CN106172415A - 一种含苯并烯氟菌唑和苯菌酮的农药组合物 - Google Patents
一种含苯并烯氟菌唑和苯菌酮的农药组合物 Download PDFInfo
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
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- A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
- A01N35/04—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aldehyde or keto groups, or thio analogues thereof, directly attached to an aromatic ring system, e.g. acetophenone; Derivatives thereof, e.g. acetals
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Abstract
本发明涉及一种含苯并烯氟菌唑和苯菌酮的杀菌组合物，其中，苯并烯氟菌唑和苯菌酮的重量比为1:50‑50：1，优选为1:10‑20：1，本发明的组后可以加工成多种不同的制剂，主要用于防治黄瓜白粉病。
Description
技术领域
本发明涉及一种杀菌组合物，具体涉及的时一种含苯并烯氟菌唑和苯菌酮的农药组合物。
背景技术
白粉病是一种广泛发生的世界性病害，生产上主要采用化学农药防治白粉病，目前主要依赖苯并咪唑类、三唑类、甲氧基丙烯酸酯类杀菌剂。然而，长期使用单一种类的杀菌剂会使病害产生不同程度的抗性，防治效果降低。
苯并烯氟菌唑是一种吡唑酰胺类杀菌剂，通过抑制线粒体内膜上电子传递链中的琥珀酸脱氢酶，使得病原真菌无法经由呼吸产生能量，进而瓦解病菌的生长，该化合物单独使用成本较高且容易又发抗性的产生，从而降低农药品种的使用寿命。
苯菌酮是巴斯夫公司开发的二苯酮类杀菌剂，主要用于防治子囊菌亚门的多种病害，尤其对农作物白粉病有特效，对各类白粉病有保护、治疗、铲除和抑制产孢的作用。低质量浓度下可以强烈抑制病原菌孢子的萌发，与目前已知的商品化杀菌剂作用机制不同，有文献报道称苯菌酮的作用机制时干扰菌丝发育，干扰极性生长和细胞极性的建立和维持的过程，可能对调节细胞骨架肌动蛋白合成的通路有影响。与那些具有二甲基化作用的抑制剂以及苯胺基嘧啶类杀菌剂无交互抗性，主要用于多种作物的白粉病防治。
为合理的保护药剂的使用周期、延缓病菌对药剂抗药性的产生以及提高药剂的防治效果，有必要进行合理的复配研究，本申请的发明人经过检索，目前还没有苯并烯氟菌唑和苯菌酮复配防治白粉病的文献报道，进一步通过试验发现，将作用机理不同的苯并烯氟菌唑和苯菌酮复配，具有预料不到的协同增效作用，可以显著提高对白粉病的防治效果，减少用药量，降低防治成本，对作物安全。
发明内容
本发明的目的在于提供一种适合农业上使用的农药组合物，所述的组合物活性成分包含苯并烯氟菌唑和苯菌酮，为达到上述目的，本发明采用如下技术方案：一种包含苯并烯氟菌唑和苯菌酮的杀菌组合物，其中，苯并烯氟菌唑和苯菌酮的重量比为1:50-50:1，优选为1:10-20:1。
进一步的，所述杀菌组合物中活性成分的重量比为1-90%，优选为10-70%。
进一步的，所述杀菌组合物可以通过农药制剂加工中常规的制备方法加工成农业上允许的任意剂型，例如可以是可湿性粉剂、水分散粒剂、水乳剂、微乳剂、可分散油悬浮剂。
本发明的组合物可以以成品制剂形式提供即组合物中各物质已经混合，也可以以单剂形式提供，使用前直接在桶或罐中按比例混合，然后稀释至所需要的浓度。
进一步的，本发明的组合物还可以加入其它农用活性成分，例如杀菌剂、杀虫剂、除草剂、肥料等农用活性成分。
本发明的杀菌组合物适用于防除黄瓜白粉病、番茄白粉病、草莓白粉病等多种病害。
与现有技术相比，本发明的农药组合物的有益效果为：
（1）本发明的组合物复配后，兼具治疗和保护作用，在一定的范围内具有明显的协同增效作用，防效与单个活性成分相比有明显的提高；
（2）本发明的组合物中活性成分作用机理各不相同，在有效防治作物病害的同时，可以延缓病原菌抗药性的产生，有利于延缓农药活性成分的使用寿命；
（3）本发明的组合物制备工艺简单，适合实际生产中推广应用。
具体实施方式
为了使本发明的目的、技术方案及优点更加清楚明白，本发明用以下具体实施例进行说明，但本发明绝非限于这些例子。以下所述仅为本发明较好的实施例，仅仅用于解释本发明，但不能因此理解为对本发明专利范围的限制。应当指出的是，凡在本发明的精神和原则之内所作的任何修改、等同替换或改进等，均应包含在本发明的保护范围之内，因此，本发明专利的保护范围应以所附权利要求为准。
一、制剂实施例
1、实施例1:21%苯并烯氟菌唑·苯菌酮可湿性粉剂（20:1）
苯并烯氟菌唑 20%
苯菌酮 1%
烷基酚聚氧乙烯醚磷酸酯 3%
烷基萘磺酸盐甲醛缩合物 2%
木质素磺酸钠 4%
白炭黑 5%
高岭土 余量
2、实施例2:40%苯并烯氟菌唑·苯菌酮水分散粒剂（3：1）
苯并烯氟菌唑 30%
苯菌酮 10%
烷基苯磺酸钙 6%
聚羧酸盐 4%
二丁基萘磺酸钠 2%
聚乙二醇 1%
淀粉 1%
硅藻土 余量
3、实施例3:30%苯并烯氟菌唑·苯菌酮水乳剂（1：1）
苯并烯氟菌唑 15%
苯菌酮 15%
N-甲基吡咯烷酮 15%
脂肪醇聚氧乙烯醚 8%
丁醇 2%
丙二醇 1%
有机硅酮 1%
去离子水 余量
4、实施例4:11%苯并烯氟菌唑·苯菌酮可分散油悬浮剂（1：10）
苯并烯氟菌唑 1%
苯菌酮 10%
蓖麻油聚氧乙烯醚 5%
白炭黑 2%
大豆油 余量
5、实施例5:21%苯并烯氟菌唑·苯菌酮悬浮剂（1：20）
苯并烯氟菌唑 1%
苯菌酮 20%
烷基萘甲醛缩合物磺酸钠 3%
木质素磺酸钠 6%
硅酸镁铝 0.5%
膨润土 0.2%
丙二醇 3%
去离子水 余量
二、室内毒力测定
试验对象：黄瓜白粉病菌
试验方法：试验参考中华人民共和国行业标准NY/T 1156.11-2008《农药室内生物测定试验准则杀菌剂第11部分：防治瓜类白粉病试验盆栽法》，采用盆栽法测定。
播种感病黄瓜品种，盆栽生长至2片真叶期备用。苯并烯氟菌唑和吡噻菌胺原药分别用二甲基甲酰胺溶解，再用0.1%吐温-80表面活性剂水溶液溶解。每处理3盆，4次重复，将10 mL药液均匀喷洒于叶面至全部润湿，待药液自然晾干备用。并设只含溶剂和表面活性剂而不含有效成分的处理作空白对照。药剂处理后24 h，喷雾接种黄瓜白粉病菌孢子悬浮液。孢子悬浮液的配制过程如下：取长满白粉病菌叶片，用加油少量吐温-80表面活性剂的无菌水将孢子洗下，双层纱布过滤，镜检后调制成1×105个/mL的悬浮液。接种后置于恒温室中，在温度24℃条件下培养7天。待空白对照病液率达到80%以上时，分级调查各处理发病情况，计算各处理的病情指数和防治效果。
防治效果换算成机率值（y）,药液浓度（ug/mL）转换成对数值（x）,以最小而乘法计算毒力方程和抑制中浓度EC50，依孙云沛法计算药剂的毒力指数及共毒系数（CTC）。试验结果见表1。
由表1可以看出，苯并烯氟菌唑与苯菌酮在1:50-50:1的范围内复配，对黄瓜白粉病菌均表现出一定的协同增效作用；其中，当苯并烯氟菌唑与苯菌酮的复配比例在1:10-20:1的范围内，共毒系数均高于170，协同增效作用更明显。
三、田间药效试验
为了进一步验证本发明的实际应用效果，采用本发明实施例的药剂进行防治黄瓜白粉病田间药效试验。
供试药剂：（1）21%苯并烯氟菌唑·苯菌酮可湿性粉剂；（2）40%苯并烯氟菌唑·苯菌酮水分散粒剂；（3）30%苯并烯氟菌唑·苯菌酮水乳剂；（4）11%苯并烯氟菌唑·苯菌酮可分散油悬浮剂；（5）21%苯并烯氟菌唑·苯菌酮悬浮剂；（6）对比例1：10%苯并烯氟菌唑悬浮剂；（7）对比例2:50%苯菌酮可湿性粉剂。
分别于药后5天、10天调查病情指数并计算防效，试验结果见表2。
田间药效试验结果表明，实施例1-5的制剂对黄瓜白粉病的防效要明显好于10%苯并烯氟菌唑悬浮剂和50%苯菌酮可湿性粉剂，药后10天，各个制剂对白粉病的防效菌高于88%，本发明的组合物可以减缓病原菌对活性成分抗药性的产生，能够降低有效成分的使用量，同时提高药剂的防治效果，有利于降低用药成分，降低对环境的风险，本发明的组合物为进一步加快新农药的开发应用提供了依据，具有重要的推广意义。
Claims (4)
1.一种含有苯并烯氟菌唑和苯菌酮的杀菌组合物，其特征在于，苯并烯氟菌唑和苯菌酮的重量比为1:50-50:1，优选为1:10-20：1。
2.根据权利要求1所述的杀菌组合物，其特征在于，苯并烯氟菌唑和苯菌酮在制剂中的总重量占整个制剂质量的0.1-90%。
3.根据权利要求1或2的杀菌组合物，其特征在于，其可以制备成适合农业上使用的任意一种剂型，优选为可湿性粉剂、水分散粒剂、水乳剂、微乳剂、可分散油悬浮剂。
4.根据权利要求1-3中任意一项权利要求所述的杀菌组合物用于防除农作物病害的用途。
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