CN106178638A - Filter - Google Patents
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- CN106178638A CN106178638A CN201510237362.7A CN201510237362A CN106178638A CN 106178638 A CN106178638 A CN 106178638A CN 201510237362 A CN201510237362 A CN 201510237362A CN 106178638 A CN106178638 A CN 106178638A
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Abstract
The present invention provides a kind of filter, there is the filtering material of lamellar, filtering material is housed in the container of the outlet being provided with the entrance of blood and blood, to be divided into the space of entrance side and the space of outlet side in container and be used for the leukocyte removing in blood, filtering material is formed by the non-woven fabrics laminated multi-layer of comprise the 1st, the 2nd and the 3rd different non-woven fabrics of average fiber footpath more than 3 kinds；1st～the 3rd non-woven fabrics according to the 1st, the 2nd, the order of the 3rd non-woven fabrics arranges towards outlet side from entrance side；Average fiber footpath according to the 1st, the 2nd, the order of the 3rd non-woven fabrics diminish, respectively 6 μm～30 μm, 3 μm～7 μm, 1 μm～4 μm；Having on the surface of the fiber of at least one non-woven fabrics in 1st～the 3rd non-woven fabrics containing nonionic hydrophilic group and the polymer covering of alkalescence nitrogen-containing functional group, the content of the basic nitrogen atom of above-mentioned cover layer is 0.2～8.0 weight %.Thus improve the wettability for blood.
Description
Technical field
The present invention relates to the filter for removing the leukocyte in blood.
Background technology
Generally, it is little that the whole blood taked from blood donor is separated into red cell preparation, blood
The blood component preparations such as plate preparation, blood plasma preparation are also stored, and are used for afterwards transfusing blood.Separately
Outward, small condensation product contained by these Blood Preparationses, leukocyte be cause various respectively
Therefore these undesirable constituentss, are removed before blood transfusion by the reason of the transfusion adverse effects of sample,
The situation carrying out the most again transfusing blood increases.In recent years, leukocyte is particularly removed
Necessity extensively recognized, will all of blood transfusion Blood Preparations be implemented white thin
The country of born of the same parents are used further to blood transfusion situation legalization after removing process increases.Make
For the method removing leukocyte for autoblood preparation, method most commonly is with white thin
Blood Preparations is processed by the filter that born of the same parents remove.Remove as leukocyte
Filter, generally uses and filtering material is housed the type constituted in a reservoir, should
Filtering material is made up of non-woven fabrics, porous plastid.
But, in the case of resinous non-woven fabrics, with moistening during contacting blood
Property is bad, has a problem in that filtration time length, cannot utilize whole filtering surface
Long-pending.
Summary of the invention
Here, in view of the above-mentioned problems, it is an object of the invention to improve for removing
The wettability for blood of the filter of the leukocyte in blood, shortens and filters
Time, effectively utilize filter, improve the performance removing leukocyte.
The present invention provides filter, and it has the filtering material of lamellar, the mistake of this lamellar
Filtering material is housed in the container of the outlet being provided with the entrance of blood and blood, is used for
The space of entrance side and the space of outlet side will be divided in said vesse and be used for removing
Leukocyte in blood, it is characterised in that above-mentioned filtering material is laminated multi-layer nonwoven
Cloth and formed, this multi-layer nonwoven fabrics is to comprise the 1st non-woven fabrics, the 2nd non-woven fabrics and the 3rd
Non-woven fabrics at the non-woven fabrics of interior more than 3 kinds, the average fiber footpath of above-mentioned 1st non-woven fabrics,
The average fiber footpath of the 2nd non-woven fabrics and the average fiber footpath of the 3rd non-woven fabrics are the most different；On
State the 1st non-woven fabrics, the 2nd non-woven fabrics and the 3rd non-woven fabrics according to above-mentioned 1st non-woven fabrics, on
State the 2nd non-woven fabrics, above-mentioned 3rd non-woven fabrics order from above-mentioned entrance side towards above-mentioned go out
Mouth side is arranged；The average fiber footpath of above-mentioned 1st non-woven fabrics, the average fibre of the 2nd non-woven fabrics
Dimension footpath and the 3rd non-woven fabrics average fiber footpath according to above-mentioned 1st non-woven fabrics, the above-mentioned 2nd
Non-woven fabrics, the order of above-mentioned 3rd non-woven fabrics diminish；The average fibre of above-mentioned 1st non-woven fabrics
Dimension footpath is 6 μm～30 μm；The average fiber footpath of above-mentioned 2nd non-woven fabrics is 3 μm～7
μm；The average fiber footpath of above-mentioned 3rd non-woven fabrics is 1 μm～4 μm；1st non-woven fabrics,
2nd non-woven fabrics, the 3rd non-woven fabrics have on the surface of the fiber of at least one non-woven fabrics
Containing nonionic hydrophilic group and the polymer covering of alkalescence nitrogen-containing functional group, above-mentioned
The content of the basic nitrogen atom of cover layer is 0.2 weight %～8.0 weight %.
In the filtering material of this filter, with average fiber footpath from upstream side (entrance
Side) towards downstream (outlet side) go the mode being sequentially reduced configure the 1st non-woven fabrics～
3rd non-woven fabrics.Thus, even if create coagulum in blood, it is also possible to utilize
The non-woven fabrics of the upstream side that eyelet is bigger catches coagulum, makes arrival eyelet less
The coagulum of the non-woven fabrics in downstream reduces.Thereby, it is possible to suppression filtering material because of
The blocking that coagulum causes.It is set to especially by by the average fiber footpath of the 1st non-woven fabrics
6 μm～30 μm, the average fiber footpath of the 2nd non-woven fabrics is set to 3 μm～7 μm, by the 3rd
The average fiber footpath of non-woven fabrics is set to 1 μm～4 μm, it is possible to the most reliably seek to press down
The blocking of filtering material processed.And in the 1st non-woven fabrics, the 2nd non-woven fabrics, the 3rd non-woven fabrics
Have containing nonionic hydrophilic group and alkali on the surface of the fiber of at least one non-woven fabrics
The polymer covering of property nitrogen-containing functional group, containing of the basic nitrogen atom of above-mentioned cover layer
Amount is 0.2 weight %～8.0 weight % such that it is able to improve non-woven fabrics for blood
The wettability of speech.
It addition, the fiber of the 1st non-woven fabrics, the 2nd non-woven fabrics and the 3rd non-woven fabrics can also wrap
Containing polyester (polyester).By so using the fiber comprising polyester, it is possible to obtain
The 1st non-woven fabrics that fiber footpath is stable～the 3rd non-woven fabrics.
It addition, filtering material is with crushing of ventilating as 600Pa～the mode of 1300Pa adjusts
The number of the 1st non-woven fabrics, the number of the 2nd non-woven fabrics, the number of the 3rd non-woven fabrics are also carried out
The filtering material being laminated such that it is able to obtain mobility and remove leukocyte performance
Between the good filter of balance.
Alternatively, it is also possible to make in the 1st non-woven fabrics, the 2nd non-woven fabrics and the 3rd non-woven fabrics extremely
The critical wetting surface tension of few a kind of non-woven fabrics is more than 70dyn/cm.Such face
The non-woven fabrics of boundary's Wetting Surface Tension is able to ensure that the stable moistening for blood
Property.
It addition, in the filter of the present invention, it is possible to so that the thickness of the 1st non-woven fabrics
Summation is the 3%～70% of the gross thickness of filtering material.By make eyelet bigger the 1st
Non-woven fabrics is thicker, it is possible to more catch coagulum with the 1st non-woven fabrics, it is possible to further
Suppression blocking.
It addition, in the filter of the present invention, it is possible to so that the thickness of the 3rd non-woven fabrics
Summation is the 20%～90% of the gross thickness of filtering material.By make eyelet less the 3rd
Non-woven fabrics is thicker, it is possible to more catch leukocyte with the 3rd non-woven fabrics, it is possible to increase white
Cell removing performance.
Use the present invention, using the teaching of the invention it is possible to provide one can shorten filtration time and remove white thin
The filter of born of the same parents' excellent performance.
Accompanying drawing explanation
Fig. 1 is the front view of an embodiment of the filter representing the present invention.
Fig. 2 is the sectional view of the II-II line along Fig. 1.
Fig. 3 is the side view of the filtering material of the filter representing Fig. 1.
Description of reference numerals
30, filtering material；31a, the 1st non-woven fabrics；32a, the 2nd non-woven fabrics；33a、
3rd non-woven fabrics；40, filter；41a, inlet portion；41b, export department；42, hold
Device.
Detailed description of the invention
Hereinafter, with reference to Fig. 1～Fig. 3 to the filter 40 as embodiments of the present invention
Illustrate.It addition, blood described below contain blood transfusion whole blood preparation,
The Blood Preparationses such as red cell preparation, platelet transfusion, blood plasma preparation.It addition, with
Under explanation in, " fresh blood " refers to start the blood within 24 hours from blood sampling, " protects
Deposit blood " refer to start to save the blood of more than 1 day from blood sampling.
As shown in Figures 1 and 2, filter 40 includes: filtering material 30, and it is used for will
Preserve the leukocyte in the blood of blood to remove；Entrance side container 43 and outlet side container 44,
Both are oppositely disposed across filtering material 30；The inlet portion 41a of blood, it is located at entrance
Side container 43；The export department 41b of blood, it is located at outlet side container 44.Utilize entrance
Side container 43 and outlet side container 44 form container 42, and container 42 is such as by Merlon
(polycarbonate:PC) constitute.
Filtering material 30 is made up of cropped conglobate non-woven fabrics, is positioned at entering of circle
Between mouth side container 43 and outlet side container 44.Filtering material 30 is to mark off inlet portion
The mode in the space of 41a side and the space of export department 41b side configures, will be from inlet portion 41a
Aggregation (condensation product), leukocyte in the blood flowed into remove, and by blood from going out
Oral area 41b discharges.
The mouth of pipe (nozzle) 41c of inlet portion 41a than by the outer rim of entrance side container 43 and
Weld portion 41e that the outer rim of outlet side container 44 is fused with one another highlights laterally.Separately
Outward, the mouth of pipe 41d of export department 41b holds than by outer rim and the outlet side of entrance side container 43
Weld portion 41e that the outer rim of device 44 is fused with one another highlights laterally.Result, it is easy to
By mouth of pipe 41c and the pipe of export department 41b of the conduit that passes through for blood and inlet portion 41a
Mouth 41d connects, it is easy to carry out the connection of blood circuit.It addition, in the present embodiment,
The mouth of pipe 41d of the mouth of pipe 41c and export department 41b of inlet portion 41a all than weld portion 41e to
Protruding outside, but can also only have one of them mouth of pipe than weld portion 41e laterally
Prominent.
It addition, filter 40 includes: inlet side edge holder 43a, it is along entrance
The periphery of side container 43 is arranged, and prominent to the inner side of entrance side container 43, and with
Filtering material 30 contacts；Outlet side edge holder 44a, it clamps with inlet side edge
Part 43a relatively and prominent to the inner side of outlet side container 44, and by with entrance side
Edge holder 43a cooperation and compressed filtering material 30, thus the spilling of anti-Hemostatic Oral Liquid.Separately
Outward, in the present embodiment, entrance side container 43 and outlet side container 44 are circular,
Therefore, inlet side edge holder 43a and outlet side edge holder 44a is also circular,
When entrance side container 43 and outlet side container 44 are other the shape such as oval, entrance
Lateral edges holder 43a and outlet side edge holder 44a is and this entrance side container 43
And other the shape such as the corresponding ellipse of the shape of outlet side container 44.
The outer surface 43b of entrance side the container 43 and outer surface 44b of outlet side container 44 is
There is fine concavo-convex matsurface.By being set to matsurface, desirably prevent AC and go out
The outer surface 43b of entrance side container 43 during bacterium (autoclaving, autoclaving)
And the outer surface 44b of outlet side container 44 and bags of blood adhesion, thus, this embodiment party
In formula, to utilizing ester moulding to form entrance side container 43 and outlet side container 44
Time the mould of injection molded that used implement the process for forming matsurface,
Formed by the transfer of the matsurface of this mould during injection molded entrance side container 43 and
The matsurface of outlet side container 44.But it is also possible to do not implement this surface process and in
Do not form the form of the matsurface wanted.Alternatively, it is also possible to do not forming matsurface
Carry out injection molded under state and after injection molded, implement surface process and formed
Matsurface.
Entrance side container 43 inner surface, i.e. with the side faced by filtering material 30
Being formed on surface: entrance side top board face 43c, it is by inlet side edge holder 43a
Surround；Entrance side rib 43d, it is prominent and and filter material from entrance side top board face 43c
Material 30 abuts and is formed for blood between entrance side top board face 43c and filtering material 30
The gap S1 of flowing；Flow passage groove 43e of lengthwise, it connects with inlet portion 41a.Entrance
Side rib 43d is concentric circles with the projection of arc-shaped from the center of entrance side container 43
Configuration and, be set across the mode that flow passage groove 43e is symmetrical.
It addition, outlet side container 44 inner surface, i.e. with filtering material 30 faced by
It is formed on the surface of side: outlet side top board face 44c, it is clamped by outlet side edge
Part 44a surrounds；Outlet side rib 44d, its prominent from outlet side top board face 44c and with mistake
Filtering material 30 abuts and is formed between outlet side top board face 44c and filtering material 30 and supply
The gap S2 of blood flowing；Flow passage groove 44e of lengthwise, it connects with export department 41b.
Export the side rib 44d projection with arc-shaped from the center of outlet side container 44 in one heart
Round shape configuration and, be set across the mode that flow passage groove 44e is symmetrical.
Here, by the distance between entrance side top board face 43c and outlet side top board face 44c
It is set to L, by the top contacted with filtering material 30 that comprises entrance side rib 43d
Plane Fa and the top contacted with filtering material 30 comprising outlet side rib 44d
Distance between plane Fb is set to Dr, by inlet side edge holder 43a and outlet side
When distance between edge holder 44a is set to Ds, Dr is the 65%～85% of L, and Ds is L
30%～45%, Ds is the 45%～55% of Dr.
It addition, the height of entrance side rib 43d is set to Ha, the height of side rib 44d will be exported
When degree is set to Hb, L is 8mm～11mm, and Ha is 0.8mm～1.5mm, and Hb is
0.8mm～1.5mm.It addition, by the width with the gap S1 formed by entrance side rib 43d
Spend suitable entrance side rib spacing be set to Pa, by with by the gap that formed of outlet side rib 44d
When the outlet side rib spacing that the width of S2 is suitable is set to Pb, Pa is 2.5mm～5mm,
Pb is 2.5mm～5mm.Use this structure, it is possible to be effectively prevented filtering material 30
Contact, by substantially ensuring that with entrance side top board face 43c or outlet side top board face 44c
The space of gap S1, S2, it is possible to prevent the rate of filtration from declining.
The most in the present embodiment, spacing Pa is more than spacing Pb.Use this structure,
Entrance side rib spacing is relatively big and can utilize filter area significantly, even if containing assembling
When the blood of thing (condensation product) enters into entrance side, it is also possible to suppression blocks.
It addition, in the present embodiment, the Ha as the height of entrance side rib 43d is used for out
The Hb of the height of mouth side rib 44d is high.Use this structure, the filter area ratio of entrance side
The filter area of outlet side is big, even if the blood containing aggregation (condensation product) enters
During to entrance side, it is also possible to suppression blocks.
It addition, inlet portion 41a be set to entrance side container 43 protruding outside, with comprising
The inside that entrance side top board face 43c carrys out cutting inlet portion 41a at interior imaginary plane Fc is empty
Between and imaginary flow path space Sa is specified and to in flow path space Sa
When the sectional area in the cross section that the blood stream of blood of flowing is orthogonal carries out regulation, stream is empty
Between Sa there is sectional area diminishing district on the direction along the blood stream of blood
Territory.Use this structure, though containing the blood of aggregation (condensation product) enter into into
During mouth side, it is also possible to suppression blocks.
It addition, export department 41b be set to outlet side container 44 protruding outside, with comprising
The inside that outlet side top board face 44c carrys out cutting export department 41b at interior imaginary plane Fd is empty
Between and imaginary flow path space Sb is specified and to in flow path space Sb
When the sectional area in the cross section that the blood stream of blood of flowing is orthogonal carries out regulation, stream is empty
Between there is the region that sectional area is gradually increased on the direction along the blood stream of blood.
Filtering material 30 is formed by 3 filter courses of stacking.That is, filtering material 30
There is the 1st filter course the 31, the 2nd filter course the 32 and the 3rd filter course 33 stacked gradually.Cross
Filtering material 30 is positioned at inlet portion 41a side with the 1st filter course 31, the 3rd filter course 33 is positioned at
Oral area 41b side towards being housed in container 42.
It addition, filtering material 30 has at inlet side edge holder 43a and outlet side
Ring-type boundary portion 30a being compressed to form under the cooperation of edge holder 44a, by border
When the internal diameter of portion 30a is set to R, R is 60mm～75mm, for representing the R of flatness
/ L is 5～10.By using such structure, it is easy to obtain the balance of the rate of filtration.
It addition, in the present embodiment, boundary portion 30a is circular, but can also be ellipse
The round shape waiting other, boundary portion 30a is that the interior diameter R during shape beyond circle is
Refer to maximum gauge.
Then, in further detail filtering material 30 is illustrated with reference to Fig. 3.As above
Described, filtering material 30 in the form of sheets include the 1st filter course the 31, the 2nd filter course 32 and
3rd filter course 33.1st filter course 31 is to be the nonwoven about 8 μm by average fiber footpath
The bigger filter course of eyelet that cloth is constituted, is mainly used in catching the cohesion contained by blood
The coagulums such as thing (aggregation).2nd filter course 32 is to be 5 μm by average fiber footpath
The barrel hole size that the non-woven fabrics of left and right is constituted is moderate filter course, is mainly used in
The more tiny coagulum etc. having passed through the 1st filter course 31 is caught.3rd filters
Layer 33 is to be that the eyelet that the non-woven fabrics about 2 μm is constituted is less by average fiber footpath
Filter course, is mainly used in catching the leukocyte in blood.
1st filter course 31 both can be formed by the non-woven fabrics of 1 lamellar, it is also possible to passes through
The non-woven fabrics stacking of multiple lamellars of the same race or the most of the same race and formed.Equally, the 2nd
Filter course the 32 and the 3rd each filter course of filter course 33 is the most all both can be by the nothing of 1 lamellar
Spin cloth to be formed, it is also possible to by the nonwoven layer of multiple lamellars of the same race or the most of the same race
Fold and formed.Formed by non-woven fabrics stacking the most of the same race 1st filter course 31,
When 2 filter courses 32 or 3 filter course 33, preferably with average fiber footpath from inlet portion 41a
Side (upstream side) goes the mode diminished successively to join towards export department 41b side (downstream)
Put each non-woven fabrics.It addition, Fig. 3 shows that the 1st filter course the 31～the 3rd filter course 33 is respectively
The example formed by 3 sheet-like nonwoven cloth, but it is not limited to this.
Hereinafter, the non-woven fabrics being used for being formed the 1st filter course 31 is referred to as " the 1st non-woven fabrics
31a ", the non-woven fabrics being used for being formed the 2nd filter course 32 is referred to as " the 2nd non-woven fabrics 32a ",
The non-woven fabrics being used for being formed the 3rd filter course 33 is referred to as " the 3rd non-woven fabrics 33a ".1st
The average fiber footpath of non-woven fabrics 31a is 6 μm～30 μm.2nd non-woven fabrics 32a's is average
Fiber footpath is 3 μm～7 μm.The average fiber footpath of the 3rd non-woven fabrics 33a is 1 μm～4
μm。
In filtering material 30, with average fiber footpath from inlet portion 41a side (upstream side)
The mode diminished successively is gone to configure non-woven fabrics towards export department 41b side (downstream).Adopt
Use this structure, when producing coagulum in blood, it is also possible to utilize bigger upper of eyelet
The non-woven fabrics of trip side catches coagulum, makes the non-woven fabrics in the downstream that arrival eyelet is less
Coagulum reduce.Thereby, it is possible to the causing because of coagulum of suppression filtering material 30
Blocking.It is set to 6 μm～30 especially by by the average fiber footpath of the 1st non-woven fabrics 31a
μm, the average fiber footpath of the 2nd non-woven fabrics 32a is set to 3 μm～7 μm, by the 3rd
The average fiber footpath of non-woven fabrics 33a is set to 1 μm～4 μm, it is possible to the most reliably
Seek to suppress the blocking of filtering material 30.
Further, at least one nonwoven in the 1st non-woven fabrics, the 2nd non-woven fabrics, the 3rd non-woven fabrics
Have on the surface of the fiber of cloth containing nonionic hydrophilic group and alkalescence nitrogen-containing functional group
Polymer covering, the content of the basic nitrogen atom of above-mentioned cover layer is 0.2 weight
Amount %～8.0 weight %.
Nonionic hydrophilic group as the polymer for forming cover layer, it is possible to row
Enumerate hydroxyl and amide groups etc., as the alkaline nitrogen-containing functional group of this polymer, it is possible to
List primary amino radical, secondary amino group, tertiary amino, quaternary ammonium group and pyridine radicals, imidazole radicals
Etc. nitrogenous fragrance ring group etc..Basic nitrogen atom refers in above-mentioned alkalescence nitrogen-containing functional group
Nitrogen-atoms.Have such hydrophilic group, functional group polymer at Japanese Patent document
In (JP 6-51060) on the books, 2 methyl can be listed as representative examples
Acrylic acid-2-hydroxyl ethyl ester and the copolymer of diethylaminoethyl methacrylate.
In the present invention, the content of the basic nitrogen atom of cover layer is 0.2 weight %～8.0
Weight % is necessary, so can improve the moistening for blood of non-woven fabrics
Property.If the content of basic nitrogen atom be less than 0.2 weight %, then filter for blood
For wettability relatively low and infiltration of the blood at initial stage is poor, when result causes filtering
Between elongated.Further, blood only passes through via the position easily flowed through of non-woven fabrics, becomes
For (the Japanese: sheet stream that is referred to as locally circulating whole non-woven fabrics not used
State れ), result filtration time is elongated, removes leukocyte degradation.On the contrary,
If the content of basic nitrogen atom is more than 8.0 weight %, coating agent is the most easily caused to be blocked in
Between fiber, easily cause erythrocyte hemolysis.For the content of basic nitrogen atom, with
In the case of whole blood preparation, 0.2 weight %～8.0 weight % are the most no problem, but enter one
Step is preferably 0.3 weight %～7.0 weight %.In the case of platelet transfusion,
For the purpose of the selection separation property improved between leukocyte and platelet, preferably alkalescence
The content of nitrogen-atoms is 0.2 weight %～4.0 weight %.
The content of basic nitrogen atom can so calculate: non-woven fabrics is impregnated into EtOH etc.
In solvent, extract cover aggregation thing out, calculate this evaporation drying by elementary analysis etc. solid
The nitrogen content of body thing.Further, nonionic hydrophilic group, alkalescence nitrogen-containing functional group can
Determined by following manner, it may be assumed that use attenuated total reflectance infrared spectrometry
(ATR-IR) or flight time secondary ion mass spectrometry with halogen labeling (TOF-SIMS),
The surface of non-woven fabrics fiber is analyzed, thus is determined.
1st non-woven fabrics 31a, the 2nd non-woven fabrics 32a and the 3rd non-woven fabrics 33a fiber preferred
Comprise polyester (polyester).As polyester, it is possible to list poly terephthalic acid second
Diol ester (polyethylene terephthalate), polybutylene terephthalate (PBT)
(Polybutylene terephthalate) etc..The fiber of polyester is comprised by employing,
The 1st non-woven fabrics 31a, the 2nd non-woven fabrics 32a and the 3rd nonwoven that fiber footpath is stable can be obtained
Cloth 33a.
Additionally, it is preferred that the ventilation crushing of filter is in the range of 600Pa～1300Pa.Logical
The measuring method that air pressure damages is: carry compression sky in filter with the flow of 3L/ minute
Gas, measures the pressure loss at that time.Filter in such range is able to ensure that surely
The fixed balance removed between leukocyte performance and filtration time.
In preferably the 1st non-woven fabrics 31a, the 2nd non-woven fabrics 32a and the 3rd non-woven fabrics 33a extremely
The critical wetting surface tension of few a kind of non-woven fabrics is more than 70dyn/cm.Such face
The non-woven fabrics of boundary's Wetting Surface Tension is able to ensure that the stable moistening for blood
Property.Further preferred 1st non-woven fabrics 31a, the 2nd non-woven fabrics 32a and the 3rd non-woven fabrics 33a
The critical wetting surface tension of all of non-woven fabrics is more than 70dyn/cm.
During it addition, filter 40 is used as to filter the filter preserving blood, preferably filter
The thickness (summation of the thickness of the 1st non-woven fabrics 31a) of the 1st filter course 31 of material 30 is
The 3%～70% of the gross thickness of filtering material 30.That is, in the filter process preserving blood,
Owing to being easier to produce the coagulum of blood, therefore to suppression blocking, remove solidifying
Gu the characteristic of thing comes into one's own.Therefore, by making the 1st filter course 31 that eyelet is bigger
Thicker, it is possible to more to catch coagulum with the 1st filter course 31, it is possible to suppression blocking.
Enumerating two specific examples, in one example, the thickness of the 1st filter course 31 accounted for
The 21% of the gross thickness of filtering material 30.It addition, in another example, the 1st filter course
The thickness of 31 accounts for the 6% of the gross thickness of filtering material 30.In this case, the suitableeest
In the filtering material preserving blood.
During it addition, filter 40 is used as the filter filtering fresh blood, preferably filter
The thickness (summation of the thickness of the 3rd non-woven fabrics 33a) of the 3rd filter course 33 of material 30 is
The 20%～90% of the gross thickness of filtering material 30.That is, in the filter process of fresh blood,
Owing to being relatively difficult to produce the coagulum of blood, therefore compared with suppression blocking, relatively
The characteristic of leukocyte is paid attention to removing in ground.Therefore, by making the 3rd filter course that eyelet is less
33 is thicker, it is possible to more catches leukocyte with the 3rd filter course 33, it is possible to increase the thinnest
Born of the same parents' removing performance.Enumerate two specific examples, in one example, the 3rd filter course
The thickness of 33 accounts for the 72% of the gross thickness of filtering material 30.It addition, at another example
In, the thickness of the 3rd filter course 33 accounts for the 89% of the gross thickness of filtering material 30.This
In the case of, it is particularly suitable for the filtering material of fresh blood.
[embodiment]
In order to be described in further detail the present invention, embodiment is used to illustrate.This
Bright scope is not limited only to these embodiments.
(embodiment 1)
2-hydroxyethyl methacry-late has been synthesized by common solution free radical polymerization
(hereinafter referred to as HEMA) and diethylaminoethyl methacrylate is (hereinafter referred to as
Make DEAMA) copolymer.As polymerizing condition, the monomer concentration in ethanol is 1
Mole/L and there is azodiisobutyronitrile (AIBN) 1/200 mole as initiator,
The polyreaction of 8 hours has been carried out at 60 DEG C.
Then, use in dip coating (Japanese: デ ィ ッ プ U ト method) utilization
Average fiber footpath is respectively by the EtOH solution of solution concentration 0.15wt% stating polymer
8 μm, 4.5 μm, 2.4 μm, the non-woven fabrics of 2.1 μm are coated.Now, enter
The content of basic nitrogen atom of the cover layer after polymer-coated of having gone is 0.28 weight
Amount %, CWST value is 90dyn/cm.
Then, nonwoven layer it is clipped between entrance side container and outlet side container and presses
Tightly making filter, wherein, above-mentioned nonwoven layer is by stacking average fiber footpath 8
μm, weight per unit area 90g/m2Non-woven fabrics two as the 1st filter course, again layer
Folded average fiber footpath 4.5 μm, weight per unit area 90g/m2Two conducts of non-woven fabrics
2nd filter course, stacking average fiber footpath 2.4 μm, weight per unit area 85g/m2Nothing
Spin cloth 9 and average fiber footpath 2.1 μm, weight per unit area 80g/m2Non-woven fabrics 4
Zhang Zuowei the 3rd filter course and formed.
Make to modulate from the fresh blood of the people that with the addition of the CPD as anticoagulant
Whole blood preparation 430mL passes through filter with the drop of 100cm, is filtered.It
After, the blood before and after filtering is sampled, use minicell enumerator (Japanese:
ミ Network ロ セ Le カ ウ Application タ) measure leukocyte count, calculate in the blood after filtration
Total white blood cells.
Result be filtration time be 16 minutes, remaining leukocyte count is 0.02 × 10E6
/ Bag, has reached good remaining leukocyte count and filtration time.
(embodiment 2)
Filtration test has been carried out with condition same as in Example 1.But, layer will be passed through
Folded average fiber footpath 8 μm, weight per unit area 90g/m2Non-woven fabrics two as
1 filter course, again stacking average fiber footpath 4.5 μm, weight per unit area 90g/m2Nothing
Spin cloth two as the 2nd filter course, stacking average fiber footpath 2.4 μm, unit are
Weight 85g/m2Non-woven fabrics 5 and average fiber footpath 2.1 μm, weight per unit area
80g/m2The nonwoven layer that formed as the 3rd filter course of non-woven fabrics 9 be clipped in entrance
Between side container and outlet side container and compress and made filter.Now, carry out
The content of the basic nitrogen atom of the cover layer after polymer-coated is 0.28 weight %,
CWST value is 90dyn/cm.
Result be filtration time be 17 minutes, remaining leukocyte count is 0.01 × 10E6
/ Bag, has reached good remaining leukocyte count and filtration time.
(embodiment 3)
Filtration test has been carried out with condition same as in Example 1.But, it is with polymerization
The coating that the EtOH solution of solution concentration 0.30wt% of thing is carried out.Now, carry out
The content of the basic nitrogen atom of the cover layer after polymer-coated is 0.63 weight %,
CWST value is 100dyn/cm.Result be filtration time be 15 minutes, remaining leukocyte
Number is 0.02 × 10E6/Bag, when having reached good remaining leukocyte count and filtered
Between.
(comparative example 1)
Filtration test has been carried out with condition same as in Example 1.But, layer will be passed through
Folded average fiber footpath 4 μm, weight per unit area 90g/m2Non-woven fabrics two as
1 filter course, again stacking average fiber footpath 3 μm, weight per unit area 90g/m2Nothing
Spin cloth two as the 2nd filter course, stacking average fiber footpath 2.4 μm, unit are
Weight 85g/m2Non-woven fabrics 9 and average fiber footpath 2.1 μm, weight per unit area
80g/m2The nonwoven layer that formed as the 3rd filter course of non-woven fabrics 4 be clipped in entrance
Between side container and outlet side container and compress and made filter.Now, carry out
The content of the basic nitrogen atom of the cover layer after polymer-coated is 0.28 weight %,
CWST value is 90dyn/cm.
Result be filtration time be 60 minutes, remaining leukocyte count is 0.02 × 10E6
/ Bag, remaining leukocyte count is good, and filtration time is the longest.Its reason is blood
In the condensation product non-woven fabrics tiny with eyelet directly contact and block.
(comparative example 2)
Filtration test has been carried out with condition same as in Example 1.Non-woven fabrics employs not
There is the non-woven fabrics being coated.
Result be filtration time be 60 minutes, remaining leukocyte count is 10 × 10E6
/ Bag, remaining leukocyte count becomes many, and filtration time is the longest.Its reason is the initial stage
The infiltration of blood require time for, and then owing to the air between non-woven fabrics does not has smooth and easy row
Go out and occur local to circulate.
Above result is collected display in table 1 below.By to the 1st, the 2nd,
The average fiber footpath of 3 non-woven fabrics is adjusted, and makes remaining leukocyte count reduce, reaches good
Good filtration time.And it is possible to find out that employing coating processing can obtain leukocyte
Removal rate and the better result of filtration time.
[table 1]
Claims (7)
1. a filter, it has the filtering material of lamellar, the filter material of this lamellar
Material is housed in the container of the outlet being provided with the entrance of blood and blood, for by
The space of entrance side and the space of outlet side it is divided into and for removing blood in stating container
In leukocyte, it is characterised in that
Above-mentioned filtering material is laminated multi-layer non-woven fabrics and is formed, this multi-layer nonwoven fabrics
It it is the nothing of more than 3 kinds that comprise the 1st non-woven fabrics, the 2nd non-woven fabrics and the 3rd non-woven fabrics
Spin cloth, the average fiber footpath of above-mentioned 1st non-woven fabrics, the average fiber footpath of the 2nd non-woven fabrics
And the 3rd the average fiber footpath of non-woven fabrics the most different；
Above-mentioned 1st non-woven fabrics, the 2nd non-woven fabrics and the 3rd non-woven fabrics are according to above-mentioned 1st nonwoven
Cloth, above-mentioned 2nd non-woven fabrics, above-mentioned 3rd non-woven fabrics order from above-mentioned entrance side towards
Above-mentioned outlet side is arranged；
The average fiber footpath of above-mentioned 1st non-woven fabrics, the average fiber footpath of the 2nd non-woven fabrics and
The average fiber footpath of the 3rd non-woven fabrics according to above-mentioned 1st non-woven fabrics, above-mentioned 2nd non-woven fabrics,
The order of above-mentioned 3rd non-woven fabrics diminishes；
The average fiber footpath of above-mentioned 1st non-woven fabrics is 6 μm～30 μm；
The average fiber footpath of above-mentioned 2nd non-woven fabrics is 3 μm～7 μm；
The average fiber footpath of above-mentioned 3rd non-woven fabrics is 1 μm～4 μm；
The fibre of at least one non-woven fabrics in 1st non-woven fabrics, the 2nd non-woven fabrics, the 3rd non-woven fabrics
Have on the surface of dimension containing nonionic hydrophilic group and the polymerization of alkalescence nitrogen-containing functional group
Thing cover layer, the content of the basic nitrogen atom of above-mentioned cover layer is 0.2 weight %～8.0
Weight %.
Filter the most according to claim 1, it is characterised in that
The fiber package of above-mentioned 1st non-woven fabrics, the 2nd non-woven fabrics and the 3rd non-woven fabrics contains polyester.
3. according to the filter described in claims 1 or 2, it is characterised in that
Ventilation crushing is 600Pa～1300Pa.
4., according to the filter according to any one of claims 1 to 3, its feature exists
In,
At least one nonwoven in above-mentioned 1st non-woven fabrics, the 2nd non-woven fabrics and the 3rd non-woven fabrics
The critical wetting surface tension of cloth is more than 70dyn/cm.
5., according to the filter according to any one of Claims 1 to 4, its feature exists
In,
The gross thickness that summation is above-mentioned filtering material of the thickness of above-mentioned 1st non-woven fabrics
3%～70%.
6., according to the filter according to any one of Claims 1 to 5, its feature exists
In,
The gross thickness that summation is above-mentioned filtering material of the thickness of above-mentioned 3rd non-woven fabrics
20%～90%.
7., according to the filter according to any one of claim 1～6, its feature exists
Being total to of 2-hydroxyethyl methacry-late and diethylaminoethyl methacrylate is comprised in, above-mentioned polymer
Polymers.
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|---|---|---|---|
| CN2015201235803 | 2015-03-03 | ||
| CN201520123580 | 2015-03-03 |
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|---|---|
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| Application Number | Title | Priority Date | Filing Date |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000185094A (en) * | 1998-12-21 | 2000-07-04 | Asahi Medical Co Ltd | Leukocyte selective removal filter device |
| CN201058159Y (en) * | 2007-06-27 | 2008-05-14 | 上海达华医疗器械有限公司 | Filter for removing white blood cell |
| CN100475307C (en) * | 2003-01-24 | 2009-04-08 | 弗雷泽纽斯血液保健意大利有限公司 | Filter for the separation of leukocytes from whole blood or blood preparations |
| CN202699682U (en) * | 2012-02-28 | 2013-01-30 | 旭化成医疗株式会社 | Filter |
| CN203469136U (en) * | 2013-07-08 | 2014-03-12 | 旭化成医疗株式会社 | White blood cell removing filter |
-
2015
- 2015-05-12 CN CN201510237362.7A patent/CN106178638A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000185094A (en) * | 1998-12-21 | 2000-07-04 | Asahi Medical Co Ltd | Leukocyte selective removal filter device |
| CN100475307C (en) * | 2003-01-24 | 2009-04-08 | 弗雷泽纽斯血液保健意大利有限公司 | Filter for the separation of leukocytes from whole blood or blood preparations |
| CN201058159Y (en) * | 2007-06-27 | 2008-05-14 | 上海达华医疗器械有限公司 | Filter for removing white blood cell |
| CN202699682U (en) * | 2012-02-28 | 2013-01-30 | 旭化成医疗株式会社 | Filter |
| CN203469136U (en) * | 2013-07-08 | 2014-03-12 | 旭化成医疗株式会社 | White blood cell removing filter |
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