and inductively-coupled plasma sources，Sprayer unit includes sample feeding pipe、Auxiliary gas path and spout，Spout is placed in annular seal space body，Seal cavity and there is the carrier gas input port connecting gas-carrier pipeline、Organic mass spectrometry Sampling Interface and inorganic mass spectrum Sampling Interface，Liquid sample forms spraying under the effect of electric field and secondary air and ionizing occurs，Produced ion enters analyzed detection in mass spectrograph by organic mass spectrometry Sampling Interface，The sample spraying of residual in annular seal space body is sent by the carrier gas of carrier gas input port input by inorganic mass spectrum Sampling Interface，And in transfer conduit takes inductively-coupled plasma sources to，There is atomization and ionizing，Elemental composition analysis is carried out again by mass spectrograph or spectrogrph.This sampling device is capable of the parallel detection of inorganic mass spectrum and organic mass spectrometry.
Description
Technical field
The present invention relates to a kind of mass spectrum sampling device and Mass Spectrometer Method equipment.
Background technology
The most strong element analysis technology that inductivity coupled plasma mass spectrometry technology (ICP-MS) is well recognized as.Electron spray
Mass spectrum (ESI-MS), as most widely used organic mass spectrometry, is provided that composition and the structural information of organic compound, and by with
Analysis in the biomacromolecule such as protein, nucleic acid detects.Along with the raising day by day of detection demand, same sample generally requires same
Shi Caiyong inorganic mass spectrometer and organic mass spectrometer carry out detecting to obtain more fully sample message.
But, restricted by input mode, be the most also difficult to two kinds of mass spectrometric parallel detections.At present, great majority
The sampling system being still solution pneumatic nebulization that ICP-MS uses.This sampling system exists that nebulization efficiency is low, efficiency of transmission is poor
(less than 5%), the problem that sample consumption is big, although the demand of conventional sense can be met, but to sample size rareness, content pole
Low detection case cannot meet.Electrospray techniques is the sampling device being widely used in organic mass spectrometry, and it is i.e. as ion source
The combination of liquid chromatograph and organic mass spectrometry is achieved again well as interfacing.Due to the difference of above-mentioned input mode,
In actual application, generally require and be associated result again analyzing after same sample is respectively adopted two kinds of mass-spectrometric technique detections.
This asynchronous detection mode not only limit detection efficiency, and by the repeatability of isolation technics, the difference of ionizing link
The opposite sex, the impact of many uncertain factors such as inhomogeneities of sample, the relatedness between its output result often hardly results in
Ensure.
Summary of the invention
The technical problem to be solved in the present invention is, proposes a kind of mass spectrum sampling device and has this mass spectrum sampling device
Mass Spectrometer Method equipment, it is possible to realize the parallel detection of inorganic mass spectrum and organic mass spectrometry.
For achieving the above object, the present invention is by the following technical solutions:
A kind of mass spectrum sampling device, including sprayer unit, seals cavity, gas-carrier pipeline, transfer conduit and inductive etc.
Plasma source, described sprayer unit includes sample feeding pipe, auxiliary gas path and spout, and described spout is placed in described sealing cavity
In, described sealing cavity has and connects the carrier gas input port of described gas-carrier pipeline, organic mass spectrometry Sampling Interface and inorganic mass spectrum and adopt
Sample interface, liquid sample flows through described spout via sample feeding pipe, at electric field with from the auxiliary gas of described auxiliary gas path
Forming spraying under the effect of stream and ionizing occurs, produced ion enters mass spectrograph by described organic mass spectrometry Sampling Interface
In analyzed detection, described carrier gas input port inputs carrier gas in described sealing cavity, will in described annular seal space body residual sample
Product spraying is sent by inorganic mass spectrum Sampling Interface, and in transfer conduit takes inductively-coupled plasma sources to, atom occurs
Change and ionizing, then carry out elemental composition analysis by mass spectrograph or spectrogrph.
Described auxiliary gas path includes that joint and auxiliary trachea, described sample feeding pipe and auxiliary trachea form the pipe that two-layer is concentric
Road, the described sample feeding pipe conveying liquid sample of internal layer, the described auxiliary trachea of outer layer is passed through auxiliary gas by described joint
And it being transported at described shower nozzle, it is preferable that described joint is that one end is closed, the other end is tightly connected described auxiliary gas
Pipe, the three way cock of the 3rd end input auxiliary gas.
Described sample feeding pipe is metal or quartz capillary.
Described sample feeding pipe stretches out or does not stretch out the outlet of described auxiliary air pipe, it is preferable that the outlet of described sample feeding pipe with
The distance of the outlet of described auxiliary trachea is-2～2mm.
Described auxiliary gas is the mixing of several gases, preferably argon in nitrogen, air, argon, helium or above-mentioned gas,
Preferably, the flow velocity of gas is 0～1L/min.
Described carrier gas is argon, and the direction of gas circuit and the flow velocity of air-flow are arranged to reach default sample transfer efficiency.
The material of described transfer conduit is glass, quartz or politef.
Gas flow rate in described transfer conduit is at 1L/min.
The intracavity air pressure of described sealing cavity is higher than the air pressure residing for described inductively-coupled plasma sources.
A kind of Mass Spectrometer Method equipment, including described mass spectrum sampling device and with described mass spectrum sampling device with the use of
Organic mass spectrometer and inorganic mass spectrometer or spectrogrph.
The Advantageous Effects of the present invention:
The invention provides a kind of mass spectrum sampling device, it is possible to realize the parallel detection of inorganic mass spectrum and organic mass spectrometry, its
Middle liquid sample flows through spout via sample feeding pipe and enters sealing cavity, at highfield with from the auxiliary gas assisting gas path
Forming spraying under the effect of stream and ionizing occurs, produced ion enters quilt in mass spectrograph by organic mass spectrometry Sampling Interface
Analyzing detection, meanwhile, the sample of residual in annular seal space body, to sealing input carrier gas in cavity, is sprayed by nothing by carrier gas input port
Machine MS acquisition interface is sent, and in transfer conduit takes inductively-coupled plasma sources to, atomization and ionizing occurs, then
Elemental composition analysis is carried out by mass spectrograph or spectrogrph.The sampling device of the present invention is reasonable in design, simple in construction, low cost
Honest and clean, it can solve, and the nebulization efficiency that the atomization of ICP source traditional, pneumatic exists is low, efficiency of transmission is poor (less than 5%), sample consumption
Big problem, simultaneously as two kinds of mass spectrometric synchronization sampling devices, truly realizes inorganic mass spectrum and biological mass spectrometry
Organically combining, this is possible not only to reduce sample consumption when analyzing, it is also possible to obtain the organic and inorganic constituents in sample simultaneously
Information, makes sample determination become more quickly and comprehensive.
The present invention realizes being combined together two kinds of mass-spectrometric techniques, can realize Electrospray Mass Spectrometry (ESI-MS) and inductive
Plasma mass (ICP-MS) is run simultaneously detection, will provide strong detection platform for analysis field, and this is to life section
The research fields such as, environmental science, medical science are respectively provided with profound significance.
Accompanying drawing explanation
Fig. 1 is the structural representation of a preferred embodiment of embodiment of the present invention mass spectrum sampling device；
Fig. 2 is the structural representation of a preferred embodiment of embodiment of the present invention Mass Spectrometer Method equipment.
Detailed description of the invention
Below in conjunction with accompanying drawing, embodiments of the invention are elaborated.It is emphasized that the description below is only shown
Example rather than in order to limit the scope of the present invention and application thereof.
As depicted in figs. 1 and 2, in one embodiment, a kind of mass spectrum sampling device, including sprayer unit, seal cavity
6, gas-carrier pipeline 5, transfer conduit 8 and inductively-coupled plasma sources, described sprayer unit includes sample feeding pipe 1, auxiliary gas path 2
And spout 4, described spout 4 is placed in described sealing cavity 6, and described sealing cavity 6 has the load connecting described gas-carrier pipeline 5
Gas input port, organic mass spectrometry Sampling Interface 7 and inorganic mass spectrum Sampling Interface, liquid sample flows through described via sample feeding pipe 1
Spout 4, forms spraying at highfield with under the effect of the secondary air of described auxiliary gas path 2 and ionizing, institute occurs
The ion produced enters analyzed detection in mass spectrograph by described organic mass spectrometry Sampling Interface 7, and described carrier gas input port is to institute
State in sealing cavity 6 and input carrier gas, the sample spraying of residual in described sealing cavity 6 is sent by inorganic mass spectrum Sampling Interface
Go out, and in transfer conduit 8 takes inductively-coupled plasma sources 9 to, atomization and ionizing occur, then by mass spectrograph or light
Spectrometer carries out elemental composition analysis.
Described sprayer unit can directly produce charged ion under the effect of high secondary air speed or high voltage electric field, logical
Cross MS acquisition interface 7 collection transmission to be analyzed to mass spectrograph.
Gas flow rate in transfer conduit 8 can be by adjusted in concert gas-carrier pipeline 5 and the gas flow rate of auxiliary gas path 2
Control and in steady statue.
In a preferred embodiment, described auxiliary gas path 2 includes joint 3 and auxiliary trachea, described sample feeding pipe 1 and auxiliary
Trachea forms the pipeline that two-layer is concentric, and the described sample feeding pipe 1 of internal layer carries liquid sample, and the auxiliary trachea of outer layer passes through institute
State joint 3 be passed through auxiliary gas and be transported at described shower nozzle 4, it is preferable that described joint 3 is closed for one end, the other end
It is tightly connected described auxiliary trachea, the three way cock of the 3rd end input auxiliary gas.
In a preferred embodiment, described sample feeding pipe 1 is metal or quartz capillary.
Described sample feeding pipe 1 can stretch out or not stretch out the outlet of described auxiliary air pipe, in a preferred embodiment, described
The outlet of sample feeding pipe 1 is-2～2mm with the distance of the outlet of described auxiliary trachea.
Described auxiliary gas can be the mixing of several gases in nitrogen, air, argon, helium or above-mentioned gas, is preferably
Argon.In a preferred embodiment, the flow velocity of gas is 0～1L/min.
In a preferred embodiment, described carrier gas is argon, and the direction of gas circuit and the flow velocity of air-flow are arranged to reach pre-
If sample transfer efficiency.
The material of described transfer conduit can be glass, quartz or politef.
In a preferred embodiment, the gas flow rate in described transfer conduit 8 is at 1L/min.
In a preferred embodiment, the intracavity air pressure of described sealing cavity 6 is higher than described inductively-coupled plasma sources 9 institute
The air pressure at place, with the air-flow desired by generation.
As in figure 2 it is shown, in one embodiment, a kind of Mass Spectrometer Method equipment, including described mass spectrum sampling device and with
Described mass spectrum sampling device with the use of organic mass spectrometer and inorganic mass spectrometer or spectrogrph.Organic mass spectrometer can be from
Sub-trap mass spectrograph.Inorganic mass spectrometer can be quadrupole mass spectrometer.
The specific embodiment of the present invention, its principle and advantage is further described below in conjunction with accompanying drawing.
One can be used for inorganic mass spectrum Tong Bu with organic mass spectrometry associated with sampling device, this device includes sprayer unit, close
Envelope cavity 6, gas-carrier pipeline, transfer conduit and inductively coupled plasma (ICP) source.The spout end of described sprayer unit is positioned at close
In envelope cavity 6, liquid sample arrives spout of spraying under the driving of syringe pump or other device, and solution is at highfield and auxiliary
Help and under the effect of air-flow, be split into charged spray drop.Along with the volatilization of solvent, drop will be by the last shape of continuous COULOMB EXPLOSION
Becoming charged solute ions, these ions enter mass spectrograph by organic mass spectrometry Sampling Interface and produce ion signal.Meanwhile, pass through
It is passed through a road-load gas toward sealing in cavity 6, takes the sample drop of residual to inductively-coupled plasma sources by transfer conduit
In, sample will occur atomization and ionizing in ICP torch, can pass through mass spectrum or spectral instrument to elemental composition therein
Carry out detection to analyze.
Sprayer unit includes sample feeding pipe 1, auxiliary gas 2, three way cock and nozzle 4, and sample introduction path 1 is preferably quartz capillary
Pipe, nozzle is made up of capillary tube and auxiliary air pipe, and capillary tube is in auxiliary air pipe, and capillary tube can stretch out or do not stretch out
Auxiliary air pipe outlet, it is preferable that capillary tube is-2～2mm with the distance of auxiliary air pipe outlet.Auxiliary gas can be nitrogen,
The mixing of several gases, preferably argon in air, argon, helium or above-mentioned gas, its gas velocity is preferably 0～1L/min.
Fluid sample arrives nozzle via capillary tube under the promotion of prime liquid chromatograph or syringe pump, at the work of high speed secondary air
With issuing fog and ionization, enter and seal cavity 6.The atomization produced by nozzle and ionization of sample some will be via
Mass spectrograph thief hatch 7 in annular seal space body enters in ion trap mass spectrometer and detects.Meanwhile, by argon path 5 introduces one
Road high-purity argon gas, its gas flow rate is adjustable.Sample and gas in annular seal space body enter mass spectrograph except a part of via thief hatch 7
Outward, remaining by entering transfer conduit 8 and ICP source will be arrived it be ionized, and be detected by quadrupole mass spectrometer.
In annular seal space body, auxiliary gas 2, argon path 5 are air inlets, and thief hatch 7 and transfer conduit 8 are to give vent to anger, for
The stability of guarantee follow-up ICP detection, the gas flow rate in transfer conduit 8 is by by auxiliary gas 2, the inlet air flow of argon path 5
The flow velocity of bleeding of speed and thief hatch 7 regulates, and mainly ensures transfer conduit 8 by the argon flow velocity of regulation argon path 5
In the stability of gas flow rate, it is preferred that the gas flow rate in transfer conduit 8 is at 1L/min.
By this device, for the sample detected, the ion of organic principle can be produced by the way of spraying ionizes,
Detected by ion trap mass spectrometry again, it is thus achieved that the organic principle information in sample, and remaining sample is transferred in ICP source send out
Raw ionization, produces substantial amounts of element ion, then is detected by quadrupole mass spectrometer, it is thus achieved that the elemental composition information in sample,
The isolation of this detection process and ambient atmosphere can be realized by sealing cavity, reduce the air interference to testing result, with this
Realize while organic in sample and elemental composition, detect accurately.
Above content is to combine concrete preferred implementation further description made for the present invention, it is impossible to assert
Being embodied as of the present invention is confined to these explanations.For general technical staff of the technical field of the invention,
On the premise of present inventive concept, it is also possible to make some simple deduction or replace, all should be considered as belonging to the present invention's
Protection domain.
Claims (10)
1. a mass spectrum sampling device, it is characterised in that include sprayer unit, seal cavity, gas-carrier pipeline, transfer conduit and electricity
Sense coupled plasma source, described sprayer unit includes sample feeding pipe (1), auxiliary gas path (2) and spout (4), described spout
In being placed in described sealing cavity (6), described sealing cavity have connect the carrier gas input port of described gas-carrier pipeline, organic mass spectrometry is adopted
Sample interface (7) and inorganic mass spectrum Sampling Interface, liquid sample flows through described spout via sample feeding pipe, at electric field with from institute
Forming spraying under the effect of the secondary air stating auxiliary gas path and ionizing occurs, produced ion passes through described organic matter
Spectrum Sampling Interface (7) enters analyzed detection in mass spectrograph, and described carrier gas input port inputs carrier gas in described sealing cavity
(5), the sample spraying of residual in described annular seal space body is sent by inorganic mass spectrum Sampling Interface, and carries through transfer conduit (8)
In inductively-coupled plasma sources (9), there is atomization and ionizing, then carry out elemental composition by mass spectrograph or spectrogrph
Analyze.
2. mass spectrum sampling device as claimed in claim 1, it is characterised in that described auxiliary gas path includes joint and auxiliary gas
Pipe, described sample feeding pipe and auxiliary trachea form the pipeline that two-layer is concentric, the described sample feeding pipe conveying liquid sample of internal layer, outward
The described auxiliary trachea of layer is passed through auxiliary gas by described joint and is transported at described shower nozzle, it is preferable that described joint
Be closed for one end, the other end is tightly connected described auxiliary trachea, the three way cock of the 3rd end input auxiliary gas.
3. mass spectrum sampling device as claimed in claim 1, it is characterised in that described sample feeding pipe is metal or quartz capillary.
4. mass spectrum sampling device as claimed in claim 2, it is characterised in that described sample feeding pipe stretches out or do not stretches out described auxiliary
The outlet of air pipe, it is preferable that the outlet of described sample feeding pipe is-2～2mm with the distance of the outlet of described auxiliary trachea.
5. the mass spectrum sampling device as described in any one of Claims 1-4, it is characterised in that described auxiliary gas is nitrogen, sky
The mixing of several gases, preferably argon in gas, argon, helium or above-mentioned gas, it is preferable that the flow velocity of gas is 0～1L/
min。
6. the mass spectrum sampling device as described in any one of Claims 1-4, it is characterised in that described carrier gas is argon, gas circuit
The flow velocity of direction and air-flow is arranged to reach default sample transfer efficiency.
7. the mass spectrum sampling device as described in any one of Claims 1-4, it is characterised in that the material of described transfer conduit is
Glass, quartz or politef.
8. the mass spectrum sampling device as described in any one of Claims 1-4, it is characterised in that the gas in described transfer conduit
Flow velocity is at 1L/min.
9. the mass spectrum sampling device as described in any one of Claims 1-4, it is characterised in that the intracavity gas of described sealing cavity
Pressure is higher than the air pressure residing for described inductively-coupled plasma sources.
10. a Mass Spectrometer Method equipment, it is characterised in that include the mass spectrum sampling device as described in any one of claim 1 to 9
And with described mass spectrum sampling device with the use of organic mass spectrometer and inorganic mass spectrometer or spectrogrph.
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| CN201610541432.2A CN106198707A (en) | 2016-07-08 | 2016-07-08 | A kind of mass spectrum sampling device and Mass Spectrometer Method equipment |
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| CN110573865A (en) * | 2016-12-19 | 2019-12-13 | 珀金埃尔默健康科学加拿大股份有限公司 | Inorganic and organic spectroscopy systems and methods of use thereof |
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| CN113624565A (en) * | 2021-08-11 | 2021-11-09 | 中国电子产品可靠性与环境试验研究所（（工业和信息化部电子第五研究所）（中国赛宝实验室）） | Trace atmosphere sampling detection device and trace atmosphere sampling detection method |
| CN114910572A (en) * | 2021-02-10 | 2022-08-16 | 上海中化科技有限公司 | Sample introduction device and method, and quantitative analysis device and method |
| CN115219581A (en) * | 2022-08-26 | 2022-10-21 | 中验检测股份有限公司 | Intelligent mass spectrum detection device for ionized products |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103048378A (en) * | 2012-12-20 | 2013-04-17 | 上海华质生物技术有限公司 | Mass spectrum sampling and ionization device for direct extraction and ionization of sample, and method of device |
| CN103545166A (en) * | 2013-11-04 | 2014-01-29 | 清华大学深圳研究生院 | Portable electrospray ion source device and mass spectrometer |
| WO2015167586A1 (en) * | 2014-05-01 | 2015-11-05 | Perkinelmer Health Sciences, Inc. | Systems and methods for detection and quantification of selenium and silicon in samples |
-
2016
- 2016-07-08 CN CN201610541432.2A patent/CN106198707A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103048378A (en) * | 2012-12-20 | 2013-04-17 | 上海华质生物技术有限公司 | Mass spectrum sampling and ionization device for direct extraction and ionization of sample, and method of device |
| CN103545166A (en) * | 2013-11-04 | 2014-01-29 | 清华大学深圳研究生院 | Portable electrospray ion source device and mass spectrometer |
| WO2015167586A1 (en) * | 2014-05-01 | 2015-11-05 | Perkinelmer Health Sciences, Inc. | Systems and methods for detection and quantification of selenium and silicon in samples |
Non-Patent Citations (2)
| Title |
|---|
| FILIP CUYCKENS ET.AL: "Use of the bromine isotope ratio in HPLC-ICP-MS and HPLC-ESI-MS analysis of a new drug in development", 《ANAL BIOANAL CHEM》 * |
| 严秀平等: "联用技术应用于元素形态分析的新进展", 《光谱学与光谱分析》 * |
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