CN106168004B - A kind of preparation method of medical packing paper Cypres - Google Patents

Abstract

The invention relates to a method for preparing a surface sizing agent for medical packaging paper, and belongs to the technical field of surface sizing agent preparation. In the present invention, the supernatant liquid containing xanthan gum is firstly obtained by culturing and fermenting Xanthomonas bacteria, then fermenting fresh bovine bone and biogas liquid together, collecting the fermented liquid, decolorizing and removing impurities to obtain the filtrate, and then adding zinc oxide, etc. After pulverizing and sieving, mixed powder is obtained, and finally the supernatant, filtrate, etc. containing xanthan gum are stirred with auxiliary agents to obtain a surface sizing agent for medical packaging paper. The sizing agent prepared by the invention solves the problem that the surface sizing agent is implicitly adhered to the packaging during the sterilization process, and the paper bag prepared by using the sizing agent of the invention has high thermal strength of paper and film and good airtightness , the paper and the film can be completely separated when peeling off, and will not cause damage to the paper bag or sticking out of the paper fiber. The medical packaging paper sized by the surface sizing agent has a certain degree of air permeability, water resistance, good surface strength and paper-plastic Binding force.

Description

A kind of preparation method of medical packaging paper surface sizing agent

technical field

The invention relates to a method for preparing a surface sizing agent for medical packaging paper, and belongs to the technical field of surface sizing agent preparation.

Background technique

With the gradual integration of our country and international packaging, the packaging requirements for medical products are becoming higher and higher. At the same time, considering the requirements for environmental protection, paper-plastic composite and paper-plastic packaging are highly recommended internationally. The medical paper bag is a product that meets the requirements of modern medical packaging. It is generally made of a composite with plastic film, and has the characteristics of reliable sealing, heat sealing and easy tearing. This product is suitable for the packaging of gloves, gauze, cotton balls, cotton swabs, masks, catheters, surgical equipment, dental equipment, syringes and other medical equipment. It has been widely used abroad, and the domestic demand is also increasing. The manufacture of medical sterilization packaging paper bags is to bond the sizing layer of the raw material with the film through the high temperature and high pressure of the bag making machine, so that it can achieve a good airtightness. The paper after surface sizing needs to have a certain degree of air permeability to meet The entry of sterilizing factors during sterilization, the surface sizing agent must not adhere to the packaging during the sterilization process to destroy the hygiene of the packaging, and the paper is required to have good surface strength and heat sealing strength during use, so that it can be used in medical When peeling the wrapping paper bag, ensure proper adhesive force and absolutely clean peeling interface. According to these characteristics of medical paper bags, special hot-melt surface sizing agents need to be selected, so that the products can meet the performance requirements of good sealing performance, non-sticking of medical devices, suitable heat-sealing strength, and non-sticking of paper and film when peeling off. The current medical packaging bags are generally coated with a circle of adhesive around the edge on one side of the medical paper, then covered with a film, heat-pressed, bonded, and cut to form a paper bag. When heat-pressing, one side is reserved for packaging. To seal the bag, you only need to seal one end of the opening on a heat-sealing edge banding machine. When in use, you only need to peel off the opening end of the paper bag from the joint of the two layers of paper to open it.

At present, the surface sizing agent used in medical packaging paper is common. During the sterilization process, the surface sizing agent is easy to adhere to the packaging and damage the hygiene of the packaging. The heat seal strength between the paper and the film is not strong enough, causing the paper bag to be sealed weakly and peel off. When the paper and the film cannot be completely separated, the paper bag is damaged or the paper fiber sticks out.

Contents of the invention

The technical problem to be solved by the present invention: in view of the ubiquity of the surface sizing agent on the medical packaging paper at present, the surface sizing agent is easy to adhere to the packaging during the sterilization process and destroys the hygiene of the packaging, and the heat sealing strength of the paper and the film is not enough, causing the paper bag The seal is not firm, and the paper and the film cannot be completely separated when peeling off, resulting in the problem of paper bag damage or paper fiber sticking out. A method for preparing a surface sizing agent for medical packaging paper is provided. The invention firstly cultivates Xanthomonas 1. Obtain the supernatant containing xanthan gum after fermentation, then clean the fresh bovine bone, and ferment it with the filtered biogas liquid, then collect the fermentation liquid and use activated carbon to decolorize and remove impurities to obtain the filtrate, and then oxidize Zinc, etc. are crushed and sieved to obtain a mixed powder. Finally, the supernatant, filtrate, etc. containing xanthan gum are stirred at high speed with auxiliary agents to obtain a surface sizing agent for medical packaging paper. The sizing agent prepared by the invention solves the problem that the surface sizing agent is implicitly adhered to the packaging during the sterilization process, and the paper bag prepared by using the sizing agent of the invention has high thermal strength of paper and film and good airtightness , the paper and the film can be completely separated when peeling off, and will not cause damage to the paper bag or sticking out of the paper fiber. The medical packaging paper sized by the surface sizing agent has a certain degree of air permeability, water resistance, good surface strength and paper-plastic Binding force.

In order to solve the problems of the technologies described above, the technical solution adopted in the present invention is:

(1) Weigh 20-30g starch, 3-5g sodium nitrate, 2-4g potassium dihydrogen phosphate, 0.4-0.6g magnesium sulfate, 6-8g citric acid and 800-1000mL deionized water, stir and place in a sterile In the tank, sterilize at 100-110°C for 5-10 minutes to obtain a culture medium, inoculate Xanthomonas bacilli into the culture medium according to the inoculum size of 8-10%, and then transfer it to an incubator, at 30-40°C, 120 Cultivate at ~130r/min for 2~3 days, then place it in a centrifuge, centrifuge at 1200~1300r/min for 20~30min, collect the supernatant, that is, the Xanthomonas bacteria liquid;

(2) Weigh 30-40g of starch, 6-8g of peptone, 2-4g of sodium nitrate and 800-1000mL of deionized water in sequence, stir evenly, transfer to a sterilization tank, and sterilize at 100-110°C for 10-20min. Obtain the fermentation medium, and then transfer it to the fermenter. After the temperature of the fermentation medium drops to 30-40°C, take 200-300mL of the above-mentioned Xanthomonas bacteria liquid and add it to the fermenter, and ferment at 30-40°C for 3 ~4 days, after the fermentation is completed, the temperature is raised to 100-110°C, stirred for 5-10 minutes, then the fermentation liquid is collected, placed in a centrifuge, centrifuged at 6000-7000r/min for 30-40 minutes, the supernatant is collected, and set aside;

(3) Weigh 200-300g of fresh beef bone, wash it with deionized water, then put it into a fermenter, filter the biogas liquid, collect the filtrate, take 1-2L of the filtrate and add it to the fermenter, and control the temperature at 30- 40°C, airtight fermentation for 2-3 days, when the fermentation is over, raise the temperature to 100-110°C, stir and sterilize for 20-30min, take out the fermented bovine bones, collect the fermentation liquid, and put it in a centrifuge at 5000-6000r Centrifuge for 30-40min at 1/min, collect the supernatant, add the supernatant to the beaker, add 2-4g of activated carbon, let stand for 1-2h, filter to obtain the filtrate, and set aside;

(4) Weigh 3-5g of zinc oxide, 2-4g of carboxymethyl cellulose, and 6-8g of calcium carbonate into a pulverizer for pulverization, and pass through a 100-200 mesh sieve to obtain a mixed powder;

(5) In parts by weight, weigh 40 to 50 parts of supernatant from step (2), 20 to 30 parts of filtrate from step (3), 5 to 8 parts of the above mixed powder, 3 to 5 parts of hard Add sodium fatty acid, 1-3 parts of sodium dodecylbenzenesulfonate, and 1-3 parts of dibutyltin dilaurate into the mixer, and stir at 10000-12000r/min for 2-3 hours to obtain surface sizing of medical packaging paper agent.

Application method of the present invention: apply a circle of the surface sizing agent prepared by the present invention on one side edge of the medical paper, then cover the film on the medical paper coated with the sizing agent, and then heat it at 150～160°C, 4～ Heat seal at 6kPa for 3 to 5 seconds, reserve one side as a seal to form a paper bag, then put the package into the paper bag, and then heat seal the open end. Peel to open.

Compared with other methods, the present invention has beneficial technical effects as follows:

(1) The sizing agent prepared by the present invention solves the problem that the surface sizing agent implicitly adheres to the packaging during the sterilization process. The paper bag prepared by using the sizing agent of the present invention has high thermal strength of paper and film, Good sealing performance, the paper and film can be completely separated when peeling off, and will not cause damage to the paper bag or sticking out of the paper fiber;

(2) The medical packaging paper sized by the surface sizing agent of the present invention has certain air permeability, water resistance, good surface strength and paper-plastic bonding force;

(3) The main preparation steps of the present invention are simple and the required cost is low.

detailed description

First weigh 20-30g starch, 3-5g sodium nitrate, 2-4g potassium dihydrogen phosphate, 0.4-0.6g magnesium sulfate, 6-8g citric acid and 800-1000mL deionized water, stir and place in a sterilized tank , sterilized at 100-110°C for 5-10 minutes to obtain a culture medium, inoculated Xanthomonas bacilli into the culture medium according to the inoculum size of 8-10%, and then transferred to an incubator, at 30-40°C, 120-130r Cultivate at 1200-1300r/min for 2-3 days, then put it in a centrifuge, centrifuge at 1200-1300r/min for 20-30min, collect the supernatant, that is, Xanthomonas bacteria liquid; then weigh 30-40g starch, 6-8g of peptone, 2-4g of sodium nitrate and 800-1000mL of deionized water, stirred evenly and then transferred to a sterilization tank, sterilized at 100-110°C for 10-20min to obtain a fermentation medium, and then transferred to a fermentation tank After the temperature of the fermentation medium drops to 30-40°C, take 200-300mL of the above-mentioned Xanthomonas bacteria liquid and add it to the fermenter, and ferment at 30-40°C for 3-4 days, and after the fermentation is completed, the temperature is raised to 100-100°C. Stir at 110°C for 5-10 minutes, then collect the fermented liquid, put it in a centrifuge, centrifuge at 6000-7000r/min for 30-40 minutes, collect the supernatant, and set aside; then weigh 200-300g of fresh beef bone, and use Wash it with deionized water, then put it into a fermenter, filter the biogas liquid, collect the filtrate, take 1-2L of filtrate and add it to the fermenter, control the temperature at 30-40°C, and ferment in an airtight manner for 2-3 days, and the fermentation is over. Raise the temperature to 100-110°C, stir and sterilize for 20-30 minutes, take out the fermented bovine bone, collect the fermentation broth, put it in a centrifuge, centrifuge at 5000-6000r/min for 30-40min, collect the supernatant, Add the supernatant to the beaker, then add 2-4g of activated carbon, let it stand for 1-2 hours, filter to obtain the filtrate, and set aside; weigh 3-5g of zinc oxide, 2-4g of carboxymethyl cellulose, 6-8g of carbonic acid Calcium is added into a pulverizer for pulverization, and passed through a 100-200 mesh sieve to obtain a mixed powder; finally, in parts by weight, 40-50 parts of the spare supernatant, 20-30 parts of the spare filtrate, 5-8 Add the above mixed powder, 3-5 parts of sodium stearate, 1-3 parts of sodium dodecylbenzenesulfonate, and 1-3 parts of dibutyltin dilaurate into the mixer, and stir at 10000-12000r/min for 2 ~3h to obtain the surface sizing agent for medical packaging paper.

Example 1

First, weigh 20g of starch, 3g of sodium nitrate, 2g of potassium dihydrogen phosphate, 0.4g of magnesium sulfate, 6g of citric acid and 800mL of deionized water, stir and place in a sterilizing tank, and sterilize at 100°C for 5 minutes to obtain a culture medium. Xanthomonas was inoculated into the culture medium according to the inoculation amount of 8%, then transferred to the incubator, cultured at 30°C and 120r/min for 2 days, then placed in a centrifuge, and centrifuged at 1200r/min for 20min, Collect the supernatant, that is, the Xanthomonas bacteria liquid; then weigh 30g starch, 6g peptone, 2g sodium nitrate and 800mL deionized water in sequence, stir evenly, transfer to a sterilization tank, and sterilize at 100°C for 10min to obtain The fermentation medium was then transferred to a fermenter. After the temperature of the fermentation medium dropped to 30°C, 200 mL of the above-mentioned Xanthomonas bacteria liquid was added to the fermenter, and fermented at 30°C for 3 days. After the fermentation was completed, the temperature was raised to Stir at 100°C for 5 minutes, then collect the fermentation broth, put it in a centrifuge, and centrifuge it at 6000r/min for 30 minutes, collect the supernatant, and set aside; then weigh 200g of fresh bovine bone, wash it with deionized water, and then put it Put it into the fermenter, filter the biogas liquid, collect the filtrate, take 1L of filtrate and add it to the fermenter, control the temperature at 30°C, and ferment in a sealed container for 2 days. Take out the bovine bone, collect the fermentation liquid, put it in a centrifuge, centrifuge at 5000r/min for 30min, collect the supernatant, add the supernatant to a beaker, add 2g of activated carbon, let stand for 1h, filter to obtain the filtrate , standby; take 3g zinc oxide, 2g carboxymethyl cellulose, 6g calcium carbonate and join in the pulverizer to pulverize, pass through 100 mesh sieves, obtain mixed powder; Clear liquid, 20 parts of spare filtrate, 5 parts of the above-mentioned mixed powder, 3 parts of sodium stearate, 1 part of sodium dodecylbenzenesulfonate, and 1 part of dibutyltin dilaurate are added to the mixer, and the mixture is mixed at 10000r/min Stir for 2 hours to obtain the surface sizing agent for medical packaging paper.

Apply a circle of the surface sizing agent prepared by the present invention on one edge of the medical paper, then cover the film on the medical paper coated with the sizing agent, then heat seal at 150°C and 4kPa for 3s, and reserve one side as Seal it to form a paper bag, then put the packaging into the paper bag, and then heat seal the opening end. When in use, just peel off the opening end of the paper bag from the adhesive part of the two layers of paper to open it.

Example 2

First, weigh 30g of starch, 5g of sodium nitrate, 4g of potassium dihydrogen phosphate, 0.6g of magnesium sulfate, 8g of citric acid and 1000mL of deionized water, stir and place in a sterilizing tank, and sterilize at 110°C for 10 minutes to obtain a culture medium. Xanthomonas was inoculated into the culture medium according to 10% of the inoculation amount, then transferred to an incubator, cultured at 40°C and 130r/min for 3 days, then placed in a centrifuge, and centrifuged at 1300r/min for 30min. Collect the supernatant, that is, the Xanthomonas bacteria liquid; then weigh 40g starch, 8g peptone, 4g sodium nitrate and 1000mL deionized water in sequence, stir them evenly, transfer them to a sterilizing tank, and sterilize at 110°C for 20min to obtain The fermentation medium was then transferred to a fermenter. After the temperature of the fermentation medium dropped to 40°C, 300 mL of the above-mentioned Xanthomonas bacteria liquid was added to the fermenter, and fermented at 40°C for 4 days. After the fermentation was completed, the temperature was raised to Stir at 110°C for 10 minutes, then collect the fermentation broth, put it in a centrifuge, and centrifuge it at 7000r/min for 40 minutes, collect the supernatant, and set aside; then weigh 300g of fresh bovine bone, wash it with deionized water, and put it in the Put it into the fermenter, filter the biogas liquid, collect the filtrate, take 2L filtrate and add it to the fermenter, control the temperature at 40°C, and ferment in a sealed container for 3 days. Take out the bovine bone, collect the fermented liquid, put it in a centrifuge, centrifuge at 6000r/min for 40min, collect the supernatant, put the supernatant into a beaker, add 4g of activated carbon, let stand for 2h, and filter to obtain the filtrate , for subsequent use; take 5g zinc oxide, 4g carboxymethyl cellulose, 8g calcium carbonate and join in the pulverizer to pulverize, cross 200 mesh sieves, obtain mixed powder; Clear liquid, 30 parts of standby filtrate, 8 parts of the above mixed powder, 5 parts of sodium stearate, 3 parts of sodium dodecylbenzenesulfonate, and 3 parts of dibutyltin dilaurate are added to the mixer, and the mixture is mixed at 12000r/min Stir for 3 hours to obtain the surface sizing agent for medical packaging paper.

Apply a circle of the surface sizing agent prepared by the present invention on one edge of the medical paper, then cover the film on the medical paper coated with the sizing agent, then heat seal at 160°C and 6kPa for 5s, and reserve one side as Seal it to form a paper bag, then put the packaging into the paper bag, and then heat seal the opening end. When in use, just peel off the opening end of the paper bag from the adhesive part of the two layers of paper to open it.

Example 3

First weigh 25g of starch, 4g of sodium nitrate, 3g of potassium dihydrogen phosphate, 0.5g of magnesium sulfate, 7g of citric acid and 900mL of deionized water, put them in a sterilizing tank after stirring, and sterilize at 105°C for 8 minutes to obtain a culture medium. Xanthomonas was inoculated into the culture medium according to the inoculation amount of 9%, and then transferred to an incubator, cultured at 35°C and 125r/min for 2.5 days, then placed in a centrifuge, and centrifuged at 1250r/min for 25min. Collect the supernatant, that is, the Xanthomonas bacteria liquid; then weigh 35g starch, 7g peptone, 3g sodium nitrate and 900mL deionized water in sequence, stir them evenly, transfer them to a sterilizing tank, and sterilize at 105°C for 15 minutes to obtain The fermentation medium was then transferred to a fermenter. After the temperature of the fermentation medium dropped to 35°C, 250 mL of the above-mentioned Xanthomonas bacterium liquid was added to the fermenter, and fermented at 35°C for 3.5 days. After the fermentation was completed, the temperature was raised to Stir at 105°C for 8 minutes, then collect the fermentation broth, put it in a centrifuge, and centrifuge it at 6500r/min for 35 minutes, collect the supernatant, and set aside; then weigh 250g of fresh bovine bone, wash it with deionized water, and put it in the Put it into the fermenter, filter the biogas liquid, collect the filtrate, take 1.5L filtrate and add it to the fermenter, control the temperature at 35°C, and ferment in a sealed container for 2.5 days. Take out the bovine bone, collect the fermentation liquid, put it in a centrifuge, centrifuge at 5500r/min for 35min, collect the supernatant, add the supernatant to a beaker, add 3g of activated carbon, let stand for 1.5h, filter, Obtain filtrate, standby; Weigh 4g zinc oxide, 3g carboxymethyl cellulose, 7g calcium carbonate and join in pulverizer and pulverize, cross 150 mesh sieves, obtain mixed powder; Finally, count 45 parts by weight for standby The supernatant, 25 parts of standby filtrate, 6 parts of the above-mentioned mixed powder, 4 parts of sodium stearate, 2 parts of sodium dodecylbenzenesulfonate, and 2 parts of dibutyltin dilaurate are added to the mixer, at 11000r/ Stir for 2.5 hours at 1 min to obtain the surface sizing agent for medical packaging paper.

Apply a circle of surface sizing agent prepared by the present invention on one edge of medical paper, then cover the film on the medical paper coated with sizing agent, heat seal at 155°C and 5kPa for 4s, and reserve one side as Seal it to form a paper bag, then put the packaging into the paper bag, and then heat seal the opening end. When in use, just peel off the opening end of the paper bag from the adhesive part of the two layers of paper to open it.

Claims (1)

1. a kind of preparation method of medical packing paper Cypres, it is characterised in that specifically preparation process is：

（1）Weigh 20~30g starch, 3~5g sodium nitrate, 2~4g potassium dihydrogen phosphates, 0.4~0.6g magnesium sulfate, 6~8g lemons Acid and 800~1000mL deionized waters, are placed in sterilization tank after stirring, and sterilize 5~10min at 100~110 DEG C, is cultivated Base, Xanthomonas campestris is inoculated into culture medium by inoculum concentration 8~10%, is subsequently transferred in incubator, 30~40 DEG C, 120 Cultivate 2~3 days, be subsequently placed in centrifuge under~130r/min, 20~30min is centrifuged under 1200~1300r/min, collect Supernatant, i.e. Xanthomonas campestris bacterium solution；

（2）30~40g starch, 6~8g peptones, 2~4g sodium nitrate and 800~1000mL deionized waters are weighed successively, are stirred It is transferred to after uniformly in sterilization tank, sterilize 10~20min at 100~110 DEG C, obtains fermentation medium, is subsequently transferred to ferment In tank, after fermentation medium temperature is down to 30~40 DEG C, the above-mentioned Xanthomonas campestris bacterium solutions of 200~300mL are taken to be added to fermentation In tank, fermented 3~4 days at 30~40 DEG C, treat that fermentation ends are warming up to 100~110 DEG C, stirred 5~10min, then collect Zymotic fluid, it is placed in centrifuge, 30~40min is centrifuged under 6000~7000r/min, collects supernatant, it is standby；

（3）The fresh ox bones of 200~300g are weighed, is washed with deionized totally, is subsequently placed into fermentation tank, takes methane liquid mistake Filter, filtrate is collected, takes 1~2L filtrates to be added in fermentation tank, control temperature sealed fermenting 2~3 days, is fermented at 30~40 DEG C Terminate, be warming up to 100~110 DEG C, stirring 20~30min of sterilizing, the ox bone after fermentation taken out, zymotic fluid is collected, is placed in In centrifuge, 30~40min is centrifuged under 5000~6000r/min, supernatant is collected, supernatant is added in beaker, then 2~4g activated carbons are added, 1~2h is stood, filtering, obtains filtrate, it is standby；

（4）Weigh 3~5g zinc oxide, 2~4g carboxymethyl celluloses, 6~8g calcium carbonate to be added in pulverizer and crushed, mistake 100~200 mesh sieves, obtain mixed-powder；

（5）Count in parts by weight, weigh 40~50 parts of steps（2）Standby supernatant, 20~30 parts of steps（3）Standby filter Liquid, 5~8 parts of above-mentioned mixed-powders, 3~5 parts of odium stearate, 1~3 part of neopelex, 1~3 part of tin dilaurate two Butyl tin is added in mixer, and 2~3h is stirred under 10000~12000r/min, obtains medical packing paper Cypres.