CN106179147B - A kind of selecting reactor and its corresponding selection linker - Google Patents
A kind of selecting reactor and its corresponding selection linker Download PDFInfo
- Publication number
- CN106179147B CN106179147B CN201610504685.2A CN201610504685A CN106179147B CN 106179147 B CN106179147 B CN 106179147B CN 201610504685 A CN201610504685 A CN 201610504685A CN 106179147 B CN106179147 B CN 106179147B
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- chamber
- reaction
- selection
- linker
- hole
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
- B01J19/087—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing electric or magnetic energy
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/24—Stationary reactors without moving elements inside
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/28—Moving reactors, e.g. rotary drums
Abstract
The present invention provides a kind of selecting reactor and its corresponding selection linker.One kind selection linker includes：Circular chamber, annulus chamber；Annulus chamber coaxial sleeve is arranged in circular chamber, the circular chamber side adjacent with annulus chamber is designed with first kind through hole, annulus chamber rotates against with circular chamber and forms first kind occasional passage, first kind occasional passage connected ring belt chamber and circular chamber by first kind through hole.A kind of stacked selection linker, including at least two select linker to be distributed along the axial direction of Pivot axle.A kind of selecting reactor, includes the selection linker of power supplying apparatus sum；Question response material is provided with selection linker, power supplying apparatus provide power for question response material.A kind of selecting reactor, including power supplying apparatus and stacked selection linker；Question response material is provided with stacked selection linker, power supplying apparatus provide power for question response material.
Description
Technical field
The present invention relates to biochemical to detect instrument field, and in particular, to a kind of selecting reactor and its correspondence
Selection linker.
Background technology
Multistep is carried out to sample due to needing in the biochemical detection fields such as immunoassay detection, detection of nucleic acids
Chemical reaction could be obtained finally using a variety of modes of operation, it is necessary to use different experiment apparatuses and biology/chemical substance
Testing result.Whole detection process is uninteresting and cumbersome.
For example, using blood sample carry out immunoassay detection when, using blood sample carry out analysis detection before, it is necessary to
Blood sample is carried out to the separation of serum and hemoglobin, routine techniques is to store blood sample reagent separate cold storage, is used
When will refrigerate reagent using the equipment such as pipettor of specialty by professional and suction out, then blood sample is carried out by manual operation
The separation of serum and hemoglobin, then the serum sample separated is injected into cuvette to be detected and cuvette in
Dilution mixed, finally by its situation of change of optical system detection and measure its content or component again, it is this in advance
By manually carry out separation serum method it is cumbersome, easily sample is polluted.Another serum and dilution using separator well
Liquid carries out the whole process of hybrid detection, and traditional method is that filling reagent and collecting sample are needed using pipettor, pipette
Etc. equipment.The liquid shifting equipment of two or more is generally required during detection to complete detection process, there are during preparation cost
Between long, cumbersome, not readily portable, easy pollution and error the shortcomings of.
It is, therefore, desirable to provide it is a kind of it is new be directed to the selection linker that reaction is selected in Biochemistry Experiment, simplify anti-
It should operate, improve work efficiency.
The content of the invention
For in the prior art the defects of, the object of the present invention is to provide a kind of selecting reactor and its it is corresponding selection connect
Logical device.
A kind of selection linker provided according to the present invention, including：Circular chamber, annulus chamber；
The annulus chamber coaxial sleeve is arranged in the circular chamber, the circular chamber side adjacent with annulus chamber
First kind through hole is designed with, the annulus chamber rotates against with circular chamber and forms the first kind by the first kind through hole and face
Shi Tongdao, the first kind occasional passage connect the annulus chamber and circular chamber.
As a kind of prioritization scheme, at least two reaction ring is radially distributed with the annulus chamber；
The first kind through hole is arranged on the reaction ring of the circular chamber；
The reaction ring is also radially provided with the second class through hole, and adjacent two reaction rings are rotated against by the second class through hole
Form the second class occasional passage, the second class occasional passage connection two adjacent reaction rings.
As a kind of prioritization scheme, at least one demarcation strip is radially equipped with the reaction ring, the demarcation strip is in week
The reaction ring is separated into several reaction lattice upwards, the reaction lattice are equipped with the first kind through hole and/or the second class is led to
Hole.
As a kind of prioritization scheme, adjacent ring wall is all vertically in gradually-reducing shape close to pivot between the reaction ring
The increase or reduction in gap between adjacent reaction ring are realized in axis, the axially opposed movement of reaction ring.
As a kind of prioritization scheme, at least one demarcation strip is radially equipped with the annulus chamber, the demarcation strip exists
The annulus chamber is separated into several reaction lattice on circumferential, the reaction lattice are equipped with the first kind through hole.
As a kind of prioritization scheme, the circular chamber includes the mutually isolated sub-chamber of at least two, and the sub-chamber sets
There is the first kind through hole.
As a kind of prioritization scheme, the circular chamber, annulus chamber radial end face on be designed with end face opening, it is described
End face opening is all detachably provided with filling capping or filling plug.
Based on same design, the present invention also provides a kind of stacked selection linker, including the selection linker, extremely
Few 2 selection linkers are distributed along the axial direction of Pivot axle.
Based on same design, the present invention also provides a kind of selecting reactor, including power supplying apparatus and the selection
Linker；Question response material is provided with the selection linker, the power supplying apparatus provide for the question response material
Power.
As a kind of prioritization scheme, the power supplying apparatus include centrifugal rotation device or field generator for magnetic or temperature
Spend controller or electric field control device.
Based on same design, the present invention also provides a kind of selecting reactor, including power supplying apparatus and the stacking
Formula selects linker；Question response material is provided with the stacked selection linker, the power supplying apparatus are treated to be described
Reactive material provides power.
As a kind of prioritization scheme, the power supplying apparatus include centrifugal rotation device or field generator for magnetic or temperature
Spend controller or electric field control device.
Compared with prior art, the present invention has following beneficial effect：
The selecting reactor of the present invention automatically can connect selection by providing the field of force or magnetic field or temperature field or electric field
Sample in device carries out traffic organising, is optionally reacted with the reactive material in annulus chamber, and can in annulus chamber
To store a variety of reactive materials, so as to fulfill carrying out or selecting to carry out while a variety of reactions.Present invention substantially reduces artificial
Labour, has saved the manual operation in biology/chemical experiment or production, and sample will not receive pollution.Institute in the present invention
Having reaction is completed in linker is selected, and external environment will not be polluted, each reaction project will not mutual shadow
Ring.Multiple reaction projects are carried out at the same time the efficiency for improving whole detection work, the function of batch detection are realized, than single sample
This detection substantially reduces the substance-measuring time.
Brief description of the drawings
In order to illustrate the technical solution of the embodiments of the present invention more clearly, required use in being described below to embodiment
Attached drawing be briefly described, it is therefore apparent that drawings in the following description are only some embodiments of the present invention, for ability
For field technique personnel, without creative efforts, other attached drawings can also be obtained according to these attached drawings.It is attached
In figure：
Fig. 1 is a kind of optional schematic diagram for selecting linker with 1 multiple reaction lattice of reaction ring；
Fig. 2 is a kind of optional schematic diagram for selecting linker with 2 multiple reaction lattice of reaction ring；
Fig. 3 is a kind of schematic diagram of optional stacked selection linker.
In figure, 1- circular chamber, 2- annulus chambers, 21- reaction lattice, 22- demarcation strips, 23- reaction rings, the 3- first kind leads to
Hole, 4- the second class through holes.
Embodiment
Below in conjunction with attached drawing, the present invention is described in detail in a manner of specific embodiment.Following embodiments will be helpful to
Those skilled in the art further understands the present invention, but the invention is not limited in any way.It should be pointed out that can be with
Using other embodiments, or modification structurally and functionally is carried out to embodiment enumerated herein, without departing from this hair
Bright scope and spirit.
In a kind of embodiment of selection linker provided by the invention, as shown in Figs. 1-3, including：Circular chamber 1, ring
Belt chamber 2；
2 coaxial sleeve of annulus chamber is arranged in the circular chamber 1, and the circular chamber 1 is adjacent with annulus chamber 2
Side is designed with first kind through hole 3, and the annulus chamber 2 is rotated against with circular chamber 1 and formed by the first kind through hole 3
First kind occasional passage, the first kind occasional passage connect the annulus chamber 2 and circular chamber 1.
Circular chamber 1,2 adjacent wall of annulus chamber are realized by rotating against between circular chamber 1, annulus chamber 2
On 3 relative position of first kind through hole change.First kind through hole 3 on circular chamber 1,2 adjacent wall of annulus chamber
When dividing or all overlapping, two first kind through holes 3 connect, and are that described first is formd between circular chamber 1, annulus chamber 2
Class occasional passage.Circular chamber 1, annulus chamber 2 are connected by the first kind occasional passage, and treating in circular chamber 1 is anti-
Thing is answered to enter annulus chamber through the first kind occasional passage under the action of centrifugal force field or electric field or magnetic field or temperature field
Material in 2, with annulus chamber 2 is reacted, and realizes material detection reaction.
As a kind of embodiment of annulus chamber 2, as shown in Fig. 2, at least two is radially distributed with the annulus chamber 2
React ring 23；
The first kind through hole 3 is arranged on the reaction ring 23 of the circular chamber 1；
The reaction ring 23 is also radially provided with the second class through hole 4, and adjacent two reaction rings 23 are rotated against by described second
Class through hole 4 forms the second class occasional passage, the second class occasional passage connection two adjacent reaction rings 23.
In the embodiment, the question response material in circular chamber 1 is introduced into the reaction ring 23 by center, with material therein
First step reaction is carried out, then next reaction ring 23 is entered to react material in ring 23 with second by the second class occasional passage
Reacted, realize that second step reacts.Needed to select the quantity of reaction ring 23 according to experiment, control question response material sequentially enters
Reacted in the reaction ring 23, finally realize that stepwise reaction obtains testing result.
As a kind of embodiment of reaction ring 23, as shown in Fig. 2, being radially equipped with least one point in the reaction ring 23
The reaction ring 23 is separated into several reaction lattice 21 by partition plate 22, the demarcation strip 22 in the circumferential, and the reaction lattice 21 are set
There is the 3 and/or second class through hole 4 of first kind through hole.
As a kind of reaction 23 embodiment of ring, adjacent ring wall is all close in gradually-reducing shape vertically between the reaction ring 23
The increase or reduction in gap between adjacent reaction ring 23 are realized in Pivot axle, the axially opposed movement of reaction ring 23.
Ring 23 is reacted in the present embodiment and is arranged to gradually-reducing shape side wall construction, rings 23 can be reacted along Pivot axle by two
Relative movement back and forth, change two reaction rings 23 between relative gap.When needing to relatively rotate, increase relative gap；When
When needing to close the second class through hole 4 or form the second stable class passage, reduce relative gap.
As a kind of embodiment of reaction ring 23, as shown in Figure 1, being radially equipped with the annulus chamber 2 at least one
The annulus chamber 2 is separated into several reaction lattice 21, the reaction lattice 21 by demarcation strip 22, the demarcation strip 22 in the circumferential
Equipped with the first kind through hole 3.
Above-described embodiment middle ring belt chamber 2 has multiple reaction lattice 21, and circular chamber 1 can have the first kind to lead to
Hole 3, and annulus chamber 2 only has a reaction ring 23, there is 3 reaction lattice 21 in the reaction ring 23, each lattice 21 that react are by circle
The side wall of shape chamber 1 is equipped with a first kind through hole 3.By taking centrifugal force field as an example, the question response thing in circular chamber 1 is centrifuging
Outwards dissipate movement from center under power effect, reacted respectively with three when circular chamber 1 rotates against with annulus chamber 2 lattice 21 it
Between form the first kind occasional passage, the question response thing in circular chamber 1 is respectively enterd in 3 reaction lattice 21, with reacting lattice
Material in 21 is reacted.Another embodiment can also be disposed on the question response material work on the scene in annulus chamber 2
To central motion under firmly, hence into the circular chamber 1, so different things can be set in different reaction lattice 21
Matter, reactive material is also equipped with hybrid reaction, or circular chamber 1 after entering circular chamber 1 and participates in reaction.
The present embodiment middle ring belt chamber 2 has multiple reaction lattice 21, and circular chamber 1 can also have multiple first kind to lead to
Hole 3, such as 3, annulus chamber 2 only have 1 or 2 reaction ring 23, and each react has 3 reaction lattice 21 in ring 23, with circle
The adjacent reaction lattice 21 of chamber 1 are equipped with first kind through hole 3 against the side wall of circular chamber 1.If thering are 2 to change a reaction ring 23,
The second class through hole 4 is respectively correspondingly provided with the adjacent side wall of two reaction rings 23.The each reaction lattice 21 reacted in ring 23 are at least right
Answer a second class through hole 4.If thering are 2 to change a reaction ring 23, first kind occasional passage is first only formed, treating in circular chamber 1 is anti-
Answer under thing active force on the scene while be carried out at the same time reaction respectively into the reaction lattice 21 in the reaction ring 23 of inner ring.Then at two
The second class occasional passage is formed between reaction ring 23, the product reacted in ring 23 of inner ring enters the reaction lattice of outer ring reaction ring 23
The second secondary response is carried out in 21.It is achieved in needing the detection work of two-step reaction.
As a kind of embodiment of circular chamber 1, the circular chamber 1 includes the mutually isolated sub-chamber of at least two, institute
State sub-chamber and be equipped with the first kind through hole 3.Circular chamber 1 arranged on center is divided into multiple sub-chamber, every sub- chamber
A part of circumference is all occupied in room, and is contacted by this part-circular periphery with exterior annulus chamber 2, the circumference shared by each sub-chamber
Part is just equipped with the first kind through hole 3.The sub-chamber can be the sector of irregular shape or standard.As
A kind of embodiment, the sub-chamber are the sector of standard, and three sub-chamber form the circular chamber 1, the fan of each sub-chamber
Shape central angle is 120 degree.
As a kind of embodiment, the circular chamber 1, annulus chamber 2 radial end face on be designed with end face opening, it is described
End face opening is all detachably provided with filling capping or filling plug.Can be to circle by opening the filling capping or filling plug
Shape chamber 1 adds question response thing, and such as blood sample, sample of nucleic acid, and filling capping or filling plug are avoided that in reaction process
Pollution environment or reactive material are polluted by exterior materials, play good buffer action.
Based on same design, the present invention also provides a kind of stacked selection linker, as shown in figure 3, including the choosing
Linker is selected, selects linker to be distributed along the axial direction of Pivot axle described at least two.The present embodiment is to connect above-mentioned selection
Device is stacked vertically, it is possible thereby to realize batch reaction and extent of reaction is uniformly controlled.
Based on same design, the present invention also provides a kind of selecting reactor, including power supplying apparatus and the selection
Linker；Question response material is provided with the selection linker, the power supplying apparatus provide for the question response material
Power.
As a kind of prioritization scheme, the power supplying apparatus include centrifugal rotation device or field generator for magnetic or temperature
Spend controller or electric field control device.
Based on same design, the present invention also provides a kind of selecting reactor, including power supplying apparatus and the stacking
Formula selects linker；Question response material is provided with the stacked selection linker, the power supplying apparatus are treated to be described
Reactive material provides power.
As a kind of prioritization scheme, the power supplying apparatus include centrifugal rotation device or field generator for magnetic or temperature
Spend controller or electric field control device.
The reactive material that centrifugal rotation device is circular chamber 1, is placed in annulus chamber 2 provides centrifugal force field so that anti-
Material is answered to be moved from circular chamber 1 to annulus chamber 2.
The reactive material that field generator for magnetic is circular chamber 1, is placed in annulus chamber 2 provides field of magnetic forece, works as circular cavity
, can be by magnetic field controlled motion direction, field generator for magnetic when the reactive material placed in room 1, annulus chamber 2 is magnetisable material
So that reactive material is moved from circular chamber 1 to annulus chamber 2.
The reactive material that temperature controller is circular chamber 1, is placed in annulus chamber 2 provides temperature field, works as circular chamber
1st, when the reactive material placed in annulus chamber 2 can be by the Temperature Field Control direction of motion, field generator for magnetic causes reactant
Matter is moved from circular chamber 1 to annulus chamber 2.
The reactive material that electric field control device is circular chamber 1, is placed in annulus chamber 2 provides electric field, works as circular chamber
1st, when the reactive material placed in annulus chamber 2 can be by the electric field controls direction of motion, field generator for magnetic causes reactive material
Moved from circular chamber 1 to annulus chamber 2.
The selecting reactor of the present invention automatically can connect selection by providing the field of force or magnetic field or temperature field or electric field
Sample in device carries out traffic organising, is optionally reacted with the reactive material in annulus chamber 2, and in annulus chamber 2
A variety of reactive materials can be stored, so as to fulfill carrying out or selecting to carry out while a variety of reactions.Present invention substantially reduces people
Work labour, has saved the manual operation in biology/chemical experiment or production, and sample will not receive pollution.In the present invention
All reactions are completed in linker is selected, and external environment will not be polluted, each reaction project will not be mutual
Influence.Multiple reaction projects are carried out at the same time the efficiency for improving whole detection work, the function of batch detection are realized, than single
Pattern detection substantially reduces the substance-measuring time.
The foregoing is merely presently preferred embodiments of the present invention, those skilled in the art know, are not departing from the essence of the present invention
In the case of refreshing and scope, various changes or equivalent substitution can be carried out to these features and embodiment.In addition, the present invention's
Under teaching, it can modify to these features and embodiment to adapt to particular situation and material without departing from the present invention's
Spirit and scope.Therefore, the present invention is not limited to the particular embodiment disclosed, and the right for falling with the application will
Embodiment in the range of asking belongs to protection scope of the present invention.
Claims (12)
1. one kind selection linker, it is characterised in that including：Circular chamber, annulus chamber；
The annulus chamber coaxial sleeve is arranged in the circular chamber, and the circular chamber side adjacent with annulus chamber is all set
There is first kind through hole, the annulus chamber rotates against with circular chamber and forms the first kind by the first kind through hole and lead to temporarily
Road, the first kind occasional passage connect the annulus chamber and circular chamber.
A kind of 2. selection linker according to claim 1, it is characterised in that the annulus chamber be radially distributed with to
Few 2 reactions ring；
The first kind through hole is arranged on the reaction ring of the circular chamber；
The reaction ring is also radially provided with the second class through hole, and adjacent two reaction rings are rotated against to be formed by the second class through hole
Second class occasional passage, the second class occasional passage connection two adjacent reaction rings.
3. a kind of selection linker according to claim 2, it is characterised in that be radially equipped with least in the reaction ring
The reaction ring is separated into several reaction lattice by one demarcation strip, the demarcation strip in the circumferential, and the reaction lattice are equipped with institute
State first kind through hole and/or the second class through hole.
4. a kind of selection linker according to claim 2, it is characterised in that adjacent ring wall is all between the reaction ring
Vertically in gradually-reducing shape close to Pivot axle, gap between adjacent reaction ring is realized in the axially opposed movement of reaction ring
Increase reduces.
5. a kind of selection linker according to claim 1, it is characterised in that be radially equipped with extremely in the annulus chamber
The annulus chamber is separated into several reaction lattice by a few demarcation strip, the demarcation strip in the circumferential, and the reaction lattice are set
There is the first kind through hole.
6. a kind of selection linker according to claim 1, it is characterised in that the circular chamber includes at least two phase
The sub-chamber mutually isolated, the sub-chamber are equipped with the first kind through hole.
7. a kind of selection linker according to claim 1, it is characterised in that the circular chamber, the footpath of annulus chamber
End face opening is designed with to end face, the end face opening is all detachably provided with filling capping or filling plug.
8. a kind of stacked selection linker, it is characterised in that including any selection linkers of claim 1-7, extremely
Few 2 selection linkers are distributed along the axial direction of Pivot axle.
9. a kind of selecting reactor, it is characterised in that connect including any selection of power supplying apparatus and claim 1-7
Logical device；Question response material is provided with the selection linker, the power supplying apparatus provide dynamic for the question response material
Power.
10. a kind of selecting reactor according to claim 9, it is characterised in that the power supplying apparatus include centrifugation
Rotating device or field generator for magnetic or temperature controller or electric field control device.
A kind of 11. selecting reactor, it is characterised in that the stacked selection described in including power supplying apparatus and claim 8
Linker；Question response material is provided with the stacked selection linker, the power supplying apparatus are the question response thing
Matter provides power.
12. a kind of selecting reactor according to claim 11, it is characterised in that the power supplying apparatus include centrifugation
Rotating device or field generator for magnetic or temperature controller or electric field control device.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201610504685.2A CN106179147B (en) | 2016-06-30 | 2016-06-30 | A kind of selecting reactor and its corresponding selection linker |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610504685.2A CN106179147B (en) | 2016-06-30 | 2016-06-30 | A kind of selecting reactor and its corresponding selection linker |
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| Publication Number | Publication Date |
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| CN106179147A CN106179147A (en) | 2016-12-07 |
| CN106179147B true CN106179147B (en) | 2018-04-17 |
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| CN201610504685.2A Active CN106179147B (en) | 2016-06-30 | 2016-06-30 | A kind of selecting reactor and its corresponding selection linker |
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| CN107638864B (en) * | 2017-10-10 | 2019-07-02 | 江苏华兴压力容器有限公司 | A kind of temp.-regulating type chemical reaction device |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7981378B2 (en) * | 2005-08-22 | 2011-07-19 | Kikuo Tamura | Water activation piece for use in flow passage, arrangement structure of the water activation piece, and water activation device using the water activation piece and the arrangement structure |
| CN205914134U (en) * | 2016-06-30 | 2017-02-01 | 朱汉敏 | Choice reaction ware and selection linker that corresponds thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012091358A (en) * | 2010-10-26 | 2012-05-17 | Sumitomo Chemical Co Ltd | Extrusion molding machine, and method for manufacturing molded object using the same |
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2016
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7981378B2 (en) * | 2005-08-22 | 2011-07-19 | Kikuo Tamura | Water activation piece for use in flow passage, arrangement structure of the water activation piece, and water activation device using the water activation piece and the arrangement structure |
| CN205914134U (en) * | 2016-06-30 | 2017-02-01 | 朱汉敏 | Choice reaction ware and selection linker that corresponds thereof |
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| CN106179147A (en) | 2016-12-07 |
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