CN106189949A - A kind of pasty state Modify bone glue and preparation method - Google Patents
A kind of pasty state Modify bone glue and preparation method Download PDFInfo
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- CN106189949A CN106189949A CN201610544697.8A CN201610544697A CN106189949A CN 106189949 A CN106189949 A CN 106189949A CN 201610544697 A CN201610544697 A CN 201610544697A CN 106189949 A CN106189949 A CN 106189949A
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J151/00—Adhesives based on graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Adhesives based on derivatives of such polymers
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F289/00—Macromolecular compounds obtained by polymerising monomers on to macromolecular compounds not provided for in groups C08F251/00 - C08F287/00
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K13/00—Use of mixtures of ingredients not covered by one single of the preceding main groups, each of these compounds being essential
- C08K13/02—Organic and inorganic ingredients
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/30—Sulfur-, selenium- or tellurium-containing compounds
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/04—Oxygen-containing compounds
- C08K5/09—Carboxylic acids; Metal salts thereof; Anhydrides thereof
- C08K5/098—Metal salts of carboxylic acids
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/04—Oxygen-containing compounds
- C08K5/13—Phenols; Phenolates
- C08K5/134—Phenols containing ester groups
- C08K5/1345—Carboxylic esters of phenolcarboxylic acids
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/16—Nitrogen-containing compounds
- C08K5/21—Urea; Derivatives thereof, e.g. biuret
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J11/00—Features of adhesives not provided for in group C09J9/00, e.g. additives
- C09J11/02—Non-macromolecular additives
- C09J11/04—Non-macromolecular additives inorganic
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J11/00—Features of adhesives not provided for in group C09J9/00, e.g. additives
- C09J11/02—Non-macromolecular additives
- C09J11/06—Non-macromolecular additives organic
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/30—Sulfur-, selenium- or tellurium-containing compounds
- C08K2003/3045—Sulfates
- C08K2003/3081—Aluminum sulfate
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Abstract
The invention discloses a kind of pasty state Modify bone glue, including osseocolla, water, modifying agent, anticoagulant and preservative.A kind of pasty state Modify bone glue disclosed by the invention, series of problems existing when solving tradition osseocolla bottoming (solves tradition osseocolla and needs cold preservation and the difficult problem carried out in air-conditioned room when bottoming, it is not required to cold preservation, not be used in during confined air is transferred house and carry out, operator's brush gets up to compare and saves labour and bottoming is uniform), just can carry out brushing limit in the Factory Building that room temperature opens wide with pasty state Modify bone glue, the environment that such air more circulates be greatly lowered in air the unpleasant varnish taste of accumulation.
Description
Technical field
The present invention relates to osseocolla preparing technical field, particularly to a kind of pasty state Modify bone glue and preparation method.
Background technology
Osseocolla is a kind of natural protein-based adhesive, when playing cards bottoming, if osseocolla the most freezing gelation shape brush limit
Bottoming can make to cause during varnishing to ooze paint, makes adhesion between card, carries out so varnishing is arranged in air-conditioned room, but varnish taste
Road is the heaviest, is difficult to disperse in airtight air-conditioned room, and the healthy impact on operator is relatively big, and bone during workman's operation
Glue becomes the broken shape that freezes, and brushes comparison difficultly, and difficulty operates and uneven.
From technical standpoint analysis, osseocolla is the protein derivatives that collagen obtains through hydrolysis, belongs to albumin glue class, by multiple
Different a-amino acid compositions, structure belongs to aminoacid, there is peptide bond in molecule, has COOH and NH2 isoreactivity in strand
Group, this carries out the probability of protein restructuring with regard to demonstrating theoretically to it, and establishes for fractionation of dissociating, selectivity restructuring
Basis on molecular structure.
At present, the research to osseocolla is modified mainly has acidolysis, alkaline hydrolysis, enzymolysis, then it is carried out cross-linked graft, is used
Cross-linking agent be the preparation that epoxychloropropane, such as application number are respectively a 200510041728.X(environmental protection bone glue adhesive
Method), the preparation method of 200410073161(modified bone-glue adhesive) Chinese patent；Or cross-linking agent is glutaraldehyde (penta
The research of dialdehyde grafting, copolymerization and modification osseocolla binding agent, " China's adhesive " the 5th phase in 2010).These methods also exist cost
The shortcomings such as height, modifying agent itself is poisonous, reaction condition is difficult to control to so that it is be difficult to industrialization.
Summary of the invention
For solving the problems referred to above present in prior art and practical situation, the present invention provides a kind of pasty state Modify bone glue,
Including osseocolla, water, modifying agent, anticoagulant and preservative.
Preferably, described modifying agent includes highly basic, acrylic acid, initiator, monosaccharide, its each component be respectively as follows: osseocolla 15%～
20%；Water: 60%～80%；Highly basic: 0.5%～1.5%；Acrylic acid: 3%～7%；Initiator: 0.4%～0.7%；Monosaccharide: 1.5%～
4%；Anticoagulant: 1%～2%；Preservative: 0.2%～0.6%.
Preferably, described highly basic is NaOH, Ca (OH)2、 Ba(OH)2, one or more in KOH, CsOH；Described initiation
Agent is one or more in Ammonium persulfate., potassium peroxydisulfate, sodium peroxydisulfate；Described monosaccharide can be glucose, fructose, galactose,
One or more in ribose, deoxyribose；Described anticoagulant can be in ethylenediaminetetraacetic acid, Disodium oxalate., heparin, sodium citrate
One or more；Described preservative can be sodium benzoate, potassium sorbate, dehydroactic acid sodium, calcium propionate, sodium diacetate, lactic acid
One or more in sodium, propyl p-hydroxybenzoate.
Preferably, described modifying agent includes aluminum sulfate, and its each component is respectively as follows: osseocolla: 15%～23%；Water: 70%～80%；
Aluminum sulfate: 1%～3%；Anticoagulant: 1.5%～3%；Preservative: 0.2%～0.6%.
Preferably, described modifying agent includes hydrochloric acid, citric acid, its respectively component be respectively as follows: osseocolla: 15%～25%；Water:
65%～80%；Hydrochloric acid: 7%～14%；Citric acid: 0.04%～0.09%；Anticoagulant: 1%～3%；Preservative: 0.2%～0.6%.
Preferably, the one or many during described anticoagulant is carbamide, ethylenediaminetetraacetic acid, Disodium oxalate., heparin, sodium citrate
Kind；Described preservative is sodium benzoate, potassium sorbate, dehydroactic acid sodium, calcium propionate, sodium diacetate, sodium lactate, para hydroxybenzene first
One or more in propyl propionate.
Another aspect of the present invention, it is provided that a kind of pasty state Modify bone glue preparation method, comprises the steps:
(1), the water of the osseocolla certain mass of certain mass is dissolved；
(2), by the modifying agent of above-mentioned solution addition certain mass, a period of time is reacted；
(3), add anticoagulant and preservative stirs.
Preferably, the processing method of described step (1) specifically includes: entered by the water of the osseocolla certain mass of certain mass
Row dissolves, and its solution temperature is 20～30 DEG C, dissolution time 20～40 minutes, mixing speed 500 revs/min；Described step (2)
Processing method specifically includes: above-mentioned solution is warming up to 40～50 DEG C, is subsequently adding the highly basic of certain mass, reacts 20～40 points
Clock；Again solution is warming up to 75～80 DEG C, is subsequently adding the acrylic acid of certain mass, initiator and monosaccharide, insulation reaction one section
Time；The processing method of described step (3) specifically includes: after waiting that solution is cooled to room temperature, adds anticoagulant and preservative stirs
Mix uniformly.
Preferably, the processing method of described step (1) specifically includes: entered by the water of the osseocolla certain mass of certain mass
Row dissolves, and its solution temperature is 30～50 DEG C, dissolution time 20～40 minutes, mixing speed 500 revs/min；Described step (2)
Processing method specifically includes: the aluminum sulfate weighing certain mass adds in the above-mentioned solution dissolved, constant temperature stirring 20～40
Minute；The processing method of described step (3) specifically includes: weigh the anticoagulant of certain mass, adds it to above-mentioned gained
Glue in, continue stirring 10～30 minutes after be cooled to room temperature, the preservative being subsequently adding certain mass stirs.
Preferably, the processing method of described step (1) specifically includes: entered by the water of the osseocolla certain mass of certain mass
Row dissolves, and its solution temperature is 30～50 DEG C, dissolution time 20～40 minutes, mixing speed 500 revs/min；Described step (2)
Processing method specifically includes: above-mentioned solution is warming up to 50～70 DEG C, is subsequently adding the salt that concentration is 5mol/L of certain mass
Acid and concentration are 2 mol/L citric acids, are cooled to room temperature after reacting 50～70 minutes.
Beneficial effect:
A kind of pasty state Modify bone glue disclosed by the invention and preparation method, state issues when solving osseocolla bottoming and preparation thereof
Method, the method preparation technology is simple, low production cost, and pasty state Modify bone glue to have collapsibility good, nontoxic, pollution-free etc. excellent
Point, also has under room temperature in the pasty state, the feature such as good stability, meets the requirement of environment-friendly products, needs when can replace currently used
Freezing, the osseocolla of non-modified；On the other hand, pasty state Modify bone glue is existing when solving tradition osseocolla bottoming a series of asks
Topic (i.e. solve tradition osseocolla need cold preservation and the difficult problem carried out in air-conditioned room when bottoming, be not required to cold preservation, not be used in close
Closing in air-conditioned room and carry out, operator's brush gets up to compare and saves labour and bottoming is uniform), just can be at room temperature with pasty state Modify bone glue
Carrying out in the Factory Building opened wide brushing limit, the environment that such air more circulates is greatly lowered in air the unpleasant varnish of accumulation
Taste.
Detailed description of the invention
Technical solution of the present invention is described in detail below.
Embodiment of the invention discloses that a kind of pasty state Modify bone glue, including osseocolla, water, modifying agent, anticoagulant and anti-
Rotten agent.
Further, described modifying agent includes highly basic, acrylic acid, initiator, monosaccharide, and its each component is respectively as follows: osseocolla 15%
～20%；Water: 60%～80%；Highly basic: 0.5%～1.5%；Acrylic acid: 3%～7%；Initiator: 0.4%～0.7%；Monosaccharide: 1.5%～
4%；Anticoagulant: 1%～2%；Preservative: 0.2%～0.6%.
Further, described highly basic is NaOH, Ca (OH)2、 Ba(OH)2, one or more in KOH, CsOH；Described draw
Sending out agent is one or more in Ammonium persulfate., potassium peroxydisulfate, sodium peroxydisulfate；Described monosaccharide can be glucose, fructose, gala
One or more in sugar, ribose, deoxyribose；Described anticoagulant can be ethylenediaminetetraacetic acid, Disodium oxalate., heparin, citric acid
One or more in sodium；Described preservative can be sodium benzoate, potassium sorbate, dehydroactic acid sodium, calcium propionate, sodium diacetate,
One or more in sodium lactate, propyl p-hydroxybenzoate.
Further, described modifying agent includes aluminum sulfate, and its each component is respectively as follows: osseocolla: 15%～23%；Water: 70%～
80%；Aluminum sulfate: 1%～3%；Anticoagulant: 1.5%～3%；Preservative: 0.2%～0.6%.
Further, described modifying agent includes hydrochloric acid, citric acid, its respectively component be respectively as follows: osseocolla: 15%～25%；Water:
65%～80%；Hydrochloric acid: 7%～14%；Citric acid: 0.04%～0.09%；Anticoagulant: 1%～3%；Preservative: 0.2%～0.6%.
Further, one during described anticoagulant is carbamide, ethylenediaminetetraacetic acid, Disodium oxalate., heparin, sodium citrate or
Multiple；Described preservative is sodium benzoate, potassium sorbate, dehydroactic acid sodium, calcium propionate, sodium diacetate, sodium lactate, para hydroxybenzene
One or more in propyl formate.
Another aspect of the present invention, open a kind of pasty state Modify bone glue preparation method, comprise the steps:
(1), the water of the osseocolla certain mass of certain mass is dissolved；
(2), by the modifying agent of above-mentioned solution addition certain mass, a period of time is reacted；
(3), add anticoagulant and preservative stirs.
The present invention is with industry osseocolla as primary raw material, first that osseocolla is soluble in water, and the osseocolla of configuration certain mass mark is molten
Liquid；Alkali or acid with certain mass carry out alkaline hydrolysis or acidolysis again, then add monosaccharide or anticoagulant in the glue after degraded,
Stir, be finally cooled to room temperature and add the preservative of certain mass and stir i.e. available a kind of pasty state modification bone
Glue.
Further, the processing method of described step (1) specifically includes: by the water of the osseocolla certain mass of certain mass
Dissolving, its solution temperature is 20～30 DEG C, dissolution time 20～40 minutes, mixing speed 500 revs/min；Described step (2)
Processing method specifically include: above-mentioned solution is warming up to 40～50 DEG C, is subsequently adding the highly basic of certain mass, react 20～40
Minute；Again solution is warming up to 75～80 DEG C, is subsequently adding the acrylic acid of certain mass, initiator and monosaccharide, insulation reaction one
The section time；The processing method of described step (3) specifically includes: after waiting that solution is cooled to room temperature, add anticoagulant and preservative
Stir.
Embodiment one: (1) this reaction is carried out under water bath with thermostatic control.Weigh the osseocolla of certain mass and the water of certain mass,
Being poured into by water in there-necked flask, bath temperature is set as 30 DEG C, mixing speed is set as 500 revs/min, is existed by the osseocolla weighed up
Being slowly added in the case of stirring in there-necked flask, constant temperature stirs 30 minutes, is completely dissolved by osseocolla；(2) by above-mentioned solution
It is warming up to 50 DEG C, is subsequently adding the NaOH of certain mass, react 40 minutes；(3) above-mentioned solution is warming up to 80 DEG C, is subsequently adding
The acrylic acid of certain mass, initiator ammonium persulfate and monosaccharide, insulation reaction a period of time, after be cooled to room temperature, be subsequently adding
Anticoagulant and preservative stir, and i.e. obtain pasty state Modify bone glue.Its formula proportion is as follows: osseocolla: 15%；Water: 75%；
NaOH:1%；Acrylic acid: 5%；Ammonium persulfate.: 0.6%；Monosaccharide: 2%；Ethylenediaminetetraacetic acid: 1.2%；Sodium benzoate: 0.2%.
Further, the processing method of described step (1) specifically includes: by the water of the osseocolla certain mass of certain mass
Dissolving, its solution temperature is 30～50 DEG C, dissolution time 20～40 minutes, mixing speed 500 revs/min；Described step (2)
Processing method specifically include: the aluminum sulfate weighing certain mass adds in the above-mentioned solution dissolved, constant temperature stir 20～
40 minutes；The processing method of described step (3) specifically includes: weigh the anticoagulant of certain mass, adds it to above-mentioned gained
Glue in, continue stirring 10～30 minutes after be cooled to room temperature, the preservative being subsequently adding certain mass stirs.
Embodiment two: (1) this reaction is carried out under water bath with thermostatic control.Weigh the osseocolla of certain mass and the water of certain mass,
Being poured into by water in there-necked flask, bath temperature is set as 30 DEG C, mixing speed is set as 500 revs/min, is existed by the osseocolla weighed up
Being slowly added in the case of stirring in there-necked flask, constant temperature stirs 40 minutes, is completely dissolved by osseocolla；(2) certain matter is weighed
The aluminum sulfate of amount adds in the above-mentioned solution dissolved, and constant temperature stirs 30 minutes；(3) carbamide of certain mass is weighed, by it
Join above-mentioned gained glue in, continue stirring 30 minutes, after be cooled to room temperature, be subsequently adding the preservative of certain mass
Stir, i.e. obtain pasty state Modify bone glue.Its formula proportion is as follows: osseocolla: 20%；Water: 75%；Aluminum sulfate: 2.1%；Carbamide:
2.5%；Sodium diacetate: 0.4%.
Further, the processing method of described step (1) specifically includes: by the water of the osseocolla certain mass of certain mass
Dissolving, its solution temperature is 30～50 DEG C, dissolution time 20～40 minutes, mixing speed 500 revs/min；Described step (2)
Processing method specifically include: above-mentioned solution is warming up to 50～70 DEG C, and the concentration being subsequently adding certain mass is 5mol/L's
Hydrochloric acid and concentration are 2 mol/L citric acids, are cooled to room temperature after reacting 50～70 minutes.
Embodiment three: (1) this reaction is carried out under water bath with thermostatic control.Weigh the osseocolla of certain mass and the water of certain mass,
Being poured into by water in there-necked flask, bath temperature is set as 40 DEG C, mixing speed is set as 500 revs/min, is existed by the osseocolla weighed up
Being slowly added in the case of stirring in there-necked flask, constant temperature stirs 30 minutes, is completely dissolved by osseocolla；(2) by above-mentioned solution
Be warming up to 70 DEG C, be subsequently adding hydrochloric acid (5mol/L) and the citric acid (2mol/L) of certain mass, react 60 minutes, after be cooled to
Room temperature, the anticoagulant and the preservative that are subsequently adding certain mass stir, and i.e. obtain pasty state Modify bone glue.Its formula proportion is such as
Under: osseocolla: 25%；Water: 65%；Hydrochloric acid: 7.33%；Citric acid: 0.07%；Heparin: 2%；Potassium sorbate: 0.6%.
A kind of pasty state Modify bone glue disclosed by the invention and preparation method, state issues when solving osseocolla bottoming and
Preparation method, the method preparation technology is simple, low production cost, and pasty state Modify bone glue has collapsibility good, nontoxic, pollution-free
Etc. advantage, also have under room temperature in the pasty state, the feature such as good stability, meet the requirement of environment-friendly products, can replace currently used
Time need the osseocolla of freezing, non-modified；On the other hand, when pasty state Modify bone glue solves tradition osseocolla bottoming, existing one is
Row problem (i.e. solve tradition osseocolla need cold preservation and the difficult problem carried out in air-conditioned room when bottoming, be not required to cold preservation, need not
Carrying out in confined air is transferred house, operator's brush gets up to compare and saves labour and bottoming is uniform), just can be with pasty state Modify bone glue
Carrying out in the Factory Building that room temperature opens wide brushing limit, the environment that such air more circulates is greatly lowered in air the unpleasant of accumulation
Varnish taste.
Finally it is noted that the foregoing is only the preferred embodiments of the present invention, it is not limited to the present invention,
Although being described in detail the present invention with reference to previous embodiment, for a person skilled in the art, it still may be used
So that the technical scheme described in foregoing embodiments to be modified, or wherein portion of techniques feature is carried out equivalent.
All within the spirit and principles in the present invention, any modification, equivalent substitution and improvement etc. made, should be included in the present invention's
Within protection domain.
Claims (10)
1. a pasty state Modify bone glue, it is characterised in that include osseocolla, water, modifying agent, anticoagulant and preservative.
A kind of pasty state Modify bone glue the most according to claim 1, it is characterised in that described modifying agent includes highly basic, propylene
Acid, initiator, monosaccharide, its each component is respectively as follows: osseocolla 15%～20%；Water: 60%～80%；Highly basic: 0.5%～1.5%；Propylene
Acid: 3%～7%；Initiator: 0.4%～0.7%；Monosaccharide: 1.5%～4%；Anticoagulant: 1%～2%；Preservative: 0.2%～0.6%.
A kind of pasty state Modify bone glue the most according to claim 2, it is characterised in that described highly basic is NaOH, Ca (OH)2、
Ba(OH)2, one or more in KOH, CsOH；Described initiator is the one in Ammonium persulfate., potassium peroxydisulfate, sodium peroxydisulfate
Or it is multiple；Described monosaccharide can be one or more in glucose, fructose, galactose, ribose, deoxyribose；Described anticoagulant
Can be one or more in ethylenediaminetetraacetic acid, Disodium oxalate., heparin, sodium citrate；Described preservative can be sodium benzoate, mountain
One or more in potassium sorbate, dehydroactic acid sodium, calcium propionate, sodium diacetate, sodium lactate, propyl p-hydroxybenzoate.
A kind of pasty state Modify bone glue the most according to claim 1, it is characterised in that described modifying agent includes aluminum sulfate, its
Each component is respectively as follows: osseocolla: 15%～23%；Water: 70%～80%；Aluminum sulfate: 1%～3%；Anticoagulant: 1.5%～3%；Preservative:
0.2%～0.6%.
A kind of pasty state Modify bone glue the most according to claim 1, it is characterised in that described modifying agent includes hydrochloric acid, Fructus Citri Limoniae
Acid, its respectively component be respectively as follows: osseocolla: 15%～25%；Water: 65%～80%；Hydrochloric acid: 7%～14%；Citric acid: 0.04%～
0.09%；Anticoagulant: 1%～3%；Preservative: 0.2%～0.6%.
6. according to a kind of pasty state Modify bone glue described in claim 4 or 5, it is characterised in that described anticoagulant is carbamide, second two
One or more in amine tetraacethyl, Disodium oxalate., heparin, sodium citrate；Described preservative is sodium benzoate, potassium sorbate, takes off
One or more in hydroacetic acid sodium, calcium propionate, sodium diacetate, sodium lactate, propyl p-hydroxybenzoate.
7. a pasty state Modify bone glue preparation method, it is characterised in that comprise the steps:
(1), the water of the osseocolla certain mass of certain mass is dissolved；
(2), by the modifying agent of above-mentioned solution addition certain mass, a period of time is reacted；
(3), add anticoagulant and preservative stirs.
A kind of pasty state Modify bone glue preparation method the most according to claim 7, it is characterised in that the place of described step (1)
Reason method specifically includes: dissolved by the water of the osseocolla certain mass of certain mass, and its solution temperature is 20～30 DEG C, molten
Solution time 20～40 minutes, mixing speed 500 revs/min；The processing method of described step (2) specifically includes: by above-mentioned solution liter
Temperature, to 40～50 DEG C, is subsequently adding the highly basic of certain mass, reacts 20～40 minutes；Again solution is warming up to 75～80 DEG C, so
Acrylic acid, initiator and the monosaccharide of rear addition certain mass, insulation reaction a period of time；The processing method tool of described step (3)
Body includes: after waiting that solution is cooled to room temperature, adds anticoagulant and preservative stirs.
A kind of pasty state Modify bone glue preparation method the most according to claim 7, it is characterised in that the place of described step (1)
Reason method specifically includes: dissolved by the water of the osseocolla certain mass of certain mass, and its solution temperature is 30～50 DEG C, molten
Solution time 20～40 minutes, mixing speed 500 revs/min；The processing method of described step (2) specifically includes: weigh certain mass
Aluminum sulfate add in the above-mentioned solution dissolved, constant temperature stirring 20～40 minutes；The processing method of described step (3) is concrete
Including: weigh the anticoagulant of certain mass, add it to above-mentioned gained glue in, continue stirring 10～30 minutes after cold
But to room temperature, the preservative being subsequently adding certain mass stirs.
A kind of pasty state Modify bone glue preparation method the most according to claim 7, it is characterised in that the place of described step (1)
Reason method specifically includes: dissolved by the water of the osseocolla certain mass of certain mass, and its solution temperature is 30～50 DEG C, molten
Solution time 20～40 minutes, mixing speed 500 revs/min；The processing method of described step (2) specifically includes: by above-mentioned solution liter
Temperature is to 50～70 DEG C, and the hydrochloric acid that concentration is 5mol/L and the concentration that are subsequently adding certain mass are 2 mol/L citric acids, reacts 50
～it is cooled to room temperature after 70 minutes.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610544697.8A CN106189949A (en) | 2016-07-12 | 2016-07-12 | A kind of pasty state Modify bone glue and preparation method |
Applications Claiming Priority (1)
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| CN102627944A (en) * | 2012-04-12 | 2012-08-08 | 陕西科技大学 | Modified bone glue adhesive and preparation method thereof |
| CN104610908A (en) * | 2015-01-16 | 2015-05-13 | 陕西科技大学 | Liquid bone glue adhesive modification method |
| CN105462539A (en) * | 2015-12-01 | 2016-04-06 | 陕西科技大学 | Preparation method of bone glue adhesive |
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| CN102627944A (en) * | 2012-04-12 | 2012-08-08 | 陕西科技大学 | Modified bone glue adhesive and preparation method thereof |
| CN104610908A (en) * | 2015-01-16 | 2015-05-13 | 陕西科技大学 | Liquid bone glue adhesive modification method |
| CN105462539A (en) * | 2015-12-01 | 2016-04-06 | 陕西科技大学 | Preparation method of bone glue adhesive |
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Application publication date: 20161207 |