CN106139157A - A kind of reinforced membranes coating pre-mixing agent and preparation method - Google Patents
A kind of reinforced membranes coating pre-mixing agent and preparation method Download PDFInfo
- Publication number
- CN106139157A CN106139157A CN201610703779.2A CN201610703779A CN106139157A CN 106139157 A CN106139157 A CN 106139157A CN 201610703779 A CN201610703779 A CN 201610703779A CN 106139157 A CN106139157 A CN 106139157A
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- China
- Prior art keywords
- cellulose
- reinforced membranes
- mixing agent
- coating pre
- correctives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of reinforced membranes coating pre-mixing agent, be made up of following raw material: hydroxypropyl methyl cellulose, polyvinyl alcohol polyethyleneglycol-graft copolymer, PVP K30, ethyl cellulose, triacetyl glycerine, microcrystalline Cellulose, coloring agent, correctives.One reinforced membranes coating pre-mixing agent of the present invention, there is good adhesive property, solve the caducous problem of Chinese medicinal tablet film coating, it also is able to for other kinds of tablet simultaneously, abnormal flavour can be isolated, prevent the quality problems such as the medicine moisture absorption, variable color, deformation, it is ensured that the stability of medicine and safety, it is ensured that the drug safety of patient；One reinforced membranes coating pre-mixing agent steady quality of the present invention, safety height, production cost is low.
Description
Technical field
The invention belongs to field of pharmaceutical preparations, be specifically related to a kind of reinforced membranes coating pre-mixing agent and preparation method.
Background technology
Film coating is the medical coating technology developed the forties in 20th century.The 1950's, Abbott Laboratories of U.S. medicine
First factory produces film coating tablet, and film coating procedure gradually develops and comes thereafter.Film coating and traditional sugar coating
Technology is compared, and has coating the shortest, more can moistureproof, lucifuge, the advantages such as medicine stability is higher, therefore film-coated technique exists
Developing rapidly, the pharmaceutic adjuvant enterprise of China also develops some coating powders with new feature.The most domestic the most normal
Solid film material, according to different dissolubilities with use requirement to be divided into three major types, i.e. hydroxypropyl methyl cellulose, ethyl is fine
Dimension element, acrylic resin, these materials or be dissolved in intestinal juice or be dissolved in gastric juice, character differs, and based on these characteristics, people develop
The differences such as water-soluble film coating powder, gastric solubility film coating powder, enteric film coating powder and slow-releasing film coating powder
The coating powder of character.But common film coating pre-mix dose easily comes off after being bundled into clothing film, especially for Chinese medicinal tablet, because of
This is for above-mentioned situation, and the present invention provides a kind of and has good adhesive property, solves Chinese medicinal tablet film coating easy to fall off
Problem, also be able to the reinforced membranes coating pre-mixing agent for other kinds of tablet simultaneously.
Summary of the invention
The present invention provides a kind of and has good adhesive property, solves the caducous problem of Chinese medicinal tablet film coating,
It also is able to the reinforced membranes coating pre-mixing agent for other kinds of tablet and preparation method simultaneously.
For reaching above-mentioned purpose, the technical solution adopted in the present invention is as follows:
A kind of reinforced membranes coating pre-mixing agent, is made up of following raw material precentagewise: hydroxypropyl methyl cellulose 35%～
65%, polyvinyl alcohol polyethyleneglycol-graft copolymer 5%～15%, PVP K30 2%～8%, ethyl cellulose 0.5%
～3%, triacetyl glycerine 2%～5%, microcrystalline Cellulose 15%～25%, coloring agent 0.6%～4%, correctives 0.8%
～3%.
The preparation method of a kind of reinforced membranes coating pre-mixing agent is as follows:
(1) precentagewise takes raw material: hydroxypropyl methyl cellulose, polyvinyl alcohol polyethyleneglycol-graft copolymer, polyvidone
K30, ethyl cellulose, triacetyl glycerine, microcrystalline Cellulose, coloring agent, correctives, standby；
(2) hydroxypropyl methyl cellulose, polyvinyl alcohol polyethyleneglycol-graft copolymer, PVP K30, ethyl cellulose are put
In mixer, carry out shearing, stir, make mixing 10min；
(3) triacetyl glycerine is dissolved in ethanol in the ratio of 1:1, adds in the material that step (2) mixes and stir
10min；
(4) being placed in drying baker by the wet feed that step (3) mixes, keep the temperature inside the box to be 55 ± 5 DEG C and be dried, drying time is
10-20 minute；
(5) by step (4) dried material adds microcrystalline Cellulose, after correctives and coloring agent uniformly mix, it is placed in powder
Broken machine is pulverized, crosses 50 mesh sieves, get product.
The present invention can select different coloring agent according to different product demand, such as: titanium dioxide or ferrum oxide or pigment
Deng, it is also possible to select different correctivess, such as: steviosin or aspartame etc., but be not limited to this.
Beneficial effects of the present invention:
One reinforced membranes coating pre-mixing agent of the present invention, has good adhesive property, solves Chinese medicinal tablet film coating
Caducous problem, also is able to for other kinds of tablet simultaneously, it is possible to isolation abnormal flavour, prevents the medicine moisture absorption, variable color, deformation
Etc. quality problems, it is ensured that the stability of medicine and safety, it is ensured that the drug safety of patient；One enhancement mode of the present invention is thin
Film coating pre-mixing agent steady quality, safety height, production cost is low.
Detailed description of the invention
Content described in this specification embodiment is only the citing of the way of realization to inventive concept, the protection of the present invention
Scope is not construed as being only limitted to the concrete form that embodiment is stated, protection scope of the present invention is also and in art technology
Personnel according to inventive concept it is conceivable that equivalent technologies means.
Embodiment 1
The preparation method of a kind of reinforced membranes coating pre-mixing agent is as follows:
(1) precentagewise takes raw material: hydroxypropyl methyl cellulose 54%, polyvinyl alcohol polyethyleneglycol-graft copolymer 13%, poly-
Dimension ketone K30 5%, ethyl cellulose 2%, triacetyl glycerine 2%, microcrystalline Cellulose 21%, coloring agent 1.5%, correctives 1.5%, standby
With；
(2) hydroxypropyl methyl cellulose, polyvinyl alcohol polyethyleneglycol-graft copolymer, PVP K30, ethyl cellulose are put
In mixer, carry out shearing, stir, make mixing 10min；
(3) triacetyl glycerine is dissolved in ethanol in the ratio of 1:1, adds in the material that step (2) mixes and stir
10min；
(4) being placed in drying baker by the wet feed that step (3) mixes, keep the temperature inside the box to be 55 DEG C and be dried, drying time is 15
Minute；
(5) by step (4) dried material adds microcrystalline Cellulose, after correctives and coloring agent uniformly mix, it is placed in powder
Broken machine is pulverized, crosses 50 mesh sieves, get product.
Embodiment 2
The preparation method of a kind of reinforced membranes coating pre-mixing agent is as follows:
(1) precentagewise takes raw material: hydroxypropyl methyl cellulose 56%, polyvinyl alcohol polyethyleneglycol-graft copolymer 11%, poly-
Dimension ketone K30 4%, ethyl cellulose 2.5%, triacetyl glycerine 3%, microcrystalline Cellulose 20%, coloring agent 1.5%, correctives 2%, standby
With；
(2) hydroxypropyl methyl cellulose, polyvinyl alcohol polyethyleneglycol-graft copolymer, PVP K30, ethyl cellulose are put
In mixer, carry out shearing, stir, make mixing 10min；
(3) triacetyl glycerine is dissolved in ethanol in the ratio of 1:1, adds in the material that step (2) mixes and stir
10min；
(4) being placed in drying baker by the wet feed that step (3) mixes, keep the temperature inside the box to be 60 DEG C and be dried, drying time is 10
Minute；
(5) by step (4) dried material adds microcrystalline Cellulose, after correctives and coloring agent uniformly mix, it is placed in powder
Broken machine is pulverized, crosses 50 mesh sieves, get product.
Embodiment 3
The preparation method of a kind of reinforced membranes coating pre-mixing agent is as follows:
(1) precentagewise takes raw material: hydroxypropyl methyl cellulose 58%, polyvinyl alcohol polyethyleneglycol-graft copolymer 10%, poly-
Dimension ketone K30 6%, ethyl cellulose 2%, triacetyl glycerine 2%, microcrystalline Cellulose 18%, coloring agent 1.5%, correctives 2.5%, standby
With；
(2) hydroxypropyl methyl cellulose, polyvinyl alcohol polyethyleneglycol-graft copolymer, PVP K30, ethyl cellulose are put
In mixer, carry out shearing, stir, make mixing 10min；
(3) triacetyl glycerine is dissolved in ethanol in the ratio of 1:1, adds in the material that step (2) mixes and stir
10min；
(4) being placed in drying baker by the wet feed that step (3) mixes, keep the temperature inside the box to be 50 DEG C and be dried, drying time is 20
Minute；
(5) by step (4) dried material adds microcrystalline Cellulose, after correctives and coloring agent uniformly mix, it is placed in powder
Broken machine is pulverized, crosses 50 mesh sieves, get product.
Claims (2)
1. a reinforced membranes coating pre-mixing agent, is made up of following raw material precentagewise: hydroxypropyl methyl cellulose 35%～
65%, polyvinyl alcohol polyethyleneglycol-graft copolymer 5%～15%, PVP K30 2%～8%, ethyl cellulose 0.5%
～3%, triacetyl glycerine 2%～5%, microcrystalline Cellulose 15%～25%, coloring agent 0.6%～4%, correctives 0.8%
～3%.
A kind of reinforced membranes coating pre-mixing agent the most according to claim 1, it is characterised in that: a kind of reinforced membranes bag
The preparation method of clothing pre-mixing agent is as follows:
(1) precentagewise takes raw material: hydroxypropyl methyl cellulose, polyvinyl alcohol polyethyleneglycol-graft copolymer, polyvidone
K30, ethyl cellulose, triacetyl glycerine, microcrystalline Cellulose, coloring agent, correctives, standby；
(2) hydroxypropyl methyl cellulose, polyvinyl alcohol polyethyleneglycol-graft copolymer, PVP K30, ethyl cellulose are put
In mixer, carry out shearing, stir, make mixing 10min；
(3) triacetyl glycerine is dissolved in ethanol in the ratio of 1:1, adds in the material that step (2) mixes and stir
10min；
(4) being placed in drying baker by the wet feed that step (3) mixes, keep the temperature inside the box to be 55 ± 5 DEG C and be dried, drying time is
10-20 minute；
(5) by step (4) dried material adds microcrystalline Cellulose, after correctives and coloring agent uniformly mix, it is placed in powder
Broken machine is pulverized, crosses 50 mesh sieves, get product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610703779.2A CN106139157A (en) | 2016-08-23 | 2016-08-23 | A kind of reinforced membranes coating pre-mixing agent and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610703779.2A CN106139157A (en) | 2016-08-23 | 2016-08-23 | A kind of reinforced membranes coating pre-mixing agent and preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106139157A true CN106139157A (en) | 2016-11-23 |
Family
ID=57341749
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610703779.2A Pending CN106139157A (en) | 2016-08-23 | 2016-08-23 | A kind of reinforced membranes coating pre-mixing agent and preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106139157A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020055794A (en) * | 2018-09-28 | 2020-04-09 | 三菱ケミカル株式会社 | Film coating composition, solid preparation and method for producing solid preparation |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102512401A (en) * | 2012-01-16 | 2012-06-27 | 北京英茂药业有限公司 | Water-soluble film coated premix agent |
-
2016
- 2016-08-23 CN CN201610703779.2A patent/CN106139157A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102512401A (en) * | 2012-01-16 | 2012-06-27 | 北京英茂药业有限公司 | Water-soluble film coated premix agent |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020055794A (en) * | 2018-09-28 | 2020-04-09 | 三菱ケミカル株式会社 | Film coating composition, solid preparation and method for producing solid preparation |
| JP7363189B2 (en) | 2018-09-28 | 2023-10-18 | 三菱ケミカル株式会社 | Film coating composition, solid preparation, and method for producing solid preparation |
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| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20161123 |
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| RJ01 | Rejection of invention patent application after publication |