CN106178007A - Equipment for quickly freezing plasma ultrahigh pressure to inactivate viruses - Google Patents
Equipment for quickly freezing plasma ultrahigh pressure to inactivate viruses Download PDFInfo
- Publication number
- CN106178007A CN106178007A CN201610810945.9A CN201610810945A CN106178007A CN 106178007 A CN106178007 A CN 106178007A CN 201610810945 A CN201610810945 A CN 201610810945A CN 106178007 A CN106178007 A CN 106178007A
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- CN
- China
- Prior art keywords
- pressure vessel
- ultrahigh pressure
- framework
- equipment
- inactivation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 241000700605 Viruses Species 0.000 title claims abstract description 42
- 238000007710 freezing Methods 0.000 title claims abstract description 39
- 230000008014 freezing Effects 0.000 title abstract description 7
- 210000004369 blood Anatomy 0.000 claims abstract description 55
- 239000008280 blood Substances 0.000 claims abstract description 55
- 210000002381 plasma Anatomy 0.000 claims abstract description 49
- 239000007788 liquid Substances 0.000 claims abstract description 34
- 238000009413 insulation Methods 0.000 claims abstract description 29
- 230000002779 inactivation Effects 0.000 claims description 34
- 230000003287 optical effect Effects 0.000 claims description 13
- 238000007789 sealing Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 19
- 230000000694 effects Effects 0.000 abstract description 7
- 238000000053 physical method Methods 0.000 abstract description 3
- 239000003640 drug residue Substances 0.000 abstract description 2
- 239000000126 substance Substances 0.000 abstract description 2
- 230000000415 inactivating effect Effects 0.000 abstract 2
- 102000015081 Blood Coagulation Factors Human genes 0.000 abstract 1
- 108010039209 Blood Coagulation Factors Proteins 0.000 abstract 1
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 239000003114 blood coagulation factor Substances 0.000 abstract 1
- 229940019700 blood coagulation factors Drugs 0.000 abstract 1
- 238000001816 cooling Methods 0.000 description 4
- 206010008469 Chest discomfort Diseases 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000002574 poison Substances 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 238000005057 refrigeration Methods 0.000 description 2
- 108090000190 Thrombin Proteins 0.000 description 1
- 238000005253 cladding Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D31/00—Other cooling or freezing apparatus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/20—Targets to be treated
- A61L2202/22—Blood or products thereof
Abstract
The invention discloses a device for quickly freezing plasma ultrahigh pressure inactivated virus, which comprises: the blood bag pressurization device comprises a supercharger, a heat insulation shell and an ultrahigh pressure container positioned in the heat insulation shell, wherein the supercharger inputs ultrahigh pressure liquid into the ultrahigh pressure container through a pipeline and is used for pressurizing a blood bag positioned in the ultrahigh pressure container; the refrigerating device is arranged on the heat-insulating shell and used for refrigerating the blood bag, and the equipment for quickly freezing the plasma ultrahigh-pressure inactivated virus can improve the refrigerating speed of the blood and is beneficial to protecting effective components in the plasma, particularly blood coagulation factors; the equipment inactivates the virus by a physical method, thereby avoiding the negative influence of drug residues for inactivating the virus by a chemical method and improving the safety of blood plasma; compared with the normal temperature, the treatment effect of the inactivated virus is better; not only simplifies the method for inactivating virus and reduces the treatment cost of blood plasma, but also completes quick freezing and virus killing simultaneously, and has obvious economic effect.
Description
Technical field
The invention belongs to the process blood plasma field of physical method, relate in particular to a kind of quick-freezing blood plasma supertension inactivation disease
The equipment of poison.
Background technology
At present, there are some researches prove, quick-freezing blood bag needs 40 minutes blood bag centers to can be only achieved-30 DEG C, is freezing
In journey, ice crystal is grown up, and has often damaged plasma fraction, and cooling time is the longest, and the degree of damage is the biggest.
Summary of the invention
For the deficiencies in the prior art, the invention provides the equipment of a kind of quick-freezing blood plasma supertension inactivation of viruses, this speed
The equipment freezing blood plasma supertension inactivation of viruses is lowered the temperature during pressure simultaneously, can reach the effect of more preferable inactivation of viruses.
To this end, technical scheme is as follows:
A kind of equipment of quick-freezing blood plasma supertension inactivation of viruses, including: supercharger, insulation shell and be positioned at described insulation cladding
The ultrahigh pressure vessel in internal portion, described supercharger inputs superhigh pressure liquid, for right by pipeline in described ultrahigh pressure vessel
It is positioned at the blood bag within described ultrahigh pressure vessel to pressurize；Described insulation shell is provided with refrigerating plant, for institute
State blood bag to freeze.
In technique scheme, described supercharger is positioned at described insulation shell outside or inside；Described ultrahigh pressure vessel
For being formed with the cylindrical of hollow cavity, it is provided around framework at described ultrahigh pressure vessel.
In technique scheme, described ultrahigh pressure vessel is laterally disposed；The two ends of described ultrahigh pressure vessel are formed respectively
There is an opening connected with described hollow cavity；The lower surface of one base plate is fixedly mounted with described framework, along longitudinally on described base plate
A plurality of line slideway is installed, is used for making described ultrahigh pressure vessel slide anteroposterior on described line slideway；Near described super
End bridging structure it is separately installed with, for sealing two openings of described ultrahigh pressure vessel, institute on the framework at the two ends of high-pressure bottle
State end bridging structure to include: for inserting that the end of described opening is stifled, the first hydraulic cylinder and the straight optical axis of Duo Gen horizontally set, described
The cylinder barrel of the first hydraulic cylinder is fixedly mounted with on said frame, and the piston rod of described first hydraulic cylinder is vertically fixed with a push pedal；Described
One end of straight optical axis is vertical with described push pedal to be fixedly mounted with, and the periphery that the other end of described straight optical axis blocks up with end is fixedly mounted with, so that
During described first hydraulic cylinder backhaul, end blocks up and stretches into the opening of the ultrahigh pressure vessel being positioned at relevant position and seal described supertension
Container；
The lower end of described framework is connected with the upper surface of base, and described base and described insulation shell form a closed chamber
Body；Described insulation shell is formed 2 swing doors, every when described ultrahigh pressure vessel slides into away from described end bridging structure
Swing door described in individual described opening the most corresponding, for loading blood bag or from described superelevation pressure-volume in described ultrahigh pressure vessel
Blood bag is taken out in device；
In described end is stifled, be formed with superhigh pressure liquid input channel, described superhigh pressure liquid input channel by pipeline with
Described supercharger connects, so that inputting superelevation hydraulic fluid in described ultrahigh pressure vessel by described superhigh pressure liquid input channel
Body.
In technique scheme, the quantity of described line slideway is 2, and every line slideway is provided with 2 slide blocks,
Described slide block all lower ends with described ultrahigh pressure vessel are fixedly mounted with.
In technique scheme, multiple framework bracing frame is installed between described framework and described base, for propping up
Support described framework.
In technique scheme, one second hydraulic cylinder is installed under the framework that each described end blocks up superstructure, its
In, the cylinder barrel of described second hydraulic cylinder is fixedly mounted with described framework, and piston rod and a parallels of described second hydraulic cylinder are fixedly mounted with, so that
Second hydraulic cylinder action described in during described first hydraulic cylinder backhaul, parallels drops to the stifled side away from ultrahigh pressure vessel of end, uses
In the axial force bearing described end bridging structure.
In technique scheme, being provided with two vertical gripper shoes in described framework, two described gripper shoes are divided
Not being positioned at the arranged on left and right sides of described ultrahigh pressure vessel, many straight optical axis of each described end bridging structure are each passed through corresponding
Described gripper shoe, be used for supporting described end bridging structure and be laterally moved.
In technique scheme, described hollow cavity is cylindrical.
In technique scheme, described ultrahigh pressure vessel is vertically to place, and the upper end of described ultrahigh pressure vessel is formed
One opening connected with described hollow cavity；Between described ultrahigh pressure vessel and described framework, pressurized cylinder is installed, so that institute
State ultrahigh pressure vessel to move at vertical direction；Under the framework of side, plunger moving guide rail, described plunger are installed over said opening
Slide block is installed under moving guide rail, under described slide block, is fixed with plunger, so that described plunger is along described plunger moving guide rail level
When sliding into the surface of described opening, described ultrahigh pressure vessel moves upward and by described plunger seal；
In described plunger, be formed with superhigh pressure liquid input channel, described superhigh pressure liquid input channel by pipeline with
Described supercharger connects, so that inputting superelevation hydraulic fluid in described ultrahigh pressure vessel by described superhigh pressure liquid input channel
Body；
Described insulation shell is provided with a sliding door, for loading blood bag in described ultrahigh pressure vessel or from described
Blood bag is taken out in ultrahigh pressure vessel.
In technique scheme, described sliding door is provided with handle.
Compared to prior art, the equipment of the quick-freezing blood plasma supertension inactivation of viruses of the present invention can improve the speed of blood refrigeration
Degree, is conducive to the effective ingredient in protection blood plasma, particularly thrombin；The quick-freezing blood plasma supertension inactivation of viruses of the present invention
Equipment is physical method inactivation of viruses, avoids the negative effect of the drug residue of chemical method inactivation of viruses, improves blood plasma
Safety；Compared with room temperature, the treatment effect of inactivation of viruses is more preferable；Use the quick-freezing blood plasma supertension inactivation disease of the present invention
The method that the equipment of poison not only simplify inactivation of viruses, reduces the processing cost of blood plasma, and quick-freezing and virus of going out is the completeest
Become, have obvious economic effect.
Accompanying drawing explanation
Fig. 1 is the front view of the equipment of the quick-freezing blood plasma supertension inactivation of viruses of the present invention；
Fig. 2 is the top view of the equipment of the quick-freezing blood plasma supertension inactivation of viruses of the present invention；
Fig. 3 is the top view of the equipment of the quick-freezing blood plasma supertension inactivation of viruses of the present invention；
Fig. 4 is the sectional view of the equipment of the quick-freezing blood plasma supertension inactivation of viruses of the present invention.
Wherein, 1: framework bracing frame 2: superhigh pressure liquid input channel 3: base
4: line slideway 5: base plate 6: straight optical axis
7: the first hydraulic cylinders 8: parallels 9: framework
10: ultrahigh pressure vessel 11: stifled 12: the second hydraulic cylinders of end
13: gripper shoe 14: insulation shell 15: swing door
16: push pedal 17: plunger 18: plunger moving guide rail
19: pressurized cylinder.
Detailed description of the invention
With embodiment, the equipment of the quick-freezing blood plasma supertension inactivation of viruses of the present invention is carried out specifically below in conjunction with the accompanying drawings
Bright.
Embodiment 1
As shown in accompanying drawing 1～3, including: supercharger (not shown), insulation shell 14 and to be positioned at insulation shell 14 internal
Ultrahigh pressure vessel 10, wherein, ultrahigh pressure vessel 10 be formed hollow cavity cylindrical (hollow cavity can also for circle
Cylinder shape), it is placed with blood bag in hollow cavity, is provided around framework 9 at ultrahigh pressure vessel 10 and (Fig. 2 and Fig. 3 does not shows that
Framework 9).Insulation shell 14 is provided with refrigerating plant (not shown), is used for the blood bag in insulation shell 14 (in figure
Not shown) freeze.
Ultrahigh pressure vessel 10 is laterally disposed, the two ends of ultrahigh pressure vessel 10 be respectively formed with one connect with hollow cavity open
Mouthful, ultrahigh pressure vessel 10 can be by ultrahigh pressure vessel inner cylinder tube and being sleeved on outside the ultrahigh pressure vessel outside ultrahigh pressure vessel inner cylinder tube
Cylinder barrel forms.The lower surface of one base plate 5 is fixedly mounted with framework 9, and along being longitudinally provided with 2 line slideways 4 on base plate 5, every straight
Being provided with 2 slide blocks on line guide rail 4,4 slide blocks all lower ends with ultrahigh pressure vessel 10 are fixedly mounted with, and are used for making ultrahigh pressure vessel 10 exist
Slide anteroposterior on line slideway 4；Framework 9 near the two ends of ultrahigh pressure vessel 10 is separately installed with end bridging structure, is used for
Seal two openings of ultrahigh pressure vessel 10.End bridging structure includes: block up the 11, first hydraulic cylinder 7 and four for inserting the end of opening
The straight optical axis 6 of root horizontally set, the cylinder barrel of the first hydraulic cylinder 7 is fixedly mounted with on the frame 9, and the piston rod of the first hydraulic cylinder 7 is vertical
It is fixed with a push pedal 16；One end of straight optical axis 6 is vertical with push pedal 16 to be fixedly mounted with, and the other end of straight optical axis 6 blocks up the circle of 11 with end
Side face is fixedly mounted with, so that end blocks up 11 and stretches into the opening of the ultrahigh pressure vessel 10 being positioned at relevant position also during the first hydraulic cylinder 7 backhaul
Seal ultrahigh pressure vessel 10, as shown in figure 1 and 2.
The lower end of framework 9 is connected with the upper surface of base 3, and framework 9 and base 3 can be integrated composition, base 3 and insulation
Housing 14 forms an airtight cavity；Insulation shell 14 is formed 2 swing doors 15, when ultrahigh pressure vessel 10 slide into away from
Each opening corresponding swing door 15 respectively during end bridging structure, for loading blood bag or from superelevation pressure-volume in ultrahigh pressure vessel 10
Blood bag is taken out in device 10.The ultra high pressure treatment of blood plasma is carried out, in extra-high tension unit pressure process under-10 to-20 DEG C of environment
Must be in full closeding state, only when dress takes blood bag, equipment automatically turns on 2 swing doors 15.
Being formed with superhigh pressure liquid input channel 2 in end stifled 11, superhigh pressure liquid input channel 2 passes through pipeline and is positioned at
Supercharger connection outside insulation shell 14, so that input super in ultrahigh pressure vessel 10 by superhigh pressure liquid input channel 2
Highly pressurised liquid, pressurizes for the blood bag being pointed in ultrahigh pressure vessel 10.
When needs dress takes blood bag, ultrahigh pressure vessel 10 can move to outside framework 9；When carrying out HIGH PRESSURE TREATMENT, return to frame
In frame 9, framework 9 bear the axial force of ultrahigh pressure vessel.
Further, multiple framework bracing frame 1 is installed between framework 9 and base 3, for support frame 9.
Further, block up the framework of superstructure at each end and one second hydraulic cylinder 12, wherein, can be installed for 9 times
The cylinder barrel of two hydraulic cylinders 12 is fixedly mounted with framework 9, and piston rod and a parallels 8 of the second hydraulic cylinder 12 are fixedly mounted with, so that the first hydraulic cylinder 7
Second hydraulic cylinder 12 action during backhaul, parallels 8 drops to the end stifled 11 side away from ultrahigh pressure vessel 10, is used for bearing end bridging
The axial force of structure.
Further, being provided with two vertical gripper shoes 13 in framework 9, two gripper shoes 13 lay respectively at supertension
The arranged on left and right sides of container 10, four straight optical axis 6 of each end bridging structure are each passed through corresponding gripper shoe 13, for propping up
Support end bridging structure is laterally moved.
Described in a kind of embodiment 1, the equipment of quick-freezing blood plasma supertension inactivation of viruses carries out low-temperature quick-freezing and superelevation to blood plasma
The method of pressure inactivation of virus, comprises the following steps:
1) blood plasma is loaded in blood bag, and discharges the air in blood bag, blood bag is put into instant freezer (not shown),
Utilize instant freezer that blood bag carries out pre-cooling: to make blood bag be cooled to-15～-25 DEG C and keep 10～20 minutes；
2) blood bag being taken out in instant freezer, slip ultrahigh pressure vessel 10 to its opening and two swing doors 15 are relatively, logical
Cross swing door 15 and put into blood bag in ultrahigh pressure vessel 10；Slip ultrahigh pressure vessel 10 to opening is stifled with end relative, the first hydraulic pressure
Cylinder 7 backhaul makes that end is stifled stretch into opening in and ultrahigh pressure vessel 10 is sealed.By superhigh pressure liquid input channel 2 to superelevation
It is passed through superhigh pressure liquid in pressure vessel 10, so that blood bag is in the environment of 200～400MPA, forms an airtight high pressure chest,
Meanwhile, utilize refrigerating plant that blood bag carries out quick-freezing: to make blood bag be cooled to-35～-40 DEG C and keep 20～40 minutes；To superelevation
Pressure vessel 10 carries out pressure release (extracting superhigh pressure liquid in ultrahigh pressure vessel 10 out by superhigh pressure liquid input channel 2).First
Hydraulic cylinder 7 action makes end block up 11 to remove in opening, and slip ultrahigh pressure vessel 10 makes the opening of ultrahigh pressure vessel 10 and two pendulum
The position of dynamic door 15 is relative, takes out blood bag.
The structure of the equipment of the quick-freezing blood plasma supertension inactivation of viruses of the present invention also can be as follows:
Embodiment 2
As shown in Figure 4, including: supercharger, insulation shell 14 and be positioned at the ultrahigh pressure vessel 10 within insulation shell 14,
Insulation shell 14 is provided with refrigerating plant (not shown), for the ultrahigh pressure vessel 10 within insulation shell 14 is entered
Row refrigeration；Ultrahigh pressure vessel 10 is the cylindrical (hollow cavity can also be for cylindrical) being formed with hollow cavity.Hollow
It is placed with blood bag in cavity, is provided around framework 9 at ultrahigh pressure vessel 10.Ultrahigh pressure vessel 10 is vertically to place, supertension
The upper end of container 10 is formed with an opening connected with hollow cavity；Between ultrahigh pressure vessel 10 and framework 9, supercharging is installed
Cylinder 19, so that ultrahigh pressure vessel 10 moves at vertical direction；Framework at overthe openings is provided with plunger moving guide rail 18 9 times,
Plunger moving guide rail is provided with for 18 times under slide block, slide block and is fixed with plunger 17, so that plunger 17 is along plunger moving guide rail 18 level
When sliding into the surface of opening, ultrahigh pressure vessel 10 moves upward and by plunger seal.
Being formed with superhigh pressure liquid input channel 2 in plunger 17, superhigh pressure liquid input channel 2 passes through pipeline and is positioned at
Supercharger connection outside insulation shell 14, so that input super in ultrahigh pressure vessel 10 by superhigh pressure liquid input channel 2
Highly pressurised liquid, pressurizes for the blood bag being pointed within ultrahigh pressure vessel 10.
Insulation shell 14 is provided with a sliding door (not shown), sliding door is provided with handle, for super
Load blood bag in high-pressure bottle 10 or in ultrahigh pressure vessel 10, take out blood bag.
Described in a kind of embodiment 2, the equipment of quick-freezing blood plasma supertension inactivation of viruses carries out low-temperature quick-freezing and superelevation to blood plasma
The method of pressure inactivation of virus, comprises the following steps:
1) blood plasma is loaded in blood bag, and discharges the air in blood bag, blood bag is put into instant freezer (not shown),
Utilize instant freezer that blood bag carries out pre-cooling: to make blood bag be cooled to-15～-25 DEG C and keep 10～20 minutes；
2) blood bag is taken out in instant freezer, open sliding door, in ultrahigh pressure vessel 10, put into blood bag；Close push-and-pull
Door.Sliding spool 17, so that plunger is positioned at the surface of the opening of ultrahigh pressure vessel 10, starts pressurized cylinder 19, so that supertension
Container 10 moves upward and plunger seal ultrahigh pressure vessel 10.By superhigh pressure liquid input channel 2 in ultrahigh pressure vessel 10
It is passed through superhigh pressure liquid, so that blood bag is in the environment of 200～400MPA, forms an airtight high pressure chest, meanwhile, utilize system
Device for cooling carries out quick-freezing to blood bag: make blood bag be cooled to-35～-40 DEG C and keep 20～40 minutes；Ultrahigh pressure vessel 10 is entered
Row pressure release (extracts superhigh pressure liquid out by superhigh pressure liquid input channel 2) in ultrahigh pressure vessel 10, moves down supertension
Container 10, makes plunger 17 remove from overthe openings by slip.Open sliding door, take out blood bag.Under-10 to-20 DEG C of environment
Carry out the ultra high pressure treatment of blood plasma, equipment pressure process must be in full closeding state, the only equipment when dress takes blood bag
Opening sliding door, sliding door can be that automatic or manual is opened.
The equipment utilizing embodiment 1 and the quick-freezing blood plasma supertension inactivation of viruses described in embodiment 2 is tested, and can obtain
Go out: under the pressure of supertension 200～400MPa, also will not freeze even if blood plasma reaches-30 DEG C, but at the moment blood of pressure release
Slurry can complete freezing process and become solid-state, and the crystal grain formed is the finest, can effectively protect the composition of blood plasma not broken
Bad, it is improved the effect of plasma purity.Under-30～-40 DEG C of temperature conditionss, apply the pressure of 200～400MPa, can inactivate
Virus in blood plasma, it is ensured that the safety of blood transfusion；After pressure discharges, blood plasma flash frozen, improve blood plasma freezes matter
Amount.
Above the present invention is done exemplary description, it should explanation, in the situation of the core without departing from the present invention
Under, any simple deformation, amendment or other those skilled in the art can not spend the equivalent of creative work equal
Fall into protection scope of the present invention.
Claims (10)
1. the equipment of a quick-freezing blood plasma supertension inactivation of viruses, it is characterised in that including: supercharger, insulation shell (14) and
Being positioned at the ultrahigh pressure vessel (10) that described insulation shell (14) is internal, described supercharger passes through pipeline to described ultrahigh pressure vessel
(10) input superhigh pressure liquid in, the blood bag being used for being pointed to described ultrahigh pressure vessel (10) internal is pressurizeed；Described guarantor
In temperature housing (14), refrigerating plant is installed, for described blood bag is freezed.
The equipment of quick-freezing blood plasma supertension inactivation of viruses the most according to claim 1, it is characterised in that described supercharger position
In described insulation shell (14) outside or inside；Described ultrahigh pressure vessel (10) is the cylindrical being formed with hollow cavity,
Described ultrahigh pressure vessel (10) is provided around framework (9).
The equipment of quick-freezing blood plasma supertension inactivation of viruses the most according to claim 2, it is characterised in that described hollow cavity
For cylindrical.
4. according to the equipment of the quick-freezing blood plasma supertension inactivation of viruses described in Claims 2 or 3, it is characterised in that described superelevation
Pressure vessel (10) is laterally disposed；The two ends of described ultrahigh pressure vessel (10) be respectively formed with one with opening that described hollow cavity connects
Mouthful；The lower surface of one base plate (5) is fixedly mounted with described framework (9), upper along being longitudinally provided with a plurality of line slideway at described base plate (5)
(4), it is used for making described ultrahigh pressure vessel (10) at the upper slide anteroposterior of described line slideway (4)；Near described ultrahigh pressure vessel
(10) it is separately installed with end bridging structure on the framework (9) at two ends, is used for sealing two openings of described ultrahigh pressure vessel (10)；
Described end bridging structure includes: for inserting end stifled (11), the first hydraulic cylinder (7) and the straight line of many horizontally sets of described opening
Optical axis (6), the cylinder barrel of described first hydraulic cylinder (7) is packed on described framework (9), the piston rod of described first hydraulic cylinder (7)
Vertically it is fixed with a push pedal (16)；One end of described straight optical axis (6) is vertical with described push pedal (16) to be fixedly mounted with, described straight optical axis
(6) periphery of the other end stifled with end (11) is fixedly mounted with, so that end stifled (11) stretches into and is positioned at during described first hydraulic cylinder (7) backhaul
The opening of the ultrahigh pressure vessel (10) of relevant position is interior and seals described ultrahigh pressure vessel (10)；
The lower end of described framework (9) is connected with the upper surface of base (3), and described base (3) is formed with described insulation shell (14)
One airtight cavity；Described insulation shell (14) is formed with 2 swing doors (15), when described ultrahigh pressure vessel (10) slides into
Away from swing door (15) described in each described opening during described end bridging structure the most corresponding, for described ultrahigh pressure vessel
(10) load blood bag in or in described ultrahigh pressure vessel (10), take out blood bag；
Being formed with superhigh pressure liquid input channel (2) in described end stifled (11), described superhigh pressure liquid input channel (2) is passed through
Pipeline connects with described supercharger, so that by described superhigh pressure liquid input channel (2) in described ultrahigh pressure vessel (10)
Input superhigh pressure liquid.
The equipment of quick-freezing blood plasma supertension inactivation of viruses the most according to claim 4, it is characterised in that described line slideway
(4) quantity is 2, and every line slideway (4) is provided with 2 slide blocks, described slide block all with described ultrahigh pressure vessel (10)
Lower end be fixedly mounted with.
The equipment of quick-freezing blood plasma supertension inactivation of viruses the most according to claim 4, it is characterised in that at described framework
(9) and multiple framework bracing frame (1) is installed between described base (3), it is used for supporting described framework (9).
The equipment of quick-freezing blood plasma supertension inactivation of viruses the most according to claim 4, it is characterised in that at each described end
Under the framework (9) of stifled superstructure, one second hydraulic cylinder (12), wherein, the cylinder barrel of described second hydraulic cylinder (12) and institute are installed
Stating framework (9) to be fixedly mounted with, piston rod and a parallels (8) of described second hydraulic cylinder (12) are fixedly mounted with, so that described first hydraulic cylinder (7)
Second hydraulic cylinder (12) action described in during backhaul, parallels (8) drops to the end stifled (11) side away from ultrahigh pressure vessel (10), uses
In the axial force bearing described end bridging structure.
The equipment of quick-freezing blood plasma supertension inactivation of viruses the most according to claim 4, it is characterised in that at described framework
(9) being provided with two vertical gripper shoes (13) in, two described gripper shoes (13) lay respectively at described ultrahigh pressure vessel (10)
Arranged on left and right sides, many straight optical axis (6) of each described end bridging structure are each passed through corresponding described gripper shoe (13),
It is laterally moved for supporting described end bridging structure.
9. according to the equipment of the quick-freezing blood plasma supertension inactivation of viruses described in Claims 2 or 3, it is characterised in that described superelevation
Pressure vessel (10) is vertically to place, the upper end of described ultrahigh pressure vessel (10) be formed one with opening that described hollow cavity connects
Mouthful；Pressurized cylinder (19) is installed between described ultrahigh pressure vessel (10) and described framework (9), so that described ultrahigh pressure vessel
(10) move at vertical direction；Being provided with plunger moving guide rail (18) under the framework (9) of side over said opening, described plunger moves
Under dynamic guide rail (18), slide block is installed, is fixed with plunger (17) under described slide block, so that described plunger (17) moves along described plunger
When dynamic guide rail (18) level slides into the surface of described opening, described ultrahigh pressure vessel (10) moves upward and by described plunger
(17) seal；
Being formed with superhigh pressure liquid input channel (2) in described plunger (17), described superhigh pressure liquid input channel (2) is passed through
Pipeline connects with described supercharger, so that by described superhigh pressure liquid input channel (2) in described ultrahigh pressure vessel (10)
Input superhigh pressure liquid；
Described insulation shell (14) is provided with a sliding door, for described ultrahigh pressure vessel (10) in filling blood bag or from
Blood bag is taken out in described ultrahigh pressure vessel (10).
The equipment of quick-freezing blood plasma supertension inactivation of viruses the most according to claim 9, it is characterised in that described sliding door
On handle is installed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610810945.9A CN106178007B (en) | 2016-09-08 | 2016-09-08 | Equipment for quickly freezing plasma ultrahigh pressure to inactivate viruses |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610810945.9A CN106178007B (en) | 2016-09-08 | 2016-09-08 | Equipment for quickly freezing plasma ultrahigh pressure to inactivate viruses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106178007A true CN106178007A (en) | 2016-12-07 |
| CN106178007B CN106178007B (en) | 2022-05-13 |
Family
ID=58066735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610810945.9A Active CN106178007B (en) | 2016-09-08 | 2016-09-08 | Equipment for quickly freezing plasma ultrahigh pressure to inactivate viruses |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110094909A (en) * | 2019-05-16 | 2019-08-06 | 广东海洋大学 | A kind of super-pressure cooling food wink jelly device for fast food freezing processing |
| CN110326733A (en) * | 2019-07-15 | 2019-10-15 | 山东华春新能源有限公司 | A kind of super-pressure quick freezing equipment |
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| US20070005048A1 (en) * | 2005-06-30 | 2007-01-04 | Niedbala R S | Method and apparatus for cryogenically treating lesions on biological tissue |
| CN105077509A (en) * | 2015-09-16 | 2015-11-25 | 中国农业大学 | Horizontal-type ultra-high pressure sterilization equipment aligning mechanism |
| CN105854039A (en) * | 2016-05-21 | 2016-08-17 | 郑州飞龙医疗设备有限公司 | Ultrahigh pressure inactivation method and equipment for pathogens in liquid biological products |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070005048A1 (en) * | 2005-06-30 | 2007-01-04 | Niedbala R S | Method and apparatus for cryogenically treating lesions on biological tissue |
| CN105077509A (en) * | 2015-09-16 | 2015-11-25 | 中国农业大学 | Horizontal-type ultra-high pressure sterilization equipment aligning mechanism |
| CN105854039A (en) * | 2016-05-21 | 2016-08-17 | 郑州飞龙医疗设备有限公司 | Ultrahigh pressure inactivation method and equipment for pathogens in liquid biological products |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110094909A (en) * | 2019-05-16 | 2019-08-06 | 广东海洋大学 | A kind of super-pressure cooling food wink jelly device for fast food freezing processing |
| CN110094909B (en) * | 2019-05-16 | 2021-02-05 | 广东海洋大学 | Ultrahigh-pressure cooling food instant freezing device for food quick-freezing processing |
| CN110326733A (en) * | 2019-07-15 | 2019-10-15 | 山东华春新能源有限公司 | A kind of super-pressure quick freezing equipment |
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| Publication number | Publication date |
|---|---|
| CN106178007B (en) | 2022-05-13 |
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Effective date of registration: 20240410 Address after: 1112-72, No. 2 Huatian Road, Huayuan Industrial Zone, Binhai New Area, Tianjin, 300384 Patentee after: Huajin (Tianjin) Hydraulic Technology Co.,Ltd. Country or region after: China Address before: Binhai New Industrial Development Zone (no.383, Haitai Road, Tianjin) Patentee before: TIANJIN HUATAI SENMIAO BIOLOGICAL ENGINEERING TECHNOLOGY CO.,LTD. Country or region before: China |