CN106145077B - A kind of preparation method of hydroxyapatite oriented growth structure - Google Patents
A kind of preparation method of hydroxyapatite oriented growth structure Download PDFInfo
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- CN106145077B CN106145077B CN201610489924.1A CN201610489924A CN106145077B CN 106145077 B CN106145077 B CN 106145077B CN 201610489924 A CN201610489924 A CN 201610489924A CN 106145077 B CN106145077 B CN 106145077B
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- hydroxyapatite
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- oriented growth
- growth structure
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- 229910052588 hydroxylapatite Inorganic materials 0.000 title claims abstract description 27
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 title claims abstract description 27
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims abstract description 24
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 20
- 239000004584 polyacrylic acid Substances 0.000 claims abstract description 19
- 238000003756 stirring Methods 0.000 claims abstract description 14
- 229910021529 ammonia Inorganic materials 0.000 claims abstract description 12
- 241000206575 Chondrus crispus Species 0.000 claims abstract description 11
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000011575 calcium Substances 0.000 claims abstract description 8
- 229910001424 calcium ion Inorganic materials 0.000 claims abstract description 8
- 239000007788 liquid Substances 0.000 claims abstract description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229910019142 PO4 Inorganic materials 0.000 claims abstract description 5
- 159000000007 calcium salts Chemical class 0.000 claims abstract description 5
- 239000010452 phosphate Substances 0.000 claims abstract description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims abstract description 5
- 239000012065 filter cake Substances 0.000 claims description 12
- 239000000679 carrageenan Substances 0.000 claims description 10
- 229920001525 carrageenan Polymers 0.000 claims description 10
- 229940113118 carrageenan Drugs 0.000 claims description 10
- ZCCIPPOKBCJFDN-UHFFFAOYSA-N calcium nitrate Chemical compound [Ca+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ZCCIPPOKBCJFDN-UHFFFAOYSA-N 0.000 claims description 8
- 239000000047 product Substances 0.000 claims description 7
- 239000000428 dust Substances 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 4
- 239000001110 calcium chloride Substances 0.000 claims description 4
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 4
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 claims description 3
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 3
- 229910000402 monopotassium phosphate Inorganic materials 0.000 claims description 3
- 235000019796 monopotassium phosphate Nutrition 0.000 claims description 3
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 3
- 235000019799 monosodium phosphate Nutrition 0.000 claims description 3
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 claims description 3
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims 2
- 150000001336 alkenes Chemical class 0.000 claims 1
- 239000003292 glue Substances 0.000 claims 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 claims 1
- 238000000034 method Methods 0.000 description 5
- 239000011521 glass Substances 0.000 description 4
- 239000012071 phase Substances 0.000 description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 239000001506 calcium phosphate Substances 0.000 description 2
- 229910000389 calcium phosphate Inorganic materials 0.000 description 2
- 235000011010 calcium phosphates Nutrition 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
- 229910014497 Ca10(PO4)6(OH)2 Inorganic materials 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 235000019738 Limestone Nutrition 0.000 description 1
- DMGNFLJBACZMRM-UHFFFAOYSA-N O[P] Chemical compound O[P] DMGNFLJBACZMRM-UHFFFAOYSA-N 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 230000018199 S phase Effects 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000033558 biomineral tissue development Effects 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 230000009920 chelation Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000006028 limestone Substances 0.000 description 1
- 239000006259 organic additive Substances 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000008844 regulatory mechanism Effects 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B25/00—Phosphorus; Compounds thereof
- C01B25/16—Oxyacids of phosphorus; Salts thereof
- C01B25/26—Phosphates
- C01B25/32—Phosphates of magnesium, calcium, strontium, or barium
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2002/00—Crystal-structural characteristics
- C01P2002/70—Crystal-structural characteristics defined by measured X-ray, neutron or electron diffraction data
- C01P2002/72—Crystal-structural characteristics defined by measured X-ray, neutron or electron diffraction data by d-values or two theta-values, e.g. as X-ray diagram
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2004/00—Particle morphology
- C01P2004/01—Particle morphology depicted by an image
- C01P2004/03—Particle morphology depicted by an image obtained by SEM
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2004/00—Particle morphology
- C01P2004/30—Particle morphology extending in three dimensions
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention provides a kind of preparation method of hydroxyapatite oriented growth structure, hydroxyapatite can be made to be grown according to assigned direction, comprised the following steps：1) according to mol ratio Ca:P=10:Soluble calcium salt and soluble phosphate are dissolved in water by 6, are configured to Ca2+Concentration is 0.01~1mol/L solution；2) carragheen and polyacrylic acid are added, the addition of carragheen is the 0.5~5% of solution quality, and the addition of polyacrylic acid is the 1~5% of solution quality, in 40~50 DEG C of stirrings to after being completely dissolved, continues 30~60min of stirring；3) room temperature is cooled to, is placed in open-top receptacle, to the ammonia that liquid level wind drift amount is 0.01~1ml/min at 5~20mm of ullage, is reacted 1~7 day；4) filter, be washed to PH as 7~8；5) alcohol is washed, and is heated 2~4h at 140~300 DEG C, is ground, obtain product.
Description
【Technical field】
The present invention relates to artificial bone field, more particularly to a kind of preparation method of hydroxyapatite oriented growth structure.
【Background technology】
Phosphorus ash stone mineral are most common calcium phosphate mineral, wherein again with hydroxyapatite (HAP, Ca10(PO4)6
(OH)2For Typical Representative), bone and the most important inorganic constituents of tooth are HAP.HAP is in organism mainly with monoclinic system
It is existence phase with hexagonal crystal system, both things mutually can be converted mutually under certain condition.In order to further explore life mistake
Journey, promoting biology --- bionical development, it is always to study heat to form HAP physiology mineralization process and life regulatory mechanism
Point.
Research finds that what is formed at first from solution in HAP forming processes is the unformed phosphoric acid of thermodynamic instability
Calcium precursor (AmorpHous calcium pHospHate, ACP).ACP possesses good mobility and plasticity, using ACP as
Interference and regulation and control of the HAP crystallization process of forerunner's phase by many factors such as temperature, pH value, solution degree of supersaturation, organic additives.
The HAP orientation of growth has been largely fixed the performances such as HAP intensity, elasticity, therefore, finds new preparation method so that
HAP is significantly for the applications of artificial HAP medically according to assigned direction oriented growth.
【The content of the invention】
For above mentioned problem of the prior art, the present invention provides a kind of preparation side of hydroxyapatite oriented growth structure
Method, hydroxyapatite can be made to be grown according to assigned direction.
The technical scheme is that：
A kind of preparation method of hydroxyapatite oriented growth structure, it is characterised in that comprise the following steps：
(1) according to mol ratio Ca:P=10:6 ratio, soluble calcium salt and soluble phosphate are dissolved in water, are configured to
Ca2+Concentration is 0.01~1mol/L solution；
(2) carragheen and polyacrylic acid (Polyacrylic acid, PAA), institute are added in the solution obtained by step (1)
The addition for stating carragheen is the 0.5~5% of step (1) solution quality, and the addition of the polyacrylic acid is step (1) solution
The 1~5% of quality, under the conditions of 40~50 DEG C, stir to after being completely dissolved, continue 30~60min of stirring；
(3) stop heating, the solution obtained by step (2) is cooled to room temperature, is placed in open-top receptacle, in ullage 5
To the ammonia that liquid level wind drift amount is 0.01~1mL/min at~20mm, react 1~7 day；
(4) mixture obtained by step (3) is filtered, filter cake is washed to pH as 7~8；
(5) the filter cake alcohol obtained by step (4) is washed, 2~4h is heated at 140~300 DEG C, is ground, obtained final
Product.
Preferably, above-mentioned soluble calcium salt refers to the one or more in calcirm-fluoride, calcium chloride, calcium nitrate.
Preferably, above-mentioned soluble phosphate refers to sodium dihydrogen phosphate, disodium hydrogen phosphate, potassium dihydrogen phosphate, dipotassium hydrogen phosphate
One or more.
Preferably, above-mentioned carragheen is lambda-carrageenan.
Preferably, the molecular weight of above-mentioned polyacrylic acid is 4000~5000.
Preferably, the addition of carragheen is the 0.5~2% of step (1) solution quality in above-mentioned steps (2).
Preferably, the addition of polyacrylic acid is the 3~5% of step (1) solution quality in above-mentioned steps (2).
Preferably, during above-mentioned steps (3), container and solution keep standing.
Preferably, the flow of ammonia is 0.05~0.1mL/min in above-mentioned steps (3).
Preferably, being provided with above above-mentioned steps (3) open-top receptacle prevents the dust cover of pollution.
The present invention has technique effect beneficial below：
1) present invention can prepare hydroxyapatite pure phase, and make hydroxyl phosphorus by appropriate formula, proportioning and step
Lime stone is grown to the umbrella cylindricality to be grown centered on the site that ammonia enters solution system；2) present invention passes through polyacrylic acid molecule
The carboxyl of carrying and the chelation of calcium ion, extend stabilization time of the ACP forerunner mutually in aqueous phase so that hydroxyapatite is given birth to
It is grown to ordered structure；3) present invention limits life of the hydroxyapatite in radial direction by the double-spiral structure between carrageenan molecule
Long spacing, its phase axial growth is limited, form specific structure, the size of radial direction can be carried out necessarily by the concentration of carragheen
The regulation and control of scope；4) in whole course of reaction, the power of crystallization is from quiet with diffusion of the ammonia to liquid internal, holding container
Other disturbances only can be reduced with appropriate ammonia flow, make structural integrity orderly.
【Brief description of the drawings】
Fig. 1 is the stereoscan photograph of embodiment one.
【Embodiment】
Below in conjunction with specific embodiment, the present invention is described further.
Embodiment provided below is simultaneously not used to the scope that the limitation present invention is covered, described step nor with
To limit its execution sequence.Those skilled in the art do conspicuously improved with reference to existing common knowledge to the present invention, also fall
Enter within the protection domain of application claims.
Embodiment one
A kind of preparation method of hydroxyapatite oriented growth structure, it is characterised in that comprise the following steps：
(1) according to mol ratio Ca:P=10:6 ratio, calcirm-fluoride and sodium dihydrogen phosphate are dissolved in water, are configured to Ca2+It is dense
Spend the solution for 0.01mol/L；
(2) lambda-carrageenan and molecular weight are added in the solution obtained by step (1) as 4000~5000 polyacrylic acid, institute
The addition for stating carragheen is the 0.5% of step (1) solution quality, and the addition of the polyacrylic acid is step (1) solution matter
The 1% of amount, under the conditions of 40~50 DEG C, stir to after being completely dissolved, continue 30~60min of stirring；
(3) stop heating, the solution obtained by step (2) is cooled to room temperature, takes and is placed in right amount in open glass container, should
It is 0.01mL/min's to liquid level wind drift amount that the dust cover for preventing polluting is provided with above open-top receptacle at ullage 5mm
Ammonia, stand reaction 7 days；
(4) mixture obtained by step (3) is filtered, filter cake is washed to pH as 7~8；
(5) the filter cake alcohol obtained by step (4) is washed, heats 2h at 300 DEG C, grind, obtain final products, such as schemed
Shown in 1.Characterized by XRD, product is hydroxyapatite, and can be seen that product from Fig. 1 SEM photograph is using any as growth
Center, radial direction is limited, prolongs the umbrella column construction of axial growth.
Embodiment two
A kind of preparation method of hydroxyapatite oriented growth structure, it is characterised in that comprise the following steps：
(1) according to mol ratio Ca:P=10:6 ratio, calcium chloride and disodium hydrogen phosphate are dissolved in water, are configured to Ca2+It is dense
Spend the solution for 0.02mol/L；
(2) lambda-carrageenan and molecular weight are added in the solution obtained by step (1) as 4000~5000 polyacrylic acid, institute
The addition for stating lambda-carrageenan is the 2% of step (1) solution quality, and the addition of the polyacrylic acid is step (1) solution matter
The 3% of amount, under the conditions of 40~50 DEG C, stir to after being completely dissolved, continue 30~60min of stirring；
(3) stop heating, the solution obtained by step (2) is cooled to room temperature, takes and is placed in right amount in open glass container, should
The dust cover that being provided with above open-top receptacle prevents from polluting is 0.05mL/min to liquid level wind drift amount at ullage 10mm
Ammonia, stand reaction 5 days；
(4) mixture obtained by step (3) is filtered, filter cake is washed to pH as 7~8；
(5) the filter cake alcohol obtained by step (4) is washed, heats 3h at 250 DEG C, grind, obtain final products.
Embodiment three
A kind of preparation method of hydroxyapatite oriented growth structure, it is characterised in that comprise the following steps：
(1) according to mol ratio Ca:P=10:6 ratio, calcium nitrate and dipotassium hydrogen phosphate are dissolved in water, are configured to Ca2+It is dense
Spend the solution for 0.5mol/L；
(2) lambda-carrageenan and molecular weight are added in the solution obtained by step (1) as 4000~5000 polyacrylic acid, institute
The addition for stating lambda-carrageenan is the 5% of step (1) solution quality, and the addition of the polyacrylic acid is step (1) solution matter
The 5% of amount, under the conditions of 40~50 DEG C, stir to after being completely dissolved, continue 30~60min of stirring；
(3) stop heating, the solution obtained by step (2) is cooled to room temperature, takes and is placed in right amount in open glass container, should
It is 0.1mL/min's to liquid level wind drift amount that the dust cover for preventing polluting is provided with above open-top receptacle at ullage 15mm
Ammonia, stand reaction 3 days；
(4) mixture obtained by step (3) is filtered, filter cake is washed to pH as 7~8；
(5) the filter cake alcohol obtained by step (4) is washed, heats 3h at 200 DEG C, grind, obtain final products.
Example IV
A kind of preparation method of hydroxyapatite oriented growth structure, it is characterised in that comprise the following steps：
(1) according to mol ratio Ca:P=10:6 ratio, calcium chloride, calcium nitrate and potassium dihydrogen phosphate are dissolved in water, configured
Into Ca2+Concentration is 0.1mol/L solution；
(2) lambda-carrageenan and molecular weight are added in the solution obtained by step (1) as 4000~5000 polyacrylic acid, institute
The addition for stating lambda-carrageenan is the 5% of step (1) solution quality, and the addition of the polyacrylic acid is step (1) solution matter
The 3% of amount, under the conditions of 40~50 DEG C, stir to after being completely dissolved, continue 30~60min of stirring；
(3) stop heating, the solution obtained by step (2) is cooled to room temperature, takes and is placed in right amount in open glass container, should
The dust cover for preventing polluting is provided with above open-top receptacle at ullage 20mm to the ammonia that liquid level wind drift amount is 1mL/min
Gas, stand reaction 1 day；
(4) mixture obtained by step (3) is filtered, filter cake is washed to pH as 7~8；
(5) the filter cake alcohol obtained by step (4) is washed, heats 4h at 140 DEG C, grind, obtain final products.
Claims (10)
1. a kind of preparation method of hydroxyapatite oriented growth structure, it is characterised in that comprise the following steps：
(1) according to mol ratio Ca:P=10:6 ratio, soluble calcium salt and soluble phosphate are dissolved in water, are configured to Ca2+
Concentration is 0.01~1mol/L solution；
(2) carragheen and polyacrylic acid are added in the solution obtained by step (1), the addition of the carragheen is step (1)
The 0.5~5% of solution quality, the addition of the polyacrylic acid is the 1~5% of step (1) solution quality, in 40~50 DEG C of bars
Under part, stir to after being completely dissolved, continue 30~60min of stirring；
(3) stop heating, the solution obtained by step (2) is cooled to room temperature, takes and is placed in right amount in open-top receptacle, in ullage
To the ammonia that liquid level wind drift amount is 0.01~1mL/min at 5~20mm, react 1~7 day；
(4) mixture obtained by step (3) is filtered, filter cake is washed to pH as 7~8；
(5) the filter cake alcohol obtained by step (4) is washed, 2~4h is heated at 140~300 DEG C, grinds, obtains final products.
2. the preparation method of hydroxyapatite oriented growth structure according to claim 1, it is characterised in that described solvable
Property calcium salt refers to the one or more in calcium chloride, calcium nitrate.
3. the preparation method of hydroxyapatite oriented growth structure according to claim 1, it is characterised in that described solvable
Acid phosphate refers to the one or more of sodium dihydrogen phosphate, disodium hydrogen phosphate, potassium dihydrogen phosphate, dipotassium hydrogen phosphate.
4. the preparation method of hydroxyapatite oriented growth structure according to claim 1, it is characterised in that the OK a karaoke club
Glue is lambda-carrageenan.
5. the preparation method of hydroxyapatite oriented growth structure according to claim 1, it is characterised in that described poly- third
The molecular weight of olefin(e) acid is 4000~5000.
6. the preparation method of hydroxyapatite oriented growth structure according to claim 1, it is characterised in that the step
(2) addition of carragheen is the 0.5~2% of step (1) solution quality in.
7. the preparation method of hydroxyapatite oriented growth structure according to claim 1, it is characterised in that the step
(2) addition of polyacrylic acid is the 3~5% of step (1) solution quality in.
8. the preparation method of hydroxyapatite oriented growth structure according to claim 1, it is characterised in that the step
(3) during, container and solution keep standing.
9. the preparation method of hydroxyapatite oriented growth structure according to claim 1, it is characterised in that the step
(3) flow of ammonia is 0.05~0.1mL/min in.
10. the preparation method of hydroxyapatite oriented growth structure according to claim 1, it is characterised in that the step
Suddenly being provided with above (3) open-top receptacle prevents the dust cover of pollution.
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| CN107522883B (en) * | 2017-08-18 | 2020-10-13 | 深圳技术大学筹备办公室 | Preparation method of hydroxyapatite composite film material |
| CN108926743B (en) * | 2018-08-20 | 2020-07-14 | 北京恒泽博泰生物科技有限公司 | Three-dimensional mineralized collagen scaffold material and bone regeneration application thereof |
| CN110236958B (en) * | 2019-06-28 | 2020-12-29 | 武汉大学 | Material for promoting repair of defective and missing tooth tissues and preparation method thereof |
| CN113603933B (en) * | 2021-07-16 | 2023-04-11 | 佛山仙湖实验室 | Method for regulating and controlling hydroxyapatite nanoparticle aggregate and application |
| CN114934389B (en) * | 2022-06-30 | 2024-01-26 | 首都医科大学 | Mineralization method of collagen fibers |
| CN118490715A (en) * | 2024-05-14 | 2024-08-16 | 江苏海洋大学 | Composite material for promoting bone and resisting tumor after osteosarcoma excision and preparation method thereof |
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| CN102502556A (en) * | 2011-12-14 | 2012-06-20 | 江南大学 | Method for preparing nano hydroxyapatite |
| CN103553013A (en) * | 2013-11-17 | 2014-02-05 | 北华航天工业学院 | Preparation method of nano hydroxyapatite powder with controllable morphology |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07187624A (en) * | 1993-12-27 | 1995-07-25 | Natl Inst For Res In Inorg Mater | Production of apatite powder |
| JP2016069243A (en) * | 2014-09-30 | 2016-05-09 | 日本製紙株式会社 | Manufacturing method of calcium monohydrogen phosphate compound and calcium monohydrogen phosphate compound |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102502556A (en) * | 2011-12-14 | 2012-06-20 | 江南大学 | Method for preparing nano hydroxyapatite |
| CN103553013A (en) * | 2013-11-17 | 2014-02-05 | 北华航天工业学院 | Preparation method of nano hydroxyapatite powder with controllable morphology |
| CN104709886A (en) * | 2013-12-12 | 2015-06-17 | 江南大学 | Dual-component template hydrothermal preparation method of nano hydroxyapatite |
| CN104986748A (en) * | 2015-06-30 | 2015-10-21 | 南方科技大学 | Carbonate radical hydroxyapatite and preparation method thereof |
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