CN106138039A - A kind of epiphysin preparation improving sleep and preparation method thereof - Google Patents

A kind of epiphysin preparation improving sleep and preparation method thereof Download PDF

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Publication number
CN106138039A
CN106138039A CN201610508434.1A CN201610508434A CN106138039A CN 106138039 A CN106138039 A CN 106138039A CN 201610508434 A CN201610508434 A CN 201610508434A CN 106138039 A CN106138039 A CN 106138039A
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parts
epiphysin
preparation
sleep
starch
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蒋健强
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Guangzhou Liancun Medicine Technology Co Ltd
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Guangzhou Liancun Medicine Technology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • A61K31/4045Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2833Organic macromolecular compounds
    • A61K9/286Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

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  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention discloses a kind of epiphysin preparation improving sleep and preparation method thereof.Including the raw material of following weight portion, epiphysin 1~3 part, starch 130~170 parts, white granulated sugar 100~156 parts, 70~144 parts of dextrin, talcum powder 2~6 parts, magnesium stearate 2~6 parts and sodium carboxymethylcellulose 0.2~2 part.The epiphysin preparation improving sleep of the present invention has that safety non-toxic, good mouthfeel, dose be few and the feature of no dependence.Test shows, the epiphysin preparation of the present invention can significantly extend yellow Jackets lengths of one's sleep, collaborative yellow Jackets sub-threshold dose syngignoscism and shorten barbital sodium Sleep latency, has the function significantly improving sleep.

Description

A kind of epiphysin preparation improving sleep and preparation method thereof
Technical field:
The invention belongs to technical field of health care products, be specifically related to a kind of epiphysin preparation improving sleep and preparation thereof Method.
Background technology:
In all one's life of people, the time of about 1/3rd is had to spend in sleep, the quality of sleep and healthy breath manner of breathing Close.Medical research shows, insomnia once in a while can cause second day tired and exercise not harmony, and chronic insomnia then can bring notice not Can concentrate, there is obstacle in memory and the consequence such as unable to do what one wishes that works, and meanwhile, not having enough sleep to make body immunity decline, disease-resistant Reduce with rehabilitation ability, usually can easily send out flu, and have the possibility increasing the weight of other diseases or inducing original disease.
The product variety improving sleep in the market is a lot, and wherein most is all Chinese patent drug composition, with epiphysin is Raw material of less types, formulation has oral liquid, capsule, medicinal tea, tablet etc., and mouthfeel is poor.
Epiphysin is the hormone of a kind of human endogenous's property, the sleep of chief leading cadre's body, clear-headed cycle.Pineal body secretion is taken off Melanocyte, when the evening draws on, pineal body discharges epiphysin, makes temperature decline, and heart rates slows down, and brain is transferred to by excitement and pressing down System, enters sleep state.As dawn gradually reveals, the secretory volume of epiphysin can be gradually lowered, and daytime, the secretory volume of epiphysin was not enough The 50% of night, here it is the rule of epiphysin daily rhythmicity change.
Content of the invention:
First purpose of the present invention is to provide that a kind of safety non-toxic, good mouthfeel, dose be few, the improvement of no dependence Epiphysin preparation of sleep and preparation method thereof.
A kind of epiphysin preparation improving sleep, including the raw material of following weight portion, epiphysin 1~3 part, starch 130~ 170 parts, white granulated sugar 100~156 parts, 70~144 parts of dextrin, talcum powder 2~6 parts, magnesium stearate 2~6 parts and carboxymethyl cellulose 0.2~2 part of sodium of element.
Preferably, including the raw material of following weight portion, epiphysin 2~3 parts, starch 150~170 parts, white granulated sugar 120~150 Part, 90~130 parts of dextrin, talcum powder 4~5 parts, magnesium stearate 4~6 parts and sodium carboxymethylcellulose 0.5~1 part.
Preferably, including the raw material of following weight portion, epiphysin 3 parts, starch 150 parts, white granulated sugar 128 parts, 110 parts of dextrin, Talcum powder 4 parts, magnesium stearate 4 parts and sodium carboxymethylcellulose 1 part.
Preferably, by weight, film coating agent 8~16 parts is also included.
Described film coating agent, including the raw material of following weight portion: Hydroxypropyl methylcellulose 3.6 parts, talcum powder 3.6 parts, Titanium dioxide 0.8 part, 1,2-PD 1.3 parts and Tween-80 1.3 parts.
Second object of the present invention is to provide the preparation method of a kind of above-mentioned epiphysin preparation improving sleep, including Following steps: a) by required weight portion in the above-mentioned epiphysin preparation improving sleep weigh respectively epiphysin, starch, dextrin, White granulated sugar, talcum powder and magnesium stearate sieve after pulverizing;B) sodium carboxymethylcellulose of required weight portion is dissolved in the water Sodium carboxymethylcellulose is starched;C) mixed material is obtained after epiphysin, starch, dextrin and white granulated sugar being mixed;D) by mixture Material mixes with sodium carboxymethylcellulose slurry, and through pelletizing, grain dry, whole obtains dry particle;E) by dry particle and talcum powder, hard Fatty acid magnesium obtains, after mixing, the material always mixing, and obtains improving the epiphysin preparation of sleep through compressing tablet, coating.
Preferably, described sodium carboxymethylcellulose slurry is starched for the sodium carboxymethylcellulose that mass fraction is 2%.
Described epiphysin, starch, dextrin and white granulated sugar are mixed after mixed material is by equal increments mixing Epiphysin and starch are first mixed by method, obtain mixed material with dextrin, white granulated sugar after then mixing.
The epiphysin preparation improving sleep of the present invention has that safety non-toxic, good mouthfeel, dose be few and no dependence Feature.Test shows, the epiphysin preparation of the present invention can significantly extend yellow Jackets lengths of one's sleep, collaborative amobarbital Sodium sub-threshold dose syngignoscism and shortening barbital sodium Sleep latency, have the function significantly improving sleep.
Brief description:
Fig. 1 is the preparation flow figure of the epiphysin preparation improving sleep of the present invention.
Detailed description of the invention:
Following example are to further illustrate the present invention, rather than limitation of the present invention.
Embodiment 1: improve the preparation of the epiphysin preparation A of sleep
The epiphysin preparation improving sleep of the present embodiment, including following raw material: epiphysin 3kg, starch 150kg, white sand Sugar 128kg, dextrin 110kg, talcum powder 4kg, magnesium stearate 4kg, sodium carboxymethylcellulose 1kg and film coating agent 10.6kg.
Improve the preparation method (as shown in Figure 1) of the epiphysin preparation A of sleep, comprise the following steps:
Step 1) weigh after the epiphysin of formula ratio, starch, white granulated sugar and dextrin are pulverized and cross 100 mesh sieves;Weigh formula ratio Talcum powder and magnesium stearate pulverize after cross 40 mesh sieves, standby;
Step 2) sodium carboxymethylcellulose of formula ratio is joined in purified water, it is heated to 50-60 DEG C, stirring is to carboxylic first Base sodium cellulosate is completely dissolved, and becomes clear transparent solutions, makes the sodium carboxymethylcellulose slurry that mass fraction is 2%, standby;
Step 3) press equal increments mixing method, first epiphysin and starch are mixed, then mix with dextrin, white granulated sugar Close, obtain mixed material;
Step 4) the sodium carboxymethylcellulose slurry that mixed material and mass fraction are 2% is mixed, cross 16 mesh sieve systems Grain, obtains wet granular, standby;
Step 5) use chamber dryer to be dried wet granular, baking temperature is 55-50 DEG C, and drying time is 1-3 Hour, be dried after 15min and stir dish endoparticle, make particles by heat uniform, obtain dry particle, the moisture of dry particle control≤ 5%;
Step 6) dry particle is crossed 16 mesh sieves carry out whole grain;
Step 7) the dry particle after whole grain and talcum powder, magnesium stearate always to be mixed, incorporation time is 15-30 minute, Obtain total mixed material;
Step 8) compressing tablet is carried out to total mixed material, obtain element piece;
Step 9) ethanol that the film coating agent volume fraction of formula ratio is 70% is made mass fraction is 9.5- The film coating slurry of 12%, puts into element piece in seed-coating machine, is subsequently adding film coating slurry, makes element piece wrap film-coating, obtains Improve the epiphysin preparation A of sleep.
Above-mentioned film coating agent, including the raw material of following weight portion: Hydroxypropyl methylcellulose 3.6 parts, talcum powder 3.6 parts, Titanium dioxide 0.8 part, 1,2-PD 1.3 parts and Tween-80 1.3 parts.
Embodiment 2: improve the preparation of the epiphysin preparation B of sleep
The epiphysin preparation improving sleep of the present embodiment, including following raw material: epiphysin 1kg, starch 130kg, white sand Sugar 120kg, dextrin 144kg, talcum powder 5kg, magnesium stearate 2kg, sodium carboxymethylcellulose 0.5kg and film coating agent 8kg.
The preparation method of the epiphysin preparation B improving sleep is identical with the preparation method of embodiment 1.
The formula of the film coating agent of the present embodiment is identical with the formula of embodiment 1.
Embodiment 3: improve the preparation of the epiphysin formulation C of sleep
The epiphysin preparation improving sleep of the present embodiment, including following raw material: epiphysin 2kg, starch 170kg, white sand Sugar 150kg, dextrin 70kg, talcum powder 2kg, magnesium stearate 4kg, sodium carboxymethylcellulose 2kg and film coating agent 12kg.
The preparation method of the epiphysin formulation C improving sleep is identical with the preparation method of embodiment 1.
The formula of the film coating agent of the present embodiment is identical with the formula of embodiment 1.
Embodiment 4: improve the preparation of the epiphysin preparation D of sleep
The epiphysin preparation improving sleep of the present embodiment, including following raw material: epiphysin 2kg, starch 130kg, white sand Sugar 100kg, dextrin 70kg, talcum powder 6kg, magnesium stearate 6kg, sodium carboxymethylcellulose 0.2kg and film coating agent 8.8kg.
The preparation method of the epiphysin preparation D improving sleep is identical with the preparation method of embodiment 1.
The formula of the film coating agent of the present embodiment is identical with the formula of embodiment 1.
Embodiment 5: improve the preparation of the epiphysin preparation E of sleep
The epiphysin preparation improving sleep of the present embodiment, including following raw material: epiphysin 3kg, starch 130kg, white sand Sugar 156kg, dextrin 90kg, talcum powder 4kg, magnesium stearate 4kg, sodium carboxymethylcellulose 2kg and film coating agent 16kg.
The preparation method of the epiphysin preparation E improving sleep is identical with the preparation method of embodiment 1.
The formula of the film coating agent of the present embodiment is identical with the formula of embodiment 1.
Embodiment 6: epiphysin preparation toxicological assessment is tested
Toxicological safety is carried out to the epiphysin preparation A~E improving sleep of embodiments of the invention 1~embodiment 5 Evaluation test.Check conclusion: 1. acute oral toxicity test: give to change with maximum dosage-feeding (dosage is 30000mg/kg BW) After the epiphysin preparation of kind sleep, having no that mouse has poisoning symptom, without animal dead, animal, gross examination of skeletal muscle are dissected in off-test No abnormality seen, belongs to non-poisonous material.2. genetic toxicity test: three genetic toxicity tests (Ames, mouse marrow cell micro nuclear test, Mouse inbred strain) result is feminine gender.3.30 days feeding trials: with the 667th, the 500th, 333mg/kg BW (be respectively equivalent to Human body recommends consumption the 100th, the 75th, 50 times) the epiphysin preparation improving sleep of 3 dosage is continuously to rat oral gavage 30 days, experiment Growing of period animal is good, and the weight of animals of each dosage group, gain in weight, food-intake, food utilization, routine blood test refer to Mark, blood biochemistry index, organ weights and internal organs/body weight ratio compare with control group, difference that there are no significant (P > 0.05);Substantially Anatomic observation and histopathological examination have no the abnormal change relevant with the epiphysin preparation improving sleep.Prompting has no that this changes The epiphysin preparation of kind sleep feeds the toxic effect to rat in 30 days.
Embodiment 7: epiphysin preparation improves sleep function test
1 material and method
1.1 samples: the epiphysin preparation A improving sleep being prepared by embodiment 1, specification is 0.4g/ piece.Put shady and cool dry and comfortable Ventilation preserves.People is oral recommends consumption to be everyone (adult) every day 1 time, and 1 every time, adult's body weight press 60kg calculating, converts into Dosage is 6.7mg/kg BW.
1.2 animals used as test and packet: select the cleaning grade (II level) of Guangxi Medical University's medical experiment animal center breeding Healthy adult Male Kunming strain mice 192, body weight is 18~22 grams, animal used as test production licence number: SCXK osmanthus 2003- 0003.Every 48 mouse are 1 group, totally 4 groups, carry out respectively direct sleep laboratory, extend test yellow Jackets lengths of one's sleep, penta Barbital sodium sub-threshold dose hypnosis test, barbital sodium Sleep Latency Test.
1.3 experimental situation conditions: animal used as test room temperature: 22~25 DEG C, relative humidity: 55~70%.Animal used as test makes With credit number: SYXK osmanthus 2006-0001.
1.4 dosage choice and the epiphysin preparation A process improving sleep: the epiphysin preparation A's according to this improvement sleep Human body recommends consumption, if the 33.6th, the 67.0th, 134.0mg/kg BW (be respectively equivalent to human body and recommend the 5th, the 10th, 20 times of consumption) 3 The test group of dosage, sets a negative control group simultaneously, often organizes 12 animals.Epiphysin preparation A because improving sleep is insoluble in Water, therefore with 3% food starch solution preparation.Weigh the epiphysin preparation A of the 0.168th, the 0.335th, 0.670g improvement sleep respectively, respectively Add 3% food starch solution to l00mL, mix, be made into the 1.68th, the 3.35th, 6.70mg/mL strength solution, give corresponding agent respectively Amount treated animal gavage, gavage volume is 0.2mL/l0g BW, and negative control group gives isopyknic distilled water, every day gavage one Secondary, continuous 30 days.
1.5 key instruments and reagent:
Instrument: animal platform balance, electronic analytical balance, stopwatch etc..
Reagent: yellow Jackets (lot number: F20030816), barbital sodium (lot number: 20040428), Chinese Medicine (collection Group) the import packing of Solution on Chemical Reagents in Shanghai company.
1.6 experimental techniques:
1.6.1 direct sleep laboratory: observe the sleep quality of mouse after to last sample, disappear with the righting reflex of animal Quenching 60 seconds and being judged to enter sleep, righting reflex recovers to be animal awakening.Result X2Inspection carries out statistical analysis.Such as examination Test group sleep number of animals and the length of one's sleep increases and has significant difference with negative control group, i.e. judge this result of the test as sun Property.
1.6.2 the yellow Jackets test length of one's sleep is extended: after to last sample 20 minutes, each treated animal is noted through abdominal cavity Penetrating yellow Jackets 45mg/kg BW, injection volume is 0.2mL/20g BW.With the righting reflex loss of animal as index, observation changes Can the epiphysin preparation A of kind sleep extend yellow Jackets lengths of one's sleep.Result variance analysis carries out statistical analysis.Such as examination The length of one's sleep testing group mouse extends and statistically significant than negative control group, i.e. judges this result of the test as the positive.
1.6.3 yellow Jackets sub-threshold dose hypnosis test: after to last sample 20 minutes, each treated animal is noted through abdominal cavity Penetrate yellow Jackets 30mg/kg BW.The sleep quality of mouse in observing 30 minutes, with righting reflex loss, more than 60 seconds persons are Fall asleep, record the sleep number of animals of each group, calculate sleep animal incidence.Result X2Check analysis.As test group is fallen asleep dynamic Thing incidence is higher than negative control group statistically significant, i.e. judges this result of the test as the positive.
1.6.4 barbital sodium Sleep latency experiment: each treated animal after to last sample 20 minutes through lumbar injection bar The appropriate sodium 300mg/kg BW of ratio, injection volume is 0.2mL/20g BW.With righting reflex loss as index, observe and improve taking off of sleep Can melanocyte preparation A shorten barbital sodium Sleep latency.Result variance analysis carries out statistical analysis.Such as test group mouse Sleep latency shortens and statistically significant than negative control group, i.e. judges this result of the test as the positive.
1.7 results judge
If mesh slept by the prolongation yellow Jackets experiment length of one's sleep, yellow Jackets sub-threshold dose hypnosis experiment, barbital sodium It is positive that the people test binomial in three experiments incubation period, and without substantially direct sleep effect, can determine that the epiphysin that this improvement is slept Preparation A has and improves sleep function effect.
2 results
2.1 improve the impact on Mouse Weight for the epiphysin preparation A of sleep
The epiphysin preparation A that table 1 improves sleep improves sleep function test mice body weight
Note: P value represents that each dosage group tests initial, mid-term and Mouse Weight and the weightening finish in latter stage are compared with control group, poor It is different that there are no significant.
From table 1, experiment initial stage, experiment mid-term, experiment improve the little of each dosage group of epiphysin preparation A of sleep latter stage Mouse Weight growth during mouse body weight and experiment is compared with between negative control group, and there are no significant for difference (P > 0.05), shows this Improve the body weight growth to mouse for the epiphysin preparation A sleeping to have no significant effect.
The direct sleep effect of the 2.2 epiphysin preparation A improving sleep
As seen from Table 2, per os gives epiphysin preparation A30 days improving sleep of mouse various dose, and each dosage group is equal Do not have animal righting reflex loss occur, i.e. all animals does not all enter into sleep state, points out the epiphysin that this improvement is slept Preparation A does not has the effect that direct inducing mouse is slept.
Table 2 improves the direct sleep laboratory result of epiphysin preparation A mouse of sleep
2.3 improve the impact on the yellow Jackets length of one's sleep for the epiphysin preparation A of sleep
The epiphysin preparation A that table 3 improves sleep extends the yellow Jackets result of the test length of one's sleep
As seen from Table 3, per os gives epiphysin preparation A30 days improving sleep of mouse various dose, and each dosage group is little The length of one's sleep of mouse all extends than negative control group, and dosage group high, middle therein has conspicuousness with the difference of negative control group (respectively P < 0.01 and P < 0.05), the epiphysin preparation A pointing out this improvement sleep has prolongation yellow Jackets lengths of one's sleep Effect.
2.4 improve the impact on yellow Jackets sub-threshold dose syngignoscism for the epiphysin preparation A of sleep
As seen from Table 4, per os gives epiphysin preparation A30 days improving sleep of mouse various dose, each dosage group Animal sleep rate is higher than negative control group, and high dose group therein has conspicuousness (P < 0.05) with the difference of negative control group, The epiphysin preparation A pointing out this improvement to sleep plays the role of collaborative hypnosis with the yellow Jackets of sub-threshold dose.
Table 4 improves the epiphysin preparation A yellow Jackets sub-threshold dose hypnosis test result of sleep
The 2.5 epiphysin preparation A preclinical impacts on barbital sodium hypnosis improving sleep
Table 5 improves the epiphysin preparation A barbital sodium Sleep Latency Test result of sleep
As seen from Table 5, per os gives the epiphysin preparation A 30 days improving sleep of mouse various dose, and each dosage group is little The all ratio shortenings of negative control group of the Sleep latency of mouse, and the difference of each dosage group and negative control group is respectively provided with conspicuousness (P < 0.01 or P < 0.05), the epiphysin preparation A pointing out this improvement to sleep has the effect that Sleep latency slept by shortening barbital sodium.
3 results judge
Respectively with the 33.6th, the 67.0th, the changing of 134.0mg/kg BW (be equivalent to human body and recommend the 5th, the 10th, 20 times of consumption) dosage The epiphysin preparation A of kind sleep gives mouse stomach 30 days continuously, can extend yellow Jackets lengths of one's sleep, collaborative yellow Jackets Sub-threshold dose syngignoscism, shorten barbital sodium Sleep latency, without direct sleep effect, on the body weight of mouse without impact, carry Show that the epiphysin preparation A that this improvement is slept has the function improving sleep.
The epiphysin preparation B~E of embodiment 2~embodiment 5 also draws identical conclusion.

Claims (8)

1. the epiphysin preparation improving sleep, it is characterised in that include the raw material of following weight portion, epiphysin 1~3 part, Starch 130~170 parts, white granulated sugar 100~156 parts, 70~144 parts of dextrin, talcum powder 2~6 parts, magnesium stearate 2~6 parts and carboxylic Sodium carboxymethylcellulose pyce 0.2~2 part.
2. the epiphysin preparation improving sleep according to claim 1, it is characterised in that include the former of following weight portion Material is epiphysin 2~3 parts, starch 150~170 parts, white granulated sugar 120~150 parts, 90~130 parts of dextrin, talcum powder 4~5 parts, hard Fatty acid magnesium 4~6 parts and sodium carboxymethylcellulose 0.5~1 part.
3. the epiphysin preparation improving sleep according to claim 2, it is characterised in that include the former of following weight portion Material, epiphysin 3 parts, starch 150 parts, white granulated sugar 128 parts, 110 parts of dextrin, talcum powder 4 parts, magnesium stearate 4 parts and carboxymethyl are fine Dimension 1 part of sodium of element.
4. the epiphysin preparation improving sleep according to claim the 1st, 2 or 3, it is characterised in that by weight, also wrap Include film coating agent 8~16 parts.
5. the epiphysin preparation improving sleep according to claim 4, it is characterised in that described film coating agent, bag Include the raw material of following weight portion: Hydroxypropyl methylcellulose 3.6 parts, talcum powder 3.6 parts, titanium dioxide 0.8 part, 1,2-PD 1.3 Part and Tween-80 1.3 parts.
6. the preparation method of claim the 1st, the epiphysin preparation improving sleep described in 2 or 3, it is characterised in that include Following steps: a) as described in claim the 1st, 2 or 3 improve sleep epiphysin preparation in required weight portion weigh respectively take off black Element, starch, dextrin, white granulated sugar, talcum powder and magnesium stearate sieve after pulverizing;B) sodium carboxymethylcellulose by required weight portion Be dissolved in the water to obtain sodium carboxymethylcellulose slurry;C) mixture is obtained after epiphysin, starch, dextrin and white granulated sugar being mixed Material;D) mixing mixed material with sodium carboxymethylcellulose slurry, through pelletizing, grain dry, whole obtains dry particle;E) by dry Grain obtains, after mixing with talcum powder, magnesium stearate, the material always mixing, and obtains improving the epiphysin system of sleep through compressing tablet, coating Agent.
7. preparation method according to claim 6, it is characterised in that described sodium carboxymethylcellulose slurry is mass fraction It is the sodium carboxymethylcellulose slurry of 2%.
8. preparation method according to claim 6, it is characterised in that described by epiphysin, starch, dextrin and white granulated sugar After mixing mixed material is first to mix epiphysin and starch by equal increments mixing method, then with dextrin, white Granulated sugar obtains mixed material after mixing.
CN201610508434.1A 2016-06-29 2016-06-29 A kind of epiphysin preparation improving sleep and preparation method thereof Pending CN106138039A (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111407761A (en) * 2020-04-28 2020-07-14 广东润源中天生物科技有限公司 Melatonin vitamin B6 tablet and production method thereof
CN114246834A (en) * 2021-12-30 2022-03-29 宣城柏维力生物工程有限公司 Melatonin orally disintegrating preparation for improving sleep and production process thereof

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CN101143135A (en) * 2007-10-10 2008-03-19 徐贵丽 Melatonin orally disintegrating tablet and preparation method thereof
CN104248630A (en) * 2014-09-11 2014-12-31 常州欧法玛制药技术有限公司 Melatonin-containing double-layered osmotic pump controlled release tablet and preparation method thereof
CN105106201A (en) * 2015-09-17 2015-12-02 福建省幸福生物科技有限公司 Melatonin healthcare capsule for improving sleeping
CN105663061A (en) * 2014-11-16 2016-06-15 刘佳迪 Preparation method and application method for melatonin dropping pill

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101143135A (en) * 2007-10-10 2008-03-19 徐贵丽 Melatonin orally disintegrating tablet and preparation method thereof
CN104248630A (en) * 2014-09-11 2014-12-31 常州欧法玛制药技术有限公司 Melatonin-containing double-layered osmotic pump controlled release tablet and preparation method thereof
CN105663061A (en) * 2014-11-16 2016-06-15 刘佳迪 Preparation method and application method for melatonin dropping pill
CN105106201A (en) * 2015-09-17 2015-12-02 福建省幸福生物科技有限公司 Melatonin healthcare capsule for improving sleeping

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111407761A (en) * 2020-04-28 2020-07-14 广东润源中天生物科技有限公司 Melatonin vitamin B6 tablet and production method thereof
CN111407761B (en) * 2020-04-28 2021-06-18 广东润源中天生物科技有限公司 Melatonin vitamin B6 tablet and production method thereof
CN114246834A (en) * 2021-12-30 2022-03-29 宣城柏维力生物工程有限公司 Melatonin orally disintegrating preparation for improving sleep and production process thereof

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